Derivation of novel human ground state naive pluripotent stem cells

Nature

Volumn 504, Issue 7479, 2013, Pages 282-286

  Gafni, Ohad ^a   Weinberger, Leehee ^a   Mansour, Abed Alfatah ^a   Manor, Yair S ^a   Chomsky, Elad ^a   Ben Yosef, Dalit ^b,c   Kalma, Yael ^b   Viukov, Sergey ^a   Maza, Itay ^a   Zviran, Asaf ^a   Rais, Yoach ^a   Shipony, Zohar ^a   Mukamel, Zohar ^a   Krupalnik, Vladislav ^a   Zerbib, Mirie ^a   Geula, Shay ^a   Caspi, Inbal ^a   Schneir, Dan ^a   Shwartz, Tamar ^a   Gilad, Shlomit ^a   Amann Zalcenstein, Daniela ^a   Benjamin, Sima ^a   Amit, Ido ^a   Tanay, Amos ^a   Massarwa, Rada ^a   Novershtern, Noa ^a   Hanna, Jacob H ^a   more..

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b LIS MATERNITY HOSPITAL   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOME; CYTOLOGY; DNA; EMBRYONIC DEVELOPMENT; GENE EXPRESSION; HOMINID; PROTEIN; RODENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLASTOCYST; CHIMERA; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; EPIGENETICS; FEMALE; HUMAN; HUMAN CELL; HUMAN DEVELOPMENT; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROINJECTION; MORULA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ORGANOGENESIS; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REGENERATIVE MEDICINE; VALIDATION STUDY;

ANIMALS; BLASTOCYST; CHIMERA; CHROMATIN; DNA METHYLATION; EMBRYO, MAMMALIAN; EMBRYONIC STEM CELLS; EPIGENESIS, GENETIC; FEMALE; GERM LAYERS; HISTONES; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MALE; MICE; MORULA; NUCLEAR REPROGRAMMING; ORGANOGENESIS; PROMOTER REGIONS, GENETIC; REGENERATIVE MEDICINE; REPRODUCIBILITY OF RESULTS; SIGNAL TRANSDUCTION; X CHROMOSOME INACTIVATION;

IPS; MURINAE;

EID: 84890439421     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12745     Document Type: Article

References (29)

1. Hanna, J. H., Saha, K. & Jaenisch, R. Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues. Cell 143, 508-525 (2010).
2. Ying, Q.-L. et al. The ground state of embryonic stemcell self-renewal. Nature 453, 519-523 (2008).
3. Marks, H. et al. The transcriptional and epigenomic foundations of ground state pluripotency. Cell 149, 590-604 (2012).
4. Brons, I. G. M. et al. Derivation of pluripotent epiblast stem cells from mammalian embryos. Nature 448, 191-195 (2007).
5. Thomson, J. A. et al. Embryonic stem cell lines derived from human blastocysts. Science 282, 1145-1147 (1998).
6. Chia, N.-Y. et al. A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature 468, 316-320 (2010).
7. Hanna, J. et al. Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. Proc. Natl Acad. Sci. USA 107, 9222-9227 (2010).
8. Hanna, J. et al. Metastable pluripotent states in NOD-mouse-derived ESCs. Cell Stem Cell 4, 513-524 (2009).
9. Greber, B. et al. Conserved and divergent roles of FGF signaling in mouse epiblast stem cells and human embryonic stem cells. Cell Stem Cell 6, 215-226 (2010).
10. Watanabe, K. et al. A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nature Biotechnol. 25, 681-686 (2007).
11. Rajendran, G. et al. Inhibitionof protein kinaseCsignaling maintains ratembryonic stem cell pluripotency. J. Biol. Chem. 288, 24351-24362 (2013).
12. Okamoto, I. et al. Eutherian mammals use diverse strategies to initiate X-chromosome inactivation during development. Nature 472, 370-374 (2011).
13. Mekhoubad, S. et al. Erosion of dosage compensation impacts human iPSC disease modeling. Cell Stem Cell 10, 595-609 (2012).
14. Chappell, J., Sun, Y., Singh, A. & Dalton, S. MYC/MAX control ERK signaling and pluripotency by regulation of dual-specificity phosphatases 2 and 7. Genes Dev. 27, 725-733 (2013).
15. Betschinger, J. et al. Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3. Cell 153, 335-347 (2013).
16. Rada-Iglesias, A. et al.Auniquechromatin signature uncovers early developmental enhancers in humans. Nature 470, 279-283 (2011).
17. Ficz, G. et al. Fgf signaling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency. Cell Stem Cell 13, 351-359 (2013).
18. Rais, Y. et al. Deterministic direct reprogramming of somatic cells to pluripotency. Nature 502, 65-70 (2013).
19. Urbach, A., Bar-Nur, O., Daley, G. Q.&Benvenisty, N. Differentialmodeling of fragileX syndrome by human embryonic stemcells and induced pluripotent stem cells. Cell Stem Cell 6, 407-411 (2010).
20. James, D., Noggle, S. A., Swigut, T. & Brivanlou, A. H. Contribution of human embryonic stem cells to mouse blastocysts. Dev. Biol. 295, 90-102 (2006).
21. Tachibana, M., Sparman, M., Ramsey, C., Ma, H.& Lee, H. S. Generation of chimeric rhesus monkeys. Cell 148, 285-295 (2012).
22. Ben-Yosef, D. et al. Female sex bias in human embryonic stem cell lines. Stem Cells Dev. 21, 363-372 (2012).
23. Lengner, C. J. et al. Derivation of pre-X inactivation human embryonic stemcells under physiological oxygen concentrations. Cell 141, 872-883 (2010).
24. Takahashi, K., Mitsui, K. & Yamanaka, S. Role of ERas in promoting tumour-like properties in mouse embryonic stem cells. Nature 423, 541-545 (2003).
25. Mansour, A. A. et al. TheH3K27 demethylase Utx regulates somatic and germcell epigenetic reprogramming. Nature 488, 409-413 (2012).
26. Massarwa, R. & Niswander, L. In toto live imaging of mouse morphogenesis and new insights into neural tube closure. Development 140, 226-236 (2013).
27. Yeom, Y. I. et al. Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells. Development 122, 881-894 (1996).
28. Pietrobono, R. et al. Quantitative analysis of DNA demethylation and transcriptional reactivation of the FMR1 gene in fragile X cells treated with 5-azadeoxycytidine. Nucleic Acids Res. 30, 3278-3285 (2002).
29. Vassena, R. et al. Waves of early transcriptional activation and pluripotency program initiation during human preimplantation development. Development 138, 3699-3709 (2011).