Genome-wide analysis reveals specificities of Cpf1 endonucleases in human cells

Nature Biotechnology

Volumn 34, Issue 8, 2016, Pages 863-868

  Kim, Daesik ^a,b   Kim, Jungeun ^a,b   Hur, Junho K ^a   Been, Kyung Wook ^a,b   Yoon, Sun Heui ^b   Kim, Jin Soo ^a,b  

^a Institute for Basic Science   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BIOTECHNOLOGY;

CLEAVAGE SITES; DISTAL REGIONS; ENDONUCLEASES; GENOME WIDE ANALYSIS; HUMAN GENOMES; PALINDROMIC; RIBONUCLEOPROTEINS; TARGET SITES;

GENES;

CPF1 PROTEIN; DNA METHYLTRANSFERASE 1; ENDONUCLEASE; GENOMIC DNA; GUIDE RNA; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; NUCLEOTIDE; OLIGONUCLEOTIDE; PROTEIN; RIBONUCLEOPROTEIN; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; PROTEIN BINDING;

ARTICLE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENE SEQUENCE; GENETIC ASSOCIATION; GENOME ANALYSIS; GENOME-WIDE ASSOCIATION STUDY; HUMAN; HUMAN CELL; HUMAN GENOME; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; PROTOSPACER ADJACENT MOTIF; SEQUENCE ANALYSIS; BASE MISPAIRING; BINDING SITE; CHROMOSOMAL MAPPING; CRISPR CAS SYSTEM; ENZYME ACTIVATION; ENZYME SPECIFICITY; GENETICS; METABOLISM; PHYSIOLOGY; PROCEDURES;

BACTERIAL PROTEINS; BASE PAIR MISMATCH; BINDING SITES; CHROMOSOME MAPPING; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-CAS SYSTEMS; ENDONUCLEASES; ENZYME ACTIVATION; GENOME, HUMAN; HUMANS; PROTEIN BINDING; SUBSTRATE SPECIFICITY;

EID: 84981318543     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.3609     Document Type: Article

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