P53-dependent apoptosis and transcription of p21(waf/cip1/sdi1) in SCID mice following γ-irradiation

Biochimie

Volumn 79, Issue 9-10, 1997, Pages 607-612

  Candeias S M ^a,b   Durum, S K ^a   Muegge, K ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b CEA GRENOBLE   (France)

Author keywords

Apoptosis; DNA dependent protein kinase; Ionizing radiation; p53; Radiosensitivity

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; PROTEIN P21; PROTEIN P53; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; CONFERENCE PAPER; CONTROLLED STUDY; DNA TRANSCRIPTION; GAMMA RADIATION; MOUSE; NONHUMAN; SCID MOUSE;

ANIMALIA;

EID: 0345244825     PISSN: 03009084     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-9084(97)82010-X     Document Type: Conference Paper

References (24)

1. Gottlieb TM, Jackson SP (1993) The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell 72, 131-142
2. Anderson CW (1993) DNA damage and the DNA-activated protein kinase. TIBS 18, 432-437
3. Gottlieb TM, Jackson SP (1994) Protein kinases and DNA damage. TIBS 19, 500-503
4. Weaver DT (1995) V (D)J recombination and double-strand break repair. Adv Immunol 58, 29-85
5. Lees-Miller SP, Sakagushi K, Ullrich SJ, Appella E, Anderson CW (1992) Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Mol Cell Biol 12, 5041-5049
6. Haffner R, Oren M (1995) Biochemical properties and biological effects of p53. Curr Opin Gene Dev 5, 84-90
7. Hainaut P (1995) The tumor suppressor protein p53: a receptor to genotoxic stress that controls cell growth and survival. Curr Opin Oncol 7, 76-82
8. Xiong Y, Haanon GJ, Zhang H, Casso D, Kobayashi R, Beach D (1993) p21 is a universal inhibitor of cyclin kinases. Nature 366, 701-704
9. El-Deiry WS, Harper JW, O'Connor PM, Valculescu VE, Canman CE, Jackman J, Pietenpol JA, Burrell M, Hill DE, Wang YW, KG, Mercer WE, Kastan MB, Kohn KW, Elledge SJ, Kinzler KW, Vogelstein B (1994) WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res 54, 1169-1174
10. Macleod KF, Sherry N, Hannon G, Beach D, Tokino T, Kinzler K, Vogelstein B, Jacks T (1995) p53-dependent and independent expression of p21 during cell growth, differentiation and DNA damage. Genes Dev 9, 935-944
11. Clarke AR, Purdie CA, Harrison DJ, Morris RG, Bird CC, Hooper ML, Wylie AH (1993) Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 362, 849-852
12. Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T (1993) p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362, 847-849
13. Blunt T, Finnie NJ, Taccioli GE, Smith GCM, Demengeot J, Gottlieb TM, Mizuta R, Varghese AJ, Alt FW, Jeggo PA, Jackson SP (1995) Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 80, 813-823
14. Kirchgessner CU, Patil CK, Evans JW, Cuomo CA, Fried LM, Carter T, Oettinger MA, Brown JJ (1995) DNA-dependent kinase (p350) as a candidate for the murine SCID defect. Science 267, 1178-1182
15. Jacks T, Remington L, Williams BO, Schmitt EM, Halachmi S, Bronson RT, Weinberg RA (1994) Tumor spectrum analysis in p53-mutant mice. Curr Biol 4, 1-7
16. Jacobs H, Vandeputte D, Tolkamp L, de Vries E, Borst J, Berns A (1994) CD3 components at the surface of pro-T cells can mediate pre-T cell development in vivo. Eur J Immunol 24, 934-939
17. Michielli P, Chedid M, Lin D, Pierce JH, Mercer WE, Givol D (1994) Induction of WAF1/CIP1 by a p53-independant pathway. Cancer Res 54, 3391-3395
18. Keith CT, Schreiber SL (1995) PIK-related kinases: DNA repair, recombination and cell cycle checkpoints. Science 270, 50-51
19. Kastan MB, Zhan Q, El-Deiry WS, Carrier F, Jacks T, Walsh WV, Plunkett BS, Vogelstein B, Fornace AJ (1992) A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in Ataxia-Telangiectasia. Cell 71, 587-597
20. Fiscella M, Ullrich SJ, Zambrano N, Shields MT, Lin D, Lees-Miller SP, Anderson CW, Mercer WE, Appella E (1993) Mutation of the serine 15 phophorylation site of human p53 reduces the ability of p53 to inhibit cell cylce progression. Oncogene 8, 1519-1528
21. Bogue MA, Zhu C, Aguilar-Cordova E, Donehower LA, Roth DB (1996) p53 is required for both radiation-induced differentiation and rescue of V (D)J rearrangement in seid mouse thymocytes. Genes Dev 10, 553-565
22. Chen J, Marechal V, Levine AJ (1993) Mapping of the p53 and mdm2 interaction domains. Mol Cell Biol 13, 4107-4114
23. Montes de Oca Luna R, Wagner DS, Lozano G (1995) Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 378, 203-206
24. Jones SN, Roe AE, Donehower LA, Bradley A (1995) Rescue of embryonic lethality in mdm2-deficient mice by absence of p53. Nature 378, 206-208