Modeling Human Severe Combined Immunodeficiency and Correction by CRISPR/Cas9-Enhanced Gene Targeting

Cell Reports

Volumn 12, Issue 10, 2015, Pages 1668-1677

  Chang, Chia Wei ^a,c   Lai, Yi Shin ^a,c   Westin, Erik ^a,c   Khodadadi Jamayran, Alireza ^a,c   Pawlik, Kevin M ^a,c   Lamb, Lawrence S ^b,c   Goldman, Frederick D ^b,c   Townes, Tim M ^a,c  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 9; CD16 ANTIGEN; CD34 ANTIGEN; CD4 ANTIGEN; CD56 ANTIGEN; CD7 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 7; JANUS KINASE 3; PROTEIN BAX; PROTEIN BCL 2; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; TRANSCRIPTION FACTOR GATA 3; BACTERIAL PROTEIN; BCL2 PROTEIN, HUMAN; CAS9 PROTEIN, FRANCISELLA NOVICIDA; ENDONUCLEASE; JAK3 PROTEIN, HUMAN;

AMINO ACID SUBSTITUTION; ARTICLE; BIOLOGICAL MODEL; CELL DIFFERENTIATION; CELL MATURATION; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; DEVELOPMENTAL STAGE; ENHANCED GENE TARGETING; GENE; GENE CORRECTION; GENE MUTATION; GENE SEQUENCE; GENE TARGETING; GENETIC PROCEDURES; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HUMAN CELL; IN VITRO STUDY; JAK3 GENE; MOLECULAR CLONING; MORTALITY; PHENOTYPE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PTCRA GENE; RAG1 GENE; RAG2 GENE; SEVERE COMBINED IMMUNODEFICIENCY; T CELL DEVELOPMENT; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; CELL CULTURE; DNA MUTATIONAL ANALYSIS; ENZYMOLOGY; GENE THERAPY; GENETICS; INDUCED PLURIPOTENT STEM CELL; MALE; METABOLISM; MISSENSE MUTATION; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PRESCHOOL CHILD;

BACTERIAL PROTEINS; BASE SEQUENCE; CELLS, CULTURED; CHILD, PRESCHOOL; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; DNA MUTATIONAL ANALYSIS; ENDONUCLEASES; GENE TARGETING; GENETIC THERAPY; HUMANS; INDUCED PLURIPOTENT STEM CELLS; JANUS KINASE 3; MALE; MUTATION, MISSENSE; PROTO-ONCOGENE PROTEINS C-BCL-2; SEVERE COMBINED IMMUNODEFICIENCY; T-LYMPHOCYTES;

EID: 84941186492     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.08.013     Document Type: Article

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