In vivo adenovirus-mediated p53 tumor suppressor gene therapy for colorectal cancer

Anticancer Research

Volumn 16, Issue 6 B, 1996, Pages 3415-3422

  Spitz, Francis R ^a   Nguyen, Dao ^a   Skibber, John M ^a   Cusack, James ^a   Roth, Jack A ^a   Cristiano, Richard J ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Adenovirus; Colon cancer; Gene therapy; p53

Indexed keywords

PROTEIN P53;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; COLORECTAL CANCER; CONTROLLED STUDY; CYTOCHEMISTRY; FEMALE; GENE MUTATION; GENE THERAPY; GENE TRANSFER; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR SUPPRESSOR GENE;

ADENOVIRIDAE; ANIMALS; CELL DEATH; CELL DIVISION; COLORECTAL NEOPLASMS; FEMALE; GENE THERAPY; GENES, P53; GENETIC VECTORS; HUMANS; MICE; MICE, NUDE; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS;

EID: 0030514283     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Boring CC, Squires TS, Tong T: Cancer statistics. CA-Cancer J Clin 44: 7-26, 1994.
2. Fearon E, Vogelstein B: A genetic model for colorectal tumorigenesis. Cell 61: 759-767, 1988.
3. Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, Nakamura Y, White R, Smits AMM, Bos JL: Genetic alterations during colorectal-tumor development. N Engl J Med 319: 525-532, 1988.
4. Hollstein M, Sidransky D, Vogelstein B. Harris CC: p53 mutations in human cancers. Science 253: 49-53, 1991.
5. Rodrigues NR, Rowan A, Smith MEF, Kerr IB, Bodmer WF, Gannon JV, Lane DP: p53 mutations in colorectal cancer. Proc Natl Acad Sci USA 87: 7555-7559, 1990.
6. Levine AJ, Momand J, Finlay CA: The p53 tumour suppressor gene. Nature 351: 453-456, 1991.
7. Bell SM, Scott N, Cross D, Sagar P, Lewis FA, Blair GE, Taylor GR, Dixon MF, Quirke P: Prognostic value of p53 overexpression and cki-ras gene mutations in colorectal cancer. Gastroenterology 104: 57-64, 1993.
8. Hamelin R, Laurent-Puig P, Olschwang S, Jego N, Asselain B, Remvikos Y, Girodet J, Salmon RJ, Thomas G: Association of p53 mutations with short survival in colorectal cancer. Gastroenterology 106: 42-48, 1994.
9. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig R: Participation of p53 protein in the cellular response to DNA damage. Cancer Res 51: 6304-6311, 1991.
10. Kastan MB, Canman CE, Leonard CJ: p53, cell cycle control and apoptosis: implications for cancer. Cancer Metastasis Rev 14: 3-15, 1995.
11. Goyette MC, Cho K, Fasching CL, Levy DB, Kinzler KW, Paraskeva C, Vogelstein B, Stanbridge EJ: Progression of colorectal cancer is associated with multiple tumor suppressor gene defects hut inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer. Mol Cell Biol 12: 1387-1395, 1992.
12. Shaw P, Bovey R, Tardy S, Sahli R, Sordat B, Costa J: Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc Natl Acad Sci USA 89: 4495-4499, 1992.
13. Wills KM, Maneval DC, Menzel P, Harris MP, Sutjipto S, Vaillancourt MT, Huang WM, Johnson DE, Anderson SC, Wen SF, et al. Development and characterization of recombinant adenoviruses encoding human p53 for gene therapy of cancer. Human Gene Ther 5: 1079-1088, 1994.
14. Zhang WW, Fang X, Mazur W, French BA, Georges RN, Roth JA: High-efficiency gene transfer and high-level expression of wild-type p53 in human lung cancer cells mediated by recombinant adenovirus. Cancer Gene Ther 1: 5-13, 1994.
15. Liu TJ, Zhang WW, Taylor DL, Roth JA, Goepfert H, Clayman GL: Growth suppression of human head and neck cancer cells by the introduction of a wild-type p53 gene via a recombinant adenovirus. Cancer Res 54: 3662-3667, 1994.
16. Liu TJ, El-Naggar AK, Mcdonnell TJ, Steck KD, Wang M, Taylor DL, Clayman GL: Apoptosis induction mediated by wild-type p53 adenoviral gene transfer in squamous cell carcinoma of the head and neck. Cancer Res 55: 3117-3122, 1995.
17. Overholt SM, Liu T, Taylor DL, et al. Head and neck squamous cell growth suppression using adenovirus-p53-FLAG: an effective marker for gene therapy trials. [In Press] 1996.
18. Graham F, Previc L: Manipulation of adenovirus vectors. In: Murray EJ, Methods in Molecular Biology: Gene Transfer and Expression Protocols 7, Humana Press, Clifton, NJ, 1991, pp. 205-225.
19. Zhang W, Alemany R, Wang J, Koch PE, Ordonez NG, Roth JA: Safety evaluation of Ad5CMV-p53 in vitro and in vivo. Human Gene Ther 6: 155-164, 1995.
20. Boviatsis EJ, Chase M, Wei MX, Tamiya T, Hurford RK, Kowall NW, Tepper RI, Breakefield XO, Chioca EA: Gene transfer into experimental brain tumors mediated by adenovirus. Herpes simelex virus, and retrovirus. Hum Gene Ther 5: 183-191, 1994.
21. Gorczyca W, Bruno S, Darzynkiewicz RJ, Gong J, Darzynkiewicz Z: DNA strand breaks occurring in apoptosis: their early detection by deoxynucleotidyl transferase and nick translation assays and prevention by serine protease inhibitors. Int J Oncol 1: 639-648, 1992.
22. Gavrieli Y, Sherman Y, Ben-Sasson SA: Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119: 493-501, 1992.
23. El-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B: WAFI, a potential mediator of p53 tumor suppression. Cell 75: 817-825, 1993.
24. Miyashita T, Reed JC: Tumor suppressor p53 is a direct transcriptional activator of human bax. Cell 80: 293-299, 1995.
25. Fujiwara T, Grimm EA, Mukhopadhyay T, Zhang WW, Owen-Schaub LB, Roth JA: Induction of chemosensitivity in human lung cancer cells in vivo by adenoviral-mediated transfer of the wild-type p53 gene. Cancer Res 54: 2287-2291, 1994.
26. Spitz FR, NSIuyen DM, Skibber JM, Meyn RE, Cristiano RJ, Roth JA: Adenoviral-mediated wild-type p53 gene expression sensitizes colorectal cancer cells to ionizing radiation. Clinical Cancer Res 1996.