Direct evidence that apoptosis enhances tumor responses to fractionated radiotherapy

Cancer Research

Volumn 58, Issue 9, 1998, Pages 1779-1784

  Rupnow, Brent A ^a   Murtha, Albert D ^a   Alarcon, Rodolfo M ^a   Giaccia, Amato J ^a   Knox, Susan J ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYTAMOXIFEN;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER RADIOTHERAPY; CELL CULTURE; CONTROLLED STUDY; DNA NICK TRANSLATION; FIBROBLAST; GENE OVEREXPRESSION; GENETIC REGULATION; GROWTH RATE; IONIZING RADIATION; LYMPHATIC SYSTEM TUMOR; MOUSE; MULTIMODALITY CANCER THERAPY; NONHUMAN; OUTCOMES RESEARCH; PRIORITY JOURNAL; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RADIOSENSITIVITY; SOLID TUMOR; SURVIVAL RATE; TUMOR GROWTH;

ANIMALS; APOPTOSIS; CELL LINE; CELL SURVIVAL; COMBINED MODALITY THERAPY; DNA FRAGMENTATION; DOSE FRACTIONATION; ESTROGEN ANTAGONISTS; FIBROBLASTS; MALE; MICE; MICE, SCID; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-MYC; RADIATION, IONIZING; RATS; SEVERE COMBINED IMMUNODEFICIENCY; TAMOXIFEN;

EID: 0032080807     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Lichter, A. S., and Lawrence, T. S. Recent advances in radiation oncology. N. Engl. J. Med., 332: 371-379, 1995.
2. Hall, E. J. Radiobiology for the Radiologist, 4th ed. Philadelphia: J. B. Lippincott Co. 1994.
3. Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Jr., Butel, J. S., and Bradley, A. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature (Lond.), 356: 215-221, 1992.
4. Williams, B. O., Remington, L., Albert, D. M., Mukai, S., Bronson, R. T., and Jacks, T. Cooperative tumorigenic effects of germline mutations in Rb and p53. Nat. Genet., 7: 480-484, 1994.
5. Kemp, C. J., Wheldon, T., and Balmain, A. p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis. Nat. Genet., 8: 66-69, 1994.
6. Symonds, H., Krall, L., Remington, L., Saenz-Robles, M., Lowe, S., Jacks, T., and Van Dyke, T. p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell, 78: 703-711, 1994.
7. Donehower, L. A., Godley, L. A., Aldaz, C. M., Pyle, R., Shi, Y. P., Pinkel, D., Gray, J., Bradley, A., Medina, D., and Varmus, H. E. Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability. Genes Dev., 9: 882-895, 1995.
8. Yin, C., Knudson, C. M., Korsmeyer, S. J., and Van Dyke, T. Bax supresses tumorigenesis and stimulates apoptosis in vivo. Nature (Lond.), 385: 637-640, 1997.
9. Graeber, T. G., Osmanian, C., Jacks, T., Housman, D. E., Koch, C. J., Lowe, S. W., and Giaccia, A. J. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature (Lond.), 379: 88-91, 1996.
10. Evan, G. I., Wyllie, A. H., Gilbert, C. S., Littlewood, T. D., Land, H., Brooks, M., Waters, C. M., Penn, L. Z., and Hancock, D. C. Induction of apoptosis in fibroblasts by c-myc protein. Cell, 69: 119-128, 1992.
11. Lee, J. M., and Bernstein, A. p53 mutations increase resistance to ionizing radiation. Proc. Natl. Acad. Sci. USA, 90: 5742-5746, 1993.
12. Lowe, S. W., Ruley, H. E., Jacks, T., and Housman, D. E. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell, 74: 957-967, 1993.
13. Haas-Kogan, D. A., Kogan, S. C., Levi, D., Dazin, P., T'Ang, A., Fung, Y. K., and Israel, M. A. Inhibition of apoptosis by the retinoblastoma gene product. EMBO J., 14: 461-472, 1995.
14. Strasser, A., Harris, A. W., Jacks, T., and Cory, S. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell, 79: 329-339, 1994.
15. Lowe, S. W., Bodis, S., McClatchey, A., Remington, L., Ruley, H. E., Fisher, D. E., Housman, D. E., and Jacks, T. p53 status and the efficacy of cancer therapy in vivo. Science (Washington DC), 266: 807-810, 1994.
16. Waldman, T., Zhang, Y., Dillehay, L., Yu, J., Kinzler, K., Vogelstein, B., and Williams, J. Cell-cycle arrest versus cell death in cancer therapy. Nat. Med., 3: 1034-1036, 1997.
17. Waf1/Cip1 sensitizes tumors to radiation by an apoptosis-independent mechanism. Cancer Res., 57: 4703-4706, 1997.
18. Lamb, J. R., and Friend, S. H. Which guesstimate is the best guesstimate? Predicting chemotherapeutic outcomes. Nat. Med., 3: 962-963, 1997.
19. Gura, T. Systems for identifying new drugs are often faulty. Science (Washington DC), 278: 1041-1042, 1997.
20. Alarcon, R. M., Rupnow, B. A., Graeber, T. G., Knox, S. J., and Giaccia, A. J. Modulation of c-Myc activity and apoptosis in vivo. Cancer Res., 56: 4315-4319, 1996.
21. Littlewood, T. D., Hancock, D. C., Danielian, P. S., Parker, M. G., and Evan, G. I. A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res., 23: 1686-1690, 1995.
22. Nicoletti, I., Migliorati, G., Pagliacci, M. C. Grignani, F., and Riccardi, C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods, 139: 271-279, 1991.
23. Wagner, A. J., Small, M. B., and Hay, N. Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2. Mol. Cell. Biol., 13: 2432-2440, 1993.