메뉴 건너뛰기




Volumn 16, Issue 9, 1996, Pages 4961-4971

A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BAX; PROTEIN P53; SOMATOMEDIN BINDING PROTEIN 3;

EID: 0029783722     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.9.4961     Document Type: Article
Times cited : (269)

References (89)
  • 1
    • 0025040233 scopus 로고
    • Suppression of human colorectal carcinoma cell growth by wild-type p53
    • Baker, S. J., S. Markowitz, E. R. Fearon, J. K. V. Willson, and B. Vogelstein. 1990. Suppression of human colorectal carcinoma cell growth by wild-type p53. Science 249:912-915.
    • (1990) Science , vol.249 , pp. 912-915
    • Baker, S.J.1    Markowitz, S.2    Fearon, E.R.3    Willson, J.K.V.4    Vogelstein, B.5
  • 3
    • 0028049474 scopus 로고
    • Regulation of mdm2 expression by p53: Alternative promoters produce transcripts with nonidentical translation potential
    • Barak, Y., E. Gottlieb, T. Juven-Gershon, and M. Oren. 1994. Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential. Genes Dev. 8:1739-1749.
    • (1994) Genes Dev. , vol.8 , pp. 1739-1749
    • Barak, Y.1    Gottlieb, E.2    Juven-Gershon, T.3    Oren, M.4
  • 4
    • 0026686753 scopus 로고
    • Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53
    • Bargonetti, J., I. Reynisdottir, P. N. Friedman, and C. Prives. 1992. Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53. Genes Dev. 6:1886-1898.
    • (1992) Genes Dev. , vol.6 , pp. 1886-1898
    • Bargonetti, J.1    Reynisdottir, I.2    Friedman, P.N.3    Prives, C.4
  • 5
    • 0028579733 scopus 로고
    • Oncogenes and the strategy of growth factors
    • Baserga, R. 1994. Oncogenes and the strategy of growth factors. Cell 79: 927-930.
    • (1994) Cell , vol.79 , pp. 927-930
    • Baserga, R.1
  • 6
    • 0029078067 scopus 로고
    • The carboxy-terminal domain of the p53 protein regulates sequence-specific DNA binding through its nonspecific nucleic acid-binding activity
    • Bayle, J. H., B. Elenbaas, and A. J. Levine. 1995. The carboxy-terminal domain of the p53 protein regulates sequence-specific DNA binding through its nonspecific nucleic acid-binding activity. Proc. Natl. Acad. Sci. USA 92:5729-5733.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5729-5733
    • Bayle, J.H.1    Elenbaas, B.2    Levine, A.J.3
  • 10
    • 0028070989 scopus 로고
    • p53-dependent apoptosis is not mediated by transcriptional activation of p53-target genes
    • Caelles, A. M., A. Helmberg, and M. Karin. 1994. p53-dependent apoptosis is not mediated by transcriptional activation of p53-target genes. Nature 370:220-223.
    • (1994) Nature , vol.370 , pp. 220-223
    • Caelles, A.M.1    Helmberg, A.2    Karin, M.3
  • 11
    • 0028958705 scopus 로고
    • Growth factor modulation of p53-mediated growth arrest verses apoptosis
    • Canman, C., E. T. M. Gilmer, S. B. Coutts, and M. B. Kastan. 1995. Growth factor modulation of p53-mediated growth arrest verses apoptosis. Genes Dev. 9:600-611.
    • (1995) Genes Dev. , vol.9 , pp. 600-611
    • Canman, C.1    Gilmer, E.T.M.2    Coutts, S.B.3    Kastan, M.B.4
  • 12
    • 0029033333 scopus 로고
    • p53, through p21 (WAF1/CIP1), induces cyclin D1 synthesis
    • Chen, X., J. Bargonetti, and C. Prives. 1995. p53, through p21 (WAF1/CIP1), induces cyclin D1 synthesis. Cancer Res. 55:4257-4263.
    • (1995) Cancer Res. , vol.55 , pp. 4257-4263
    • Chen, X.1    Bargonetti, J.2    Prives, C.3
  • 13
    • 0028222955 scopus 로고
    • Bcl-2 blocks p53-dependent apoptosis
    • Chiou, S.-K., L. Rao, and E. White. 1994. Bcl-2 blocks p53-dependent apoptosis. Mol. Cell. Biol. 14:2556-2563.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 2556-2563
    • Chiou, S.-K.1    Rao, L.2    White, E.3
  • 15
    • 0028131554 scopus 로고
    • Transcriptional activation by p53 correlates with suppression of growth but not transformation
    • Crook, T., N. Marston, E. Sara, and K. Vousden. 1994. Transcriptional activation by p53 correlates with suppression of growth but not transformation. Cell 79:617-627.
    • (1994) Cell , vol.79 , pp. 617-627
    • Crook, T.1    Marston, N.2    Sara, E.3    Vousden, K.4
  • 16
    • 0027251720 scopus 로고
    • Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B
    • Debbas, M., and E. White. 1993. Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B. Genes Dev. 7:546-554.
    • (1993) Genes Dev. , vol.7 , pp. 546-554
    • Debbas, M.1    White, E.2
  • 17
    • 0028157171 scopus 로고
    • Subcellular localization of the bcl-2 protein in malignant and normal lymphoid cells
    • de Jong, D., F. A. Prins, D. Y. Mason, J. C. Reed, G. B. van Ommen, and P. M. Kluin. 1994. Subcellular localization of the bcl-2 protein in malignant and normal lymphoid cells. Cancer Res. 54:256-260.
    • (1994) Cancer Res. , vol.54 , pp. 256-260
    • De Jong, D.1    Prins, F.A.2    Mason, D.Y.3    Reed, J.C.4    Van Ommen, G.B.5    Kluin, P.M.6
  • 18
    • 0028978183 scopus 로고
    • CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
    • CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82:675-684.
    • (1995) Cell , vol.82 , pp. 675-684
    • Deng, C.1    Zhang, P.2    Harper, J.W.3    Elledge, S.J.4    Leder, P.5
  • 20
    • 0028220204 scopus 로고
    • p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
    • Dulic, V., W. K. Kaufman, S. J. Wilson, T. D. Tlsty, E. Lees, J. W. Harper, S. J. Elledge, and S. I. Reed. 1994. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 76:1013-1023.
    • (1994) Cell , vol.76 , pp. 1013-1023
    • Dulic, V.1    Kaufman, W.K.2    Wilson, S.J.3    Tlsty, T.D.4    Lees, E.5    Harper, J.W.6    Elledge, S.J.7    Reed, S.I.8
  • 23
    • 0028880293 scopus 로고
    • The control of apoptosis and drug resistance in ovarian cancer: Influence of p53 and Bcl-2
    • Eliopoulos, A. G., D. J. Kerr, J. Herod, L. Hodgkins, S. Krajewski, J. C. Reed, and L. S. Young. 1995. The control of apoptosis and drug resistance in ovarian cancer: influence of p53 and Bcl-2. Oncogene 11:1217-1228.
    • (1995) Oncogene , vol.11 , pp. 1217-1228
    • Eliopoulos, A.G.1    Kerr, D.J.2    Herod, J.3    Hodgkins, L.4    Krajewski, S.5    Reed, J.C.6    Young, L.S.7
  • 24
    • 0026722655 scopus 로고
    • Cooperative interaction between c-myc and bcl-2 proto-oncogenes
    • Fanidi, A., E. A. Harrington, and G. I. Evan. 1992. Cooperative interaction between c-myc and bcl-2 proto-oncogenes. Nature (London) 359:554-556.
    • (1992) Nature (London) , vol.359 , pp. 554-556
    • Fanidi, A.1    Harrington, E.A.2    Evan, G.I.3
  • 26
    • 0025689204 scopus 로고
    • Wild-type, but not mutant, human p53 proteins inhibit the replication activities of simian virus 40 large tumor antigen
    • Friedman, P., S. Scott, B. Vogelstein, and C. Prives. 1990. Wild-type, but not mutant, human p53 proteins inhibit the replication activities of simian virus 40 large tumor antigen. Proc. Natl. Acad. Sci. USA 87:9275-9279.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 9275-9279
    • Friedman, P.1    Scott, S.2    Vogelstein, B.3    Prives, C.4
  • 27
    • 0025887476 scopus 로고
    • Wild-type p53 can down-modulate the activity of various promoters
    • Ginsberg, D., F. Mechta, M. Yaniv, and M. Oren. 1991. Wild-type p53 can down-modulate the activity of various promoters. Proc. Natl. Acad. Sci. USA 88:9979-9983.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 9979-9983
    • Ginsberg, D.1    Mechta, F.2    Yaniv, M.3    Oren, M.4
  • 28
    • 0025964061 scopus 로고
    • Induction of growth arrest by a temperature-sensitive p53 mutant is correlated with increased nuclear localization and decreased stability of the protein
    • Ginsberg, D., D. Michael-Michalovitz, D. Ginsberg, and M. Oren. 1991. Induction of growth arrest by a temperature-sensitive p53 mutant is correlated with increased nuclear localization and decreased stability of the protein. Mol. Cell. Biol. 11:582-585.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 582-585
    • Ginsberg, D.1    Michael-Michalovitz, D.2    Ginsberg, D.3    Oren, M.4
  • 29
    • 0028294898 scopus 로고
    • Down-regulation of wild-type p53 activity interferes with apoptosis of Il-3 dependent hematopoetic cells following Il-3 withdrawal
    • Gottlieb, E., R. Haffner, T. von Ruden, E. F. Wagner, and M. Oren. 1994. Down-regulation of wild-type p53 activity interferes with apoptosis of Il-3 dependent hematopoetic cells following Il-3 withdrawal. EMBO J. 13:1368-1374.
    • (1994) EMBO J. , vol.13 , pp. 1368-1374
    • Gottlieb, E.1    Haffner, R.2    Von Ruden, T.3    Wagner, E.F.4    Oren, M.5
  • 30
    • 0029823623 scopus 로고    scopus 로고
    • Relationship of sequence-specific transactivation and p53-regulated apoptosis in IL-3-dependent hematopoetic cells
    • Gottlieb, E., S. Linder, and M. Oren. 1996. Relationship of sequence-specific transactivation and p53-regulated apoptosis in IL-3-dependent hematopoetic cells. Cell Growth Differ. 7:301-310.
    • (1996) Cell Growth Differ. , vol.7 , pp. 301-310
    • Gottlieb, E.1    Linder, S.2    Oren, M.3
  • 33
    • 0028899283 scopus 로고
    • Biochemical properties and biological effects of p53
    • Haffner, R., and M. Oren. 1995. Biochemical properties and biological effects of p53. Curr. Opin. Genet. Dev. 5:84-90.
    • (1995) Curr. Opin. Genet. Dev. , vol.5 , pp. 84-90
    • Haffner, R.1    Oren, M.2
  • 34
  • 35
    • 0019401161 scopus 로고
    • Monoclonal antibodies specific for simian virus 40 tumor antigens
    • Harlow, E., L. V. Crawford, D. C. Pim, and N. M. Williamson. 1981. Monoclonal antibodies specific for simian virus 40 tumor antigens. J. Virol. 39: 861-869.
    • (1981) J. Virol. , vol.39 , pp. 861-869
    • Harlow, E.1    Crawford, L.V.2    Pim, D.C.3    Williamson, N.M.4
  • 36
    • 0027496935 scopus 로고
    • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    • Harper, J. W., G. R. Adami, N. Wei, K. Keyomarsi, and S. J. Elledge. 1993. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75:805-816.
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 37
    • 0029985647 scopus 로고    scopus 로고
    • Cell type specific inhibition of p53-mediated apoptosis by mdm2
    • Haupt, Y., Y. Barak, and M. Oren. 1996. Cell type specific inhibition of p53-mediated apoptosis by mdm2. EMBO J. 15:1596-1606.
    • (1996) EMBO J. , vol.15 , pp. 1596-1606
    • Haupt, Y.1    Barak, Y.2    Oren, M.3
  • 38
    • 85035177623 scopus 로고    scopus 로고
    • p53-mediated apoptosis: Mechanisms and regulation
    • in press
    • Haupt, Y., and M. Oren. p53-mediated apoptosis: mechanisms and regulation. Behring Inst. Res. Commun., in press.
    • Behring Inst. Res. Commun.
    • Haupt, Y.1    Oren, M.2
  • 39
    • 0028999429 scopus 로고
    • p53-mediated apoptosis in HeLa cells can be overcome by excess pRB
    • Haupt, Y., S. Rowan, and M. Oren. 1995. p53-mediated apoptosis in HeLa cells can be overcome by excess pRB. Oncogene 10:1563-1571.
    • (1995) Oncogene , vol.10 , pp. 1563-1571
    • Haupt, Y.1    Rowan, S.2    Oren, M.3
  • 40
    • 0029092356 scopus 로고
    • Induction of apoptosis in HeLa cells by trans-activation deficient p53
    • Haupt, Y., S. Rowan, E. Shaulian, H. Vousden, and M. Oren. 1995. Induction of apoptosis in HeLa cells by trans-activation deficient p53. Genes Dev. 9:2170-2183.
    • (1995) Genes Dev. , vol.9 , pp. 2170-2183
    • Haupt, Y.1    Rowan, S.2    Shaulian, E.3    Vousden, H.4    Oren, M.5
  • 41
    • 0028171968 scopus 로고
    • Mediation of c-myc-induced apoptosis by p53
    • Hemerking, H., and D. Eick. 1994. Mediation of c-myc-induced apoptosis by p53. Science 265:2091-2093.
    • (1994) Science , vol.265 , pp. 2091-2093
    • Hemerking, H.1    Eick, D.2
  • 42
  • 43
    • 0027406964 scopus 로고
    • Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators
    • Hoey, T., R. O. J. Weinzierl, G. Gill, J. Chen, B. D. Dynlacht, and R. Tjian. 1993. Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators. Cell 72:247-260.
    • (1993) Cell , vol.72 , pp. 247-260
    • Hoey, T.1    Weinzierl, R.O.J.2    Gill, G.3    Chen, J.4    Dynlacht, B.D.5    Tjian, R.6
  • 45
    • 0029028352 scopus 로고
    • Mutational analysis of the carboxy-terminal portion of p53 using both yeast and mammalian assays in vivo
    • Ishioka, C., C. Engler, P. Winge, Y. X. Yen, M. Engelstein, and S. H. Friend. 1993. Mutational analysis of the carboxy-terminal portion of p53 using both yeast and mammalian assays in vivo. Oncogene 10:1485-1492.
    • (1993) Oncogene , vol.10 , pp. 1485-1492
    • Ishioka, C.1    Engler, C.2    Winge, P.3    Yen, Y.X.4    Engelstein, M.5    Friend, S.H.6
  • 46
    • 0027466609 scopus 로고
    • Wild-type p53 down-regulates transcription from different virus enhancer/promoters
    • Jackson, P., E. Bos, and A. W. Braithwaite. 1993. Wild-type p53 down-regulates transcription from different virus enhancer/promoters. Oncogene 8:589-597.
    • (1993) Oncogene , vol.8 , pp. 589-597
    • Jackson, P.1    Bos, E.2    Braithwaite, A.W.3
  • 48
    • 0027501841 scopus 로고
    • Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene
    • Juven, T., Y. Barak, A. Zauberman, D. L. George, and M. Oren. 1993. Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene. Oncogene 8:3411-3416.
    • (1993) Oncogene , vol.8 , pp. 3411-3416
    • Juven, T.1    Barak, Y.2    Zauberman, A.3    George, D.L.4    Oren, M.5
  • 52
    • 0029129088 scopus 로고
    • Cell-specific transcriptional activation of the mdm2-gene by ectopically expressed wild-type form of a temperature-sensitive mutant p53
    • Knippschild, U., T. Kolzau, and W. Deppert. 1995. Cell-specific transcriptional activation of the mdm2-gene by ectopically expressed wild-type form of a temperature-sensitive mutant p53. Oncogene 11:683-690.
    • (1995) Oncogene , vol.11 , pp. 683-690
    • Knippschild, U.1    Kolzau, T.2    Deppert, W.3
  • 53
    • 0028859541 scopus 로고
    • Bax-deficient mice with lymphoid hyperplasia and male germ cell death
    • Knudson, M., K. Tung, G. Tourtellotte, G. A. J. Brown, and S. J. Korsmeyer. 1995. Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270:96-98.
    • (1995) Science , vol.270 , pp. 96-98
    • Knudson, M.1    Tung, K.2    Tourtellotte, G.3    Brown, G.A.J.4    Korsmeyer, S.J.5
  • 54
    • 0029972806 scopus 로고    scopus 로고
    • p53: Puzzle and paradigm
    • Ko, L. J., and C. Prives. 1996. p53: puzzle and paradigm. Genes Dev. 10:1054-1072.
    • (1996) Genes Dev. , vol.10 , pp. 1054-1072
    • Ko, L.J.1    Prives, C.2
  • 55
    • 0029416970 scopus 로고
    • Activation of p21WAF1/Cip1 expression by a temperature-sensitive mutant of human p53 does not lead to apoptosis
    • Kobayashi, T., U. Consoli, M. Andreeff, H. Shiku, A. B. Deisseroth, and W. Zhang. 1995. Activation of p21WAF1/Cip1 expression by a temperature-sensitive mutant of human p53 does not lead to apoptosis. Oncogene 11: 2311-2316.
    • (1995) Oncogene , vol.11 , pp. 2311-2316
    • Kobayashi, T.1    Consoli, U.2    Andreeff, M.3    Shiku, H.4    Deisseroth, A.B.5    Zhang, W.6
  • 56
    • 0027362667 scopus 로고
    • Investigation of the subcellular distribution of the bcl-2 oncoprotein: Residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes
    • Krajewski, S., S. Tanaka, S. Takayama, M. Schibler, W. Fenton, and J. C. Reed. 1993. Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res. 53:4701-4714.
    • (1993) Cancer Res. , vol.53 , pp. 4701-4714
    • Krajewski, S.1    Tanaka, S.2    Takayama, S.3    Schibler, M.4    Fenton, W.5    Reed, J.C.6
  • 57
  • 58
    • 0027283604 scopus 로고
    • Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents
    • Lotem, J., and L. Sachs. 1993. Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents. Blood 82:1092-1096.
    • (1993) Blood , vol.82 , pp. 1092-1096
    • Lotem, J.1    Sachs, L.2
  • 59
    • 0027451668 scopus 로고
    • p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
    • Lowe, S. W., H. E. Ruley, T. Jacks, and D. E. Housman. 1993. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74:957-967.
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3    Housman, D.E.4
  • 60
    • 0027319521 scopus 로고
    • p53 is required for radiation-induced apoptosis in mouse thymocytes
    • Lowe, S. W., E. M. Schmitt, S. W. Smith, B. A. Osborne, and T. Jacks. 1993. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature (London) 362:847-852.
    • (1993) Nature (London) , vol.362 , pp. 847-852
    • Lowe, S.W.1    Schmitt, E.M.2    Smith, S.W.3    Osborne, B.A.4    Jacks, T.5
  • 61
    • 0027332996 scopus 로고
    • Differential induction of transcriptionally active p53 following UV or ionizing radiation: Defects in chromosome instability syndromes?
    • Lu, X., and D. P. Lane. 1993. Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes? Cell 75:765-778.
    • (1993) Cell , vol.75 , pp. 765-778
    • Lu, X.1    Lane, D.P.2
  • 62
    • 0029742781 scopus 로고    scopus 로고
    • Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function
    • Ludwig, R. L., S. Bates, and K. H. Vousden. 1996. Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function. Mol. Cell. Biol. 16:4952-4960.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4952-4960
    • Ludwig, R.L.1    Bates, S.2    Vousden, K.H.3
  • 63
    • 0021616838 scopus 로고
    • UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells
    • Maltzman, W., and L. Czyzyk. 1984. UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells. Mol. Cell. Biol. 4:1689-1694.
    • (1984) Mol. Cell. Biol. , vol.4 , pp. 1689-1694
    • Maltzman, W.1    Czyzyk, L.2
  • 65
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita, T., and J. Reed. 1995. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80:293-299.
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.2
  • 66
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
    • Oltavi, Z., M. Curt, and S. J. Korsmeyer. 1993. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609-619.
    • (1993) Cell , vol.74 , pp. 609-619
    • Oltavi, Z.1    Curt, M.2    Korsmeyer, S.J.3
  • 67
    • 0027994037 scopus 로고
    • Analysis of the most representative tumor-derived p53 mutants reveals that changes in the protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation
    • Ory, K., Y. Legros, C. Auguin, and T. Soussi. 1994. Analysis of the most representative tumor-derived p53 mutants reveals that changes in the protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation. EMBO J. 13:3496-3504.
    • (1994) EMBO J. , vol.13 , pp. 3496-3504
    • Ory, K.1    Legros, Y.2    Auguin, C.3    Soussi, T.4
  • 68
    • 0025375345 scopus 로고
    • Functional domains and upstream activation properties of cloned human TATA binding protein
    • Peterson, M. G., N. Tanese, B. F. Pugh, and R. Tjian. 1990. Functional domains and upstream activation properties of cloned human TATA binding protein. Science 248:1626-1630.
    • (1990) Science , vol.248 , pp. 1626-1630
    • Peterson, M.G.1    Tanese, N.2    Pugh, B.F.3    Tjian, R.4
  • 69
    • 0029034047 scopus 로고
    • p53-dependent growth arrest following calcium phosphate-mediated transfection of murine fibroblasts
    • Renzing, J., and D. P. Lane. 1995. p53-dependent growth arrest following calcium phosphate-mediated transfection of murine fibroblasts. Oncogene 10:1865-1868.
    • (1995) Oncogene , vol.10 , pp. 1865-1868
    • Renzing, J.1    Lane, D.P.2
  • 70
    • 0030021748 scopus 로고    scopus 로고
    • Specific loss of apoptotic but not cell cycle arrest function in a human tumor derived p53 mutant
    • Rowan, S., R. L. Ludwig, Y. Haupt, S. Bates, X. Lu, M. Oren, and K. H. Vousden. 1996. Specific loss of apoptotic but not cell cycle arrest function in a human tumor derived p53 mutant. EMBO J. 15:827-838.
    • (1996) EMBO J. , vol.15 , pp. 827-838
    • Rowan, S.1    Ludwig, R.L.2    Haupt, Y.3    Bates, S.4    Lu, X.5    Oren, M.6    Vousden, K.H.7
  • 71
    • 0029143395 scopus 로고
    • Essential role for p53-mediated transcription in E1A-induced apoptosis
    • Sabbatini, P., J. Lin, A. J. Levine, and E. White. 1995. Essential role for p53-mediated transcription in E1A-induced apoptosis. Genes Dev. 9:2184-2192.
    • (1995) Genes Dev. , vol.9 , pp. 2184-2192
    • Sabbatini, P.1    Lin, J.2    Levine, A.J.3    White, E.4
  • 72
    • 0025775929 scopus 로고
    • Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product
    • Santhanam, U., A. Ray, and P. B. Sehgal. 1991. Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product. Proc. Natl. Acad. Sci. USA 88:7605-7609.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 7605-7609
    • Santhanam, U.1    Ray, A.2    Sehgal, P.B.3
  • 73
    • 0028238213 scopus 로고
    • Immediate early up-regulation of bax expression by p53 but not TGFb1: A paradigm for distinct apoptotic pathways
    • Selvakumaran, M., H. Lin, T. Miyashia, H. G. Wang, S. Krajewski, J. C. Reed, B. Hoffman, and D. Lieberman. 1994. Immediate early up-regulation of bax expression by p53 but not TGFb1: a paradigm for distinct apoptotic pathways. Oncogene 9:1791-1798.
    • (1994) Oncogene , vol.9 , pp. 1791-1798
    • Selvakumaran, M.1    Lin, H.2    Miyashia, T.3    Wang, H.G.4    Krajewski, S.5    Reed, J.C.6    Hoffman, B.7    Lieberman, D.8
  • 74
    • 0028930859 scopus 로고
    • Transcriptional repression by the C-terminal domain of p53
    • Shaulian, E., I. Haviv, Y. Shaul, and M. Oren. 1995. Transcriptional repression by the C-terminal domain of p53. Oncogene 10:671-680.
    • (1995) Oncogene , vol.10 , pp. 671-680
    • Shaulian, E.1    Haviv, I.2    Shaul, Y.3    Oren, M.4
  • 76
    • 0026669469 scopus 로고
    • p53 function and dysfunction
    • Vogelstein, B., and K. Kinzler. 1992. p53 function and dysfunction. Cell 70:523-526.
    • (1992) Cell , vol.70 , pp. 523-526
    • Vogelstein, B.1    Kinzler, K.2
  • 78
    • 0024589807 scopus 로고
    • The murine p53 protein blocks replication of SV40 DNA in vitro by inhibiting the initiation functions of SV40 large T antigen
    • Wang, E. H., P. N. Friedman, and C. Prives. 1989. The murine p53 protein blocks replication of SV40 DNA in vitro by inhibiting the initiation functions of SV40 large T antigen. Cell 57:379-392.
    • (1989) Cell , vol.57 , pp. 379-392
    • Wang, E.H.1    Friedman, P.N.2    Prives, C.3
  • 79
    • 0029029743 scopus 로고
    • R-ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressable mechanism
    • Wang, H.-G., J. A. Milan, A. D. Cox, C. J. Der, U. R. Rapp, T. Beck, H. Zha, and J. C. Reed. 1995. R-ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressable mechanism. J. Cell. Biol. 129:1103-1114.
    • (1995) J. Cell. Biol. , vol.129 , pp. 1103-1114
    • Wang, H.-G.1    Milan, J.A.2    Cox, A.D.3    Der, C.J.4    Rapp, U.R.5    Beck, T.6    Zha, H.7    Reed, J.C.8
  • 80
    • 0029003061 scopus 로고
    • Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases
    • Wang, Y., and C. Prives. 1995. Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases. Nature (London) 376:88-91.
    • (1995) Nature (London) , vol.376 , pp. 88-91
    • Wang, Y.1    Prives, C.2
  • 81
    • 0030046508 scopus 로고    scopus 로고
    • Life, death, and the pursuit of apoptosis
    • White, E. 1996. Life, death, and the pursuit of apoptosis. Genes Dev. 10:1-15.
    • (1996) Genes Dev. , vol.10 , pp. 1-15
    • White, E.1
  • 82
    • 0028915813 scopus 로고
    • Alternatively spliced forms in the carboxy-terminal domain of the p53 protein regulate its ability to promote annealing of complementary single strands of nucleic acids
    • Wu, L., J. H. Bayle, B. Elenbaas, N. P. Pavletich, and A. J. Levine. 1995. Alternatively spliced forms in the carboxy-terminal domain of the p53 protein regulate its ability to promote annealing of complementary single strands of nucleic acids. Mol. Cell. Biol. 15:497-504.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 497-504
    • Wu, L.1    Bayle, J.H.2    Elenbaas, B.3    Pavletich, N.P.4    Levine, A.J.5
  • 84
    • 0029278864 scopus 로고
    • Elevated levels of wild-type p53 induced by radiolabeling of cells leads to apoptosis or sustained growth arrest
    • Yeargin, J., and M. Haas. 1995. Elevated levels of wild-type p53 induced by radiolabeling of cells leads to apoptosis or sustained growth arrest. Curr. Biol. 5:423-431.
    • (1995) Curr. Biol. , vol.5 , pp. 423-431
    • Yeargin, J.1    Haas, M.2
  • 85
    • 0028115501 scopus 로고
    • Induction of apoptosis by transiently transfected metabollically stable wt p53 in transformed cell lines
    • Yonish-Rouach, E., J. Borde, M. Gotteland, Z. Mishal, A. Viron, and E. May. 1994. Induction of apoptosis by transiently transfected metabollically stable wt p53 in transformed cell lines. Cell Death Differ. 1:39-47.
    • (1994) Cell Death Differ. , vol.1 , pp. 39-47
    • Yonish-Rouach, E.1    Borde, J.2    Gotteland, M.3    Mishal, Z.4    Viron, A.5    May, E.6
  • 86
    • 0027248782 scopus 로고
    • Sequence-specific DNA binding by p53: Identification of target sites and lack of binding to p53-MDM2 complexes
    • Zauberman, A., Y. Barak, N. Ragimov, N. Levy, and M. Oren. 1993. Sequence-specific DNA binding by p53: identification of target sites and lack of binding to p53-MDM2 complexes. EMBO J. 12:2799-2808.
    • (1993) EMBO J. , vol.12 , pp. 2799-2808
    • Zauberman, A.1    Barak, Y.2    Ragimov, N.3    Levy, N.4    Oren, M.5
  • 87
    • 0029006743 scopus 로고
    • Identification of p53 target genes through immune selection of genomic DNA: The cyclin g gene contains two distinct p53 binding sites
    • Zauberman, A., A. Lupro, and M. Oren. 1995. Identification of p53 target genes through immune selection of genomic DNA: the cyclin g gene contains two distinct p53 binding sites. Oncogene 10:2361-2366.
    • (1995) Oncogene , vol.10 , pp. 2361-2366
    • Zauberman, A.1    Lupro, A.2    Oren, M.3
  • 88
    • 0027944228 scopus 로고
    • Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis
    • Zhan, Q., S. Pan, I. Bae, C. Guillouf, D. A. Liebermann, P. M. O'Conner, and A. J. Fornace, Jr. 1994. Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis. Oncogene 9:3743-3751.
    • (1994) Oncogene , vol.9 , pp. 3743-3751
    • Zhan, Q.1    Pan, S.2    Bae, I.3    Guillouf, C.4    Liebermann, D.A.5    O'Conner, P.M.6    Fornace Jr., A.J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.