Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 15, 1997, Pages 8076-8081

  Gu, Yansong ^b,c   Jin, Shengfang ^c,d   Gao, Yijie ^c   Weaver, David T ^c,d   Alt, Frederick W ^a,b,c  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; IMMUNOGLOBULIN RECEPTOR; PROTEIN KINASE;

ANIMAL CELL; ARTICLE; DNA BINDING; DNA STRAND BREAKAGE; ENZYME SUBUNIT; GAMMA IRRADIATION; GENE TARGETING; GENETIC RECOMBINATION; IMMUNE DEFICIENCY; NONHUMAN; PRIORITY JOURNAL; RADIOSENSITIVITY;

ANIMALS; ANTIGENS, NUCLEAR; CHO CELLS; CRICETINAE; DNA HELICASES; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; EMBRYO; GAMMA RAYS; GENE TARGETING; IMMUNOGLOBULIN JOINING REGION; IMMUNOGLOBULIN VARIABLE REGION; MICE; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; RADIATION TOLERANCE; RECOMBINATION, GENETIC; STEM CELLS;

ANIMALIA; MURINAE;

EID: 0030858967     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.15.8076     Document Type: Article

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