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Volumn 6, Issue 1, 2017, Pages

May I cut in? Gene editing approaches in human induced pluripotent stem cells

Author keywords

CRISPR Cas9; Genome editing; Homology directed repair; Human induced pluripotent stem cells (hiPSCs); TALEN; ZFN

Indexed keywords

ALPHA 1 ANTITRYPSIN; CASPASE 9; CRISPR ASSOCIATED PROTEIN; GANCICLOVIR; LIPOPROTEIN; PRESENILIN 1; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE; ZINC FINGER NUCLEASE;

EID: 85056746775     PISSN: None     EISSN: 20734409     Source Type: Journal    
DOI: 10.3390/cells6010005     Document Type: Review
Times cited : (37)

References (197)
  • 1
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • [CrossRef] [PubMed]
    • Takahashi, K.; Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126, 663–676. [CrossRef] [PubMed]
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 2
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • [CrossRef] [PubMed]
    • Takahashi, K.; Tanabe, K.; Ohnuki, M.; Narita, M.; Ichisaka, T.; Tomoda, K.; Yamanaka, S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007, 131, 861–872. [CrossRef] [PubMed]
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6    Yamanaka, S.7
  • 3
    • 84887135802 scopus 로고    scopus 로고
    • An improved method for the derivation of high quality iPSCs in the absence of c-myc
    • [CrossRef] [PubMed]
    • Habib, O.; Habib, G.; Choi, H.W.; Hong, K.S.; Do, J.T.; Moon, S.H.; Chung, H.M. An improved method for the derivation of high quality iPSCs in the absence of c-myc. Exp. Cell Res. 2013, 319, 3190–3200. [CrossRef] [PubMed]
    • (2013) Exp. Cell Res , vol.319 , pp. 3190-3200
    • Habib, O.1    Habib, G.2    Choi, H.W.3    Hong, K.S.4    Do, J.T.5    Moon, S.H.6    Chung, H.M.7
  • 4
    • 84877956498 scopus 로고    scopus 로고
    • Efficient generation of integration-free ips cells from human adult peripheral blood using bcl-xl together with yamanaka factors
    • [CrossRef] [PubMed]
    • Su, R.J.; Baylink, D.J.; Neises, A.; Kiroyan, J.B.; Meng, X.; Payne, K.J.; Tschudy-Seney, B.; Duan, Y.; Appleby, N.; Kearns-Jonker, M. et al. Efficient generation of integration-free ips cells from human adult peripheral blood using bcl-xl together with yamanaka factors. PLoS ONE 2013, 8, e64496. [CrossRef] [PubMed]
    • (2013) Plos ONE , vol.8
    • Su, R.J.1    Baylink, D.J.2    Neises, A.3    Kiroyan, J.B.4    Meng, X.5    Payne, K.J.6    Tschudy-Seney, B.7    Duan, Y.8    Appleby, N.9    Kearns-Jonker, M.10
  • 5
    • 77958536106 scopus 로고    scopus 로고
    • Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA
    • [CrossRef] [PubMed]
    • Warren, L.; Manos, P.D.; Ahfeldt, T.; Loh, Y.H.; Li, H.; Lau, F.; Ebina, W.; Mandal, P.K.; Smith, Z.D.; Meissner, A. et al. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 2010, 7, 618–630. [CrossRef] [PubMed]
    • (2010) Cell Stem Cell , vol.7 , pp. 618-630
    • Warren, L.1    Manos, P.D.2    Ahfeldt, T.3    Loh, Y.H.4    Li, H.5    Lau, F.6    Ebina, W.7    Mandal, P.K.8    Smith, Z.D.9    Meissner, A.10
  • 6
    • 66049135249 scopus 로고    scopus 로고
    • Generation of induced pluripotent stem cells using recombinant proteins
    • [CrossRef] [PubMed]
    • Zhou, H.; Wu, S.; Joo, J.Y.; Zhu, S.; Han, D.W.; Lin, T.; Trauger, S.; Bien, G.; Yao, S.; Zhu, Y. et al. Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell 2009, 4, 381–384. [CrossRef] [PubMed]
    • (2009) Cell Stem Cell , vol.4 , pp. 381-384
    • Zhou, H.1    Wu, S.2    Joo, J.Y.3    Zhu, S.4    Han, D.W.5    Lin, T.6    Trauger, S.7    Bien, G.8    Yao, S.9    Zhu, Y.10
  • 7
    • 84881256653 scopus 로고    scopus 로고
    • Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds
    • [CrossRef] [PubMed]
    • Hou, P.; Li, Y.; Zhang, X.; Liu, C.; Guan, J.; Li, H.; Zhao, T.; Ye, J.; Yang, W.; Liu, K. et al. Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science 2013, 341, 651–654. [CrossRef] [PubMed]
    • (2013) Science , vol.341 , pp. 651-654
    • Hou, P.1    Li, Y.2    Zhang, X.3    Liu, C.4    Guan, J.5    Li, H.6    Zhao, T.7    Ye, J.8    Yang, W.9    Liu, K.10
  • 8
    • 46949085597 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds
    • [CrossRef] [PubMed]
    • Huangfu, D.; Maehr, R.; Guo, W.; Eijkelenboom, A.; Snitow, M.; Chen, A.E.; Melton, D.A. Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat. Biotechnol. 2008, 26, 795–797. [CrossRef] [PubMed]
    • (2008) Nat Biotechnol , vol.26 , pp. 795-797
    • Huangfu, D.1    Maehr, R.2    Guo, W.3    Eijkelenboom, A.4    Snitow, M.5    Chen, A.E.6    Melton, D.A.7
  • 12
    • 85018239209 scopus 로고    scopus 로고
    • Advances in stem cell research- a ray of hope in better diagnosis and prognosis in neurodegenerative diseases
    • [CrossRef] [PubMed]
    • Singh, S.; Srivastava, A.; Srivastava, P.; Dhuriya, Y.K.; Pandey, A.; Kumar, D.; Rajpurohit, C.S.: Advances in stem cell research- a ray of hope in better diagnosis and prognosis in neurodegenerative diseases. Front. Mol. Biosci. 2016, 3, 72. [CrossRef] [PubMed]
    • (2016) Front. Mol. Biosci , vol.3 , pp. 72
    • Singh, S.1    Srivastava, A.2    Srivastava, P.3    Dhuriya, Y.K.4    Pandey, A.5    Kumar, D.6    Rajpurohit, C.S.7
  • 13
    • 84975126931 scopus 로고    scopus 로고
    • Modeling Alzheimer's disease with induced pluripotent stem cells: Current challenges and future concerns
    • [CrossRef] [PubMed]
    • Zhang, W.; Jiao, B.; Zhou, M.; Zhou, T.; Shen, L. Modeling Alzheimer's disease with induced pluripotent stem cells: Current challenges and future concerns. Stem Cells Int. 2016, 2016, 7828049. [CrossRef] [PubMed]
    • (2016) Stem Cells Int , vol.2016
    • Zhang, W.1    Jiao, B.2    Zhou, M.3    Zhou, T.4    Shen, L.5
  • 14
    • 84988977028 scopus 로고    scopus 로고
    • Review: Induced pluripotent stem cell models of frontotemporal dementia
    • [CrossRef] [PubMed]
    • Preza, E.; Hardy, J.; Warner, T.; Wray, S. Review: Induced pluripotent stem cell models of frontotemporal dementia. Neuropathol. Appl. Neurobiol. 2016, 42, 497–520. [CrossRef] [PubMed]
    • (2016) Neuropathol. Appl. Neurobiol , vol.42 , pp. 497-520
    • Preza, E.1    Hardy, J.2    Warner, T.3    Wray, S.4
  • 15
    • 84969233464 scopus 로고    scopus 로고
    • Induced pluripotent stem cells in Alzheimer's Disease: Applications for disease modeling and cell-replacement therapy
    • [CrossRef] [PubMed]
    • Yang, J.; Li, S.; He, X.B.; Cheng, C.; Le, W. Induced pluripotent stem cells in Alzheimer's Disease: Applications for disease modeling and cell-replacement therapy. Mol. Neurodegener. 2016, 11, 39. [CrossRef] [PubMed]
    • (2016) Mol. Neurodegener , vol.11 , pp. 39
    • Yang, J.1    Li, S.2    He, X.B.3    Cheng, C.4    Le, W.5
  • 16
    • 84959077713 scopus 로고    scopus 로고
    • Modeling Alzheimer’s disease with human induced pluripotent stem (IPS) cells
    • [CrossRef] [PubMed]
    • Mungenast, A.E.; Siegert, S.; Tsai, L.H. Modeling Alzheimer’s disease with human induced pluripotent stem (iPS) cells. Mol. Cell. Neurosci. 2016, 73, 13–31. [CrossRef] [PubMed]
    • (2016) Mol. Cell. Neurosci , vol.73 , pp. 13-31
    • Mungenast, A.E.1    Siegert, S.2    Tsai, L.H.3
  • 17
    • 84945152039 scopus 로고    scopus 로고
    • Modeling developmental neuropsychiatric disorders with iPSC technology: Challenges and opportunities
    • [CrossRef] [PubMed]
    • Young-Pearse, T.L.; Morrow, E.M. Modeling developmental neuropsychiatric disorders with iPSC technology: Challenges and opportunities. Curr. Opin. Neurobiol. 2016, 36, 66–73. [CrossRef] [PubMed]
    • (2016) Curr. Opin. Neurobiol , vol.36 , pp. 66-73
    • Young-Pearse, T.L.1    Morrow, E.M.2
  • 18
    • 84983775724 scopus 로고    scopus 로고
    • Human induced pluripotent stem cells as a platform for personalized and precision cardiovascular medicine
    • [CrossRef] [PubMed]
    • Matsa, E.; Ahrens, J.H.; Wu, J.C. Human induced pluripotent stem cells as a platform for personalized and precision cardiovascular medicine. Physiol. Rev. 2016, 96, 1093–1126. [CrossRef] [PubMed]
    • (2016) Physiol. Rev , vol.96 , pp. 1093-1126
    • Matsa, E.1    Ahrens, J.H.2    Wu, J.C.3
  • 19
    • 84939240419 scopus 로고    scopus 로고
    • Cardiovascular disease modeling using patient-specific induced pluripotent stem cells
    • [CrossRef] [PubMed]
    • Tanaka, A.; Yuasa, S.; Node, K.; Fukuda, K. Cardiovascular disease modeling using patient-specific induced pluripotent stem cells. Int. J. Mol. Sci. 2015, 16, 18894–18922. [CrossRef] [PubMed]
    • (2015) Int. J. Mol. Sci , vol.16 , pp. 18894-18922
    • Tanaka, A.1    Yuasa, S.2    Node, K.3    Fukuda, K.4
  • 20
    • 84981722718 scopus 로고    scopus 로고
    • Modeling kidney disease with ips cells
    • [CrossRef] [PubMed]
    • Freedman, B.S.: Modeling kidney disease with ips cells. Biomark. Insights 2015, 10, 153–169. [CrossRef] [PubMed]
    • (2015) Biomark. Insights , vol.10 , pp. 153-169
    • Freedman, B.S.1
  • 21
    • 84941071308 scopus 로고    scopus 로고
    • Personalized medicine for cystic fibrosis: Establishing human model systems
    • [CrossRef] [PubMed]
    • Mou, H.; Brazauskas, K.; Rajagopal, J. Personalized medicine for cystic fibrosis: Establishing human model systems. Pediatr. Pulmonol. 2015, 50 (Suppl S40), S14–S23. [CrossRef] [PubMed]
    • (2015) Pediatr. Pulmonol , vol.50 , pp. S14-S23
    • Mou, H.1    Brazauskas, K.2    Rajagopal, J.3
  • 22
    • 84942290958 scopus 로고    scopus 로고
    • Clinical potentials of human pluripotent stem cells in lung diseases
    • [CrossRef] [PubMed]
    • Quan, Y.; Wang, D. Clinical potentials of human pluripotent stem cells in lung diseases. Clin. Transl. Med. 2014, 3, 15. [CrossRef] [PubMed]
    • (2014) Clin. Transl. Med , vol.3 , pp. 15
    • Quan, Y.1    Wang, D.2
  • 23
    • 84957589086 scopus 로고    scopus 로고
    • Use of human stem cells in huntington disease modeling and translational research
    • [CrossRef] [PubMed]
    • Golas, M.M.; Sander, B. Use of human stem cells in huntington disease modeling and translational research. Exp. Neurol. 2016, 278, 76–90. [CrossRef] [PubMed]
    • (2016) Exp. Neurol , vol.278 , pp. 76-90
    • Golas, M.M.1    Sander, B.2
  • 24
    • 84958748622 scopus 로고    scopus 로고
    • Recent advances in disease modeling and drug discovery for diabetes mellitus using induced pluripotent stem cells
    • [CrossRef] [PubMed]
    • Kawser Hossain, M.; Abdal Dayem, A.; Han, J.; Kumar Saha, S.; Yang, G.M.; Choi, H.Y.; Cho, S.G.: Recent advances in disease modeling and drug discovery for diabetes mellitus using induced pluripotent stem cells. Int. J. Mol. Sci. 2016, 17, 256. [CrossRef] [PubMed]
    • (2016) Int. J. Mol. Sci , vol.17 , pp. 256
    • Kawser Hossain, M.1    Abdal Dayem, A.2    Han, J.3    Kumar Saha, S.4    Yang, G.M.5    Choi, H.Y.6    Cho, S.G.7
  • 25
    • 84970937934 scopus 로고    scopus 로고
    • Human pluripotent stem cell based islet models for diabetes research
    • [CrossRef] [PubMed]
    • Balboa, D.; Otonkoski, T. Human pluripotent stem cell based islet models for diabetes research. Best Pract. Res. Clin. Endocrinol. Metab. 2015, 29, 899–909. [CrossRef] [PubMed]
    • (2015) Best Pract. Res. Clin. Endocrinol. Metab , vol.29 , pp. 899-909
    • Balboa, D.1    Otonkoski, T.2
  • 26
    • 84964344025 scopus 로고    scopus 로고
    • Concise review: Heteroplasmic mitochondrial DNA mutations and mitochondrial diseases: Toward iPSC-based disease modeling, drug discovery, and regenerative therapeutics
    • [CrossRef] [PubMed]
    • Hatakeyama, H.; Goto, Y. Concise review: Heteroplasmic mitochondrial DNA mutations and mitochondrial diseases: Toward iPSC-based disease modeling, drug discovery, and regenerative therapeutics. Stem Cells 2016, 34, 801–808. [CrossRef] [PubMed]
    • (2016) Stem Cells , vol.34 , pp. 801-808
    • Hatakeyama, H.1    Goto, Y.2
  • 27
    • 84955497904 scopus 로고    scopus 로고
    • Mitochondrial resetting and metabolic reprogramming in induced pluripotent stem cells and mitochondrial disease modeling
    • [CrossRef] [PubMed]
    • Hsu, Y.C.; Chen, C.T.; Wei, Y.H. Mitochondrial resetting and metabolic reprogramming in induced pluripotent stem cells and mitochondrial disease modeling. Biochim. Biophys. Acta. 2016, 1860, 686–693. [CrossRef] [PubMed]
    • (2016) Biochim. Biophys. Acta , vol.1860 , pp. 686-693
    • Hsu, Y.C.1    Chen, C.T.2    Wei, Y.H.3
  • 28
    • 85051604758 scopus 로고    scopus 로고
    • Induced pluripotent stem cells: Applications in regenerative medicine, disease modeling, and drug discovery
    • [CrossRef] [PubMed]
    • Singh, V.K.; Kalsan, M.; Kumar, N.; Saini, A.; Chandra, R. Induced pluripotent stem cells: Applications in regenerative medicine, disease modeling, and drug discovery. Front. Cell Dev. Biol. 2015, 3, 2. [CrossRef] [PubMed]
    • (2015) Front. Cell Dev. Biol , vol.3 , pp. 2
    • Singh, V.K.1    Kalsan, M.2    Kumar, N.3    Saini, A.4    Chandra, R.5
  • 29
    • 84893748014 scopus 로고    scopus 로고
    • Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application
    • [CrossRef] [PubMed]
    • Kamao, H.; Mandai, M.; Okamoto, S.; Sakai, N.; Suga, A.; Sugita, S.; Kiryu, J.; Takahashi, M. Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application. Stem Cell Rep. 2014, 2, 205–218. [CrossRef] [PubMed]
    • (2014) Stem Cell Rep , vol.2 , pp. 205-218
    • Kamao, H.1    Mandai, M.2    Okamoto, S.3    Sakai, N.4    Suga, A.5    Sugita, S.6    Kiryu, J.7    Takahashi, M.8
  • 32
  • 33
    • 79958096048 scopus 로고    scopus 로고
    • Generating gene knockout rats by homologous recombination in embryonic stem cells
    • [CrossRef] [PubMed]
    • Tong, C.; Huang, G.; Ashton, C.; Li, P.; Ying, Q.L. Generating gene knockout rats by homologous recombination in embryonic stem cells. Nat. Protoc. 2011, 6, 827–844. [CrossRef] [PubMed]
    • (2011) Nat. Protoc , vol.6 , pp. 827-844
    • Tong, C.1    Huang, G.2    Ashton, C.3    Li, P.4    Ying, Q.L.5
  • 34
    • 0026771287 scopus 로고
    • Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs
    • [CrossRef] [PubMed]
    • Te Riele, H.; Maandag, E.R.; Berns, A. Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs. Proc. Natl. Acad. Sci. USA 1992, 89, 5128–5132. [CrossRef] [PubMed]
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 5128-5132
    • Te Riele, H.1    Maandag, E.R.2    Berns, A.3
  • 35
    • 0002768524 scopus 로고    scopus 로고
    • Gene targeting in human cells without isogenic DNA
    • [CrossRef]
    • Sedivy, J.M. Gene targeting in human cells without isogenic DNA. Science 1999, 283, 9. [CrossRef]
    • (1999) Science , vol.283 , pp. 9
    • Sedivy, J.M.1
  • 36
    • 3543030995 scopus 로고    scopus 로고
    • Modeling for lesch-nyhan disease by gene targeting in human embryonic stem cells
    • [CrossRef] [PubMed]
    • Urbach, A.; Schuldiner, M.; Benvenisty, N. Modeling for lesch-nyhan disease by gene targeting in human embryonic stem cells. Stem Cells 2004, 22, 635–641. [CrossRef] [PubMed]
    • (2004) Stem Cells , vol.22 , pp. 635-641
    • Urbach, A.1    Schuldiner, M.2    Benvenisty, N.3
  • 37
    • 0033032454 scopus 로고    scopus 로고
    • Gene targeting and somatic cell genetics–a rebirth or a coming of age?
    • [CrossRef]
    • Sedivy, J.M.; Dutriaux, A. Gene targeting and somatic cell genetics–a rebirth or a coming of age? Trends Genet. 1999, 15, 88–90. [CrossRef]
    • (1999) Trends Genet , vol.15 , pp. 88-90
    • Sedivy, J.M.1    Dutriaux, A.2
  • 38
    • 67649216732 scopus 로고    scopus 로고
    • Gene targeting in a hues line of human embryonic stem cells via electroporation
    • [CrossRef] [PubMed]
    • Ruby, K.M.; Zheng, B. Gene targeting in a hues line of human embryonic stem cells via electroporation. Stem Cells 2009, 27, 1496–1506. [CrossRef] [PubMed]
    • (2009) Stem Cells , vol.27 , pp. 1496-1506
    • Ruby, K.M.1    Zheng, B.2
  • 39
    • 0037336820 scopus 로고    scopus 로고
    • Homologous recombination in human embryonic stem cells
    • [CrossRef] [PubMed]
    • Zwaka, T.P.; Thomson, J.A. Homologous recombination in human embryonic stem cells. Nat. Biotechnol. 2003, 21, 319–321. [CrossRef] [PubMed]
    • (2003) Nat. Biotechnol , vol.21 , pp. 319-321
    • Zwaka, T.P.1    Thomson, J.A.2
  • 40
    • 44349158319 scopus 로고    scopus 로고
    • Sequential genetic modification of the hprt locus in human escs combining gene targeting and recombinase-mediated cassette exchange
    • [CrossRef] [PubMed]
    • Di Domenico, A.I.; Christodoulou, I.; Pells, S.C.; McWhir, J.; Thomson, A.J. Sequential genetic modification of the hprt locus in human escs combining gene targeting and recombinase-mediated cassette exchange. Cloning Stem Cells 2008, 10, 217–230. [CrossRef] [PubMed]
    • (2008) Cloning Stem Cells , vol.10 , pp. 217-230
    • Di Domenico, A.I.1    Christodoulou, I.2    Pells, S.C.3    McWhir, J.4    Thomson, A.J.5
  • 41
    • 36849012549 scopus 로고    scopus 로고
    • Identification and targeting of the rosa26 locus in human embryonic stem cells
    • [CrossRef] [PubMed]
    • Irion, S.; Luche, H.; Gadue, P.; Fehling, H.J.; Kennedy, M.; Keller, G.: Identification and targeting of the rosa26 locus in human embryonic stem cells. Nat. Biotechnol. 2007, 25, 1477–1482. [CrossRef] [PubMed]
    • (2007) Nat. Biotechnol , vol.25 , pp. 1477-1482
    • Irion, S.1    Luche, H.2    Gadue, P.3    Fehling, H.J.4    Kennedy, M.5    Keller, G.6
  • 43
    • 85015604516 scopus 로고    scopus 로고
    • Site-specific genome engineering in human pluripotent stem cells
    • [CrossRef] [PubMed]
    • Merkert, S.; Martin, U. Site-specific genome engineering in human pluripotent stem cells. Int. J. Mol. Sci. 2016, 17, 1000. [CrossRef] [PubMed]
    • (2016) Int. J. Mol. Sci , vol.17 , pp. 1000
    • Merkert, S.1    Martin, U.2
  • 44
    • 84894460947 scopus 로고    scopus 로고
    • A cut above the rest: Targeted genome editing technologies in human pluripotent stem cells
    • [CrossRef] [PubMed]
    • Li, M.; Suzuki, K.; Kim, N.Y.; Liu, G.H.; Izpisua Belmonte, J.C. A cut above the rest: Targeted genome editing technologies in human pluripotent stem cells. J. Biol. Chem. 2014, 289, 4594–4599. [CrossRef] [PubMed]
    • (2014) J. Biol. Chem , vol.289 , pp. 4594-4599
    • Li, M.1    Suzuki, K.2    Kim, N.Y.3    Liu, G.H.4    Izpisua Belmonte, J.C.5
  • 45
    • 48149108735 scopus 로고    scopus 로고
    • Mouse but not human embryonic stem cells are deficient in rejoining of ionizing radiation-induced DNA double-strand breaks
    • [CrossRef] [PubMed]
    • Banuelos, C.A.; Banath, J.P.; MacPhail, S.H.; Zhao, J.; Eaves, C.A.; O’Connor, M.D.; Lansdorp, P.M.; Olive, P.L. Mouse but not human embryonic stem cells are deficient in rejoining of ionizing radiation-induced DNA double-strand breaks. DNA Repair (Amst.) 2008, 7, 1471–1483. [CrossRef] [PubMed]
    • (2008) DNA Repair (Amst.) , vol.7 , pp. 1471-1483
    • Banuelos, C.A.1    Banath, J.P.2    Macphail, S.H.3    Zhao, J.4    Eaves, C.A.5    O’Connor, M.D.6    Lansdorp, P.M.7    Olive, P.L.8
  • 48
    • 77953229115 scopus 로고    scopus 로고
    • The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
    • [CrossRef] [PubMed]
    • Lieber, M.R. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu. Rev. Biochem. 2010, 79, 181–211. [CrossRef] [PubMed]
    • (2010) Annu. Rev. Biochem , vol.79 , pp. 181-211
    • Lieber, M.R.1
  • 50
    • 70350504453 scopus 로고    scopus 로고
    • The DNA-damage response in human biology and disease
    • [CrossRef] [PubMed]
    • Jackson, S.P.; Bartek, J. The DNA-damage response in human biology and disease. Nature 2009, 461, 1071–1078. [CrossRef] [PubMed]
    • (2009) Nature , vol.461 , pp. 1071-1078
    • Jackson, S.P.1    Bartek, J.2
  • 51
    • 84949470075 scopus 로고    scopus 로고
    • Induced pluripotency and gene editing in disease modelling: Perspectives and challenges
    • [CrossRef] [PubMed]
    • Seah, Y.F.; El Farran, C.A.; Warrier, T.; Xu, J.; Loh, Y.H.: Induced pluripotency and gene editing in disease modelling: Perspectives and challenges. Int. J. Mol. Sci. 2015, 16, 28614–28634. [CrossRef] [PubMed]
    • (2015) Int. J. Mol. Sci , vol.16 , pp. 28614-28634
    • Seah, Y.F.1    El Farran, C.A.2    Warrier, T.3    Xu, J.4    Loh, Y.H.5
  • 52
    • 62349103878 scopus 로고    scopus 로고
    • DNA repair in mammalian cells: DNA double-strand break repair: How to fix a broken relationship
    • [CrossRef] [PubMed]
    • Pardo, B.; Gomez-Gonzalez, B.; Aguilera, A. DNA repair in mammalian cells: DNA double-strand break repair: How to fix a broken relationship. Cell. Mol. Life Sci. 2009, 66, 1039–1056. [CrossRef] [PubMed]
    • (2009) Cell. Mol. Life Sci , vol.66 , pp. 1039-1056
    • Pardo, B.1    Gomez-Gonzalez, B.2    Aguilera, A.3
  • 53
    • 84870766296 scopus 로고    scopus 로고
    • Repair of strand breaks by homologous recombination
    • [CrossRef] [PubMed]
    • Jasin, M.; Rothstein, R. Repair of strand breaks by homologous recombination. Cold Spring Harb. Perspect. Biol. 2013, 5, a012740. [CrossRef] [PubMed]
    • (2013) Cold Spring Harb. Perspect. Biol , vol.5
    • Jasin, M.1    Rothstein, R.2
  • 54
    • 0028061666 scopus 로고
    • Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease
    • [CrossRef] [PubMed]
    • Rouet, P.; Smih, F.; Jasin, M. Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease. Mol. Cell. Biol. 1994, 14, 8096–8106. [CrossRef] [PubMed]
    • (1994) Mol. Cell. Biol , vol.14 , pp. 8096-8106
    • Rouet, P.1    Smih, F.2    Jasin, M.3
  • 55
    • 0028237305 scopus 로고
    • Expression of a site-specific endonuclease stimulates homologous recombination in mammalian cells
    • [CrossRef] [PubMed]
    • Rouet, P.; Smih, F.; Jasin, M. Expression of a site-specific endonuclease stimulates homologous recombination in mammalian cells. Proc. Natl. Acad. Sci. USA 1994, 91, 6064–6068. [CrossRef] [PubMed]
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 6064-6068
    • Rouet, P.1    Smih, F.2    Jasin, M.3
  • 56
    • 0029598505 scopus 로고
    • Double-strand breaks at the target locus stimulate gene targeting in embryonic stem cells
    • [CrossRef] [PubMed]
    • Smih, F.; Rouet, P.; Romanienko, P.J.; Jasin, M. Double-strand breaks at the target locus stimulate gene targeting in embryonic stem cells. Nucleic Acids Res. 1995, 23, 5012–5019. [CrossRef] [PubMed]
    • (1995) Nucleic Acids Res , vol.23 , pp. 5012-5019
    • Smih, F.1    Rouet, P.2    Romanienko, P.J.3    Jasin, M.4
  • 57
    • 80051535219 scopus 로고    scopus 로고
    • Genome engineering with zinc-finger nucleases
    • [CrossRef] [PubMed]
    • Carroll, D. Genome engineering with zinc-finger nucleases. Genetics 2011, 188, 773–782. [CrossRef] [PubMed]
    • (2011) Genetics , vol.188 , pp. 773-782
    • Carroll, D.1
  • 58
    • 33749155924 scopus 로고    scopus 로고
    • Structure of aart, a designed six-finger zinc finger peptide, bound to DNA
    • [CrossRef] [PubMed]
    • Segal, D.J.; Crotty, J.W.; Bhakta, M.S.; Barbas, C.F., III; Horton, N.C. Structure of aart, a designed six-finger zinc finger peptide, bound to DNA. J. Mol. Biol. 2006, 363, 405–421. [CrossRef] [PubMed]
    • (2006) J. Mol. Biol , vol.363 , pp. 405-421
    • Segal, D.J.1    Crotty, J.W.2    Bhakta, M.S.3    Barbas, C.F.4    Horton, N.C.5
  • 59
    • 23044460704 scopus 로고    scopus 로고
    • Binding of two zinc finger nuclease monomers to two specific sites is required for effective double-strand DNA cleavage
    • [CrossRef] [PubMed]
    • Mani, M.; Smith, J.; Kandavelou, K.; Berg, J.M.; Chandrasegaran, S. Binding of two zinc finger nuclease monomers to two specific sites is required for effective double-strand DNA cleavage. Biochem. Biophys. Res. Commun. 2005, 334, 1191–1197. [CrossRef] [PubMed]
    • (2005) Biochem. Biophys. Res. Commun , vol.334 , pp. 1191-1197
    • Mani, M.1    Smith, J.2    Kandavelou, K.3    Berg, J.M.4    Chandrasegaran, S.5
  • 60
    • 0038523969 scopus 로고    scopus 로고
    • Chimeric nucleases stimulate gene targeting in human cells
    • [CrossRef] [PubMed]
    • Porteus, M.H.; Baltimore, D. Chimeric nucleases stimulate gene targeting in human cells. Science 2003, 300, 763. [CrossRef] [PubMed]
    • (2003) Science , vol.300 , pp. 763
    • Porteus, M.H.1    Baltimore, D.2
  • 61
    • 84890350615 scopus 로고    scopus 로고
    • Pre-clinical modeling of CCR5 knockout in human hematopoietic stem cells by zinc finger nucleases using humanized mice
    • [CrossRef] [PubMed]
    • Hofer, U.; Henley, J.E.; Exline, C.M.; Mulhern, O.; Lopez, E.; Cannon, P.M. Pre-clinical modeling of CCR5 knockout in human hematopoietic stem cells by zinc finger nucleases using humanized mice. J. Infect. Dis 2013, 208 (Suppl S2), S160–164. [CrossRef] [PubMed]
    • (2013) J. Infect. Dis , vol.208 , pp. S160-S164
    • Hofer, U.1    Henley, J.E.2    Exline, C.M.3    Mulhern, O.4    Lopez, E.5    Cannon, P.M.6
  • 64
    • 84856466896 scopus 로고    scopus 로고
    • Zinc-finger nucleases: How to play two good hands
    • [CrossRef] [PubMed]
    • Isalan, M.: Zinc-finger nucleases: How to play two good hands. Nat. Methods 2011, 9, 32–34. [CrossRef] [PubMed]
    • (2011) Nat. Methods , vol.9 , pp. 32-34
    • Isalan, M.1
  • 68
    • 77956126894 scopus 로고    scopus 로고
    • Xanthomonas AvrBs3 family-type III effectors: Discovery and function
    • [CrossRef] [PubMed]
    • Boch, J.; Bonas, U. Xanthomonas AvrBs3 family-type III effectors: Discovery and function. Annu. Rev. Phytopathol. 2010, 48, 419–436. [CrossRef] [PubMed]
    • (2010) Annu. Rev. Phytopathol , vol.48 , pp. 419-436
    • Boch, J.1    Bonas, U.2
  • 70
    • 72149090954 scopus 로고    scopus 로고
    • A simple cipher governs DNA recognition by TAL effectors
    • [CrossRef] [PubMed]
    • Moscou, M.J.; Bogdanove, A.J. A simple cipher governs DNA recognition by TAL effectors. Science 2009, 326, 1501. [CrossRef] [PubMed]
    • (2009) Science , vol.326 , pp. 1501
    • Moscou, M.J.1    Bogdanove, A.J.2
  • 72
    • 79751487297 scopus 로고    scopus 로고
    • Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription
    • [CrossRef] [PubMed]
    • Zhang, F.; Cong, L.; Lodato, S.; Kosuri, S.; Church, G.M.; Arlotta, P. Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription. Nat. Biotechnol. 2011, 29, 149–153. [CrossRef] [PubMed]
    • (2011) Nat. Biotechnol , vol.29 , pp. 149-153
    • Zhang, F.1    Cong, L.2    Lodato, S.3    Kosuri, S.4    Church, G.M.5    Arlotta, P.6
  • 73
    • 77955867185 scopus 로고    scopus 로고
    • Genome editing with engineered zinc finger nucleases
    • [CrossRef] [PubMed]
    • Urnov, F.D.; Rebar, E.J.; Holmes, M.C.; Zhang, H.S.; Gregory, P.D. Genome editing with engineered zinc finger nucleases. Nat. Rev. Genet. 2010, 11, 636–646. [CrossRef] [PubMed]
    • (2010) Nat. Rev. Genet , vol.11 , pp. 636-646
    • Urnov, F.D.1    Rebar, E.J.2    Holmes, M.C.3    Zhang, H.S.4    Gregory, P.D.5
  • 74
    • 84897954502 scopus 로고    scopus 로고
    • Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity
    • [CrossRef] [PubMed]
    • Guilinger, J.P.; Pattanayak, V.; Reyon, D.; Tsai, S.Q.; Sander, J.D.; Joung, J.K.; Liu, D.R. Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity. Nat. Methods 2014, 11, 429–435. [CrossRef] [PubMed]
    • (2014) Nat. Methods , vol.11 , pp. 429-435
    • Guilinger, J.P.1    Pattanayak, V.2    Reyon, D.3    Tsai, S.Q.4    Sander, J.D.5    Joung, J.K.6    Liu, D.R.7
  • 75
    • 84866879789 scopus 로고    scopus 로고
    • Iterative capped assembly: Rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers
    • [CrossRef] [PubMed]
    • Briggs, A.W.; Rios, X.; Chari, R.; Yang, L.; Zhang, F.; Mali, P.; Church, G.M. Iterative capped assembly: Rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers. Nucleic Acids Res. 2012, 40, e117. [CrossRef] [PubMed]
    • (2012) Nucleic Acids Res , vol.40
    • Briggs, A.W.1    Rios, X.2    Chari, R.3    Yang, L.4    Zhang, F.5    Mali, P.6    Church, G.M.7
  • 76
    • 84872203111 scopus 로고    scopus 로고
    • Ligation-independent cloning technique for high-throughput assembly of transcription activator-like effector genes
    • [CrossRef] [PubMed]
    • Schmid-Burgk, J.L.; Schmidt, T.; Kaiser, V.; Honing, K.; Hornung, V. A ligation-independent cloning technique for high-throughput assembly of transcription activator-like effector genes. Nat. Biotechnol. 2013, 31, 76–81. [CrossRef] [PubMed]
    • (2013) Nat. Biotechnol , vol.31 , pp. 76-81
    • Schmid-Burgk, J.L.1    Schmidt, T.2    Kaiser, V.3    Honing, K.4    Hornung, V.A.5
  • 78
    • 80053039555 scopus 로고    scopus 로고
    • A novel tale nuclease scaffold enables high genome editing activity in combination with low toxicity
    • [CrossRef] [PubMed]
    • Mussolino, C.; Morbitzer, R.; Lutge, F.; Dannemann, N.; Lahaye, T.; Cathomen, T. A novel tale nuclease scaffold enables high genome editing activity in combination with low toxicity. Nucleic Acids Res. 2011, 39, 9283–9293. [CrossRef] [PubMed]
    • (2011) Nucleic Acids Res , vol.39 , pp. 9283-9293
    • Mussolino, C.1    Morbitzer, R.2    Lutge, F.3    Dannemann, N.4    Lahaye, T.5    Cathomen, T.6
  • 79
    • 84888090695 scopus 로고    scopus 로고
    • TALENoffer: Genome-wide TALEN off-target prediction
    • [CrossRef] [PubMed]
    • Grau, J.; Boch, J.; Posch, S. TALENoffer: Genome-wide TALEN off-target prediction. Bioinformatics 2013, 29, 2931–2932. [CrossRef] [PubMed]
    • (2013) Bioinformatics , vol.29 , pp. 2931-2932
    • Grau, J.1    Boch, J.2    Posch, S.3
  • 80
    • 84923106217 scopus 로고    scopus 로고
    • Therapeutic genome editing: Prospects and challenges
    • [CrossRef] [PubMed]
    • Cox, D.B.; Platt, R.J.; Zhang, F. Therapeutic genome editing: Prospects and challenges. Nat. Med. 2015, 21, 121–131. [CrossRef] [PubMed]
    • (2015) Nat. Med , vol.21 , pp. 121-131
    • Cox, D.B.1    Platt, R.J.2    Zhang, F.3
  • 81
    • 84863201964 scopus 로고    scopus 로고
    • Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer tales and inhibition of epigenetic modifiers
    • [CrossRef] [PubMed]
    • Bultmann, S.; Morbitzer, R.; Schmidt, C.S.; Thanisch, K.; Spada, F.; Elsaesser, J.; Lahaye, T.; Leonhardt, H. Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer tales and inhibition of epigenetic modifiers. Nucleic Acids Res. 2012, 40, 5368–5377. [CrossRef] [PubMed]
    • (2012) Nucleic Acids Res , vol.40 , pp. 5368-5377
    • Bultmann, S.1    Morbitzer, R.2    Schmidt, C.S.3    Thanisch, K.4    Spada, F.5    Elsaesser, J.6    Lahaye, T.7    Leonhardt, H.8
  • 83
    • 79251567720 scopus 로고    scopus 로고
    • DNA methylation of the first exon is tightly linked to transcriptional silencing
    • [CrossRef] [PubMed]
    • Brenet, F.; Moh, M.; Funk, P.; Feierstein, E.; Viale, A.J.; Socci, N.D.; Scandura, J.M. DNA methylation of the first exon is tightly linked to transcriptional silencing. PLoS ONE 2011, 6, e14524. [CrossRef] [PubMed]
    • (2011) Plos ONE , vol.6
    • Brenet, F.1    Moh, M.2    Funk, P.3    Feierstein, E.4    Viale, A.J.5    Socci, N.D.6    Scandura, J.M.7
  • 85
    • 77249170201 scopus 로고    scopus 로고
    • CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea
    • [CrossRef] [PubMed]
    • Marraffini, L.A.; Sontheimer, E.J. CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea. Nat. Rev. Genet. 2010, 11, 181–190. [CrossRef] [PubMed]
    • (2010) Nat. Rev. Genet , vol.11 , pp. 181-190
    • Marraffini, L.A.1    Sontheimer, E.J.2
  • 88
    • 84857097177 scopus 로고    scopus 로고
    • RNA-guided genetic silencing systems in bacteria and archaea
    • [CrossRef] [PubMed]
    • Wiedenheft, B.; Sternberg, S.H.; Doudna, J.A. RNA-guided genetic silencing systems in bacteria and archaea. Nature 2012, 482, 331–338. [CrossRef] [PubMed]
    • (2012) Nature , vol.482 , pp. 331-338
    • Wiedenheft, B.1    Sternberg, S.H.2    Doudna, J.A.3
  • 90
    • 84876567971 scopus 로고    scopus 로고
    • RNA-programmed genome editing in human cells
    • [CrossRef] [PubMed]
    • Jinek, M.; East, A.; Cheng, A.; Lin, S.; Ma, E.; Doudna, J. RNA-programmed genome editing in human cells. Elife. 2013, 2, e00471. [CrossRef] [PubMed]
    • (2013) Elife , vol.2
    • Jinek, M.1    East, A.2    Cheng, A.3    Lin, S.4    Ma, E.5    Doudna, J.6
  • 91
    • 84874624936 scopus 로고    scopus 로고
    • Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
    • [CrossRef] [PubMed]
    • Cho, S.W.; Kim, S.; Kim, J.M.; Kim, J.S. Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease. Nat. Biotechnol. 2013, 31, 230–232. [CrossRef] [PubMed]
    • (2013) Nat. Biotechnol , vol.31 , pp. 230-232
    • Cho, S.W.1    Kim, S.2    Kim, J.M.3    Kim, J.S.4
  • 92
    • 84875963894 scopus 로고    scopus 로고
    • Enhanced efficiency of human pluripotent stem cell genome editing through replacing TALENs with CRISPRs
    • [CrossRef] [PubMed]
    • Ding, Q.; Regan, S.N.; Xia, Y.; Oostrom, L.A.; Cowan, C.A.; Musunuru, K. Enhanced efficiency of human pluripotent stem cell genome editing through replacing TALENs with CRISPRs. Cell Stem Cell 2013, 12, 393–394. [CrossRef] [PubMed]
    • (2013) Cell Stem Cell , vol.12 , pp. 393-394
    • Ding, Q.1    Regan, S.N.2    Xia, Y.3    Oostrom, L.A.4    Cowan, C.A.5    Musunuru, K.6
  • 93
    • 84877707375 scopus 로고    scopus 로고
    • One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering
    • [CrossRef] [PubMed]
    • Wang, H.; Yang, H.; Shivalila, C.S.; Dawlaty, M.M.; Cheng, A.W.; Zhang, F.; Jaenisch, R. One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell 2013, 153, 910–918. [CrossRef] [PubMed]
    • (2013) Cell , vol.153 , pp. 910-918
    • Wang, H.1    Yang, H.2    Shivalila, C.S.3    Dawlaty, M.M.4    Cheng, A.W.5    Zhang, F.6    Jaenisch, R.7
  • 94
    • 84986203439 scopus 로고    scopus 로고
    • Genome engineering tools for building cellular models of disease
    • [CrossRef] [PubMed]
    • Lin, J.; Musunuru, K. Genome engineering tools for building cellular models of disease. FEBS J. 2016, 283, 3222–3231. [CrossRef] [PubMed]
    • (2016) FEBS J , vol.283 , pp. 3222-3231
    • Lin, J.1    Musunuru, K.2
  • 96
    • 84880570576 scopus 로고    scopus 로고
    • High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
    • [CrossRef] [PubMed]
    • Fu, Y.; Foden, J.A.; Khayter, C.; Maeder, M.L.; Reyon, D.; Joung, J.K.; Sander, J.D. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. Nat. Biotechnol. 2013, 31, 822–826. [CrossRef] [PubMed]
    • (2013) Nat. Biotechnol , vol.31 , pp. 822-826
    • Fu, Y.1    Foden, J.A.2    Khayter, C.3    Maeder, M.L.4    Reyon, D.5    Joung, J.K.6    Sander, J.D.7
  • 97
    • 84891710947 scopus 로고    scopus 로고
    • Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
    • [CrossRef] [PubMed]
    • Cho, S.W.; Kim, S.; Kim, Y.; Kweon, J.; Kim, H.S.; Bae, S.; Kim, J.S. Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases. Genome Res. 2014, 24, 132–141. [CrossRef] [PubMed]
    • (2014) Genome Res , vol.24 , pp. 132-141
    • Cho, S.W.1    Kim, S.2    Kim, Y.3    Kweon, J.4    Kim, H.S.5    Bae, S.6    Kim, J.S.7
  • 98
    • 84897954175 scopus 로고    scopus 로고
    • Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects
    • [CrossRef] [PubMed]
    • Shen, B.; Zhang, W.; Zhang, J.; Zhou, J.; Wang, J.; Chen, L.; Wang, L.; Hodgkins, A.; Iyer, V.; Huang, X. et al. Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects. Nat. Methods 2014, 11, 399–402. [CrossRef] [PubMed]
    • (2014) Nat. Methods , vol.11 , pp. 399-402
    • Shen, B.1    Zhang, W.2    Zhang, J.3    Zhou, J.4    Wang, J.5    Chen, L.6    Wang, L.7    Hodgkins, A.8    Iyer, V.9    Huang, X.10
  • 101
    • 84902210542 scopus 로고    scopus 로고
    • Fusion of catalytically inactive Cas9 to foki nuclease improves the specificity of genome modification
    • [CrossRef] [PubMed]
    • Guilinger, J.P.; Thompson, D.B.; Liu, D.R. Fusion of catalytically inactive Cas9 to foki nuclease improves the specificity of genome modification. Nat. Biotechnol. 2014, 32, 577–582. [CrossRef] [PubMed]
    • (2014) Nat. Biotechnol , vol.32 , pp. 577-582
    • Guilinger, J.P.1    Thompson, D.B.2    Liu, D.R.3
  • 102
    • 84990042035 scopus 로고    scopus 로고
    • A Cas9 variant for efficient generation of indel-free knockin or gene-corrected human pluripotent stem cells
    • [CrossRef] [PubMed]
    • Howden, S.E.; McColl, B.; Glaser, A.; Vadolas, J.; Petrou, S.; Little, M.H.; Elefanty, A.G.; Stanley, E.G. A Cas9 variant for efficient generation of indel-free knockin or gene-corrected human pluripotent stem cells. Stem Cell Rep. 2016, 7, 508–517. [CrossRef] [PubMed]
    • (2016) Stem Cell Rep , vol.7 , pp. 508-517
    • Howden, S.E.1    McColl, B.2    Glaser, A.3    Vadolas, J.4    Petrou, S.5    Little, M.H.6    Elefanty, A.G.7    Stanley, E.G.8
  • 103
    • 51849121635 scopus 로고    scopus 로고
    • DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells
    • [CrossRef] [PubMed]
    • Mao, Z.; Bozzella, M.; Seluanov, A.; Gorbunova, V. DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells. Cell Cycle 2008, 7, 2902–2906. [CrossRef] [PubMed]
    • (2008) Cell Cycle , vol.7 , pp. 2902-2906
    • Mao, Z.1    Bozzella, M.2    Seluanov, A.3    Gorbunova, V.4
  • 104
    • 84971006562 scopus 로고    scopus 로고
    • Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
    • [CrossRef] [PubMed]
    • Komor, A.C.; Kim, Y.B.; Packer, M.S.; Zuris, J.A.; Liu, D.R. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage. Nature 2016, 533, 420–424. [CrossRef] [PubMed]
    • (2016) Nature , vol.533 , pp. 420-424
    • Komor, A.C.1    Kim, Y.B.2    Packer, M.S.3    Zuris, J.A.4    Liu, D.R.5
  • 105
    • 84981318543 scopus 로고    scopus 로고
    • Genome-wide analysis reveals specificities of Cpf1 endonucleases in human cells
    • [CrossRef] [PubMed]
    • Kim, D.; Kim, J.; Hur, J.K.; Been, K.W.; Yoon, S.H.; Kim, J.S. Genome-wide analysis reveals specificities of Cpf1 endonucleases in human cells. Nat. Biotechnol. 2016, 34, 863–868. [CrossRef] [PubMed]
    • (2016) Nat. Biotechnol , vol.34 , pp. 863-868
    • Kim, D.1    Kim, J.2    Hur, J.K.3    Been, K.W.4    Yoon, S.H.5    Kim, J.S.6
  • 108
    • 84913600795 scopus 로고    scopus 로고
    • Genomic editing tools to model human diseases with isogenic pluripotent stem cells
    • [CrossRef] [PubMed]
    • Kim, H.S.; Bernitz, J.M.; Lee, D.F.; Lemischka, I.R. Genomic editing tools to model human diseases with isogenic pluripotent stem cells. Stem Cells Dev. 2014, 23, 2673–2686. [CrossRef] [PubMed]
    • (2014) Stem Cells Dev , vol.23 , pp. 2673-2686
    • Kim, H.S.1    Bernitz, J.M.2    Lee, D.F.3    Lemischka, I.R.4
  • 109
    • 0025943412 scopus 로고
    • The length of homology required for gene targeting in embryonic stem cells
    • [CrossRef] [PubMed]
    • Hasty, P.; Rivera-Perez, J.; Bradley, A. The length of homology required for gene targeting in embryonic stem cells. Mol. Cell. Biol. 1991, 11, 5586–5591. [CrossRef] [PubMed]
    • (1991) Mol. Cell. Biol , vol.11 , pp. 5586-5591
    • Hasty, P.1    Rivera-Perez, J.2    Bradley, A.3
  • 110
    • 0026753186 scopus 로고
    • Reexamination of gene targeting frequency as a function of the extent of homology between the targeting vector and the target locus
    • [CrossRef] [PubMed]
    • Deng, C.; Capecchi, M.R.: Reexamination of gene targeting frequency as a function of the extent of homology between the targeting vector and the target locus. Mol. Cell. Biol. 1992, 12, 3365–3371. [CrossRef] [PubMed]
    • (1992) Mol. Cell. Biol , vol.12 , pp. 3365-3371
    • Deng, C.1    Capecchi, M.R.2
  • 111
    • 73049105546 scopus 로고    scopus 로고
    • Modeling disease in human escs using an efficient BAC-based homologous recombination system
    • [CrossRef] [PubMed]
    • Song, H.; Chung, S.K.; Xu, Y. Modeling disease in human escs using an efficient BAC-based homologous recombination system. Cell Stem Cell 2010, 6, 80–89. [CrossRef] [PubMed]
    • (2010) Cell Stem Cell , vol.6 , pp. 80-89
    • Song, H.1    Chung, S.K.2    Xu, Y.3
  • 112
    • 0035487293 scopus 로고    scopus 로고
    • Recombineering: A powerful new tool for mouse functional genomics
    • [CrossRef] [PubMed]
    • Copeland, N.G.; Jenkins, N.A.; Court, D.L. Recombineering: A powerful new tool for mouse functional genomics. Nat. Rev. Genet. 2001, 2, 769–779. [CrossRef] [PubMed]
    • (2001) Nat. Rev. Genet , vol.2 , pp. 769-779
    • Copeland, N.G.1    Jenkins, N.A.2    Court, D.L.3
  • 113
    • 84922199467 scopus 로고    scopus 로고
    • Enhanced gene targeting of adult and pluripotent stem cells using evolved adeno-associated virus
    • [PubMed]
    • Bartel, M.A.; Schaffer, D.V.: Enhanced gene targeting of adult and pluripotent stem cells using evolved adeno-associated virus. Methods Mol. Biol. 2014, 1114, 169–179. [PubMed]
    • (2014) Methods Mol. Biol , vol.1114 , pp. 169-179
    • Bartel, M.A.1    Schaffer, D.V.2
  • 114
    • 79960046970 scopus 로고    scopus 로고
    • AAV-mediated gene targeting methods for human cells
    • [CrossRef] [PubMed]
    • Khan, I.F.; Hirata, R.K.; Russell, D.W. AAV-mediated gene targeting methods for human cells. Nat. Protoc. 2011, 6, 482–501. [CrossRef] [PubMed]
    • (2011) Nat. Protoc , vol.6 , pp. 482-501
    • Khan, I.F.1    Hirata, R.K.2    Russell, D.W.3
  • 117
    • 28144437766 scopus 로고    scopus 로고
    • Precise hit: Adeno-associated virus in gene targeting
    • [CrossRef] [PubMed]
    • Vasileva, A.; Jessberger, R. Precise hit: Adeno-associated virus in gene targeting. Nat. Rev. Microbiol. 2005, 3, 837–847. [CrossRef] [PubMed]
    • (2005) Nat. Rev. Microbiol , vol.3 , pp. 837-847
    • Vasileva, A.1    Jessberger, R.2
  • 118
    • 38449103494 scopus 로고    scopus 로고
    • Stem cell engineering using transducible cre recombinase
    • [PubMed]
    • Nolden, L.; Edenhofer, F.; Peitz, M.; Brustle, O. Stem cell engineering using transducible cre recombinase. Methods Mol. Med. 2007, 140, 17–32. [PubMed]
    • (2007) Methods Mol. Med , vol.140 , pp. 17-32
    • Nolden, L.1    Edenhofer, F.2    Peitz, M.3    Brustle, O.4
  • 121
    • 0030736079 scopus 로고    scopus 로고
    • Transcriptional behavior of lcr enhancer elements integrated at the same chromosomal locus by recombinase-mediated cassette exchange
    • [PubMed]
    • Bouhassira, E.E.; Westerman, K.; Leboulch, P. Transcriptional behavior of lcr enhancer elements integrated at the same chromosomal locus by recombinase-mediated cassette exchange. Blood 1997, 90, 3332–3344. [PubMed]
    • (1997) Blood , vol.90 , pp. 3332-3344
    • Bouhassira, E.E.1    Westerman, K.2    Leboulch, P.3
  • 123
    • 84857254364 scopus 로고    scopus 로고
    • Oligonucleotide-directed gene-editing technology: Mechanisms and future prospects
    • [CrossRef] [PubMed]
    • Papaioannou, I.; Simons, J.P.; Owen, J.S. Oligonucleotide-directed gene-editing technology: Mechanisms and future prospects. Expert Opin. Biol. Ther. 2012, 12, 329–342. [CrossRef] [PubMed]
    • (2012) Expert Opin. Biol. Ther , vol.12 , pp. 329-342
    • Papaioannou, I.1    Simons, J.P.2    Owen, J.S.3
  • 124
    • 33750969980 scopus 로고    scopus 로고
    • Targeted chromosomal gene modification in human cells by single-stranded oligodeoxynucleotides in the presence of a DNA double-strand break
    • [CrossRef] [PubMed]
    • Radecke, F.; Peter, I.; Radecke, S.; Gellhaus, K.; Schwarz, K.; Cathomen, T. Targeted chromosomal gene modification in human cells by single-stranded oligodeoxynucleotides in the presence of a DNA double-strand break. Mol. Ther. 2006, 14, 798–808. [CrossRef] [PubMed]
    • (2006) Mol. Ther , vol.14 , pp. 798-808
    • Radecke, F.1    Peter, I.2    Radecke, S.3    Gellhaus, K.4    Schwarz, K.5    Cathomen, T.6
  • 125
    • 84983792922 scopus 로고    scopus 로고
    • Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery
    • [CrossRef] [PubMed]
    • Lin, S.; Staahl, B.T.; Alla, R.K.; Doudna, J.A. Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery. Elife. 2014, 3, e04766. [CrossRef] [PubMed]
    • (2014) Elife , vol.3
    • Lin, S.1    Staahl, B.T.2    Alla, R.K.3    Doudna, J.A.4
  • 127
    • 79960833952 scopus 로고    scopus 로고
    • Generation of isogenic pluripotent stem cells differing exclusively at two early onset parkinson point mutations
    • [CrossRef] [PubMed]
    • Soldner, F.; Laganiere, J.; Cheng, A.W.; Hockemeyer, D.; Gao, Q.; Alagappan, R.; Khurana, V.; Golbe, L.I.; Myers, R.H.; Lindquist, S. et al. Generation of isogenic pluripotent stem cells differing exclusively at two early onset parkinson point mutations. Cell 2011, 146, 318–331. [CrossRef] [PubMed]
    • (2011) Cell , vol.146 , pp. 318-331
    • Soldner, F.1    Laganiere, J.2    Cheng, A.W.3    Hockemeyer, D.4    Gao, Q.5    Alagappan, R.6    Khurana, V.7    Golbe, L.I.8    Myers, R.H.9    Lindquist, S.10
  • 128
    • 35648962962 scopus 로고    scopus 로고
    • Genetic modification of human embryonic stem cells
    • [CrossRef] [PubMed]
    • Xia, X.; Zhang, S.C. Genetic modification of human embryonic stem cells. Biotechnol. Genet. Eng. Rev. 2007, 24, 297–309. [CrossRef] [PubMed]
    • (2007) Biotechnol. Genet. Eng. Rev , vol.24 , pp. 297-309
    • Xia, X.1    Zhang, S.C.2
  • 129
    • 80054743206 scopus 로고    scopus 로고
    • Lentivirus-mediated modification of pluripotent stem cells
    • [PubMed]
    • Bajpai, R.: Lentivirus-mediated modification of pluripotent stem cells. Methods Mol. Biol. 2011, 767, 315–331. [PubMed]
    • (2011) Methods Mol. Biol , vol.767 , pp. 315-331
    • Bajpai, R.1
  • 131
    • 84916219205 scopus 로고    scopus 로고
    • TALEN/CRISPR-mediated eGFP knock-in add-on at the OCT4 locus does not impact differentiation of human embryonic stem cells towards endoderm
    • [CrossRef] [PubMed]
    • Krentz, N.A.; Nian, C.; Lynn, F.C. TALEN/CRISPR-mediated eGFP knock-in add-on at the OCT4 locus does not impact differentiation of human embryonic stem cells towards endoderm. PLoS ONE 2014, 9, e114275. [CrossRef] [PubMed]
    • (2014) Plos ONE , vol.9
    • Krentz, N.A.1    Nian, C.2    Lynn, F.C.3
  • 133
    • 84930928815 scopus 로고    scopus 로고
    • A CRISPR/Cas-mediated selection-free knockin strategy in human embryonic stem cells
    • [CrossRef] [PubMed]
    • Zhu, Z.; Verma, N.; Gonzalez, F.; Shi, Z.D.; Huangfu, D. A CRISPR/Cas-mediated selection-free knockin strategy in human embryonic stem cells. Stem Cell Rep. 2015, 4, 1103–1111. [CrossRef] [PubMed]
    • (2015) Stem Cell Rep , vol.4 , pp. 1103-1111
    • Zhu, Z.1    Verma, N.2    Gonzalez, F.3    Shi, Z.D.4    Huangfu, D.5
  • 136
    • 84954399120 scopus 로고    scopus 로고
    • Generation of gfap::Gfp astrocyte reporter lines from human adult fibroblast-derived iPS cells using zinc-finger nuclease technology
    • [CrossRef] [PubMed]
    • Zhang, P.W.; Haidet-Phillips, A.M.; Pham, J.T.; Lee, Y.; Huo, Y.; Tienari, P.J.; Maragakis, N.J.; Sattler, R.; Rothstein, J.D. Generation of gfap::Gfp astrocyte reporter lines from human adult fibroblast-derived iPS cells using zinc-finger nuclease technology. Glia 2016, 64, 63–75. [CrossRef] [PubMed]
    • (2016) Glia , vol.64 , pp. 63-75
    • Zhang, P.W.1    Haidet-Phillips, A.M.2    Pham, J.T.3    Lee, Y.4    Huo, Y.5    Tienari, P.J.6    Maragakis, N.J.7    Sattler, R.8    Rothstein, J.D.9
  • 137
    • 84961306282 scopus 로고    scopus 로고
    • Generation and validation of PAX7 reporter lines from human iPS cells using CRISPR/Cas9 technology
    • [CrossRef] [PubMed]
    • Wu, J.; Hunt, S.D.; Xue, H.; Liu, Y.; Darabi, R. Generation and validation of PAX7 reporter lines from human iPS cells using CRISPR/Cas9 technology. Stem Cell Res. 2016, 16, 220–228. [CrossRef] [PubMed]
    • (2016) Stem Cell Res , vol.16 , pp. 220-228
    • Wu, J.1    Hunt, S.D.2    Xue, H.3    Liu, Y.4    Darabi, R.5
  • 138
    • 84953335543 scopus 로고    scopus 로고
    • Generation and characterization of a MYF5 reporter human iPS cell line using CRISPR/Cas9 mediated homologous recombination
    • [CrossRef] [PubMed]
    • Wu, J.; Hunt, S.D.; Xue, H.; Liu, Y.; Darabi, R.: Generation and characterization of a MYF5 reporter human iPS cell line using CRISPR/Cas9 mediated homologous recombination. Sci. Rep. 2016, 6, 18759. [CrossRef] [PubMed]
    • (2016) Sci. Rep , vol.6 , pp. 18759
    • Wu, J.1    Hunt, S.D.2    Xue, H.3    Liu, Y.4    Darabi, R.5
  • 139
    • 77955157281 scopus 로고    scopus 로고
    • Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome
    • [CrossRef] [PubMed]
    • DeKelver, R.C.; Choi, V.M.; Moehle, E.A.; Paschon, D.E.; Hockemeyer, D.; Meijsing, S.H.; Sancak, Y.; Cui, X.; Steine, E.J.; Miller, J.C. et al. Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. Genome Res. 2010, 20, 1133–1142. [CrossRef] [PubMed]
    • (2010) Genome Res , vol.20 , pp. 1133-1142
    • Dekelver, R.C.1    Choi, V.M.2    Moehle, E.A.3    Paschon, D.E.4    Hockemeyer, D.5    Meijsing, S.H.6    Sancak, Y.7    Cui, X.8    Steine, E.J.9    Miller, J.C.10
  • 140
    • 84885920900 scopus 로고    scopus 로고
    • Targeted transgene insertion into the AAVS1 locus driven by baculoviral vector-mediated zinc finger nuclease expression in human-induced pluripotent stem cells
    • [CrossRef] [PubMed]
    • Tay, F.C.; Tan, W.K.; Goh, S.L.; Ramachandra, C.J.; Lau, C.H.; Zhu, H.; Chen, C.; Du, S.; Phang, R.Z.; Shahbazi, M. et al. Targeted transgene insertion into the AAVS1 locus driven by baculoviral vector-mediated zinc finger nuclease expression in human-induced pluripotent stem cells. J. Gene Med. 2013, 15, 384–395. [CrossRef] [PubMed]
    • (2013) J. Gene Med , vol.15 , pp. 384-395
    • Tay, F.C.1    Tan, W.K.2    Goh, S.L.3    Ramachandra, C.J.4    Lau, C.H.5    Zhu, H.6    Chen, C.7    Du, S.8    Phang, R.Z.9    Shahbazi, M.10
  • 141
    • 84871539019 scopus 로고    scopus 로고
    • Genome editing of human embryonic stem cells and induced pluripotent stem cells with zinc finger nucleases for cellular imaging. Circ
    • [CrossRef] [PubMed]
    • Wang, Y.; Zhang, W.Y.; Hu, S.; Lan, F.; Lee, A.S.; Huber, B.; Lisowski, L.; Liang, P.; Huang, M.; de Almeida, P.E. et al. Genome editing of human embryonic stem cells and induced pluripotent stem cells with zinc finger nucleases for cellular imaging. Circ. Res. 2012, 111, 1494–1503. [CrossRef] [PubMed]
    • (2012) Res , vol.111 , pp. 1494-1503
    • Wang, Y.1    Zhang, W.Y.2    Hu, S.3    Lan, F.4    Lee, A.S.5    Huber, B.6    Lisowski, L.7    Liang, P.8    Huang, M.9    De Almeida, P.E.10
  • 142
    • 84885939240 scopus 로고    scopus 로고
    • Baculoviral transduction facilitates TALEN-mediated targeted transgene integration and Cre/LoxP cassette exchange in human-induced pluripotent stem cells
    • [CrossRef] [PubMed]
    • Zhu, H.; Lau, C.H.; Goh, S.L.; Liang, Q.; Chen, C.; Du, S.; Phang, R.Z.; Tay, F.C.; Tan, W.K.; Li, Z. et al. Baculoviral transduction facilitates TALEN-mediated targeted transgene integration and Cre/LoxP cassette exchange in human-induced pluripotent stem cells. Nucleic Acids Res. 2013, 41, e180. [CrossRef] [PubMed]
    • (2013) Nucleic Acids Res , vol.41
    • Zhu, H.1    Lau, C.H.2    Goh, S.L.3    Liang, Q.4    Chen, C.5    Du, S.6    Phang, R.Z.7    Tay, F.C.8    Tan, W.K.9    Li, Z.10
  • 143
    • 84903539809 scopus 로고    scopus 로고
    • Stable enhanced green fluorescent protein expression after differentiation and transplantation of reporter human induced pluripotent stem cells generated by AAVS1 transcription activator-like effector nucleases
    • [CrossRef] [PubMed]
    • Luo, Y.; Liu, C.; Cerbini, T.; San, H.; Lin, Y.; Chen, G.; Rao, M.S.; Zou, J.: Stable enhanced green fluorescent protein expression after differentiation and transplantation of reporter human induced pluripotent stem cells generated by AAVS1 transcription activator-like effector nucleases. Stem Cells Transl. Med. 2014, 3, 821–835. [CrossRef] [PubMed]
    • (2014) Stem Cells Transl. Med , vol.3 , pp. 821-835
    • Luo, Y.1    Liu, C.2    Cerbini, T.3    San, H.4    Lin, Y.5    Chen, G.6    Rao, M.S.7    Zou, J.8
  • 144
    • 80055069793 scopus 로고    scopus 로고
    • Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease
    • [CrossRef] [PubMed]
    • Zou, J.; Mali, P.; Huang, X.; Dowey, S.N.; Cheng, L. Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease. Blood 2011, 118, 4599–4608. [CrossRef] [PubMed]
    • (2011) Blood , vol.118 , pp. 4599-4608
    • Zou, J.1    Mali, P.2    Huang, X.3    Dowey, S.N.4    Cheng, L.5
  • 145
    • 80054918967 scopus 로고    scopus 로고
    • In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases
    • [CrossRef] [PubMed]
    • Sebastiano, V.; Maeder, M.L.; Angstman, J.F.; Haddad, B.; Khayter, C.; Yeo, D.T.; Goodwin, M.J.; Hawkins, J.S.; Ramirez, C.L.; Batista, L.F. et al. In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases. Stem Cells 2011, 29, 1717–1726. [CrossRef] [PubMed]
    • (2011) Stem Cells , vol.29 , pp. 1717-1726
    • Sebastiano, V.1    Maeder, M.L.2    Angstman, J.F.3    Haddad, B.4    Khayter, C.5    Yeo, D.T.6    Goodwin, M.J.7    Hawkins, J.S.8    Ramirez, C.L.9    Batista, L.F.10
  • 146
    • 84890115517 scopus 로고    scopus 로고
    • Isogenic human iPSC Parkinson’s model shows nitrosative stress-induced dysfunction in MEF2-PGC1alpha transcription
    • [CrossRef] [PubMed]
    • Ryan, S.D.; Dolatabadi, N.; Chan, S.F.; Zhang, X.; Akhtar, M.W.; Parker, J.; Soldner, F.; Sunico, C.R.; Nagar, S.; Talantova, M. et al. Isogenic human iPSC Parkinson’s model shows nitrosative stress-induced dysfunction in MEF2-PGC1alpha transcription. Cell 2013, 155, 1351–1364. [CrossRef] [PubMed]
    • (2013) Cell , vol.155 , pp. 1351-1364
    • Ryan, S.D.1    Dolatabadi, N.2    Chan, S.F.3    Zhang, X.4    Akhtar, M.W.5    Parker, J.6    Soldner, F.7    Sunico, C.R.8    Nagar, S.9    Talantova, M.10
  • 147
  • 149
    • 56749095159 scopus 로고    scopus 로고
    • New approaches to the treatment of frontotemporal lobar degeneration
    • [CrossRef] [PubMed]
    • Vossel, K.A.; Miller, B.L. New approaches to the treatment of frontotemporal lobar degeneration. Curr. Opin. Neurol. 2008, 21, 708–716. [CrossRef] [PubMed]
    • (2008) Curr. Opin. Neurol , vol.21 , pp. 708-716
    • Vossel, K.A.1    Miller, B.L.2
  • 150
    • 84994060574 scopus 로고    scopus 로고
    • Tau and tauopathies
    • [CrossRef] [PubMed]
    • Arendt, T.; Stieler, J.T.; Holzer, M.: Tau and tauopathies. Brain Res. Bull. 2016, 126, 238–292. [CrossRef] [PubMed]
    • (2016) Brain Res. Bull , vol.126 , pp. 238-292
    • Arendt, T.1    Stieler, J.T.2    Holzer, M.3
  • 151
    • 84863882357 scopus 로고    scopus 로고
    • Biochemistry and cell biology of tau protein in neurofibrillary degeneration
    • [CrossRef] [PubMed]
    • Mandelkow, E.M.; Mandelkow, E.: Biochemistry and cell biology of tau protein in neurofibrillary degeneration. Cold Spring Harb. Perspect. Med. 2012, 2, a006247. [CrossRef] [PubMed]
    • (2012) Cold Spring Harb. Perspect. Med , vol.2
    • Mandelkow, E.M.1    Mandelkow, E.2
  • 152
    • 84920853711 scopus 로고    scopus 로고
    • Precise correction of the dystrophin gene in duchenne muscular dystrophy patient induced pluripotent stem cells by TALEN and CRISPR-Cas 9
    • [CrossRef] [PubMed]
    • Li, H.L.; Fujimoto, N.; Sasakawa, N.; Shirai, S.; Ohkame, T.; Sakuma, T.; Tanaka, M.; Amano, N.; Watanabe, A.; Sakurai, H. et al. Precise correction of the dystrophin gene in duchenne muscular dystrophy patient induced pluripotent stem cells by TALEN and CRISPR-Cas 9. Stem Cell Rep. 2015, 4, 143–154. [CrossRef] [PubMed]
    • (2015) Stem Cell Rep , vol.4 , pp. 143-154
    • Li, H.L.1    Fujimoto, N.2    Sasakawa, N.3    Shirai, S.4    Ohkame, T.5    Sakuma, T.6    Tanaka, M.7    Amano, N.8    Watanabe, A.9    Sakurai, H.10
  • 153
    • 84902161379 scopus 로고    scopus 로고
    • Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from niemann-pick type c patient-specific iPS cells
    • [CrossRef] [PubMed]
    • Maetzel, D.; Sarkar, S.; Wang, H.; Abi-Mosleh, L.; Xu, P.; Cheng, A.W.; Gao, Q.; Mitalipova, M.; Jaenisch, R. Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from niemann-pick type c patient-specific iPS cells. Stem Cell Rep. 2014, 2, 866–880. [CrossRef] [PubMed]
    • (2014) Stem Cell Rep , vol.2 , pp. 866-880
    • Maetzel, D.1    Sarkar, S.2    Wang, H.3    Abi-Mosleh, L.4    Xu, P.5    Cheng, A.W.6    Gao, Q.7    Mitalipova, M.8    Jaenisch, R.9
  • 154
    • 84887030890 scopus 로고    scopus 로고
    • A modified TALEN-based system for robust generation of knock-out human pluripotent stem cell lines and disease models
    • [CrossRef] [PubMed]
    • Frank, S.; Skryabin, B.V.; Greber, B. A modified TALEN-based system for robust generation of knock-out human pluripotent stem cell lines and disease models. BMC Genomics 2013, 14, 773. [CrossRef] [PubMed]
    • (2013) BMC Genomics , vol.14 , pp. 773
    • Frank, S.1    Skryabin, B.V.2    Greber, B.3
  • 156
    • 84897042820 scopus 로고    scopus 로고
    • Seamless correction of the sickle cell disease mutation of the hbb gene in human induced pluripotent stem cells using TALENs
    • [CrossRef] [PubMed]
    • Sun, N.; Zhao, H. Seamless correction of the sickle cell disease mutation of the hbb gene in human induced pluripotent stem cells using TALENs. Biotechnol. Bioeng. 2014, 111, 1048–1053. [CrossRef] [PubMed]
    • (2014) Biotechnol. Bioeng , vol.111 , pp. 1048-1053
    • Sun, N.1    Zhao, H.2
  • 157
    • 84942552249 scopus 로고    scopus 로고
    • Targeted gene correction of RUNX1 in induced pluripotent stem cells derived from familial platelet disorder with propensity to myeloid malignancy restores normal megakaryopoiesis
    • [CrossRef] [PubMed]
    • Iizuka, H.; Kagoya, Y.; Kataoka, K.; Yoshimi, A.; Miyauchi, M.; Taoka, K.; Kumano, K.; Yamamoto, T.; Hotta, A.; Arai, S. et al. Targeted gene correction of RUNX1 in induced pluripotent stem cells derived from familial platelet disorder with propensity to myeloid malignancy restores normal megakaryopoiesis. Exp. Hematol. 2015, 43, 849–857. [CrossRef] [PubMed]
    • (2015) Exp. Hematol , vol.43 , pp. 849-857
    • Iizuka, H.1    Kagoya, Y.2    Kataoka, K.3    Yoshimi, A.4    Miyauchi, M.5    Taoka, K.6    Kumano, K.7    Yamamoto, T.8    Hotta, A.9    Arai, S.10
  • 158
    • 84949537443 scopus 로고    scopus 로고
    • Generation of a high number of healthy erythroid cells from gene-edited pyruvate kinase deficiency patient-specific induced pluripotent stem cells
    • [CrossRef] [PubMed]
    • Garate, Z.; Quintana-Bustamante, O.; Crane, A.M.; Olivier, E.; Poirot, L.; Galetto, R.; Kosinski, P.; Hill, C.; Kung, C.; Agirre, X. et al. Generation of a high number of healthy erythroid cells from gene-edited pyruvate kinase deficiency patient-specific induced pluripotent stem cells. Stem Cell Rep. 2015, 5, 1053–1066. [CrossRef] [PubMed]
    • (2015) Stem Cell Rep , vol.5 , pp. 1053-1066
    • Garate, Z.1    Quintana-Bustamante, O.2    Crane, A.M.3    Olivier, E.4    Poirot, L.5    Galetto, R.6    Kosinski, P.7    Hill, C.8    Kung, C.9    Agirre, X.10
  • 159
    • 84903436131 scopus 로고    scopus 로고
    • Targeted inversion and reversion of the blood coagulation factor 8 gene in human iPS cells using TALENs
    • [CrossRef] [PubMed]
    • Park, C.Y.; Kim, J.; Kweon, J.; Son, J.S.; Lee, J.S.; Yoo, J.E.; Cho, S.R.; Kim, J.H.; Kim, J.S.; Kim, D.W.: Targeted inversion and reversion of the blood coagulation factor 8 gene in human iPS cells using TALENs. Proc. Natl. Acad. Sci. USA 2014, 111, 9253–9258. [CrossRef] [PubMed]
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 9253-9258
    • Park, C.Y.1    Kim, J.2    Kweon, J.3    Son, J.S.4    Lee, J.S.5    Yoo, J.E.6    Cho, S.R.7    Kim, J.H.8    Kim, J.S.9    Kim, D.W.10
  • 160
    • 84888433312 scopus 로고    scopus 로고
    • The presenilin-1 DeltaE9 mutation results in reduced gamma-secretase activity, but not total loss of PS1 function, in isogenic human stem cells
    • [CrossRef] [PubMed]
    • Woodruff, G.; Young, J.E.; Martinez, F.J.; Buen, F.; Gore, A.; Kinaga, J.; Li, Z.; Yuan, S.H.; Zhang, K.; Goldstein, L.S. The presenilin-1 DeltaE9 mutation results in reduced gamma-secretase activity, but not total loss of PS1 function, in isogenic human stem cells. Cell. Rep. 2013, 5, 974–985. [CrossRef] [PubMed]
    • (2013) Cell. Rep , vol.5 , pp. 974-985
    • Woodruff, G.1    Young, J.E.2    Martinez, F.J.3    Buen, F.4    Gore, A.5    Kinaga, J.6    Li, Z.7    Yuan, S.H.8    Zhang, K.9    Goldstein, L.S.10
  • 163
    • 84992223540 scopus 로고    scopus 로고
    • Defective transcytosis of app and lipoproteins in human iPSC-derived neurons with familial Alzheimer’s disease mutations
    • [CrossRef] [PubMed]
    • Woodruff, G.; Reyna, S.M.; Dunlap, M.; van Der Kant, R.; Callender, J.A.; Young, J.E.; Roberts, E.A.; Goldstein, L.S. Defective transcytosis of app and lipoproteins in human iPSC-derived neurons with familial Alzheimer’s disease mutations. Cell Rep. 2016, 17, 759–773. [CrossRef] [PubMed]
    • (2016) Cell Rep , vol.17 , pp. 759-773
    • Woodruff, G.1    Reyna, S.M.2    Dunlap, M.3    Van Der Kant, R.4    Callender, J.A.5    Young, J.E.6    Roberts, E.A.7    Goldstein, L.S.8
  • 164
    • 84907364703 scopus 로고    scopus 로고
    • More than cholesterol transporters: Lipoprotein receptors in CNS function and neurodegeneration
    • [CrossRef] [PubMed]
    • Lane-Donovan, C.; Philips, G.T.; Herz, J. More than cholesterol transporters: Lipoprotein receptors in CNS function and neurodegeneration. Neuron 2014, 83, 771–787. [CrossRef] [PubMed]
    • (2014) Neuron , vol.83 , pp. 771-787
    • Lane-Donovan, C.1    Philips, G.T.2    Herz, J.3
  • 167
    • 84907219050 scopus 로고    scopus 로고
    • Seamless gene correction of beta-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac
    • [CrossRef] [PubMed]
    • Xie, F.; Ye, L.; Chang, J.C.; Beyer, A.I.; Wang, J.; Muench, M.O.; Kan, Y.W. Seamless gene correction of beta-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac. Genome Res. 2014, 24, 1526–1533. [CrossRef] [PubMed]
    • (2014) Genome Res , vol.24 , pp. 1526-1533
    • Xie, F.1    Ye, L.2    Chang, J.C.3    Beyer, A.I.4    Wang, J.5    Muench, M.O.6    Kan, Y.W.7
  • 168
    • 84934285785 scopus 로고    scopus 로고
    • Improved hematopoietic differentiation efficiency of gene-corrected beta-thalassemia induced pluripotent stem cells by CRISPR/Cas9 system
    • [CrossRef] [PubMed]
    • Song, B.; Fan, Y.; He, W.; Zhu, D.; Niu, X.; Wang, D.; Ou, Z.; Luo, M.; Sun, X. Improved hematopoietic differentiation efficiency of gene-corrected beta-thalassemia induced pluripotent stem cells by CRISPR/Cas9 system. Stem Cells Dev. 2015, 24, 1053–1065. [CrossRef] [PubMed]
    • (2015) Stem Cells Dev , vol.24 , pp. 1053-1065
    • Song, B.1    Fan, Y.2    He, W.3    Zhu, D.4    Niu, X.5    Wang, D.6    Ou, Z.7    Luo, M.8    Sun, X.9
  • 169
    • 84938751866 scopus 로고    scopus 로고
    • Functional correction of large factor viii gene chromosomal inversions in hemophilia a patient-derived iPSCs using CRISPR-Cas 9
    • [CrossRef] [PubMed]
    • Park, C.Y.; Kim, D.H.; Son, J.S.; Sung, J.J.; Lee, J.; Bae, S.; Kim, J.H.; Kim, D.W.; Kim, J.S. Functional correction of large factor viii gene chromosomal inversions in hemophilia a patient-derived iPSCs using CRISPR-Cas 9. Cell Stem Cell 2015, 17, 213–220. [CrossRef] [PubMed]
    • (2015) Cell Stem Cell , vol.17 , pp. 213-220
    • Park, C.Y.1    Kim, D.H.2    Son, J.S.3    Sung, J.J.4    Lee, J.5    Bae, S.6    Kim, J.H.7    Kim, D.W.8    Kim, J.S.9
  • 170
    • 84885112722 scopus 로고    scopus 로고
    • Generation of an icf syndrome model by efficient genome editing of human induced pluripotent stem cells using the CRISPR system
    • [CrossRef] [PubMed]
    • Horii, T.; Tamura, D.; Morita, S.; Kimura, M.; Hatada, I. Generation of an icf syndrome model by efficient genome editing of human induced pluripotent stem cells using the CRISPR system. Int. J. Mol. Sci. 2013, 14, 19774–19781. [CrossRef] [PubMed]
    • (2013) Int. J. Mol. Sci , vol.14 , pp. 19774-19781
    • Horii, T.1    Tamura, D.2    Morita, S.3    Kimura, M.4    Hatada, I.5
  • 171
    • 84928577551 scopus 로고    scopus 로고
    • Production of gene-corrected adult beta globin protein in human erythrocytes differentiated from patient iPSCs after genome editing of the sickle point mutation
    • [CrossRef] [PubMed]
    • Huang, X.; Wang, Y.; Yan, W.; Smith, C.; Ye, Z.; Wang, J.; Gao, Y.; Mendelsohn, L.; Cheng, L. Production of gene-corrected adult beta globin protein in human erythrocytes differentiated from patient iPSCs after genome editing of the sickle point mutation. Stem Cells 2015, 33, 1470–1479. [CrossRef] [PubMed]
    • (2015) Stem Cells , vol.33 , pp. 1470-1479
    • Huang, X.1    Wang, Y.2    Yan, W.3    Smith, C.4    Ye, Z.5    Wang, J.6    Gao, Y.7    Mendelsohn, L.8    Cheng, L.9
  • 172
    • 84941186492 scopus 로고    scopus 로고
    • Modeling human severe combined immunodeficiency and correction by CRISPR/Cas9-enhanced gene targeting
    • [CrossRef] [PubMed]
    • Chang, C.W.; Lai, Y.S.; Westin, E.; Khodadadi-Jamayran, A.; Pawlik, K.M.; Lamb, L.S., Jr.; Goldman, F.D.; Townes, T.M.: Modeling human severe combined immunodeficiency and correction by CRISPR/Cas9-enhanced gene targeting. Cell. Rep. 2015, 12, 1668–1677. [CrossRef] [PubMed]
    • (2015) Cell. Rep , vol.12 , pp. 1668-1677
    • Chang, C.W.1    Lai, Y.S.2    Westin, E.3    Khodadadi-Jamayran, A.4    Pawlik, K.M.5    Lamb, L.S.6    Goldman, F.D.7    Townes, T.M.8
  • 173
    • 84940793000 scopus 로고    scopus 로고
    • Functional gene correction for cystic fibrosis in lung epithelial cells generated from patient iPSCs
    • [CrossRef] [PubMed]
    • Firth, A.L.; Menon, T.; Parker, G.S.; Qualls, S.J.; Lewis, B.M.; Ke, E.; Dargitz, C.T.; Wright, R.; Khanna, A.; Gage, F.H. et al. Functional gene correction for cystic fibrosis in lung epithelial cells generated from patient iPSCs. Cell Rep. 2015, 12, 1385–1390. [CrossRef] [PubMed]
    • (2015) Cell Rep , vol.12 , pp. 1385-1390
    • Firth, A.L.1    Menon, T.2    Parker, G.S.3    Qualls, S.J.4    Lewis, B.M.5    Ke, E.6    Dargitz, C.T.7    Wright, R.8    Khanna, A.9    Gage, F.H.10
  • 174
    • 84902087268 scopus 로고    scopus 로고
    • Modeling the mitochondrial cardiomyopathy of barth syndrome with induced pluripotent stem cell and heart-on-chip technologies
    • [CrossRef] [PubMed]
    • Wang, G.; McCain, M.L.; Yang, L.; He, A.; Pasqualini, F.S.; Agarwal, A.; Yuan, H.; Jiang, D.; Zhang, D.; Zangi, L. et al. Modeling the mitochondrial cardiomyopathy of barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nat. Med. 2014, 20, 616–623. [CrossRef] [PubMed]
    • (2014) Nat. Med , vol.20 , pp. 616-623
    • Wang, G.1    McCain, M.L.2    Yang, L.3    He, A.4    Pasqualini, F.S.5    Agarwal, A.6    Yuan, H.7    Jiang, D.8    Zhang, D.9    Zangi, L.10
  • 178
    • 84862630220 scopus 로고    scopus 로고
    • CCR5-targeted hematopoietic stem cell gene approaches for hiv disease: Current progress and future prospects
    • [CrossRef] [PubMed]
    • Lai, Y. CCR5-targeted hematopoietic stem cell gene approaches for hiv disease: Current progress and future prospects. Curr. Stem Cell. Res. Ther. 2012, 7, 310–317. [CrossRef] [PubMed]
    • (2012) Curr. Stem Cell. Res. Ther , vol.7 , pp. 310-317
    • Lai, Y.1
  • 179
    • 84903729497 scopus 로고    scopus 로고
    • Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5delta32 mutation confers resistance to HIV infection
    • [CrossRef] [PubMed]
    • Ye, L.; Wang, J.; Beyer, A.I.; Teque, F.; Cradick, T.J.; Qi, Z.; Chang, J.C.; Bao, G.; Muench, M.O.; Yu, J. et al. Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5delta32 mutation confers resistance to HIV infection. Proc. Natl. Acad. Sci. USA 2014, 111, 9591–9596. [CrossRef] [PubMed]
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 9591-9596
    • Ye, L.1    Wang, J.2    Beyer, A.I.3    Teque, F.4    Cradick, T.J.5    Qi, Z.6    Chang, J.C.7    Bao, G.8    Muench, M.O.9    Yu, J.10
  • 180
    • 84924911665 scopus 로고    scopus 로고
    • Small molecules enhance CRISPR genome editing in pluripotent stem cells
    • [CrossRef] [PubMed]
    • Yu, C.; Liu, Y.; Ma, T.; Liu, K.; Xu, S.; Zhang, Y.; Liu, H.; La Russa, M.; Xie, M.; Ding, S. et al. Small molecules enhance CRISPR genome editing in pluripotent stem cells. Cell Stem Cell 2015, 16, 142–147. [CrossRef] [PubMed]
    • (2015) Cell Stem Cell , vol.16 , pp. 142-147
    • Yu, C.1    Liu, Y.2    Ma, T.3    Liu, K.4    Xu, S.5    Zhang, Y.6    Liu, H.7    La Russa, M.8    Xie, M.9    Ding, S.10
  • 181
    • 85117873058 scopus 로고    scopus 로고
    • The impact of chromatin dynamics on Cas9-mediated genome editing in human cells
    • [CrossRef] [PubMed]
    • Daer, R.; Cutts, J.P.; Brafman, D.A.; Haynes, K.A. The impact of chromatin dynamics on Cas9-mediated genome editing in human cells. ACS Synth Biol. 2016. [CrossRef] [PubMed]
    • (2016) ACS Synth Biol
    • Daer, R.1    Cutts, J.P.2    Brafman, D.A.3    Haynes, K.A.4
  • 182
    • 79957807595 scopus 로고    scopus 로고
    • Immunogenicity of induced pluripotent stem cells
    • [CrossRef] [PubMed]
    • Zhao, T.; Zhang, Z.N.; Rong, Z.; Xu, Y. Immunogenicity of induced pluripotent stem cells. Nature 2011, 474, 212–215. [CrossRef] [PubMed]
    • (2011) Nature , vol.474 , pp. 212-215
    • Zhao, T.1    Zhang, Z.N.2    Rong, Z.3    Xu, Y.4
  • 183
    • 84941025378 scopus 로고    scopus 로고
    • Humanized mice reveal differential immunogenicity of cells derived from autologous induced pluripotent stem cells
    • [CrossRef] [PubMed]
    • Zhao, T.; Zhang, Z.N.; Westenskow, P.D.; Todorova, D.; Hu, Z.; Lin, T.; Rong, Z.; Kim, J.; He, J.; Wang, M. et al. Humanized mice reveal differential immunogenicity of cells derived from autologous induced pluripotent stem cells. Cell Stem Cell 2015, 17, 353–359. [CrossRef] [PubMed]
    • (2015) Cell Stem Cell , vol.17 , pp. 353-359
    • Zhao, T.1    Zhang, Z.N.2    Westenskow, P.D.3    Todorova, D.4    Hu, Z.5    Lin, T.6    Rong, Z.7    Kim, J.8    He, J.9    Wang, M.10
  • 184
    • 84916891554 scopus 로고    scopus 로고
    • Negligible immunogenicity of induced pluripotent stem cells derived from human skin fibroblasts
    • [CrossRef] [PubMed]
    • Lu, Q.; Yu, M.; Shen, C.; Chen, X.; Feng, T.; Yao, Y.; Li, J.; Li, H.; Tu, W. Negligible immunogenicity of induced pluripotent stem cells derived from human skin fibroblasts. PLoS ONE 2014, 9, e114949. [CrossRef] [PubMed]
    • (2014) Plos ONE , vol.9
    • Lu, Q.1    Yu, M.2    Shen, C.3    Chen, X.4    Feng, T.5    Yao, Y.6    Li, J.7    Li, H.8    Tu, W.9
  • 185
    • 84920029335 scopus 로고    scopus 로고
    • Pyrosequencing revealed highly microbial phylogenetic diversity in ferromanganese nodules from farmland
    • [CrossRef] [PubMed]
    • Hu, M.; Li, F.; Lei, J.; Fang, Y.; Tong, H.; Wu, W.; Liu, C. Pyrosequencing revealed highly microbial phylogenetic diversity in ferromanganese nodules from farmland. Environ. Sci. Process. Impacts 2015, 17, 213–224. [CrossRef] [PubMed]
    • (2015) Environ. Sci. Process. Impacts , vol.17 , pp. 213-224
    • Hu, M.1    Li, F.2    Lei, J.3    Fang, Y.4    Tong, H.5    Wu, W.6    Liu, C.7
  • 186
    • 84960806972 scopus 로고    scopus 로고
    • Cardiomyocytes derived from mhc-homozygous induced pluripotent stem cells exhibit reduced allogeneic immunogenicity in mhc-matched non-human primates
    • [CrossRef] [PubMed]
    • Kawamura, T.; Miyagawa, S.; Fukushima, S.; Maeda, A.; Kashiyama, N.; Kawamura, A.; Miki, K.; Okita, K.; Yoshida, Y.; Shiina, T. et al. Cardiomyocytes derived from mhc-homozygous induced pluripotent stem cells exhibit reduced allogeneic immunogenicity in mhc-matched non-human primates. Stem Cell Rep. 2016, 6, 312–320. [CrossRef] [PubMed]
    • (2016) Stem Cell Rep , vol.6 , pp. 312-320
    • Kawamura, T.1    Miyagawa, S.2    Fukushima, S.3    Maeda, A.4    Kashiyama, N.5    Kawamura, A.6    Miki, K.7    Okita, K.8    Yoshida, Y.9    Shiina, T.10
  • 187
    • 84891673525 scopus 로고    scopus 로고
    • An effective approach to prevent immune rejection of human esc-derived allografts
    • [CrossRef] [PubMed]
    • Rong, Z.; Wang, M.; Hu, Z.; Stradner, M.; Zhu, S.; Kong, H.; Yi, H.; Goldrath, A.; Yang, Y.G.; Xu, Y. et al. An effective approach to prevent immune rejection of human esc-derived allografts. Cell Stem Cell 2014, 14, 121–130. [CrossRef] [PubMed]
    • (2014) Cell Stem Cell , vol.14 , pp. 121-130
    • Rong, Z.1    Wang, M.2    Hu, Z.3    Stradner, M.4    Zhu, S.5    Kong, H.6    Yi, H.7    Goldrath, A.8    Yang, Y.G.9    Xu, Y.10
  • 188
    • 84978438340 scopus 로고    scopus 로고
    • DNA-guided genome editing using the natronobacterium gregoryi argonaute
    • [CrossRef] [PubMed]
    • Gao, F.; Shen, X.Z.; Jiang, F.; Wu, Y.; Han, C. DNA-guided genome editing using the natronobacterium gregoryi argonaute. Nat. Biotechnol. 2016, 34, 768–773. [CrossRef] [PubMed]
    • (2016) Nat. Biotechnol , vol.34 , pp. 768-773
    • Gao, F.1    Shen, X.Z.2    Jiang, F.3    Wu, Y.4    Han, C.5
  • 189
    • 84994761246 scopus 로고    scopus 로고
    • NgAgo-based fabp11a gene knockdown causes eye developmental defects in zebrafish
    • [CrossRef] [PubMed]
    • Qi, J.; Dong, Z.; Shi, Y.; Wang, X.; Qin, Y.; Wang, Y.; Liu, D. NgAgo-based fabp11a gene knockdown causes eye developmental defects in zebrafish. Cell Res. 2016, 26, 1349–1352. [CrossRef] [PubMed]
    • (2016) Cell Res , vol.26 , pp. 1349-1352
    • Qi, J.1    Dong, Z.2    Shi, Y.3    Wang, X.4    Qin, Y.5    Wang, Y.6    Liu, D.7
  • 190
    • 85000538831 scopus 로고    scopus 로고
    • Updated: NgAgo gene-editing controversy escalates in peer-reviewed papers
    • [CrossRef] [PubMed]
    • Cyranoski, D. Updated: NgAgo gene-editing controversy escalates in peer-reviewed papers. Nature 2016, 540, 20–21. [CrossRef] [PubMed]
    • (2016) Nature , vol.540 , pp. 20-21
    • Cyranoski, D.1
  • 191
    • 84982151864 scopus 로고    scopus 로고
    • Replications, ridicule and a recluse: The controversy over ngago gene-editing intensifies
    • [CrossRef] [PubMed]
    • Cyranoski, D. Replications, ridicule and a recluse: The controversy over ngago gene-editing intensifies. Nature 2016, 536, 136–137. [CrossRef] [PubMed]
    • (2016) Nature , vol.536 , pp. 136-137
    • Cyranoski, D.1
  • 193
    • 84885850258 scopus 로고    scopus 로고
    • Opportunities and challenges of pluripotent stem cell neurodegenerative disease models
    • [CrossRef] [PubMed]
    • Sandoe, J.; Eggan, K.: Opportunities and challenges of pluripotent stem cell neurodegenerative disease models. Nat. Neurosci. 2013, 16, 780–789. [CrossRef] [PubMed]
    • (2013) Nat. Neurosci , vol.16 , pp. 780-789
    • Sandoe, J.1    Eggan, K.2
  • 194
    • 84951860090 scopus 로고    scopus 로고
    • Human pluripotent stem cells: Prospects and challenges as a source of cardiomyocytes for in vitro modeling and cell-based cardiac repair
    • [CrossRef] [PubMed]
    • Hartman, M.E.; Dai, D.F.; Laflamme, M.A. Human pluripotent stem cells: Prospects and challenges as a source of cardiomyocytes for in vitro modeling and cell-based cardiac repair. Adv. Drug Deliv. Rev. 2016, 96, 3–17. [CrossRef] [PubMed]
    • (2016) Adv. Drug Deliv. Rev , vol.96 , pp. 3-17
    • Hartman, M.E.1    Dai, D.F.2    Laflamme, M.A.3
  • 195
    • 84905739577 scopus 로고    scopus 로고
    • Translational strategies and challenges in regenerative medicine
    • [CrossRef] [PubMed]
    • Dimmeler, S.; Ding, S.; Rando, T.A.; Trounson, A.: Translational strategies and challenges in regenerative medicine. Nat. Med. 2014, 20, 814–821. [CrossRef] [PubMed]
    • (2014) Nat. Med , vol.20 , pp. 814-821
    • Dimmeler, S.1    Ding, S.2    Rando, T.A.3    Trounson, A.4
  • 196
    • 84959330157 scopus 로고    scopus 로고
    • Pluripotent stem cells progressing to the clinic
    • [CrossRef] [PubMed]
    • Trounson, A.; DeWitt, N.D. Pluripotent stem cells progressing to the clinic. Nat. Rev. Mol. Cell Biol. 2016, 17, 194–200. [CrossRef] [PubMed]
    • (2016) Nat. Rev. Mol. Cell Biol , vol.17 , pp. 194-200
    • Trounson, A.1    Dewitt, N.D.2
  • 197
    • 84896901825 scopus 로고    scopus 로고
    • Can pluripotent stem cells be used in cell-based therapy?
    • [CrossRef] [PubMed]
    • Picanco-Castro, V.; Moreira, L.F.; Kashima, S.; Covas, D.T. Can pluripotent stem cells be used in cell-based therapy? Cell Reprogram 2014, 16, 98–107. [CrossRef] [PubMed]
    • (2014) Cell Reprogram , vol.16 , pp. 98-107
    • Picanco-Castro, V.1    Moreira, L.F.2    Kashima, S.3    Covas, D.T.4


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