Amyloid precursor protein controls cholesterol turnover needed for neuronal activity

EMBO Molecular Medicine

Volumn 5, Issue 4, 2013, Pages 608-625

  Pierrot, Nathalie ^a,b   Tyteca, Donatienne ^a,c   D'auria, Ludovic ^a,c   Dewachter, Ilse ^a,b   Gailly, Philippe ^a,b   Hendrickx, Aurélie ^a,b   Tasiaux, Bernadette ^a,b   Haylani, Laetitia El ^a,b   Muls, Nathalie ^a,b   N'Kuli, Francisca ^a,c   Laquerrière, Annie ^d   Demoulin, Jean Baptiste ^a,c   Campion, Dominique ^e,f   Brion, Jean Pierre ^g   Courtoy, Pierre J ^a,c   Kienlen Campard, Pascal ^a,b   Octave, Jean Noël ^a,b  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b Institute of Neuroscience   (Belgium)

^c DE DUVE INSTITUTE   (Belgium)

^d ROUEN UNIVERSITY HOSPITAL   (France)

^e INSERM   (France)

^f CHS du Rouvray   (France)

^g UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

Alzheimer's disease; Calcium oscillations; Cholesterol turnover; Neuron; SREBP 1

Indexed keywords

AMYLOID PRECURSOR PROTEIN; COMPACTIN; GERANYLGERANIOL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MEVALONIC ACID; OXYGENASE; STEROID 24 HYDROXYLASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; ASTROCYTE; CHOLESTEROL SYNTHESIS; DOWN REGULATION; IMMUNOPRECIPITATION; LIPID METABOLISM; NERVE CELL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CELLS, CULTURED; CHOLESTEROL; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURONS; RATS; RATS, WISTAR; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

EID: 84875762000     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.1002/emmm.201202215     Document Type: Article

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