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Volumn 16, Issue 10, 1996, Pages 5507-5517

Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GENE PRODUCT; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE;

EID: 0029791450     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.10.5507     Document Type: Article
Times cited : (182)

References (64)
  • 1
    • 0025083331 scopus 로고
    • Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors
    • Adam, S. A., R. S. Marr, and L. Gerace. 1990. Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors. J. Cell Biol. 111:807-816.
    • (1990) J. Cell Biol. , vol.111 , pp. 807-816
    • Adam, S.A.1    Marr, R.S.2    Gerace, L.3
  • 2
    • 0027490279 scopus 로고
    • DNA damage and the DNA-activated protein kinase
    • Anderson, C. W. 1993. DNA damage and the DNA-activated protein kinase. Trends Biochem. Sci. 18:433-437.
    • (1993) Trends Biochem. Sci. , vol.18 , pp. 433-437
    • Anderson, C.W.1
  • 3
    • 0026071588 scopus 로고
    • Scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair
    • Biedermann, K. A., J. Sun, A. J. Giaccia, L. M. Tosto, and J. M. Brown. 1991. Scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. Proc. Natl. Acad. Sci. USA 88:1394-1397.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 1394-1397
    • Biedermann, K.A.1    Sun, J.2    Giaccia, A.J.3    Tosto, L.M.4    Brown, J.M.5
  • 6
    • 0029881698 scopus 로고    scopus 로고
    • p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes
    • Bogue, M. A., C. Zhu, E. Aguilar-Cordova, L. A. Donehower, and D. B. Roth. 1996. p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes. Genes Dev. 10:553-565.
    • (1996) Genes Dev. , vol.10 , pp. 553-565
    • Bogue, M.A.1    Zhu, C.2    Aguilar-Cordova, E.3    Donehower, L.A.4    Roth, D.B.5
  • 7
    • 0025811882 scopus 로고
    • The SCID mouse mutant: Definition, characterization, and potential uses
    • Bosma, M. J., and A. M. Carroll. 1991. The SCID mouse mutant: definition, characterization, and potential uses. Annu. Rev. Immunol. 9:323-350.
    • (1991) Annu. Rev. Immunol. , vol.9 , pp. 323-350
    • Bosma, M.J.1    Carroll, A.M.2
  • 9
    • 0029143646 scopus 로고
    • scid cells are deficient in Ku and replication protein A phosphorylation by the DNA-dependent protein kinase
    • Boubnov, N. V., and D. T. Weaver. 1995. scid cells are deficient in Ku and replication protein A phosphorylation by the DNA-dependent protein kinase. Mol. Cell. Biol. 15:5700-5706.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 5700-5706
    • Boubnov, N.V.1    Weaver, D.T.2
  • 10
    • 0024202730 scopus 로고
    • Detection and characterization of functional T cells in mice with severe combined immune deficiency
    • Carroll, A. M., and M. J. Bosma. 1988. Detection and characterization of functional T cells in mice with severe combined immune deficiency. Eur. J. Immunol. 18:1965-1971.
    • (1988) Eur. J. Immunol. , vol.18 , pp. 1965-1971
    • Carroll, A.M.1    Bosma, M.J.2
  • 11
    • 0026018228 scopus 로고
    • T-lymphocyte development in scid mice is arrested shortly after the initiation of T-cell receptor δ chain recombination
    • Carroll, A. M., and M. J. Bosma. 1991. T-lymphocyte development in scid mice is arrested shortly after the initiation of T-cell receptor δ chain recombination. Genes Dev. 5:1357-1366.
    • (1991) Genes Dev. , vol.5 , pp. 1357-1366
    • Carroll, A.M.1    Bosma, M.J.2
  • 12
    • 0000564570 scopus 로고
    • Occurence of mature B (Ig+ and B220+) and T (CD3+) lymphocytes in scid mice
    • Carroll, A. M., R. R. Hardy, and M. J. Bosma. 1989. Occurence of mature B (Ig+ and B220+) and T (CD3+) lymphocytes in scid mice. J. Immunol. 17:1467-1471.
    • (1989) J. Immunol. , vol.17 , pp. 1467-1471
    • Carroll, A.M.1    Hardy, R.R.2    Bosma, M.J.3
  • 14
    • 0029890823 scopus 로고    scopus 로고
    • Apopain/CPP32 cleaves proteins that are essential for cellular repair: A fundamental principle of apoptotic cell death
    • Casciola-Rosen, L., D. W. Nicholson, T. Chong, K. R. Rowan, N. A. Thornberry, D. K. Miller, and A. Rosen. 1996. Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic cell death. J. Exp. Med. 183:1957-1964.
    • (1996) J. Exp. Med. , vol.183 , pp. 1957-1964
    • Casciola-Rosen, L.1    Nicholson, D.W.2    Chong, T.3    Rowan, K.R.4    Thornberry, N.A.5    Miller, D.K.6    Rosen, A.7
  • 15
    • 0028881847 scopus 로고
    • DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis
    • Casciola-Rosen, L. A., G. J. Anhalt, and A. Rosen. 1995. DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis. J. Exp. Med. 182:1625-1634.
    • (1995) J. Exp. Med. , vol.182 , pp. 1625-1634
    • Casciola-Rosen, L.A.1    Anhalt, G.J.2    Rosen, A.3
  • 16
    • 0027512522 scopus 로고
    • Characterization of the DNA double strand break repair defect in scid mice
    • Chang, C., K. A. Biedermann, M. Mezzina, and J. M. Brown. 1993. Characterization of the DNA double strand break repair defect in scid mice. Cancer Res. 53:1244-1248.
    • (1993) Cancer Res. , vol.53 , pp. 1244-1248
    • Chang, C.1    Biedermann, K.A.2    Mezzina, M.3    Brown, J.M.4
  • 17
    • 0018639079 scopus 로고
    • Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
    • Chirgwin, J. M., A. E. Przybyla, R. J. MacDonald, and W. J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294-5299.
    • (1979) Biochemistry , vol.18 , pp. 5294-5299
    • Chirgwin, J.M.1    Przybyla, A.E.2    MacDonald, R.J.3    Rutter, W.J.4
  • 19
    • 0025283333 scopus 로고
    • The presumptive CDR3 of both T cell receptor α and β chains mediate recognition of myoglobin peptides
    • Danska, J. S., A. M. Livingstone, V. Paragas, and C. C. Fathman. 1990. The presumptive CDR3 of both T cell receptor α and β chains mediate recognition of myoglobin peptides. J. Exp. Med. 172:27-33.
    • (1990) J. Exp. Med. , vol.172 , pp. 27-33
    • Danska, J.S.1    Livingstone, A.M.2    Paragas, V.3    Fathman, C.C.4
  • 20
    • 0028151601 scopus 로고
    • Rescue of T cell-specific V(D)J recombination in SCID mice by DNA-damaging agents
    • Danska, J. S., F. Pflumio, C. Williams, O. Huner, J. E. Dick, and C. J. Guidos. 1994. Rescue of T cell-specific V(D)J recombination in SCID mice by DNA-damaging agents. Science 266:450-455.
    • (1994) Science , vol.266 , pp. 450-455
    • Danska, J.S.1    Pflumio, F.2    Williams, C.3    Huner, O.4    Dick, J.E.5    Guidos, C.J.6
  • 23
    • 0028897304 scopus 로고
    • DNA-dependent protein kinase activity is absent in xrs-6 cells: Implications for site-specific recombination and DNA double-strand break repair
    • Finnie, N. J., T. M. Gottlieb, T. Blunt, P. A. Jeggo, and S. P. Jackson. 1995. DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair. Proc. Natl. Acad. Sci. USA 92:320-324.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 320-324
    • Finnie, N.J.1    Gottlieb, T.M.2    Blunt, T.3    Jeggo, P.A.4    Jackson, S.P.5
  • 24
    • 0025011134 scopus 로고
    • The scid mutation in mice causes a general defect in DNA repair
    • Fulop, G. M., and R. A. Phillips. 1990. The scid mutation in mice causes a general defect in DNA repair. Nature (London) 347:479-482.
    • (1990) Nature (London) , vol.347 , pp. 479-482
    • Fulop, G.M.1    Phillips, R.A.2
  • 25
    • 0027397867 scopus 로고
    • The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen
    • Gottlieb, T. M., and S. P. Jackson. 1993. The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell 72:131-142.
    • (1993) Cell , vol.72 , pp. 131-142
    • Gottlieb, T.M.1    Jackson, S.P.2
  • 27
    • 0029858143 scopus 로고    scopus 로고
    • V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors
    • Guidos, C. J., C. Williams, I. Grandal, G. Knowles, M. T. Huang, and J. S. Danska. 1996. V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors. Genes Dev. 10:2038-2054.
    • (1996) Genes Dev. , vol.10 , pp. 2038-2054
    • Guidos, C.J.1    Williams, C.2    Grandal, I.3    Knowles, G.4    Huang, M.T.5    Danska, J.S.6
  • 30
  • 31
    • 0028856331 scopus 로고
    • When is a lipid kinase not a lipid kinase? When it is a protein kinase
    • Hunter, T. 1995. When is a lipid kinase not a lipid kinase? When it is a protein kinase. Cell 83:1-4.
    • (1995) Cell , vol.83 , pp. 1-4
    • Hunter, T.1
  • 32
    • 0025971104 scopus 로고
    • Genetic analysis of ionizing radiation sensitive mutants of cultured mammalian cell lines
    • Jeggo, P. A., J. Tesmer, and D. J. Chen. 1991. Genetic analysis of ionizing radiation sensitive mutants of cultured mammalian cell lines. Mutat. Res. 245:125-133.
    • (1991) Mutat. Res. , vol.245 , pp. 125-133
    • Jeggo, P.A.1    Tesmer, J.2    Chen, D.J.3
  • 33
    • 0021280994 scopus 로고
    • Monoclonal antibodies localize oestrogen receptor in the nucleii of target cells
    • King, W. J., and G. L. Greene. 1984. Monoclonal antibodies localize oestrogen receptor in the nucleii of target cells. Nature (London) 307:745-747.
    • (1984) Nature (London) , vol.307 , pp. 745-747
    • King, W.J.1    Greene, G.L.2
  • 35
    • 0027315271 scopus 로고
    • Scid mouse pre-B cells with intracellular μ chains: Analysis of recombinase activity and IgH gene rearrangements
    • Kotloff, D. B., M. J. Bosma, and N. R. Ruetsch. 1993. Scid mouse pre-B cells with intracellular μ chains: analysis of recombinase activity and IgH gene rearrangements. Int. Immunol. 5:383-391.
    • (1993) Int. Immunol. , vol.5 , pp. 383-391
    • Kotloff, D.B.1    Bosma, M.J.2    Ruetsch, N.R.3
  • 36
    • 0026687883 scopus 로고
    • Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain in human p53
    • Lees-Miller, S. P., K. Sakaguchi, S. J. Ullrich, E. Appella, and C. W. Anderson. 1992. Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain in human p53. Mol. Cell. Biol. 12:5041-5049.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 5041-5049
    • Lees-Miller, S.P.1    Sakaguchi, K.2    Ullrich, S.J.3    Appella, E.4    Anderson, C.W.5
  • 37
    • 0028048275 scopus 로고
    • The mechanism of V(D)J joining: Lessons from molecular, immunological, and comparative analyses
    • Lewis, S. M. 1994. The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses. Adv. Immunol. 56:27-150.
    • (1994) Adv. Immunol. , vol.56 , pp. 27-150
    • Lewis, S.M.1
  • 38
    • 0023801238 scopus 로고
    • The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination
    • Lieber, M. R., J. E. Hesse, S. Lewis, G. C. Bosma, N. Rosenber, K. Mizuuchi, M. J. Bosma, and M. Gellert. 1988. The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination. Cell 55:7-16.
    • (1988) Cell , vol.55 , pp. 7-16
    • Lieber, M.R.1    Hesse, J.E.2    Lewis, S.3    Bosma, G.C.4    Rosenber, N.5    Mizuuchi, K.6    Bosma, M.J.7    Gellert, M.8
  • 39
    • 0029788298 scopus 로고    scopus 로고
    • Transient restoration of gene rearrangement at multiple T cell receptor loci in γ irradiated scid mice
    • Livak, F., S. Welsh, C. J. Guidos, I. N. Crispe, J. S. Danska, and D. G. Schatz. 1996. Transient restoration of gene rearrangement at multiple T cell receptor loci in γ irradiated scid mice. J. Exp. Med. 184:419-428.
    • (1996) J. Exp. Med. , vol.184 , pp. 419-428
    • Livak, F.1    Welsh, S.2    Guidos, C.J.3    Crispe, I.N.4    Danska, J.S.5    Schatz, D.G.6
  • 43
    • 0025301095 scopus 로고
    • RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
    • Oettinger, M. A., D. G. Schatz, C. Gorka, and D. Baltimore. 1990. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248:1517-1523.
    • (1990) Science , vol.248 , pp. 1517-1523
    • Oettinger, M.A.1    Schatz, D.G.2    Gorka, C.3    Baltimore, D.4
  • 44
    • 0027275499 scopus 로고
    • High frequency of normal DJH joints in B cell progenitors in severe combined immune deficiency mice
    • Pennycook, J. L., Y. Chang, J. Celler, R. A. Phillips, and G. E. Wu. 1993. High frequency of normal DJH joints in B cell progenitors in severe combined immune deficiency mice. J. Exp. Med. 178:1007-1016.
    • (1993) J. Exp. Med. , vol.178 , pp. 1007-1016
    • Pennycook, J.L.1    Chang, Y.2    Celler, J.3    Phillips, R.A.4    Wu, G.E.5
  • 45
    • 0027245559 scopus 로고
    • V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair
    • Pergola, F., M. Z. Zdzienicka, and M. R. Lieber. 1993. V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair. Mol. Cell. Biol. 13:3464-3471.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 3464-3471
    • Pergola, F.1    Zdzienicka, M.Z.2    Lieber, M.R.3
  • 46
    • 0028902932 scopus 로고
    • Loss of catalytic subunit of the DNA-dependent protein kinase in DNA double-strand break repair mutant mammalian cells
    • Peterson, S. R., A. Kurimasa, M. Oshimura, W. S. Dynan, E. M. Bradbury, and D. J. Chen. 1995. Loss of catalytic subunit of the DNA-dependent protein kinase in DNA double-strand break repair mutant mammalian cells. Proc. Natl. Acad. Sci. USA 92:3171-3174.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3171-3174
    • Peterson, S.R.1    Kurimasa, A.2    Oshimura, M.3    Dynan, W.S.4    Bradbury, E.M.5    Chen, D.J.6
  • 47
    • 0025294780 scopus 로고
    • T-cell receptor gene rearrangements in functional T-cell clones from scid mice: Reversion of the scid phenotype in individual lymphocyte progenitors
    • Petrini, J. H., A. M. Carroll, and M. J. Bosma. 1990. T-cell receptor gene rearrangements in functional T-cell clones from scid mice: reversion of the scid phenotype in individual lymphocyte progenitors. Proc. Natl. Acad. Sci. USA 87:3450-3453.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 3450-3453
    • Petrini, J.H.1    Carroll, A.M.2    Bosma, M.J.3
  • 48
    • 0028342645 scopus 로고
    • A DNA end-binding factor involved in double-strand break repair and V(D)J recombination
    • Rathmell, W. K., and G. Chu. 1994. A DNA end-binding factor involved in double-strand break repair and V(D)J recombination. Mol. Cell. Biol. 14: 4741-4748.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 4741-4748
    • Rathmell, W.K.1    Chu, G.2
  • 49
    • 0027966126 scopus 로고
    • Involvement of the Ku autoantigen in the cellular response to DNA double-strand breaks
    • Rathmell, W. K., and G. Chu. 1994. Involvement of the Ku autoantigen in the cellular response to DNA double-strand breaks. Proc. Natl. Acad. Sci. USA 91:7623-7627.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 7623-7627
    • Rathmell, W.K.1    Chu, G.2
  • 50
    • 0026792892 scopus 로고
    • V(D)J recombination: Broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes
    • Roth, D. B., J. P. Menetski, P. Nakajima, M. Bosma, and M. Gellert. 1992. V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes. Cell 70:983-991.
    • (1992) Cell , vol.70 , pp. 983-991
    • Roth, D.B.1    Menetski, J.P.2    Nakajima, P.3    Bosma, M.4    Gellert, M.5
  • 51
    • 0026762509 scopus 로고
    • V(D)J recombination in mouse thymocytes: Double-strand breaks near T cell receptor δ rearrangement signals
    • Roth, D. B., P. B. Nakajima, J. Menetski, M. Bosma, and M. Gellert. 1992. V(D)J recombination in mouse thymocytes: double-strand breaks near T cell receptor δ rearrangement signals. Cell 69:41-53.
    • (1992) Cell , vol.69 , pp. 41-53
    • Roth, D.B.1    Nakajima, P.B.2    Menetski, J.3    Bosma, M.4    Gellert, M.5
  • 52
    • 0024846088 scopus 로고
    • The V(D)J recombination activating gene, RAG-1
    • Schatz, D. G., M. A. Oettinger, and D. Baltimore. 1989. The V(D)J recombination activating gene, RAG-1. Cell 59:1035-1048.
    • (1989) Cell , vol.59 , pp. 1035-1048
    • Schatz, D.G.1    Oettinger, M.A.2    Baltimore, D.3
  • 53
    • 0027769386 scopus 로고
    • Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′ phosphorylated, RAG-dependent, and cell cycle regulated
    • Schlissel, M., A. Constantinescu, T. Morrow, M. Baxter, and A. Peng. 1993. Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′ phosphorylated, RAG-dependent, and cell cycle regulated. Genes Dev. 7:2520-2532.
    • (1993) Genes Dev. , vol.7 , pp. 2520-2532
    • Schlissel, M.1    Constantinescu, A.2    Morrow, T.3    Baxter, M.4    Peng, A.5
  • 56
    • 0028112944 scopus 로고
    • Restoration of x-ray resistance and V(D)J recombination in mutant cells by Ku cDNA
    • Smider, V., W. K. Rathmell, M. R. Lieber, and G. Chu. 1994. Restoration of x-ray resistance and V(D)J recombination in mutant cells by Ku cDNA. Science 266:288-291.
    • (1994) Science , vol.266 , pp. 288-291
    • Smider, V.1    Rathmell, W.K.2    Lieber, M.R.3    Chu, G.4
  • 58
    • 0028364447 scopus 로고
    • A DNA repair defect in Chinese hamster ovary cells affects V(D)J recombination similarly to the murine scid mutation
    • Taccioli, G. E., H.-L. Cheng, A. J. Varghese, G. Whitmore, and F. W. Alt. 1994. A DNA repair defect in Chinese hamster ovary cells affects V(D)J recombination similarly to the murine scid mutation. J. Biol. Chem. 269: 7439-7442.
    • (1994) J. Biol. Chem. , vol.269 , pp. 7439-7442
    • Taccioli, G.E.1    Cheng, H.-L.2    Varghese, A.J.3    Whitmore, G.4    Alt, F.W.5
  • 60
    • 0027156278 scopus 로고
    • Impairment of V(D)J recombination in double-strand break repair mutants
    • Taccioli, G. E., G. Rathbun, E. Oltz, T. Starnato, P. A. Jeggo, and F. W. Alt. 1993. Impairment of V(D)J recombination in double-strand break repair mutants. Science 260:207-210.
    • (1993) Science , vol.260 , pp. 207-210
    • Taccioli, G.E.1    Rathbun, G.2    Oltz, E.3    Starnato, T.4    Jeggo, P.A.5    Alt, F.W.6
  • 62
    • 0021271929 scopus 로고
    • Nuclear localization of unoccupied oestrogen receptors
    • Welshons, W. V., M. E. Lieberman, and J. Gorski. 1984. Nuclear localization of unoccupied oestrogen receptors. Nature (London) 307:747-749.
    • (1984) Nature (London) , vol.307 , pp. 747-749
    • Welshons, W.V.1    Lieberman, M.E.2    Gorski, J.3
  • 64
    • 0028958942 scopus 로고
    • Characterization of coding ends in thymocytes of scid mice: Implications for the mechanism of V(D)J recombination
    • Zhu, C., and D. B. Roth. 1995. Characterization of coding ends in thymocytes of scid mice: implications for the mechanism of V(D)J recombination. Immunity 2:101-112.
    • (1995) Immunity , vol.2 , pp. 101-112
    • Zhu, C.1    Roth, D.B.2


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