Alternate splice-site utilization in the gene for the catalytic subunit of the DNA-activated protein kinase, DNA-PK(cs)

Gene

Volumn 175, Issue 1-2, 1996, Pages 271-273

  Connelly, Margery A ^a   Zhang, Hong ^a,b   Kieleczawa, Jan ^a   Anderson, Carl W ^a  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

DNA double strand break repair; Phosphatidylinositol kinase related protein; V(D)J recombination

Indexed keywords

COMPLEMENTARY DNA; DNA; POLYADENYLATED RNA; PROTEIN SERINE THREONINE KINASE;

ALTERNATIVE RNA SPLICING; ARTICLE; ENZYME ACTIVE SITE; EXON; HUMAN; HUMAN CELL; MOLECULAR CLONING; MOLECULAR WEIGHT; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA STRUCTURE;

EID: 0030579121     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-1119(96)00135-7     Document Type: Article

References (17)

1. Andersen, C.W. (1993) DNA damage and the DNA-activated protein kinase. Trends Biochem. Sci. 18, 433-437.
2. Anderson, C.W. and Carter, T.H.: The DNA-activated protein kinase - DNA-PK. Curr. Topics Microbiol. Immunol. (in press).
3. Anderson, C.W. and Lees-Miller, S.P. (1992) The human DNA-activated protein kinase, DNA-PK. Crit. Rev. Eukaryotic Gene Expression 2, 283-314.
4. Blunt, T., Finnie, N.J., Taccioli, G.E., Smith, G.C.M., Demengeot, J., Gottlieb, T.M., Mizuta, R., Varghese. A.J., Alt, F.W., Jeggo, P.A. and Jackson, S.P. (1995) Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 80, 813-823.
5. Carter, T., Vanćurová, I., Sun, I., Lou, W. and DeLeon, S. (1990) A DNA-activated protein kinase from HeLa cell nuclei. Mol. Cell. Biol. 10, 6460-6471.
6. Hartley, K.O., Gell, D., Zhang, H., Smith, G.C.M., Divecha, N., Connelly, M.A., Admon. A., Lees-Miller, S.P., Anderson, C.W. and Jackson, S.P. (1995) DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell 82, 849-856.
7. Hanks, S.K. and Hunter, T. (1995) Protein kinases 6: the eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J. 9, 576-596.
8. Hunter, T. (1995) When is a lipid kinase not a lipid kinase? When it is a protein kinase. Cell 83, 1-4.
9. Jackson, S.P. and Jeggo, P.A. (1995) DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK. Trends Biochem. Sci. 20, 412-415.
10. Keith, C.T. and Schreiber, S.L. (1995) PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints. Science 270, 50-51.
11. Lees-Miller, S.P., Chen, Y.-R. and Anderson, C.W. (1990) Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53 and the human Ku autoantigen. Mol. Cell. Biol. 10, 6472-6481.
12. Peterson, S.R., Kurimasa, A., Oshimura, M., Dynan, W.S., Bradbury, E.M. and Chen, D.J. (1995) Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells. Proc. Natl. Acad. Sci. USA 92, 3171-3174.
13. Poltoratsky, V.P., Shi, X., York, J.D. Lieber, M.L. and Carter, T.H. (1996) Human DNA-PK is homologous to PI kinases. J. Immunol. 155, 4529-4533.
14. Roth, D.B., Lindahl, T. and Gellert, M. (1995) How to make ends meet. Curr. Biol. 5, 496-499.
15. Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D.A., Smith, S., Uziel, T., Sfez, S., Ashkenazi, M., Pecker, I., Frydman, M., Harnik, R., Patanjali, S. R., Simmons, A., Clines, G.A., Sartiel, A., Gatti, R.A., Chessa, L., Sanal, O., Lavin, M.F., Jaspers, N.J., Taylor, A.R., Arlett, C.F., Miki, T., Weissman, S.M., Lovett, M., Collins F. S. and Shiloh, Y. (1995) A single ataxia-telangi-ectasia gene with a product similar to PI 3-kinase. Science 268, 1749-1752.
16. Sipley, J.D., Menninger, J.C., Hartley, K.O., Ward, D.C., Jackson, S.P. and Anderson, C.W. (1995) Gene for the catalytic subunit of the human DNA-activated protein kinase maps to the site of the XRCC7 gene on chromosome 8. Proc. Natl. Acad. Sci. USA 92, 7515-7519.
17. Zakian, V.A. (1995) ATM-related genes: what do they tell us about functions of the human gene? Cell 82, 685-687.