A newly identified DNA ligase of Saccharomyces cerevisiae involved in RAD52-independent repair of DNA double-strand breaks

Genes and Development

Volumn 11, Issue 15, 1997, Pages 1912-1924

  Schär, Primo ^a,b   Herrmann, Gernot ^b   Daly, Graham ^b   Lindahl, Tomas ^b  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

CDC9; DNA ligase IV; DNA repair; Illegitimate recombination; Meiosis

Indexed keywords

DOUBLE STRANDED DNA; POLYDEOXYRIBONUCLEOTIDE SYNTHASE;

ARTICLE; DNA REPAIR; DNA REPLICATION; DNA STRAND BREAKAGE; ENZYME ACTIVITY; MEIOSIS; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

EUKARYOTA; MAMMALIA; SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES; SCHIZOSACCHAROMYCES POMBE;

EID: 0030749258     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.11.15.1912     Document Type: Article

References (55)

1. Andaluz, E., G. Larriba, and R. Calderone. 1996. A Candida albicans gene encoding a DNA ligase. Yeast 12: 893-898.
2. Bähler, J., G. Hagens, G. Holzinger, H. Schertan, and W.-D. Heyer. 1994. Saccharomyces cerevisiae cells lacking the homologous pairing protein p175SEP1 arrest at pachytene during meiotic prophase. Chromosoma 103: 129-141.
3. Barker, D.G., J.H. White, and L.H. Johnston. 1985. The nucleotide sequence of the DNA ligase gene (CDC9) from Saccharomyces cerevisiae: A gene which is cell-cycle regulated and induced in response to DNA damage. Nucleic Acids Res. 13: 8323-8337.
4. _. 1987. Molecular characterisation of the DNA ligase gene, CDC17, from the fission yeast Schizosaccharomyces pombe. Eur. J. Biochem. 162: 659-667.
5. Barnes, D.E., L.H. Johnston, K. Kodama, A.E. Tomkinson, D.D. Lasko, and T. Lindahl. 1990. Human DNA ligase I cDNA: Cloning and functional expression in Saccharomyces cerevisiae. PIOC. Natl. Acad. Sci. 87: 6679-6683.
6. Barnes, D.E., A.E. Tomkinson, A.R. Lehmann, A.D.B. Webster, and T. Lindahl. 1992. Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents. Cell 69: 495-503.
7. Barnes, G. and D. Rio. 1997. DNA double strand break sensitivity, DNA replication, and cell cycle arrest phenotypes of Ku-deficient Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. 94: 867-872.
8. Boulton, S.J. and S.P. Jackson. 1996a. Identification of a Saccharomyces cerevisiae Ku80 homologue; Roles in DNA double strand break rejoining and in telomeric maintenance. Nucleic Acids Res. 24: 4639-4648.
9. _. 1996b. Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways. EMBO J. 15: 5093-5103.
10. Callebaut, I. and J.P. Mornon. 1997. From BRCA1 to RAP1: A widespread BRCT module closely associated with DNA repair. FEBS Lett. 400: 25-30.
11. Chen, J., A.E. Tomkinson, W. Ramos, Z.B. Mackey, S. Danehower, C.A. Walter, R.A. Schultz, J.M. Besterman, and I. Husain. 1995. Mammalian DNA ligase III: Molecular cloning, chromosomal localization, and expression in spermatocytes undergoing meiotic recombination. Mol Cell. Biol, 15: 5412-5422.
12. Derr, L.K., J.N. Strathern, and D.J. Garfinkel. 1991. RNA-mediated recombination in S. cerevisiae. Cell 67: 355-364.
13. Devereux, J., P. Haeberli, and O. Smithies. 1984. A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res. 16: 7025-7042.
14. Feldmann, H. and E.L. Winnacker. 1993. A putative homologue . of the human autoantigen Ku from Saccharomyces cerevisiae. J. Biol. Chem. 268: 12895-12900.
15. Friedberg, E.G., G.G. Walker, and W. Siede. 1995. DNA repair and mutagenesis. pp. 662-669. American Society for Microbiology, Washington, D.C.
16. Gietz, R.D. and R.H. Schiestl. 1991. Applications of high efficiency lithium acetate transformation of intact yeast cells using single-stranded nucleic acids as carrier. Yeast 7: 253-263.
17. Haber, J.E. 1992a. Exploring the pathways of homologous recombination. Curr. Opin. Cell Biol. 4: 401-412.
18. _. 1992b. Mating-type gene switching in Saccharomyces cerevisiae. Trends Genet. 8: 446-452.
19. Jesnowski, R., J. Naehring, and K. Wolf. 1995. A rapid and reliable method for PCR-based amplification of chromosomal and mitochodrial DNA from intact yeast cells. Curr. Genet. 27: 318-319.
20. Johnston, L.H. and K.A. Nasmyth. 1978. Saccharomyces cerevisiae cell cycle mutant cdc9 is defective in DNA ligase. Nature 274: 891-893.
21. Kramer, K.M., J.A. Brock, K. Bloom, K. Moore, and J.E. Haber. 1994. Two different types of double strand breaks in Saccharomyces cerevisiae are repaired by similar RAD52 independent, nonhomologous recombination events. Mol Cell. Biol. 14: 1293-1301.
22. Kubota, Y., R.A. Nash, A. Klungland, P. Schär, D.E. Barnes, and T. Lindahl. 1996. Reconstitution of DNA base excision-repair with purified human proteins: Interaction between DNA polymerase β and the XRCC1 protein. EMBO J. 15: 6662-6670.
23. Lindahl, T. and D.E. Barnes. 1992. Mammalian DNA ligases. Annu. Rev. Biochem. 61: 251-281.
24. Mackenney, V.J., D.E. Barnes, and T. Lindahl. 1997. Specific function of DNA ligase I in SV40 DNA replication by human cell-free extracts is mediated by the amino terminal non-catalytic domain. J. Biol. Chem. 272: 11550-11556.
25. Mages, G.J., H.M. Feldmann, and E.L. Winnacker. 1996. Involvement of Saccharomyces cerevisiae HDF1 gene in DNA double-strand break repair and recombination. J. Biol Chem. 271: 7910-7915.
26. Mezard, C. and A. Nicolas. 1994. Homologous, homeologous, and illegitimate repair of double-strand breaks during transformation of a wild-type strain and a rad52 mutant strain of Saccharomyces cerevisiae. Mol. Cell. Biol. 14: 1278-1292.
27. Milne, G.T., S. Jin, K.B. Shannon, and D.T. Weaver. 1996. Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae. Mol. Cell. Biol. 16: 4189-1198.
28. Moore, J.K. and I.E. Haber. 1996. Cell cycle and genetic requiremerits of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae. Mol. Cell. Biol 16: 2164-2173.
29. Nash, R.A., K.W. Caldecott, D.E. Barnes, and T. Lindahl. 1997. XRCC1 protein interacts with one of two distinct forms of DNA ligase III. Biochemistry 36: 5207-5211.
30. Nicolas, A. and T.D. Petes. 1994. Polarity of meiotic gene conversion in fungi: Contrasting views. Experientia 50: 242-252.
31. Padmore, R., L. Cao, and N. Kleckner. 1991. Temporal comparison of recombination and synaptonemal complex formation during meiosis in S. cerevisiae. Cell 66: 1239-1256.
32. Petes, T.D., R.E. Malone, and L.S. Symington. 1991. Recombination in yeast. In The molecular and cellular biology of the yeast Saccharomyces: Genome dynamics, protein synthesis and energetics (ed. J.R. Broach, E. Jones, and J. Pringle), Vol. 1, pp. 407-521. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
33. Petrini, J.H.J., Y. Xiao, and D.T. Weaver. 1995. DNA ligase I mediates essential functions in mammalian cells. Mol Cell. Biol. 15: 4303-4308.
34. Prigent, C., M.S. Satoh, G. Daly, D.E. Barnes, and T. Lindahl. 1994. Aberrant DNA repair and DNA replication due to an inherited enzymatic defect in human DNA ligase I. Mol Cell. Biol. 14: 310-317.
35. Ramos, W., N. Tappe, J. Talamantez, E.G. Friedberg, and A.E. Tomkinson. 1997. Two distinct DNA ligase activities in mitotic extracts of the yeast Saccharomyces cerevisiae. Nucleic Acids Res. 25: 1485-1492.
36. Roberts, E., R.A. Nash, P. Robins, and T. Lindahl. 1994. Different active sites of mammalian DNA ligases I and II. J. Biol. Chem. 269: 3789-3792.
37. Robins, P. and T. Lindahl. 1996. DNA ligase IV from HeLa cell nuclei. J. Biol. Chem. 271: 24257-24266.
38. Roeder, G.S. 1995. Sex and the single cell: Meiosis in yeast. Proc. Natl Acad. Sci. 92: 10450-10456.
39. Schiestl, R.H. and T.D. Petes. 1991. Integration of DNA fragments by illegitimate recombination in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. 88: 7585-7589.
40. Schiestl, R.H., J. Zhu, and T.D. Petes. 1994. Effect of mutations in genes affecting homologous recombination on restriction enzyme-mediated and illegitimate recombination in Saccharomyces cerevisiae. Mol. Cell. Biol. 14: 4493-4500.
41. Sherman, F., G.K. Fink, and J.B. Hicks. 1982. Methods in yeast genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
42. Shuman, S. and B. Schwer. 1995. RNA capping enzyme and DNA ligase: A superfamily of covalent nucleotide transferases. Mol. Microbiol. 17: 405-410.
43. Siede, W., A.A. Friedl, I. Dianova, F. Eckardt-Schupp, and E.G. Friedberg. 1996. The Saccharomyces cerevisiae Ku autoantigen homologue affects radiosensitivity only in the absence of homologous recombination. Genetics 142: 91-102.
44. Simchen, G. 1974. Are mitotic functions required in meiosisGenetics 76: 745-753.
45. Sipiczki, M., A.M. Grossenbacher-Grunder, and Z. Bodi. 1990. Recombination and mating-type switching in a ligase-deficient mutant of Schizosaccharomyces pombe. Mol & Gen. Genet. 220: 307-313.
46. Sterky, F., A. Holmberg, B. Pettersson, and M. Uhlén. 1996. The sequence of a 30 kb fragment on the left arm of chromosome XV from Saccharomyces cerevisiae reveals 15 open reading frames, five of which correspond to previously identified genes. Yeast 12: 1091-1095.
47. Subramanya, H.S., A.J. Doherty, S.R. Ashford, and D.B. Wigley. 1996. Crystal structure of an ATP-dependent DNA ligase from bacteriophage T7. Cell 85: 607-615.
48. Teo, S.-H. and S.P. Jackson. 1997. Identification of Saccharomyces cerevisiae DNA ligase IV: Involvement in DNA doublestrand-break repair. EMBO J. (in press).
49. Thompson, L.H., K.W. Brookman, N.J. Jones, S.A. Allen, and A.V. Carrano. 1990. Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange. Mol Cell Biol 10: 6160-6171.
50. Tomkinson, A.E., N.F. Totty, M. Ginsburg, and T. Lindahl. 1991. Location of the active site for enzyme-adenylate formation in DNA ligases. Proc. Natl. Acad. Sci. 88: 400-404.
51. Tomkinson, A.E., N.J. Tappe, and E.G. Friedberg. 1992. DNA ligase I from Saccharomyces cerevisiae: Physical and biochemical characterization of the CDC9 gene product. Biochemistry 31: 11762-11771.
52. Tsukamoto, Y., J.-i. Kato, and H. Ikeda. 1996. Hdf1, a yeast Ku-protein homologue, is involved in illegitimate recombination, but not in homologous recombination. Nucleic Acids Res. 24: 2067-2072.
53. Wach, A., A. Brachat, R. Pöhlmann, and P. Philippsen. 1994. New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae. Yeast 10: 1793-1808.
54. Waga, S., G. Bauer, and B. Stillman. 1994. Reconstitution of complete SV40 DNA replication with purified replication factors. J. Biol. Chem. 269: 10923-10934.
55. Wei, Y.-F., P. Robins, K. Carter, K. Caldecott, D.J.C. Pappin, G.-L. Yu, R.-P. Wang, B.K. Shell, R.A. Nash, P. Schär, D.E. Barnes, W.A. Haseltine, and T. Lindahl. 1995. Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination. Mol Cell. Biol. 15: 3206-3216.