-
1
-
-
84927592484
-
Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling
-
Abaci, H. E. and Shuler, M. L. (2015). Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling. Integr Biol 7, 383-391. doi:10.1039/C4IB00292J
-
(2015)
Integr Biol
, vol.7
, pp. 383-391
-
-
Abaci, H. E.1
Shuler, M. L.2
-
2
-
-
79956348442
-
Alternative (non-animal) methods for cosmetics testing: Current status and future prospects
-
Adler, S., Basketter, D., Creton, S. et al. (2011). Alternative (non-animal) methods for cosmetics testing: Current status and future prospects. Arch Toxicol 85, 367-485. doi:10.1007/s00204-011-0693-2
-
(2011)
Arch Toxicol
, vol.85
, pp. 367-485
-
-
Adler, S.1
Basketter, D.2
Creton, S.3
-
3
-
-
84960853970
-
Weight of evidence evaluation and systematic review in EU chemical risk assessment: Foundation is laid but guidance is needed
-
Ågerstrand, M. and Beronius, A. (2016). Weight of evidence evaluation and systematic review in EU chemical risk assessment: Foundation is laid but guidance is needed. Env Int 92-93, 590-596. doi:10.1016/j.envint.2015.10.008
-
(2016)
Env Int
, vol.92-93
, pp. 590-596
-
-
Ågerstrand, M.1
Beronius, A.2
-
4
-
-
84961289290
-
Applicability and feasibility of systematic review for performing evidence-based risk assessment in food and feed safety
-
Aiassa, E., Higgins, J. P. T., Frampton, G. K. et al. (2015). Applicability and feasibility of systematic review for performing evidence-based risk assessment in food and feed safety. Crit Rev Food Sci Nutr 55, 1026-1034. doi:10.1080/10408398.20 13.769933
-
(2015)
Crit Rev Food Sci Nutr
, vol.55
, pp. 1026-1034
-
-
Aiassa, E.1
Higgins, J. P. T.2
Frampton, G. K.3
-
5
-
-
79955850527
-
A critical review of the effectiveness of rodent pharmaceutical carcinogenesis testing in predicting human risk
-
Alden, C. L., Lynn, A., Bourdeau, A. et al. (2011). A critical review of the effectiveness of rodent pharmaceutical carcinogenesis testing in predicting human risk. Vet Pathol 48, 772-784. doi:10.1177/0300985811400445
-
(2011)
Vet Pathol
, vol.48
, pp. 772-784
-
-
Alden, C. L.1
Lynn, A.2
Bourdeau, A.3
-
7
-
-
53049089942
-
Cancer is a preventable disease that requires major lifestyle changes
-
Anand, P., Kunnumakara, B. A., Sundaram, C. et al. (2008). Cancer is a preventable disease that requires major lifestyle changes. Pharm Res 25, 2097-2116. doi:10.1007/s11095-008-9661-9
-
(2008)
Pharm Res
, vol.25
, pp. 2097-2116
-
-
Anand, P.1
Kunnumakara, B. A.2
Sundaram, C.3
-
8
-
-
84904901205
-
Developing microphysiological systems for use as regulatory tools – Challenges and opportunities
-
Andersen, M. E., Betts, K., Dragan, Y. et al. (2014). Developing microphysiological systems for use as regulatory tools – Challenges and opportunities. ALTEX 31, 364-367. doi:10.14573/ altex.1405151
-
(2014)
ALTEX
, vol.31
, pp. 364-367
-
-
Andersen, M. E.1
Betts, K.2
Dragan, Y.3
-
9
-
-
26044442246
-
Cancer in rodents: Does it tell us about cancer in humans?
-
Anisimov, V. N., Ukraintseva, S. V. and Yashin, A. I. (2005). Cancer in rodents: Does it tell us about cancer in humans? Nat Rev Cancer 5, 807-819. doi:10.1038/nrc1715
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 807-819
-
-
Anisimov, V. N.1
Ukraintseva, S. V.2
Yashin, A. I.3
-
10
-
-
0000973407
-
Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP
-
Ashby, J. and Tennant, R. W. (1991). Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP. Mutat Res 257, 229-306. doi:10.1016/0165-1110(91)90003-E
-
(1991)
Mutat Res
, vol.257
, pp. 229-306
-
-
Ashby, J.1
Tennant, R. W.2
-
11
-
-
85051034983
-
Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity
-
Epub ahead of print
-
Bal-Price, A., Hogberg, H. T., Crofton, K. M. et al. (2018). Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity. ALTEX, Epub ahead of print. doi:10.14573/altex.1712081
-
(2018)
ALTEX
-
-
Bal-Price, A.1
Hogberg, H. T.2
Crofton, K. M.3
-
12
-
-
21344468371
-
The future of teratology research is in vitro
-
Bailey, J., Knight, A. and Balcombe, J. (2005). The future of teratology research is in vitro. Biogenic Amines 19, 97-145. doi:10.1163/1569391053722755
-
(2005)
Biogenic Amines
, vol.19
, pp. 97-145
-
-
Bailey, J.1
Knight, A.2
Balcombe, J.3
-
13
-
-
84975246894
-
Is there a reproducibility crisis?
-
Baker, M. (2016). Is there a reproducibility crisis? Nature 533, 452-454. doi:10.1038/533452a
-
(2016)
Nature
, vol.533
, pp. 452-454
-
-
Baker, M.1
-
14
-
-
84861744139
-
A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing
-
Basketter, D. A., Clewell, H., Kimber, I. et al. (2012). A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing. ALTEX 29, 3-91. doi:10.14573/ altex.2012.1.003
-
(2012)
ALTEX
, vol.29
, pp. 3-91
-
-
Basketter, D. A.1
Clewell, H.2
Kimber, I.3
-
15
-
-
84875627954
-
Relevance of non-guideline studies for risk assessment: The coverage model based on most frequent targets in repeated dose toxicity studies
-
Batke, M., Aldenberg, T., Escher, S. and Mangelsdorf, I. (2013). Relevance of non-guideline studies for risk assessment: The coverage model based on most frequent targets in repeated dose toxicity studies. Toxicol Lett 218, 293-298. doi:10.1016/j. toxlet.2012.09.002
-
(2013)
Toxicol Lett
, vol.218
, pp. 293-298
-
-
Batke, M.1
Aldenberg, T.2
Escher, S.3
Mangelsdorf, I.4
-
16
-
-
37049008719
-
Exposure-triggered reproductive toxicity testing under the REACH legislation: A proposal to define significant/ relevant exposure
-
Bernauer, U., Heinemeyer, G., Heinrich-Hirsch, B. et al. (2008). Exposure-triggered reproductive toxicity testing under the REACH legislation: A proposal to define significant/ relevant exposure. Toxicol Lett 176, 68-76. doi:10.1016/j. toxlet.2007.10.008
-
(2008)
Toxicol Lett
, vol.176
, pp. 68-76
-
-
Bernauer, U.1
Heinemeyer, G.2
Heinrich-Hirsch, B.3
-
17
-
-
77957179957
-
Some tautologous aspects of the comparison of carcinogenic potency in rats and mice
-
Bernstein, L., Gold, L. S., Ames, B. N. et al. (1985). Some tautologous aspects of the comparison of carcinogenic potency in rats and mice. Fundam Appl Toxicol 5, 79-86. doi:10.1016/0272-0590(85)90051-X
-
(1985)
Fundam Appl Toxicol
, vol.5
, pp. 79-86
-
-
Bernstein, L.1
Gold, L. S.2
Ames, B. N.3
-
18
-
-
0038746906
-
Cancer and developmental exposure to endocrine disruptors
-
Birnbaum, L. S. and Fenton, S. (2003). Cancer and developmental exposure to endocrine disruptors. Environ Health Perspect 111, 389-394. doi:10.1289/ehp.5686
-
(2003)
Environ Health Perspect
, vol.111
, pp. 389-394
-
-
Birnbaum, L. S.1
Fenton, S.2
-
19
-
-
34447133039
-
Deriving a data-based interspecies assessment factor using the NOAEL and the benchmark dose approach
-
Bokkers, B. G. H. and Slob, W. (2007). Deriving a data-based interspecies assessment factor using the NOAEL and the benchmark dose approach. Crit Rev Toxicol 37, 355-373. doi:10.1080/10408440701249224
-
(2007)
Crit Rev Toxicol
, vol.37
, pp. 355-373
-
-
Bokkers, B. G. H.1
Slob, W.2
-
20
-
-
49449112576
-
Optimization of the post-validation process. The report and recommendations of ECVAM workshop 67
-
Bottini, A. A., Alepee, N., De Silva, O. et al. (2008). Optimization of the post-validation process. The report and recommendations of ECVAM workshop 67. Altern Lab Anim 36, 353-366.
-
(2008)
Altern Lab Anim
, vol.36
, pp. 353-366
-
-
Bottini, A. A.1
Alepee, N.2
De Silva, O.3
-
21
-
-
84927594869
-
The human toxome project
-
Bouhifd, M., Andersen, M. E., Baghdikian, C. et al. (2015). The human toxome project. ALTEX 32, 112-124. doi:10.14573/ altex.1502091
-
(2015)
ALTEX
, vol.32
, pp. 112-124
-
-
Bouhifd, M.1
Andersen, M. E.2
Baghdikian, C.3
-
22
-
-
4344562814
-
The use of embryonic stem cells for regulatory developmental toxicity testing in vitro – The current status of test development
-
Bremer, S. and Hartung, T. (2004). The use of embryonic stem cells for regulatory developmental toxicity testing in vitro – The current status of test development. Curr Pharm Des 10, 2733-2747. doi:10.2174/1381612043383700
-
(2004)
Curr Pharm Des
, vol.10
, pp. 2733-2747
-
-
Bremer, S.1
Hartung, T.2
-
23
-
-
34249879680
-
The development of new concepts for assessing reproductive toxicity applicable to large scale toxicological programs
-
Bremer, S., Pellizzer, C., Hoffmann, S. et al. (2007). The development of new concepts for assessing reproductive toxicity applicable to large scale toxicological programs. Curr Pharm Des 13, 3047-3058. doi:10.2174/138161207782110462
-
(2007)
Curr Pharm Des
, vol.13
, pp. 3047-3058
-
-
Bremer, S.1
Pellizzer, C.2
Hoffmann, S.3
-
24
-
-
0020525511
-
The value of animal teratogenicity testing for predicting human risk
-
Brown, N. A. and Fabro, S. (1983). The value of animal teratogenicity testing for predicting human risk. Clin Obstet Gynecol 26, 467-477. doi:10.1097/00003081-198306000-00028
-
(1983)
Clin Obstet Gynecol
, vol.26
, pp. 467-477
-
-
Brown, N. A.1
Fabro, S.2
-
25
-
-
85012014885
-
The need for strategic development of safety sciences
-
Busquet, F. and Hartung, T. (2017). The need for strategic development of safety sciences. ALTEX 34, 3-21. doi:10.14573/ altex.1701031
-
(2017)
ALTEX
, vol.34
, pp. 3-21
-
-
Busquet, F.1
Hartung, T.2
-
26
-
-
80054695345
-
Critical evaluation of current developmental toxicity testing strategies: A case of babies and their bathwater
-
Carney, E. W., Ellis, A. L., Tyl, R. W. et al. (2011). Critical evaluation of current developmental toxicity testing strategies: A case of babies and their bathwater. Birth Defects Res B: Develop Reprod Toxicol 92, 395-403. doi:10.1002/bdrb.20318
-
(2011)
Birth Defects Res B: Develop Reprod Toxicol
, vol.92
, pp. 395-403
-
-
Carney, E. W.1
Ellis, A. L.2
Tyl, R. W.3
-
27
-
-
84894372252
-
Toward predictive models for drug-induced liver injury in humans: Are we there yet?
-
Chen, M., Bisgin, H., Tong, L. et al. (2014). Toward predictive models for drug-induced liver injury in humans: Are we there yet? Biomark Med 8, 201-213. doi:10.2217/bmm.13.146
-
(2014)
Biomark Med
, vol.8
, pp. 201-213
-
-
Chen, M.1
Bisgin, H.2
Tong, L.3
-
28
-
-
84960847121
-
Schedule-dependent interaction between anticancer treatments
-
Chen, S.-H., Forrester, W. and Lahav, G. (2016). Schedule-dependent interaction between anticancer treatments. Science 351, 1204-1208. doi:10.1126/science.aac5610
-
(2016)
Science
, vol.351
, pp. 1204-1208
-
-
Chen, S.-H.1
Forrester, W.2
Lahav, G.3
-
29
-
-
85045209260
-
Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups
-
Chiu, W. A., Guyton, K. Z., Martin, M. T. et al. (2018). Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups. ALTEX 35, 51-64. doi:10.14573/altex.1703231
-
(2018)
ALTEX
, vol.35
, pp. 51-64
-
-
Chiu, W. A.1
Guyton, K. Z.2
Martin, M. T.3
-
31
-
-
22044435932
-
Guidance on good cell culture practice
-
Coecke, S., Balls, M., Bowe, G. et al. (2005). Guidance on good cell culture practice. Altern Lab Anim 33, 261-287.
-
(2005)
Altern Lab Anim
, vol.33
, pp. 261-287
-
-
Coecke, S.1
Balls, M.2
Bowe, G.3
-
32
-
-
84861411076
-
Preventability of cancer: The relative contributions of biologic and social and physical environmental determinants of cancer mortality
-
Colditz, G. A. and Wei, E. K. (2012). Preventability of cancer: The relative contributions of biologic and social and physical environmental determinants of cancer mortality. Annual Rev Publ Health 33, 137-156. doi:10.1146/annurev-publhealth-031811-124627
-
(2012)
Annual Rev Publ Health
, vol.33
, pp. 137-156
-
-
Colditz, G. A.1
Wei, E. K.2
-
33
-
-
33745099965
-
History and evolution of reproductive and developmental toxicology guidelines
-
Collins, T. F. (2006). History and evolution of reproductive and developmental toxicology guidelines. Curr Pharm Des 12, 1449-1465. doi:10.2174/138161206776389813
-
(2006)
Curr Pharm Des
, vol.12
, pp. 1449-1465
-
-
Collins, T. F.1
-
34
-
-
0032716592
-
Cell transformation assay as predictors of human carcinogenicity
-
Combes, R., Balls, M., Curren, R. et al. (1999). Cell transformation assay as predictors of human carcinogenicity. Altern Lab Anim 27, 745-767.
-
(1999)
Altern Lab Anim
, vol.27
, pp. 745-767
-
-
Combes, R.1
Balls, M.2
Curren, R.3
-
35
-
-
46349085573
-
ECVAM retrospective validation of in vitro micronucleus test (MNT)
-
Corvi, R., Albertini, S., Hartung, T. et al. (2008). ECVAM retrospective validation of in vitro micronucleus test (MNT). Mutagenesis 23, 271-283. doi:10.1093/mutage/gen010
-
(2008)
Mutagenesis
, vol.23
, pp. 271-283
-
-
Corvi, R.1
Albertini, S.2
Hartung, T.3
-
36
-
-
84859426909
-
ECVAM prevalidation study on in vitro cell transformation assays: General outline and conclusions of the study
-
Corvi, R., Aardema, M. J., Gribaldo, L. et al. (2012). ECVAM prevalidation study on in vitro cell transformation assays: General outline and conclusions of the study. Mut Res 744, 12-19. doi:10.1016/j.mrgentox.2011.11.009
-
(2012)
Mut Res
, vol.744
, pp. 12-19
-
-
Corvi, R.1
Aardema, M. J.2
Gribaldo, L.3
-
37
-
-
84988979900
-
Validation of transcriptomics-based in vitro methods
-
C. Eskes and M. Whelan (eds), Switzerland: Springer
-
Corvi, R., Vilardell, M., Aubrecht, J. and Piersma, A. (2016). Validation of transcriptomics-based in vitro methods. In C. Eskes and M. Whelan (eds.), Validation of Alternative Methods for Toxicity Testing, Advances in Experimental Medicine and Biology. Vol. 856, 243-257. Switzerland: Springer. doi:10.1007/978-3-319-33826-2_10
-
(2016)
Validation of Alternative Methods for Toxicity Testing, Advances in Experimental Medicine and Biology
, vol.856
, pp. 243-257
-
-
Corvi, R.1
Vilardell, M.2
Aubrecht, J.3
Piersma, A.4
-
38
-
-
84994516231
-
In vitro genotoxicity testing: Can the performance be enhanced?
-
Corvi, R. and Madia, F. (2017). In vitro genotoxicity testing: Can the performance be enhanced? Food Chem Toxicol 106, 600-608. doi:10.1016/j.fct.2016.08.024
-
(2017)
Food Chem Toxicol
, vol.106
, pp. 600-608
-
-
Corvi, R.1
Madia, F.2
-
39
-
-
85030635655
-
Moving forward in carcinogenicity assessment: Report of an EURL ECVAMESTIV workshop
-
Corvi, R., Madia, F., Guyton, K. Z. et al. (2017). Moving forward in carcinogenicity assessment: Report of an EURL ECVAMESTIV workshop. Toxicol In Vitro 45, 278-286. doi:10.1016/j. tiv.2017.09.010
-
(2017)
Toxicol In Vitro
, vol.45
, pp. 278-286
-
-
Corvi, R.1
Madia, F.2
Guyton, K. Z.3
-
40
-
-
84946721769
-
Animal use for science in Europe
-
Daneshian, M., Busquet, F., Hartung, T. and Leist, M. (2015). Animal use for science in Europe. ALTEX 32, 261-274. doi:10.14573/altex.1509081
-
(2015)
ALTEX
, vol.32
, pp. 261-274
-
-
Daneshian, M.1
Busquet, F.2
Hartung, T.3
Leist, M.4
-
41
-
-
84961653980
-
Highlight report: Launch of a large integrated European in vitro toxicology project: EU-ToxRisk
-
Daneshian, M., Kamp, H., Hengstler, J. et al. (2016). Highlight report: Launch of a large integrated European in vitro toxicology project: EU-ToxRisk. Arch Toxicol 90, 1021-1024. doi:10.1007/s00204-016-1698-7
-
(2016)
Arch Toxicol
, vol.90
, pp. 1021-1024
-
-
Daneshian, M.1
Kamp, H.2
Hengstler, J.3
-
42
-
-
37849017124
-
Skeletal malformations and variations in developmental toxicity studies: Interpretation issues for human risk assessment
-
Daston, G. P. and Seed, J. (2007). Skeletal malformations and variations in developmental toxicity studies: Interpretation issues for human risk assessment. Birth Defects Res B Dev Reprod Toxicol 80, 421-424. doi:10.1002/bdrb.20135
-
(2007)
Birth Defects Res B Dev Reprod Toxicol
, vol.80
, pp. 421-424
-
-
Daston, G. P.1
Seed, J.2
-
43
-
-
33644865820
-
A tiered approach to systemic toxicity testing for agricultural chemical safety assessment
-
Doe, J. E., Boobis, A. R., Blacker, A. et al. (2006). A tiered approach to systemic toxicity testing for agricultural chemical safety assessment. Crit Rev Toxicol 36, 37-68. doi:10.1080/10408440500534370
-
(2006)
Crit Rev Toxicol
, vol.36
, pp. 37-68
-
-
Doe, J. E.1
Boobis, A. R.2
Blacker, A.3
-
44
-
-
84901604281
-
Testing chemical carcinogenicity by using a transcriptomics HepaRG-based model?
-
Doktorova, T. Y., Yildirimman, R., Celeen, L. et al. (2014). Testing chemical carcinogenicity by using a transcriptomics HepaRG-based model? EXCLI J 13, 623-637.
-
(2014)
EXCLI J
, vol.13
, pp. 623-637
-
-
Doktorova, T. Y.1
Yildirimman, R.2
Celeen, L.3
-
45
-
-
85018524242
-
Embryonic vascular disruption adverse outcomes: Linking HTS signatures with functional consequences
-
Ellis-Hutchings, R., Settivari, R., McCoy, A. et al. (2017). Embryonic vascular disruption adverse outcomes: Linking HTS signatures with functional consequences. Reprod Toxicol 70, 82-96. doi:10.1016/j.reprotox.2017.04.003
-
(2017)
Reprod Toxicol
, vol.70
, pp. 82-96
-
-
Ellis-Hutchings, R.1
Settivari, R.2
McCoy, A.3
-
46
-
-
0023144955
-
The predictivity of animal bioassays and short-term genotoxicity tests for carcinogenicity and non-carcinogenicity to humans
-
Ennever, F. K., Noonan, T. J. and Rosenkranz, H. S. (1987). The predictivity of animal bioassays and short-term genotoxicity tests for carcinogenicity and non-carcinogenicity to humans. Mutagenesis 2, 73-78. doi:10.1093/mutage/2.2.73
-
(1987)
Mutagenesis
, vol.2
, pp. 73-78
-
-
Ennever, F. K.1
Noonan, T. J.2
Rosenkranz, H. S.3
-
47
-
-
0038159914
-
Implications of the lack of accuracy of the lifetime rodent bioassay for predicting human carcinogenicity
-
Ennever, F. K. and Lave, L. B. (2003). Implications of the lack of accuracy of the lifetime rodent bioassay for predicting human carcinogenicity. Regul Toxicol Pharmacol 38, 52-57. doi:10.1016/S0273-2300(03)00068-0
-
(2003)
Regul Toxicol Pharmacol
, vol.38
, pp. 52-57
-
-
Ennever, F. K.1
Lave, L. B.2
-
48
-
-
85019569593
-
Good cell culture practices & in vitro toxicology
-
Eskes, C., Boström, A.-C., Bowe, G. et al. (2017). Good cell culture practices & in vitro toxicology. Toxicol In Vitro 45, 272-277. doi:10.1016/j.tiv.2017.04.022
-
(2017)
Toxicol In Vitro
, vol.45
, pp. 272-277
-
-
Eskes, C.1
Boström, A.-C.2
Bowe, G.3
-
52
-
-
85032338592
-
Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective
-
Ewart, L., Fabre, K., Chakilam, A. et al. (2017). Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective. Exp Biol Med 242, 1579-1585. doi:10.1177/1535370217715441
-
(2017)
Exp Biol Med
, vol.242
, pp. 1579-1585
-
-
Ewart, L.1
Fabre, K.2
Chakilam, A.3
-
53
-
-
84904905976
-
Glossary of reference terms for alternative test methods and their validation
-
Ferrario, D., Brustio, R. and Hartung, T. (2014). Glossary of reference terms for alternative test methods and their validation. ALTEX 31, 319-335. doi:10.14573/altex.140331
-
(2014)
ALTEX
, vol.31
, pp. 319-335
-
-
Ferrario, D.1
Brustio, R.2
Hartung, T.3
-
54
-
-
84972526675
-
From mouse to man: The quantitative assessment of cancer risks
-
Freedman, D. A. and Zeisel, H. (1988). From mouse to man: The quantitative assessment of cancer risks. Statist Sci 3, 3-56. doi:10.1214/ss/1177012993
-
(1988)
Statist Sci
, vol.3
, pp. 3-56
-
-
Freedman, D. A.1
Zeisel, H.2
-
55
-
-
84934323188
-
The economics of reproducibility in preclinical research
-
Freedman, L. P., Cockburn, I. M. and Simcoe, T. S. (2015). The economics of reproducibility in preclinical research. PLoS Biol 13, e1002165. doi:10.1371/journal.pbio.1002165
-
(2015)
PLoS Biol
, vol.13
, pp. e1002165
-
-
Freedman, L. P.1
Cockburn, I. M.2
Simcoe, T. S.3
-
56
-
-
13244286533
-
Are tumor incidence rates from chronic bioassays telling us what we need to know about carcinogens?
-
Gaylor, D. W. (2005). Are tumor incidence rates from chronic bioassays telling us what we need to know about carcinogens? Regul Toxicol Pharmacol 41, 128-133. doi:10.1016/j. yrtph.2004.11.001
-
(2005)
Regul Toxicol Pharmacol
, vol.41
, pp. 128-133
-
-
Gaylor, D. W.1
-
57
-
-
85049491557
-
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: A systematic analysis for the global burden of disease study 2013
-
GBD 2013 Risk Factors Collaborators (2013). Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: A systematic analysis for the global burden of disease study 2013. Lancet 386, 2287-2323. doi:10.1016/S0140-6736(15)00128-2
-
(2013)
Lancet
, vol.386
, pp. 2287-2323
-
-
-
58
-
-
8744223170
-
Validation of the embryonic stem cell test in the international ECVAM validation study on three in vitro embryotoxicity tests
-
Genschow, E., Spielmann, H., Scholz, G. et al. (2004). Validation of the embryonic stem cell test in the international ECVAM validation study on three in vitro embryotoxicity tests. Altern Lab Anim 32, 209-244.
-
(2004)
Altern Lab Anim
, vol.32
, pp. 209-244
-
-
Genschow, E.1
Spielmann, H.2
Scholz, G.3
-
59
-
-
0025941884
-
Target organs in chronic bioassays of 533 chemical carcinogens
-
Gold, L. S., Slone, T. H., Manley, N. B. et al. (1991). Target organs in chronic bioassays of 533 chemical carcinogens. Environ Health Perspect 93, 233-246. doi:10.1289/ehp.9193233
-
(1991)
Environ Health Perspect
, vol.93
, pp. 233-246
-
-
Gold, L. S.1
Slone, T. H.2
Manley, N. B.3
-
60
-
-
0031830786
-
What do animal cancer tests tell us about human cancer risk? Overview of analyses of the carcinogenic potency database
-
Gold, L. S., Slone, T. H. and Ames, B. N. (1998). What do animal cancer tests tell us about human cancer risk? Overview of analyses of the carcinogenic potency database. Drug Metab Rev 30, 359-404. doi:10.3109/03602539808996318
-
(1998)
Drug Metab Rev
, vol.30
, pp. 359-404
-
-
Gold, L. S.1
Slone, T. H.2
Ames, B. N.3
-
61
-
-
84976907426
-
Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology
-
Gordon, S., Daneshian, M., Bouwstra, J. et al. (2015). Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology. ALTEX 32, 327-378. doi:10.14573/altex.1510051
-
(2015)
ALTEX
, vol.32
, pp. 327-378
-
-
Gordon, S.1
Daneshian, M.2
Bouwstra, J.3
-
62
-
-
0035325211
-
Data quality in predictive toxicology: Reproducibility of rodent carcinogenicity experiments
-
Gottmann, E., Kramer, S., Pfahringer, B. and Helma, C. (2001). Data quality in predictive toxicology: Reproducibility of rodent carcinogenicity experiments. Environ Health Perspect 109, 509-514. doi:/10.1289/ehp.01109509
-
(2001)
Environ Health Perspect
, vol.109
, pp. 509-514
-
-
Gottmann, E.1
Kramer, S.2
Pfahringer, B.3
Helma, C.4
-
63
-
-
0029559260
-
An empirical examination of factors influencing prediction of carcinogenic hazard across species
-
Gray, G. M., Li, P., Shlyakhter, I. and Wilson, R. (1995). An empirical examination of factors influencing prediction of carcinogenic hazard across species. Regul Toxicol Pharmacol 22, 283-291. doi:10.1006/rtph.1995.0011
-
(1995)
Regul Toxicol Pharmacol
, vol.22
, pp. 283-291
-
-
Gray, G. M.1
Li, P.2
Shlyakhter, I.3
Wilson, R.4
-
64
-
-
85188678707
-
-
Conference Centre Spazio Villa Erba, Como, Italy. 15-18 October 2007. Human Exp Toxicol 28, Spec Issue: Evidence-Based Toxicology (EBT) 2009
-
Griesinger, C., Hoffmann, S., Kinsner-Ovaskainen, A. et al. (2008). Proceedings of the First International Forum Towards Evidence-Based Toxicology. Conference Centre Spazio Villa Erba, Como, Italy. 15-18 October 2007. Human Exp Toxicol 28, Spec Issue: Evidence-Based Toxicology (EBT) 2009, 71-163.
-
(2008)
Proceedings of the First International Forum Towards Evidence-Based Toxicology
, pp. 71-163
-
-
Griesinger, C.1
Hoffmann, S.2
Kinsner-Ovaskainen, A.3
-
65
-
-
84860815641
-
Food for thought ... A toxicology ontology roadmap
-
Hardy, B., Apic, G., Carthew, P. et al. (2012a). Food for thought ... A toxicology ontology roadmap. ALTEX 29, 129-137. doi:10.14573/altex.2012.2.129
-
(2012)
ALTEX
, vol.29
, pp. 129-137
-
-
Hardy, B.1
Apic, G.2
Carthew, P.3
-
66
-
-
84860805424
-
Toxicology ontology perspectives
-
Hardy, B., Apic, G., Carthew, P. et al. (2012b). Toxicology ontology perspectives. ALTEX 29, 139-156. doi:10.14573/ altex.2012.2.139
-
(2012)
ALTEX
, vol.29
, pp. 139-156
-
-
Hardy, B.1
Apic, G.2
Carthew, P.3
-
67
-
-
21744435739
-
The integrated project ReProTect: A novel approach in reproductive toxicity hazard assessment
-
Hareng, L., Pellizzer, C., Bremer, S. et al. (2005). The integrated project ReProTect: A novel approach in reproductive toxicity hazard assessment. Reprod Toxicol 20, 441-452. doi:10.1016/j. reprotox.2005.04.003
-
(2005)
Reprod Toxicol
, vol.20
, pp. 441-452
-
-
Hareng, L.1
Pellizzer, C.2
Bremer, S.3
-
68
-
-
19944430250
-
A modular approach to the ECVAM principles on test validity
-
Hartung, T., Bremer, S., Casati, S. et al. (2004). A modular approach to the ECVAM principles on test validity. Altern Lab Anim 32, 467-472.
-
(2004)
Altern Lab Anim
, vol.32
, pp. 467-472
-
-
Hartung, T.1
Bremer, S.2
Casati, S.3
-
69
-
-
34249915306
-
Food for thought … on validation
-
Hartung, T. (2007). Food for thought … on validation. ALTEX 24, 67-72. doi:10.14573/altex.2007.2.67
-
(2007)
ALTEX
, vol.24
, pp. 67-72
-
-
Hartung, T.1
-
70
-
-
48949104862
-
Food for thought … on animal tests
-
Hartung, T. (2008a). Food for thought … on animal tests. ALTEX 25, 3-9. doi:10.14573/altex.2008.1.3
-
(2008)
ALTEX
, vol.25
, pp. 3-9
-
-
Hartung, T.1
-
71
-
-
59849091019
-
Toward a new toxicology – Evolution or revolution?
-
Hartung, T. (2008b). Toward a new toxicology – Evolution or revolution? Altern Lab Anim 36, 635-639.
-
(2008)
Altern Lab Anim
, vol.36
, pp. 635-639
-
-
Hartung, T.1
-
72
-
-
57749201720
-
Food for thought … on alternative methods for cosmetics safety testing
-
Hartung, T. (2008c). Food for thought … on alternative methods for cosmetics safety testing. ALTEX 25, 147-162. doi:10.14573/ altex.2008.3.147
-
(2008)
ALTEX
, vol.25
, pp. 147-162
-
-
Hartung, T.1
-
73
-
-
77953932768
-
Food for thought … on evidence-based toxicology
-
Hartung, T. (2009a). Food for thought … on evidence-based toxicology. ALTEX 26, 75-82. doi:10.14573/altex.2009.2.75
-
(2009)
ALTEX
, vol.26
, pp. 75-82
-
-
Hartung, T.1
-
74
-
-
67650445156
-
Toxicology for the twenty-first century
-
Hartung, T. (2009b). Toxicology for the twenty-first century. Nature 460, 208-212. doi:10.1038/460208a
-
(2009)
Nature
, vol.460
, pp. 208-212
-
-
Hartung, T.1
-
75
-
-
69349104947
-
Chemical regulators have overreached
-
Hartung, T. and Rovida, C. (2009). Chemical regulators have overreached. Nature 460, 1080-1081. doi:10.1038/4601080a
-
(2009)
Nature
, vol.460
, pp. 1080-1081
-
-
Hartung, T.1
Rovida, C.2
-
76
-
-
73949095137
-
Food for thought … on in silico methods in toxicology
-
Hartung, T. and Hoffmann, S. (2009). Food for thought … on in silico methods in toxicology. ALTEX 26, 155-166. doi:10.14573/ altex.2009.3.155
-
(2009)
ALTEX
, vol.26
, pp. 155-166
-
-
Hartung, T.1
Hoffmann, S.2
-
77
-
-
79952311389
-
st century?
-
st century? ALTEX 27, 241-251. doi:10.14573/altex.2010.4.253
-
(2010)
ALTEX
, vol.27
, pp. 241-251
-
-
Hartung, T.1
-
78
-
-
77954744712
-
Food for thought… on alternative methods for chemical safety testing
-
Hartung, T. (2010b). Food for thought… on alternative methods for chemical safety testing. ALTEX 27, 3-14. doi:10.14573/ altex.2010.1.3
-
(2010)
ALTEX
, vol.27
, pp. 3-14
-
-
Hartung, T.1
-
79
-
-
80053546181
-
An expert consortium review of the EC-commissioned report “Alternative (non-animal) methods for cosmetics testing: current status and future prospects – 2010”
-
Hartung, T., Blaauboer, G. J., Bosgra, S. et al. (2011). An expert consortium review of the EC-commissioned report “Alternative (non-animal) methods for cosmetics testing: current status and future prospects – 2010”. ALTEX 28, 183-209. doi:10.14573/ altex.2011.3.183
-
(2011)
ALTEX
, vol.28
, pp. 183-209
-
-
Hartung, T.1
Blaauboer, G. J.2
Bosgra, S.3
-
80
-
-
84860798653
-
Systems toxicology
-
Hartung, T., van Vliet, E., Jaworska, J. et al. (2012). Systems toxicology. ALTEX 29, 119-128. doi:10.14573/altex.2012.2.119
-
(2012)
ALTEX
, vol.29
, pp. 119-128
-
-
Hartung, T.1
van Vliet, E.2
Jaworska, J.3
-
81
-
-
84883880887
-
Look back in anger – What clinical studies tell us about preclinical work
-
Hartung, T. (2013). Look back in anger – What clinical studies tell us about preclinical work. ALTEX 30, 275-291. doi:10.14573/ altex.2013.3.275
-
(2013)
ALTEX
, vol.30
, pp. 275-291
-
-
Hartung, T.1
-
82
-
-
84876323285
-
Integrated testing strategies for safety assessments
-
Hartung, T., Luechtefeld, T., Maertens, A. and Kleensang, A. (2013). Integrated testing strategies for safety assessments. ALTEX 30, 3-18. doi:10.14573/altex.2013.1.003
-
(2013)
ALTEX
, vol.30
, pp. 3-18
-
-
Hartung, T.1
Luechtefeld, T.2
Maertens, A.3
Kleensang, A.4
-
83
-
-
84899809184
-
3D – A new dimension of in vitro research
-
vi. Preface Special “Innovative tissue models for in vitro drug development
-
Hartung, T. (2014). 3D – A new dimension of in vitro research. Adv Drug Deliv Rev 69-70, vi. Preface Special Issue “Innovative tissue models for in vitro drug development”.
-
(2014)
Adv Drug Deliv Rev
, pp. 69-70
-
-
Hartung, T.1
-
84
-
-
84962874749
-
Making big sense from big data in toxicology by read-across
-
Hartung, T. (2016). Making big sense from big data in toxicology by read-across. ALTEX 33, 83-93. doi:10.14573/altex.1603091
-
(2016)
ALTEX
, vol.33
, pp. 83-93
-
-
Hartung, T.1
-
85
-
-
85018645800
-
Food for thought ... the first ten years
-
Hartung, T. (2017a). Food for thought ... the first ten years. ALTEX 34, 187-192. doi:10.14573/altex.1703311
-
(2017)
ALTEX
, vol.34
, pp. 187-192
-
-
Hartung, T.1
-
86
-
-
85025086614
-
Opinion versus evidence for the need to move away from animal testing
-
Hartung, T. (2017b). Opinion versus evidence for the need to move away from animal testing. ALTEX 34, 193-200. doi:10.14573/ altex.1703291
-
(2017)
ALTEX
, vol.34
, pp. 193-200
-
-
Hartung, T.1
-
87
-
-
85026262697
-
Thresholds of toxicological concern – Setting a threshold for testing where there is little concern
-
Hartung, T. (2017c). Thresholds of toxicological concern – Setting a threshold for testing where there is little concern. ALTEX 34, 331-351. doi:10.14573/altex.1707011
-
(2017)
ALTEX
, vol.34
, pp. 331-351
-
-
Hartung, T.1
-
88
-
-
84992161916
-
Utility of the adverse outcome pathway concept in drug development
-
Hartung, T. (2017d). Utility of the adverse outcome pathway concept in drug development. Exp Opin Drug Metabol Toxicol 13, 1-3. doi:10.1080/17425255.2017.1246535
-
(2017)
Exp Opin Drug Metabol Toxicol
, vol.13
, pp. 1-3
-
-
Hartung, T.1
-
89
-
-
85018472124
-
Systems toxicology – Real world applications and opportunities
-
Hartung, T., FitzGerald, R., Jennings, P. et al. (2017a). Systems toxicology – Real world applications and opportunities. Chem Res Toxicol 30, 870-882. doi:10.1021/acs.chemrestox.7b00003
-
(2017)
Chem Res Toxicol
, vol.30
, pp. 870-882
-
-
Hartung, T.1
FitzGerald, R.2
Jennings, P.3
-
90
-
-
85018524897
-
Systems toxicology II: A special issue
-
Hartung, T., Kavlock, R. and Sturla, S. (2017b). Systems toxicology II: A special issue. Chem Res Toxicol 30, 869-869. doi:10.1021/acs.chemrestox.7b00038
-
(2017)
Chem Res Toxicol
, vol.30
, pp. 869-869
-
-
Hartung, T.1
Kavlock, R.2
Sturla, S.3
-
91
-
-
85037043671
-
Perspectives on in vitro to in vivo extrapolations
-
press
-
Hartung, T. (2018). Perspectives on in vitro to in vivo extrapolations. J Appl In Vitro Toxicol, in press. doi:10.1089/ aivt.2016.0026
-
(2018)
J Appl In Vitro Toxicol
-
-
Hartung, T.1
-
92
-
-
0031225910
-
Value of historical control data and other issues related to the evaluation of long-term rodent carcinogenicity studies
-
Haseman, J. K., Boorman, G. A. and Huff, J. (1997). Value of historical control data and other issues related to the evaluation of long-term rodent carcinogenicity studies. Toxicol Pathol 25, 524-527. doi:10.1177/019262339702500518
-
(1997)
Toxicol Pathol
, vol.25
, pp. 524-527
-
-
Haseman, J. K.1
Boorman, G. A.2
Huff, J.3
-
93
-
-
77949685981
-
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
-
Hatzivassiliou, G., Song, K., Yen, I. et al. (2010). RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature 464, 431-435. doi:10.1038/nature08833
-
(2010)
Nature
, vol.464
, pp. 431-435
-
-
Hatzivassiliou, G.1
Song, K.2
Yen, I.3
-
94
-
-
0032747614
-
Interspecies differences in cancer susceptibility and toxicity
-
Hengstler, J. G., van der Burg, B., Steinberg, P. and Oesch, F. (1999). Interspecies differences in cancer susceptibility and toxicity. Drug Metab Rev 31, 917-970. doi:10.1081/DMR-100101946
-
(1999)
Drug Metab Rev
, vol.31
, pp. 917-970
-
-
Hengstler, J. G.1
van der Burg, B.2
Steinberg, P.3
Oesch, F.4
-
95
-
-
84856967407
-
Highlight report: Towards the replacement of in vivo repeated dose systemic toxicity testing
-
Hengstler, J. G., Marchan, R. and Leist, M. (2012). Highlight report: Towards the replacement of in vivo repeated dose systemic toxicity testing. Arch Toxicol 86, 13-15. doi:10.1007/ s00204-011-0798-7
-
(2012)
Arch Toxicol
, vol.86
, pp. 13-15
-
-
Hengstler, J. G.1
Marchan, R.2
Leist, M.3
-
96
-
-
84946114411
-
Inter-laboratory study of human in vitro toxicogenomics-based tests as alternative methods for evaluating chemical carcinogenicity: A bioinformatics perspective
-
Herwig, R., Gmuender, H., Corvi, R. et al. (2016). Inter-laboratory study of human in vitro toxicogenomics-based tests as alternative methods for evaluating chemical carcinogenicity: A bioinformatics perspective. Arch Toxicol 90, 2215-2229. doi:10.1007/s00204-015-1617-3
-
(2016)
Arch Toxicol
, vol.90
, pp. 2215-2229
-
-
Herwig, R.1
Gmuender, H.2
Corvi, R.3
-
97
-
-
33748801463
-
Towards an evidence-based toxicology
-
Hoffmann, S. and Hartung, T. (2006). Towards an evidence-based toxicology. Hum Exp Toxicol 25, 497-513. doi:10.1191/0960327106het648oa
-
(2006)
Hum Exp Toxicol
, vol.25
, pp. 497-513
-
-
Hoffmann, S.1
Hartung, T.2
-
98
-
-
49449115074
-
Points of reference in validation – The report and recommendations of ECVAM Workshop
-
Hoffmann, S., Edler, L., Gardner, I. et al. (2008). Points of reference in validation – The report and recommendations of ECVAM Workshop. Altern Lab Anim 36, 343-352.
-
(2008)
Altern Lab Anim
, vol.36
, pp. 343-352
-
-
Hoffmann, S.1
Edler, L.2
Gardner, I.3
-
99
-
-
85019269575
-
A primer on systematic reviews in toxicology
-
Hoffmann, S., de Vries, R. B. M., Stephens, M. L. et al. (2017). A primer on systematic reviews in toxicology. Arch Toxicol 91, 2551-2575. doi:10.1007/s00204-017-1980-3
-
(2017)
Arch Toxicol
, vol.91
, pp. 2551-2575
-
-
Hoffmann, S.1
de Vries, R. B. M.2
Stephens, M. L.3
-
100
-
-
26844443386
-
Application of frog embryo teratogenesis assay-Xenopus to ecological risk assessment
-
Hoke, R. A. and Ankley, G. T. (2005). Application of frog embryo teratogenesis assay-Xenopus to ecological risk assessment. Environ Toxicol Chem 24, 2677-2690. doi:10.1897/04-506R.1
-
(2005)
Environ Toxicol Chem
, vol.24
, pp. 2677-2690
-
-
Hoke, R. A.1
Ankley, G. T.2
-
101
-
-
51849136543
-
Fifteen years after “Wingspread” – Environmental endocrine disrupters and human and wildlife health: Where we are today and where we need to go
-
Hotchkiss, A. K., Rider, C. V., Blystone, C. R. et al. (2008). Fifteen years after “Wingspread” – Environmental endocrine disrupters and human and wildlife health: Where we are today and where we need to go. Toxicol Sci 105, 235-259. doi:10.1093/ toxsci/kfn030
-
(2008)
Toxicol Sci
, vol.105
, pp. 235-259
-
-
Hotchkiss, A. K.1
Rider, C. V.2
Blystone, C. R.3
-
102
-
-
0037401126
-
Proposal for a tiered approach to developmental toxicity testing for veterinary pharmaceutical products for food-producing animals
-
Hurtt, M. E., Cappon, G. D. and Browning, A. (2003). Proposal for a tiered approach to developmental toxicity testing for veterinary pharmaceutical products for food-producing animals. Food Chem Toxicol 41, 611-619. doi:10.1016/S0278-6915(02)00326-5
-
(2003)
Food Chem Toxicol
, vol.41
, pp. 611-619
-
-
Hurtt, M. E.1
Cappon, G. D.2
Browning, A.3
-
103
-
-
85018500801
-
Computational model of secondary palate fusion and disruption
-
Hutson, M. S., Leung, M., Baker, N. C. et al. (2017). Computational model of secondary palate fusion and disruption. Chem Res Toxicol 30, 965-979. doi:10.1021/acs.chemrestox.6b00350
-
(2017)
Chem Res Toxicol
, vol.30
, pp. 965-979
-
-
Hutson, M. S.1
Leung, M.2
Baker, N. C.3
-
106
-
-
85035805293
-
The ICHS1 Regulatory Testing Paradigm of Carcinogenicity in rats – Status Report
-
2 March
-
ICH Status Report (2016). The ICHS1 Regulatory Testing Paradigm of Carcinogenicity in rats – Status Report. Safety Guidelines, 2 March, 1-5. https://bit.ly/2IzczwZ
-
(2016)
Safety Guidelines
, pp. 1-5
-
-
-
107
-
-
0011002692
-
ILSI HESI Alternatives to carcinogenicity testing project
-
ILSI HESI ACT Suppl
-
ILSI HESI ACT (2001). ILSI HESI Alternatives to carcinogenicity testing project. Toxicol Pathol 29, Suppl, 1-351.
-
(2001)
Toxicol Pathol
, vol.29
, pp. 1-351
-
-
-
108
-
-
84994742972
-
International regulatory needs for development of an IATA for non-genotoxic carcinogenic chemical substances
-
Jacobs, M. N., Colacci, A., Louekari, K. et al. (2016). International regulatory needs for development of an IATA for non-genotoxic carcinogenic chemical substances. ALTEX 33, 359-392. doi:10.14573/altex.1601201
-
(2016)
ALTEX
, vol.33
, pp. 359-392
-
-
Jacobs, M. N.1
Colacci, A.2
Louekari, K.3
-
109
-
-
34447265983
-
A retrospective analysis of the two-generation study: What is the added value of the second generation?
-
Janer, G., Hakkert, B. C., Slob, W. et al. (2007). A retrospective analysis of the two-generation study: What is the added value of the second generation? Reprod Toxicol 24, 97-102. doi:10.1016/j.reprotox.2007.04.068
-
(2007)
Reprod Toxicol
, vol.24
, pp. 97-102
-
-
Janer, G.1
Hakkert, B. C.2
Slob, W.3
-
110
-
-
67650874081
-
Cancer statistics, 2009
-
Jemal, A., Siegel, R., Ward, E. et al. (2009). Cancer statistics, 2009. CA Cancer J Clin 59, 225-249. doi:10.3322/caac.20006
-
(2009)
CA Cancer J Clin
, vol.59
, pp. 225-249
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
-
111
-
-
84977500789
-
The road to reproducibility in animal research
-
Jilka, R. L. (2016). The road to reproducibility in animal research. J Bone Mineral Res 31, 1317-1319. doi:10.1002/jbmr.2881
-
(2016)
J Bone Mineral Res
, vol.31
, pp. 1317-1319
-
-
Jilka, R. L.1
-
112
-
-
0008269936
-
ResponsetoTennantetal.:Attemptstoreplace the NTProdent bioassay with transgenic alternatives are unlikely to succeed
-
Johnson,F.M.(2001).ResponsetoTennantetal.:Attemptstoreplace the NTProdent bioassay with transgenic alternatives are unlikely to succeed. Environ Mol Mutagen 37, 89-92. doi:10.1002/1098-2280(2001)37:1<89::AID-EM1011>3.0.CO;2-4
-
(2001)
Environ Mol Mutagen
, vol.37
, pp. 89-92
-
-
Johnson, F.M.1
-
113
-
-
79951963979
-
Ten questions about systems biology
-
Joyner, M. J. and Pedersen, B. K. (2011). Ten questions about systems biology. J Physiol 589, 1017-1030. doi:10.1113/ jphysiol.2010.201509
-
(2011)
J Physiol
, vol.589
, pp. 1017-1030
-
-
Joyner, M. J.1
Pedersen, B. K.2
-
114
-
-
84992690576
-
Analysis of the effects of cell stress and cytotoxicity on in vitro assay activity across a diverse chemical and assay space
-
Judson, R., Houck, K., Martin, M. et al. (2016). Analysis of the effects of cell stress and cytotoxicity on in vitro assay activity across a diverse chemical and assay space. Toxicol Sci 152, 323-339. doi:10.1093/toxsci/kfw092
-
(2016)
Toxicol Sci
, vol.152
, pp. 323-339
-
-
Judson, R.1
Houck, K.2
Martin, M.3
-
115
-
-
0030886937
-
Managing the drug discovery/development interface
-
Kennedy, T. (1997). Managing the drug discovery/development interface. Drug Discov Today 2, 436-444. doi:10.1016/S1359-6446(97)01099-4
-
(1997)
Drug Discov Today
, vol.2
, pp. 436-444
-
-
Kennedy, T.1
-
116
-
-
84901642559
-
Air of danger
-
Kessler, R. (2014). Air of danger. Nature S62, 509. doi:10.1038/509S62a
-
(2014)
Nature
, vol.S62
, pp. 509
-
-
Kessler, R.1
-
117
-
-
84942818525
-
Drug resistance resulting from kinase dimerization is rationalized by thermodynamic factors describing allosteric inhibitor effects
-
Kholodenko, B. N. (2015). Drug resistance resulting from kinase dimerization is rationalized by thermodynamic factors describing allosteric inhibitor effects. Cell Reports 12, 1939-1949. doi:10.1016/j.celrep.2015.08.014
-
(2015)
Cell Reports
, vol.12
, pp. 1939-1949
-
-
Kholodenko, B. N.1
-
118
-
-
85012054785
-
Systems toxicology: Systematic approach to predict toxicity
-
Kiani, N. A., Shang, M.-M. and Tegner, J. (2016). Systems toxicology: Systematic approach to predict toxicity. Curr Pharm Des 22, 6911-6917. doi:10.2174/13816128226661610031156 29
-
(2016)
Curr Pharm Des
, vol.22
, pp. 6911-6917
-
-
Kiani, N. A.1
Shang, M.-M.2
Tegner, J.3
-
119
-
-
84992418466
-
Microphysiological brain model enables analysis of neuronal differentiation and chemotaxis
-
Kilic, O., Pamies, D., Lavell, E. et al. (2016). Microphysiological brain model enables analysis of neuronal differentiation and chemotaxis. Lab Chip 16, 4152-4162. doi:10.1039/ C6LC00946H
-
(2016)
Lab Chip
, vol.16
, pp. 4152-4162
-
-
Kilic, O.1
Pamies, D.2
Lavell, E.3
-
120
-
-
79960983975
-
Thalidomide: The tragedy of birth defects and the effective treatment of disease
-
Kim, J. H. and Scialli, A. R. (2011). Thalidomide: The tragedy of birth defects and the effective treatment of disease. Toxicol Sci 122, 1-6. doi:10.1093/toxsci/kfr088
-
(2011)
Toxicol Sci
, vol.122
, pp. 1-6
-
-
Kim, J. H.1
Scialli, A. R.2
-
121
-
-
21544473568
-
Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens I. Sensitivity, specificity and relative predictivity
-
Kirkland, D., Aardema, M., Henderson, L. and Müller, L. (2005). Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens I. Sensitivity, specificity and relative predictivity. Mutat Res 584, 1-256. doi:10.1016/j.mrgentox.2005.02.004
-
(2005)
Mutat Res
, vol.584
, pp. 1-256
-
-
Kirkland, D.1
Aardema, M.2
Henderson, L.3
Müller, L.4
-
122
-
-
33847325174
-
How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow up animal tests: Report of an ECVAM Workshop
-
Kirkland, D., Pfuhler, S., Tweatsm, D. et al. (2007). How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow up animal tests: Report of an ECVAM Workshop. Mutat Res 628, 31-55. doi:10.1016/j.mrgentox.2006.11.008
-
(2007)
Mutat Res
, vol.628
, pp. 31-55
-
-
Kirkland, D.1
Pfuhler, S.2
Tweatsm, D.3
-
123
-
-
79951679077
-
A core in vitro genotoxicity battery comprising the Ames test plus the in vitro micronucleus test is sufficient to detect rodent carcinogens and in vivo genotoxins
-
Kirkland, D., Reeve, L., Gatehouse, D. and Vanparys, P. (2011). A core in vitro genotoxicity battery comprising the Ames test plus the in vitro micronucleus test is sufficient to detect rodent carcinogens and in vivo genotoxins. Mutat Res 721, 27-73. doi:10.1016/j.mrgentox.2010.12.015
-
(2011)
Mutat Res
, vol.721
, pp. 27-73
-
-
Kirkland, D.1
Reeve, L.2
Gatehouse, D.3
Vanparys, P.4
-
124
-
-
84872386643
-
In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis
-
Kleinstreuer, N., Dix, D., Houck, K. et al. (2013a). In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis. Toxicol Sci 131, 40-55. doi:10.1093/ toxsci/kfs285
-
(2013)
Toxicol Sci
, vol.131
, pp. 40-55
-
-
Kleinstreuer, N.1
Dix, D.2
Houck, K.3
-
125
-
-
84876922933
-
A computational model predicting disruption of blood vessel development
-
Kleinstreuer, N., Dix, D., Rountree, M. et al. (2013b). A computational model predicting disruption of blood vessel development. PLoS Comput Biol 9, e1002996. doi:10.1371/journal. pcbi.1002996
-
(2013)
PLoS Comput Biol
, vol.9
, pp. e1002996
-
-
Kleinstreuer, N.1
Dix, D.2
Rountree, M.3
-
126
-
-
84902166194
-
Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms
-
Kleinstreuer, N., Houck, K., Yang, J. et al. (2014). Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms. Nat Biotechnol 32, 583-591. doi:10.1038/nbt.2914
-
(2014)
Nat Biotechnol
, vol.32
, pp. 583-591
-
-
Kleinstreuer, N.1
Houck, K.2
Yang, J.3
-
127
-
-
85018493200
-
Development and validation of a computational model for androgen receptor activity
-
Kleinstreuer, N. C., Ceger, P., Watt, E. D. et al. (2016). Development and validation of a computational model for androgen receptor activity. Chem Res Toxicol 30, 946-964. doi:10.1021/ acs.chemrestox.6b00347
-
(2016)
Chem Res Toxicol
, vol.30
, pp. 946-964
-
-
Kleinstreuer, N. C.1
Ceger, P.2
Watt, E. D.3
-
128
-
-
85043467315
-
Non-animal methods to predict skin sensitization (II): An assessment of defined approaches
-
Kleinstreuer, N., Hoffmann, S., Alepee, N. et al. (2018). Non-animal methods to predict skin sensitization (II): An assessment of defined approaches. Crit Rev Toxicol 23, 1-16. doi:10.1080/10 408444.2018.1429386
-
(2018)
Crit Rev Toxicol
, vol.23
, pp. 1-16
-
-
Kleinstreuer, N.1
Hoffmann, S.2
Alepee, N.3
-
129
-
-
33644850151
-
Animal carcinogenicity studies: 2. Obstacles to extrapolation of data to humans
-
Knight, A., Bailey, J. and Balcombe, J. (2006a). Animal carcinogenicity studies: 2. Obstacles to extrapolation of data to humans. Altern Lab Anim 34, 29-38.
-
(2006)
Altern Lab Anim
, vol.34
, pp. 29-38
-
-
Knight, A.1
Bailey, J.2
Balcombe, J.3
-
130
-
-
85088734288
-
Animal carcinogenicity studies: 1. Poor human predictivity
-
Knight, A., Bailey, J. and Balcombe, J. (2006b). Animal carcinogenicity studies: 1. Poor human predictivity. Altern Lab Anim 34, 19-27.
-
(2006)
Altern Lab Anim
, vol.34
, pp. 19-27
-
-
Knight, A.1
Bailey, J.2
Balcombe, J.3
-
131
-
-
80054691906
-
Developmental toxicity testing for safety assessment: New approaches and technologies
-
Knudsen, T. B., Kavlock, R. J., Daston, G. P. et al. (2011). Developmental toxicity testing for safety assessment: New approaches and technologies. Birth Defects Res B Dev Reprod Toxicol 92, 413-420. doi:10.1002/bdrb.20315
-
(2011)
Birth Defects Res B Dev Reprod Toxicol
, vol.92
, pp. 413-420
-
-
Knudsen, T. B.1
Kavlock, R. J.2
Daston, G. P.3
-
132
-
-
84856241088
-
Disruption of embryonic vascular development in predictive toxicology
-
Knudsen, T. B and Kleinstreuer, N. C. (2012). Disruption of embryonic vascular development in predictive toxicology. Birth Defects Res C Embryo Today 93, 312-323. doi:10.1002/bdrc.20223
-
(2012)
Birth Defects Res C Embryo Today
, vol.93
, pp. 312-323
-
-
Knudsen, T. B1
Kleinstreuer, N. C.2
-
133
-
-
4344645978
-
Can the pharmaceutical industry reduce attrition rates?
-
Kola, I. and Landis, J. (2004). Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov 3, 711-715. doi:10.1038/nrd1470
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 711-715
-
-
Kola, I.1
Landis, J.2
-
134
-
-
0043069489
-
Drug research: Myths, hype and reality
-
Kubinyi, H. (2003). Drug research: Myths, hype and reality. Nat Rev Drug Discov 2, 665-668. doi:10.1038/nrd1156
-
(2003)
Nat Rev Drug Discov
, vol.2
, pp. 665-668
-
-
Kubinyi, H.1
-
135
-
-
84856225029
-
Correlation of chemical structure with reproductive and developmental toxicity as it relates to the use of the threshold of toxicological concern
-
Laufersweiler, M. C., Gadagbui, B., Baskerville-Abraham, I. M. et al. (2012). Correlation of chemical structure with reproductive and developmental toxicity as it relates to the use of the threshold of toxicological concern. Regulat Toxicol Pharmacol 62, 160-182. doi:10.1016/j.yrtph.2011.09.004
-
(2012)
Regulat Toxicol Pharmacol
, vol.62
, pp. 160-182
-
-
Laufersweiler, M. C.1
Gadagbui, B.2
Baskerville-Abraham, I. M.3
-
136
-
-
0024289475
-
Information value of the rodent bioassay
-
Lave, L. B., Ennever, F. K., Rosenkranz, H. S. and Omenn, G. S. (1988). Information value of the rodent bioassay. Nature 336, 631-633. doi:10.1038/336631a0
-
(1988)
Nature
, vol.336
, pp. 631-633
-
-
Lave, L. B.1
Ennever, F. K.2
Rosenkranz, H. S.3
Omenn, G. S.4
-
137
-
-
0032603049
-
Use of Syrian hamster embryo and BALB/c 3T3 cell transformation for assessing the carcinogenic potential of chemicals
-
LeBoeuf, R. A., Kerckaert, K. A., Aardema, M. J. and Isfort, R. J. (1999). Use of Syrian hamster embryo and BALB/c 3T3 cell transformation for assessing the carcinogenic potential of chemicals. IARC Sci Publ 146, 409-425.
-
(1999)
IARC Sci Publ
, vol.146
, pp. 409-425
-
-
LeBoeuf, R. A.1
Kerckaert, K. A.2
Aardema, M. J.3
Isfort, R. J.4
-
138
-
-
84860851412
-
Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks
-
Lee, M. J., Ye, A. S., Gardino, A. K. et al. (2012). Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell 149, 780-794. doi:10.1016/j. cell.2012.03.031
-
(2012)
Cell
, vol.149
, pp. 780-794
-
-
Lee, M. J.1
Ye, A. S.2
Gardino, A. K.3
-
139
-
-
58949087263
-
The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy
-
Leist, M., Bremer, S., Brundin, P. et al. (2008). The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy. ALTEX 25, 163-190. doi:10.14573/altex.2008.3.163
-
(2008)
ALTEX
, vol.25
, pp. 163-190
-
-
Leist, M.1
Bremer, S.2
Brundin, P.3
-
140
-
-
84864593532
-
Validation and quality control of replacement alternatives – Current status and future challenges
-
Leist, M., Hasiwa, M., Daneshian, M. and Hartung, T. (2012). Validation and quality control of replacement alternatives – Current status and future challenges. Toxicol Res 1, 8. doi:10.1039/ c2tx20011b
-
(2012)
Toxicol Res
, vol.1
, pp. 8
-
-
Leist, M.1
Hasiwa, M.2
Daneshian, M.3
Hartung, T.4
-
141
-
-
84904901979
-
Consensus report on the future of animal-free systemic toxicity testing
-
Leist, M., Hasiwa, N., Rovida, C. et al. (2014). Consensus report on the future of animal-free systemic toxicity testing. ALTEX 31, 341-356. doi:10.14573/altex.1406091
-
(2014)
ALTEX
, vol.31
, pp. 341-356
-
-
Leist, M.1
Hasiwa, N.2
Rovida, C.3
-
142
-
-
85031799653
-
Adverse outcome pathways: Opportunities, limitations and open questions
-
Leist, M., Ghallab, A., Graepel, R. et al. (2017). Adverse outcome pathways: Opportunities, limitations and open questions. Arch Toxicol 91, 3477-3505. doi:10.1007/s00204-017-2045-3
-
(2017)
Arch Toxicol
, vol.91
, pp. 3477-3505
-
-
Leist, M.1
Ghallab, A.2
Graepel, R.3
-
143
-
-
84977160684
-
Systems toxicology of male reproductive development: Profiling 774 chemicals for molecular targets and adverse outcomes
-
Leung, M. C., Phuong, J., Baker, N. C. et al. (2016). Systems toxicology of male reproductive development: Profiling 774 chemicals for molecular targets and adverse outcomes. Environ Health Perspect 124, 1050-1061. doi:10.1289/ehp.1510385
-
(2016)
Environ Health Perspect
, vol.124
, pp. 1050-1061
-
-
Leung, M. C.1
Phuong, J.2
Baker, N. C.3
-
144
-
-
84962788737
-
Global analysis of publicly available safety data for 9,801 substances registered under REACH from 2008-2014
-
Luechtefeld, T., Maertens, A., Russo, D. P. et al. (2016a). Global analysis of publicly available safety data for 9,801 substances registered under REACH from 2008-2014. ALTEX 33, 95-109. doi:10.14573/altex.1510052
-
(2016)
ALTEX
, vol.33
, pp. 95-109
-
-
Luechtefeld, T.1
Maertens, A.2
Russo, D. P.3
-
145
-
-
84962786551
-
Analysis of public oral toxicity data from REACH registrations 2008-2014
-
Luechtefeld, T., Maertens, A., Russo, D. P. et al. (2016b). Analysis of public oral toxicity data from REACH registrations 2008-2014. ALTEX 33, 111-122. doi:10.14573/altex.1510054
-
(2016)
ALTEX
, vol.33
, pp. 111-122
-
-
Luechtefeld, T.1
Maertens, A.2
Russo, D. P.3
-
146
-
-
85035752865
-
Computational approaches to chemical hazard assessment
-
Luechtefeld, T. and Hartung, T. (2017). Computational approaches to chemical hazard assessment. ALTEX 34, 459-478. doi:10.14573/altex.1710141
-
(2017)
ALTEX
, vol.34
, pp. 459-478
-
-
Luechtefeld, T.1
Hartung, T.2
-
147
-
-
10744226756
-
The utility of genetically modified mouse assays for identifying human carcinogens: A basic understanding and path forward
-
MacDonald, J., French, J. E., Gerson, R. J. et al. (2004). The utility of genetically modified mouse assays for identifying human carcinogens: A basic understanding and path forward. Toxicol Sci 77, 188-194. doi:10.1093/toxsci/kfh037
-
(2004)
Toxicol Sci
, vol.77
, pp. 188-194
-
-
MacDonald, J.1
French, J. E.2
Gerson, R. J.3
-
149
-
-
84952690785
-
Evidence from toxicology: The most essential science for prevention
-
Mandrioli, D. and Silbergeld, E. K. (2016). Evidence from toxicology: The most essential science for prevention. Environ Health Perspect 124, 6-11. doi:10.1289/ehp.1509880
-
(2016)
Environ Health Perspect
, vol.124
, pp. 6-11
-
-
Mandrioli, D.1
Silbergeld, E. K.2
-
150
-
-
64049119418
-
Profiling chemicals based on chronic toxicity results from the U.S. EPA ToxRef database
-
Martin, M. T., Judson, R. S., Reif, D. M. et al. (2009a). Profiling chemicals based on chronic toxicity results from the U.S. EPA ToxRef database. Environ Health Perspect 117, 392-399. doi:10.1289/ehp.0800074
-
(2009)
Environ Health Perspect
, vol.117
, pp. 392-399
-
-
Martin, M. T.1
Judson, R. S.2
Reif, D. M.3
-
151
-
-
67649233774
-
Profiling the reproductive toxicity of chemicals from multigenerationstudies in the toxicity reference database
-
Martin, M. T., Mendez, E., Corum, D. G. et al. (2009b). Profiling the reproductive toxicity of chemicals from multigenerationstudies in the toxicity reference database. Toxicol Sci 110, 181-190. doi:10.1093/toxsci/kfp080
-
(2009)
Toxicol Sci
, vol.110
, pp. 181-190
-
-
Martin, M. T.1
Mendez, E.2
Corum, D. G.3
-
152
-
-
0037471081
-
Building better mouse models for studying cancer
-
Marx, J. (2003). Building better mouse models for studying cancer. Science 299, 1972-1975. doi:10.1126/science.299.5615.1972
-
(2003)
Science
, vol.299
, pp. 1972-1975
-
-
Marx, J.1
-
153
-
-
84979255712
-
Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing using animals
-
Marx, U., Andersson, T. B., Bahinski, A. et al. (2016). Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing using animals. ALTEX 33, 272-321. doi:10.14573/altex.1603161
-
(2016)
ALTEX
, vol.33
, pp. 272-321
-
-
Marx, U.1
Andersson, T. B.2
Bahinski, A.3
-
154
-
-
69849088915
-
A review of the implementation of the embryonic stem cell test (EST). The report and recommendations of an ECVAM/ReProTect Workshop
-
Marx-Stoelting, P., Adriaens, E., Ahr, H. J. et al. (2009). A review of the implementation of the embryonic stem cell test (EST). The report and recommendations of an ECVAM/ReProTect Workshop. Altern Lab Anim 37, 313-328.
-
(2009)
Altern Lab Anim
, vol.37
, pp. 313-328
-
-
Marx-Stoelting, P.1
Adriaens, E.2
Ahr, H. J.3
-
155
-
-
77952287333
-
Environmental exposures and development
-
Mattison, D. R. (2010). Environmental exposures and development. Curr Opin Pediatrics 22, 208-218. doi:10.1097/ MOP.0b013e32833779bf
-
(2010)
Curr Opin Pediatrics
, vol.22
, pp. 208-218
-
-
Mattison, D. R.1
-
156
-
-
85006847195
-
Identification of vascular disruptor compounds by analysis in zebrafish embryos and mouse embryonic endothelial cells
-
McCollum, C. W., de Vancells, J. C., Hans, C. et al. (2016). Identification of vascular disruptor compounds by analysis in zebrafish embryos and mouse embryonic endothelial cells. Reprod Toxicol 70, 60-69. doi:10.1016/j.reprotox.2016.11.005
-
(2016)
Reprod Toxicol
, vol.70
, pp. 60-69
-
-
McCollum, C. W.1
de Vancells, J. C.2
Hans, C.3
-
157
-
-
84899846413
-
Improving reproducibility in toxicology
-
Miller, G. W. (2014). Improving reproducibility in toxicology. Toxicol Sci 139, 1-3. doi:10.1093/toxsci/kfu050
-
(2014)
Toxicol Sci
, vol.139
, pp. 1-3
-
-
Miller, G. W.1
-
158
-
-
67649586930
-
A modular approach to the extended one-generation reproduction toxicity study: Outcome of an ECETOC task force and International ECETOC/ECVAM workshop
-
Moore, N., Bremer, S., Carmichael, N. et al. (2009). A modular approach to the extended one-generation reproduction toxicity study: Outcome of an ECETOC task force and International ECETOC/ECVAM workshop. Altern Lab Anim 37, 219-225.
-
(2009)
Altern Lab Anim
, vol.37
, pp. 219-225
-
-
Moore, N.1
Bremer, S.2
Carmichael, N.3
-
159
-
-
84955565066
-
GRADE: Assessing the quality of evidence in environmental and occupational health
-
Morgan, R. L., Thayer, K. A., Bero, L. et al. (2016). GRADE: Assessing the quality of evidence in environmental and occupational health. Environ Int 92-93, 611-616. doi:10.1016/j. envint.2016.01.004
-
(2016)
Environ Int
, vol.92-93
, pp. 611-616
-
-
Morgan, R. L.1
Thayer, K. A.2
Bero, L.3
-
161
-
-
85188725598
-
-
Paris: OECD Publishing
-
MONO(2005)14. Paris: OECD Publishing. http://www.oecd.org/officialdocuments/publicdisplaydocumentpdf/?doclanguag e=en&cote=env/jm/mono(2005)14
-
(2005)
, pp. 14
-
-
-
162
-
-
59849102430
-
-
Series on Testing and Assessment No. 31. Paris: OECD Publishing
-
OECD (2007). Detailed Review Paper on Cell Transformation Assays for Detection of Chemical Carcinogens. Series on Testing and Assessment No. 31. Paris: OECD Publishing. http://www.oecd.org/officialdocuments/publicdisplaydocumentpdf/?cote=ENV/JM/MONO%282007%2918&docLanguage=En
-
(2007)
Detailed Review Paper on Cell Transformation Assays for Detection of Chemical Carcinogens
-
-
-
163
-
-
85046839978
-
-
OECD Guidelines for Chemical Testing, T 451
-
OECD (2009). Carcinogenicity Studies. OECD Guidelines for Chemical Testing, TG No. 451. http://www.oecd.org/dataoecd/30/46/41753121.pdf
-
(2009)
Carcinogenicity Studies
-
-
-
166
-
-
85017829399
-
-
Series on Testing and Assessment 231. Paris: OECD Publishing
-
OECD (2016). Guidance Document on the in vitro Bhas 42 Cell Transformation Assay. Series on Testing and Assessment, No. 231. Paris: OECD Publishing. https://www.oecd.org/env/ehs/testing/ENV_JM_MONO(2016)1.pdf
-
(2016)
Guidance Document on the in vitro Bhas 42 Cell Transformation Assay
-
-
-
168
-
-
85026243203
-
A human brain microphysiological system derived from iPSC to study central nervous system toxicity and disease
-
Pamies, D., Barreras, P., Block, K. et al. (2017a). A human brain microphysiological system derived from iPSC to study central nervous system toxicity and disease. ALTEX 34, 362-376. doi:10.14573/altex.1609122
-
(2017)
ALTEX
, vol.34
, pp. 362-376
-
-
Pamies, D.1
Barreras, P.2
Block, K.3
-
169
-
-
85012027021
-
Good cell culture practice for stem cells and stem-cell-derived models
-
Pamies, D., Bal-Price, A., Simeonov, A. et al. (2017b). Good cell culture practice for stem cells and stem-cell-derived models. ALTEX 34, 95-132. doi:10.14573/altex.1607121
-
(2017)
ALTEX
, vol.34
, pp. 95-132
-
-
Pamies, D.1
Bal-Price, A.2
Simeonov, A.3
-
170
-
-
85042655982
-
Rotenone exerts developmental neurotoxicity in a human brain spheroid model
-
Epub ahead of print
-
Pamies, D., Block, K., Lau, P. et al. (2018a). Rotenone exerts developmental neurotoxicity in a human brain spheroid model. Toxicol Appl Pharmacol, Epub ahead of print. doi:10.1016/j. taap.2018.02.003
-
(2018)
Toxicol Appl Pharmacol
-
-
Pamies, D.1
Block, K.2
Lau, P.3
-
171
-
-
85055522034
-
Advanced good cell culture practice for human primary, stem cell-derived and organoid models as well as microphysiological systems
-
Epub ahead of print
-
Pamies, D., Bal-Price, A., Chesne, C. et al. (2018b). Advanced good cell culture practice for human primary, stem cell-derived and organoid models as well as microphysiological systems. ALTEX, Epub ahead of print. doi:10.14573/altex.1710081.
-
(2018)
ALTEX
-
-
Pamies, D.1
Bal-Price, A.2
Chesne, C.3
-
172
-
-
84877604097
-
Uncertainty of testing methods – What do we (want to) know?
-
Paparella, M., Daneshian, M., Hornek-Gausterer, R. et al. (2013). Uncertainty of testing methods – What do we (want to) know? ALTEX 30, 131-144. doi:10.14573/altex.2013.2.131
-
(2013)
ALTEX
, vol.30
, pp. 131-144
-
-
Paparella, M.1
Daneshian, M.2
Hornek-Gausterer, R.3
-
173
-
-
85018622397
-
Uncertainties of testing methods: What do we (want to) know about carcinogenicity?
-
Paparella, M., Colacci, A. and Jacobs, M. N. (2016). Uncertainties of testing methods: What do we (want to) know about carcinogenicity? ALTEX 34, 235-252. doi:10.14573/altex.1608281
-
(2016)
ALTEX
, vol.34
, pp. 235-252
-
-
Paparella, M.1
Colacci, A.2
Jacobs, M. N.3
-
174
-
-
79958838662
-
Moving forward in human cancer risk assessment
-
Paules, R. S., Aubrecht, J., Corvi, R. et al. (2011). Moving forward in human cancer risk assessment. Environ Health Persp 119, 739-743. doi:10.1289/ehp.1002735
-
(2011)
Environ Health Persp
, vol.119
, pp. 739-743
-
-
Paules, R. S.1
Aubrecht, J.2
Corvi, R.3
-
175
-
-
8744293605
-
Validation of the postimplantation rat whole-embryo culture test in the international ECVAM validation study on three in vitro embryotoxicity tests
-
Piersma, A. H., Genschow, E., Verhoef, A. et al. (2004). Validation of the postimplantation rat whole-embryo culture test in the international ECVAM validation study on three in vitro embryotoxicity tests. Altern Lab Anim 32, 275-307.
-
(2004)
Altern Lab Anim
, vol.32
, pp. 275-307
-
-
Piersma, A. H.1
Genschow, E.2
Verhoef, A.3
-
176
-
-
79951552557
-
-
President’s Cancer Panel (2010). Reducing environmental cancer risk, NIH. https://deainfo.nci.nih.gov/advisory/pcp/annualreports/pcp08-09rpt/pcp_report_08-09_508.pdf
-
(2010)
Reducing environmental cancer risk, NIH
-
-
-
177
-
-
84901706695
-
Is animal research sufficiently evidence based to be a cornerstone of biomedical research?
-
Pound, P. and Bracken, M. B. (2014). Is animal research sufficiently evidence based to be a cornerstone of biomedical research? BMJ 348, g3387. doi:10.1136/bmj.g3387
-
(2014)
BMJ
, vol.348
, pp. g3387
-
-
Pound, P.1
Bracken, M. B.2
-
178
-
-
0038408736
-
The role of transgenic mouse models in carcinogen identification
-
Pritchard, J. B., French, J. E., Davis, B. J. and Haseman, J. K. (2003). The role of transgenic mouse models in carcinogen identification. Environ Health Perspect 111, 444-454. doi:10.1289/ehp.5778
-
(2003)
Environ Health Perspect
, vol.111
, pp. 444-454
-
-
Pritchard, J. B.1
French, J. E.2
Davis, B. J.3
Haseman, J. K.4
-
180
-
-
85030532422
-
Environmental chemicals and breast cancer: An updated review of epidemiological literature informed by biological mechanisms
-
Drug Metab Rev 32, 119 182. 10.1016/j. envres.2017.08.045
-
Drug Metab Rev 32, 119-128. doi:10.1081/DMR-100100565 Rodgers, K. M., Udesky, J. O., Rudel, R. A. and Brody, J. G. (2018). Environmental chemicals and breast cancer: An updated review of epidemiological literature informed by biological mechanisms. Environ Res 160, 152-182. doi:10.1016/j. envres.2017.08.045
-
(2018)
Environ Res
, vol.160
, pp. 152-128
-
-
Rodgers, K. M.1
Udesky, J. O.2
Rudel, R. A.3
Brody, J. G.4
-
181
-
-
84455189560
-
How are reproductive toxicity and developmental toxicity addressed in REACH dossiers?
-
Rovida, C., Longo, F. and Rabbit, R. R. (2011). How are reproductive toxicity and developmental toxicity addressed in REACH dossiers? ALTEX 28, 273-294. doi:10.14573/altex.2011.4.273
-
(2011)
ALTEX
, vol.28
, pp. 273-294
-
-
Rovida, C.1
Longo, F.2
Rabbit, R. R.3
-
182
-
-
84921415920
-
Integrated testing strategies (ITS) for safety assessment
-
Rovida, C., Alépée, N., Api, A. M. et al. (2015). Integrated testing strategies (ITS) for safety assessment. ALTEX 32, 171-181. doi:10.14573/altex.1411011
-
(2015)
ALTEX
, vol.32
, pp. 171-181
-
-
Rovida, C.1
Alépée, N.2
Api, A. M.3
-
183
-
-
85035327690
-
Legacy data sharing to improve drug safety assessment: The eTOX project
-
Sanz, F., Pognan, F., Steger-Hartmann, T. et al. (2017). Legacy data sharing to improve drug safety assessment: The eTOX project. Nat Rev Drug Discov 16, 811-812. doi:10.1038/ nrd.2017.177
-
(2017)
Nat Rev Drug Discov
, vol.16
, pp. 811-812
-
-
Sanz, F.1
Pognan, F.2
Steger-Hartmann, T.3
-
184
-
-
84937496036
-
Systems toxicology: The future of risk assessment
-
Sauer, J. M., Hartung, T., Leist, M. et al. (2015). Systems toxicology: The future of risk assessment. Int J Toxicol 34, 346-348. doi:10.1177/1091581815576551
-
(2015)
Int J Toxicol
, vol.34
, pp. 346-348
-
-
Sauer, J. M.1
Hartung, T.2
Leist, M.3
-
185
-
-
84949293901
-
A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens
-
Schaap, M. M., Wackers, P. F., Zwart, E. P. et al. (2015). A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens. Arch Toxicol 89, 2413-2427. doi:10.1007/s00204-014-1368-6
-
(2015)
Arch Toxicol
, vol.89
, pp. 2413-2427
-
-
Schaap, M. M.1
Wackers, P. F.2
Zwart, E. P.3
-
186
-
-
0036107873
-
Assessing assays
-
Schmidt, C. W. (2002). Assessing assays. Environ Health Perspect 110, A248-251. doi:10.1289/ehp.110-a248
-
(2002)
Environ Health Perspect
, vol.110
, pp. A248-A251
-
-
Schmidt, C. W.1
-
187
-
-
84949309314
-
Screening for chemical contributions to breast cancer risk: A case study for chemical safety evaluation
-
Schwarzman, M. R., Ackerman, J. R., Dairkee, S. H. et al. (2015). Screening for chemical contributions to breast cancer risk: A case study for chemical safety evaluation. Environ Health Perspect 123, 1255-1264. doi:10.1289/ehp.1408337
-
(2015)
Environ Health Perspect
, vol.123
, pp. 1255-1264
-
-
Schwarzman, M. R.1
Ackerman, J. R.2
Dairkee, S. H.3
-
189
-
-
84858441603
-
Feasibility study of the zebrafish assay as an alternative method to screen for developmental toxicity and embryotoxicity using a training set of 27 compounds
-
Selderslaghs, I. W. T., Blust, R. and Witters, H. E. (2012). Feasibility study of the zebrafish assay as an alternative method to screen for developmental toxicity and embryotoxicity using a training set of 27 compounds. Reprod Toxicol 33, 142-154. doi:10.1016/j.reprotox.2011.08.003
-
(2012)
Reprod Toxicol
, vol.33
, pp. 142-154
-
-
Selderslaghs, I. W. T.1
Blust, R.2
Witters, H. E.3
-
190
-
-
1842784863
-
Commentary: The role of toxicology in prevention and precaution
-
Silbergeld, E. K. (2004). Commentary: The role of toxicology in prevention and precaution. Int J Occup Med Environ Health 17, 91-102.
-
(2004)
Int J Occup Med Environ Health
, vol.17
, pp. 91-102
-
-
Silbergeld, E. K.1
-
191
-
-
79959429790
-
An analysis of pharmaceutical experience with decades of rat carcinogenicity testing: Support for a proposal to modify current regulatory guidelines
-
Sistare, F. D., Morton, D., Alden, C. et al. (2011). An analysis of pharmaceutical experience with decades of rat carcinogenicity testing: Support for a proposal to modify current regulatory guidelines. Toxicol Pathol 9, 716-744. doi:10.1177/0192623311406935
-
(2011)
Toxicol Pathol
, vol.9
, pp. 716-744
-
-
Sistare, F. D.1
Morton, D.2
Alden, C.3
-
192
-
-
84981734428
-
Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling
-
Skardal, A., Shupe, T. and Atala, A. (2016). Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling. Drug Discov Today 21, 1399-1411. doi:10.1016/j. drudis.2016.07.003
-
(2016)
Drug Discov Today
, vol.21
, pp. 1399-1411
-
-
Skardal, A.1
Shupe, T.2
Atala, A.3
-
193
-
-
85027888827
-
Multitissue interactions in an integrated three-tissue organ-on-a-chip platform
-
Skardal, A., Murphy, S., Devarasetty, M. et al. (2017). Multitissue interactions in an integrated three-tissue organ-on-a-chip platform. Sci Rep 7, 8837. doi:10.1038/s41598-017-08879-x
-
(2017)
Sci Rep
, vol.7
, pp. 8837
-
-
Skardal, A.1
Murphy, S.2
Devarasetty, M.3
-
194
-
-
84907008403
-
Of human-on-a-chip and humans: Considerations for creating and using microphysiological systems
-
Slikker, W. (2014). Of human-on-a-chip and humans: Considerations for creating and using microphysiological systems. Exp Biol Med 239, 1078-1079. doi:10.1177/1535370214537754
-
(2014)
Exp Biol Med
, vol.239
, pp. 1078-1079
-
-
Slikker, W.1
-
195
-
-
84946742600
-
Cellular resilience
-
Smirnova, L., Harris, G., Leist, M. and Hartung, T. (2015). Cellular resilience. ALTEX 32, 247-260. doi:10.14573/altex.1509271
-
(2015)
ALTEX
, vol.32
, pp. 247-260
-
-
Smirnova, L.1
Harris, G.2
Leist, M.3
Hartung, T.4
-
196
-
-
84971510313
-
Key characteristics of carcinogens as a basis for organizing data on mechanisms of carcinogenesis
-
Smith, M. T., Guyton, K. Z., Gibbons, C. F. et al. (2016). Key characteristics of carcinogens as a basis for organizing data on mechanisms of carcinogenesis. Environ Health Perspect 124, 713-721. doi:10.1289/ehp.1509912
-
(2016)
Environ Health Perspect
, vol.124
, pp. 713-721
-
-
Smith, M. T.1
Guyton, K. Z.2
Gibbons, C. F.3
-
197
-
-
8744315357
-
Validation of the rat limb bud micromass test in the international ECVAM validation study on three in vitro embryotoxicity tests
-
Spielmann, H., Genschow, E., Brown, N. A. et al. (2004). Validation of the rat limb bud micromass test in the international ECVAM validation study on three in vitro embryotoxicity tests. Altern Lab Anim 32, 245-274.
-
(2004)
Altern Lab Anim
, vol.32
, pp. 245-274
-
-
Spielmann, H.1
Genschow, E.2
Brown, N. A.3
-
198
-
-
33751541385
-
The practical application of three validated in vitro embryotoxicity tests. The report and recommendations of an ECVAM/ZEBET workshop (ECVAM workshop 57)
-
Spielmann, H., Seiler, A., Bremer, S. et al. (2006). The practical application of three validated in vitro embryotoxicity tests. The report and recommendations of an ECVAM/ZEBET workshop (ECVAM workshop 57). Altern Lab Anim 34, 527-538.
-
(2006)
Altern Lab Anim
, vol.34
, pp. 527-538
-
-
Spielmann, H.1
Seiler, A.2
Bremer, S.3
-
199
-
-
84873143423
-
st century: Opportunities and challenges
-
10.14573/altex.2013.1.074 Stephens, M. L., Betts, K., Beck, N. B. et al. (2016).The emergence of systematic review in toxicology. Toxicol Sci 152, 10-16
-
st century: Opportunities and challenges. ALTEX 30, 74-103. doi:10.14573/altex.2013.1.074 Stephens, M. L., Betts, K., Beck, N. B. et al. (2016).The emergence of systematic review in toxicology. Toxicol Sci 152, 10-16. doi:10.1093/toxsci/kfw059
-
(2013)
ALTEX
, vol.30
, pp. 74-103
-
-
Stephens, M. L.1
Andersen, M.2
Becker, R. A.3
-
200
-
-
84896366331
-
Systems toxicology: From basic research to risk assessment
-
Sturla, S. J., Boobis, A. R., FitzGerald, R. E. et al. (2014). Systems toxicology: From basic research to risk assessment. Chem Res Toxicol 27, 314-329. doi:10.1021/tx400410s
-
(2014)
Chem Res Toxicol
, vol.27
, pp. 314-329
-
-
Sturla, S. J.1
Boobis, A. R.2
FitzGerald, R. E.3
-
201
-
-
79955107544
-
Zebrafish for drug toxicity screening: Bridging the in vitro cell-based models and in vivo mammalian models
-
Sukardi, H., Chang, H. T., Chan, E. C. et al. (2011). Zebrafish for drug toxicity screening: Bridging the in vitro cell-based models and in vivo mammalian models. Expert Opin Drug Metab Toxicol 7, 579-589. doi:10.1517/17425255.2011.562197
-
(2011)
Expert Opin Drug Metab Toxicol
, vol.7
, pp. 579-589
-
-
Sukardi, H.1
Chang, H. T.2
Chan, E. C.3
-
202
-
-
84929593604
-
Stem cell-derived systems in toxicology assessment
-
Suter-Dick, L., Alves, P. M., Blaauboer, B. J. et al. (2015). Stem cell-derived systems in toxicology assessment. Stem Cells Develop 24, 1284-1296. doi:10.1089/scd.2014.0540
-
(2015)
Stem Cells Develop
, vol.24
, pp. 1284-1296
-
-
Suter-Dick, L.1
Alves, P. M.2
Blaauboer, B. J.3
-
203
-
-
45349093856
-
Chemical carcinogenesis studies in nonhuman primates
-
Takayama, S., Thorgeirsson, U. P. and Adamson, R. H. (2008). Chemical carcinogenesis studies in nonhuman primates. Proc Jpn Acad Ser B Phys Biol Sci 84, 176-188. doi:10.2183/ pjab.84.176
-
(2008)
Proc Jpn Acad Ser B Phys Biol Sci
, vol.84
, pp. 176-188
-
-
Takayama, S.1
Thorgeirsson, U. P.2
Adamson, R. H.3
-
204
-
-
85009253008
-
Screening for angiogenic inhibitors in zebrafish to evaluate a predictive model for developmental vascular toxicity
-
Tal, T., Kilty, C., Smith, A. et al. (2016). Screening for angiogenic inhibitors in zebrafish to evaluate a predictive model for developmental vascular toxicity. Reprod Toxicol 70, 70-81. doi:10.1016/j.reprotox.2016.12.004
-
(2016)
Reprod Toxicol
, vol.70
, pp. 70-81
-
-
Tal, T.1
Kilty, C.2
Smith, A.3
-
205
-
-
0032617798
-
Genetically altered mouse models for identifying carcinogens
-
Tennant, R. W., Stasiewicz, S., Mennear, J. et al. (1999). Genetically altered mouse models for identifying carcinogens. IARC Sci Publ 146, 123-150.
-
(1999)
IARC Sci Publ
, vol.146
, pp. 123-150
-
-
Tennant, R. W.1
Stasiewicz, S.2
Mennear, J.3
-
206
-
-
0037716639
-
Have environmental mutagens caused oncomutations in people?
-
Thilly, W. G. (2003). Have environmental mutagens caused oncomutations in people? Nat Genet 34, 255-259. doi:10.1038/ ng1205
-
(2003)
Nat Genet
, vol.34
, pp. 255-259
-
-
Thilly, W. G.1
-
207
-
-
84994758736
-
Evidence-based absorption, distribution, metabolism, excretion and toxicity (ADMET) and the role of alternative methods
-
Tsaioun, K., Blaauboer, B. J. and Hartung, T. (2016). Evidence-based absorption, distribution, metabolism, excretion and toxicity (ADMET) and the role of alternative methods. ALTEX 33, 343-358. doi:10.14573/altex.1610101
-
(2016)
ALTEX
, vol.33
, pp. 343-358
-
-
Tsaioun, K.1
Blaauboer, B. J.2
Hartung, T.3
-
208
-
-
84930754498
-
Identification of pathway-based toxicity in the BALB/c 3T3 cell model
-
Vaccari, M., Mascolo, M.G., Rotondo, F. et al. (2015). Identification of pathway-based toxicity in the BALB/c 3T3 cell model. Toxicol In Vitro 29, 1240-1253. doi:10.1016/j. tiv.2014.10.002
-
(2015)
Toxicol In Vitro
, vol.29
, pp. 1240-1253
-
-
Vaccari, M.1
Mascolo, M.G.2
Rotondo, F.3
-
209
-
-
84979307884
-
Critical analysis of carcinogenicity study outcomes. Relationship with pharmacological properties
-
van der Laan, J. W., Kasper, P., Silva Lima, B. et al. (2016). Critical analysis of carcinogenicity study outcomes. Relationship with pharmacological properties. Crit Rev Toxicol 46, 587-614. doi:10.3109/10408444.2016.1163664
-
(2016)
Crit Rev Toxicol
, vol.46
, pp. 587-614
-
-
van der Laan, J. W.1
Kasper, P.2
Silva Lima, B.3
-
210
-
-
0031080023
-
The utility of two rodent species in carcinogenic risk assessment of pharmaceuticals in Europe
-
Van Oosterhout, J. P., Van der Laan, J. W., De Waal, E. J. et al. (1997). The utility of two rodent species in carcinogenic risk assessment of pharmaceuticals in Europe. Regul Toxicol Pharmacol 25, 6-17. doi:10.1006/rtph.1996.1077
-
(1997)
Regul Toxicol Pharmacol
, vol.25
, pp. 6-17
-
-
Van Oosterhout, J. P.1
Van der Laan, J. W.2
De Waal, E. J.3
-
211
-
-
79955978152
-
Initiatives to decrease redundancy in animal testing of pesticides
-
van Ravenzwaay, B. (2010). Initiatives to decrease redundancy in animal testing of pesticides. ALTEX 27, 159-161.
-
(2010)
ALTEX
, vol.27
, pp. 159-161
-
-
van Ravenzwaay, B.1
-
212
-
-
78751581601
-
The threshold of toxicological concern for prenatal developmental toxicity
-
van Ravenzwaay, B., Dammann, M., Buesen, R. et al. (2011). The threshold of toxicological concern for prenatal developmental toxicity. Regulat Toxicol Pharmacol 59, 81-90. doi:10.1016/j. yrtph.2010.09.009
-
(2011)
Regulat Toxicol Pharmacol
, vol.59
, pp. 81-90
-
-
van Ravenzwaay, B.1
Dammann, M.2
Buesen, R.3
-
213
-
-
84863513749
-
The threshold of toxicological concern for prenatal developmental toxicity in rabbits and a comparison to TTC values in rats
-
van Ravenzwaay, B., Dammann, M., Buesen, R. et al. (2012). The threshold of toxicological concern for prenatal developmental toxicity in rabbits and a comparison to TTC values in rats. Regul Toxicol Pharmacol 64, 1-8. doi:10.1016/j.yrtph.2012.06.004
-
(2012)
Regul Toxicol Pharmacol
, vol.64
, pp. 1-8
-
-
van Ravenzwaay, B.1
Dammann, M.2
Buesen, R.3
-
214
-
-
85021155279
-
The threshold of toxicological concern for prenatal developmental toxicity in rats and rabbits
-
van Ravenzwaay, B., Jiang, X., Luechtefeld, T. and Hartung, T. (2017). The threshold of toxicological concern for prenatal developmental toxicity in rats and rabbits. Regul Toxicol Pharmacol 88, 157-172. doi:10.1016/j.yrtph.2017.06.008
-
(2017)
Regul Toxicol Pharmacol
, vol.88
, pp. 157-172
-
-
van Ravenzwaay, B.1
Jiang, X.2
Luechtefeld, T.3
Hartung, T.4
-
215
-
-
85043706933
-
Reproducibility of preclinical animal research improves with heterogeneity of study samples
-
Voelkl, B., Vogt, L., Sena, E. S. and Würbel, H. (2018). Reproducibility of preclinical animal research improves with heterogeneity of study samples. PLoS Biology 16, e2003693. doi:10.1371/ journal.pbio.2003693
-
(2018)
PLoS Biology
, vol.16
, pp. e2003693
-
-
Voelkl, B.1
Vogt, L.2
Sena, E. S.3
Würbel, H.4
-
216
-
-
84937034325
-
Concordance of Noncarcinogenic Endpoints in Rodent Chemical Bioassays
-
Wang, B. and Gray, G. (2015). Concordance of Noncarcinogenic Endpoints in Rodent Chemical Bioassays. Risk Analysis 35, 1154-1166. doi:10.1111/risa.12314
-
(2015)
Risk Analysis
, vol.35
, pp. 1154-1166
-
-
Wang, B.1
Gray, G.2
-
217
-
-
85070652811
-
Introduction to predictive carcinogenicity
-
(Waters MD and Thomas RS, eds). Cambridge, UK: Royal Society of Chemistry
-
Waters, M. D. (2016). Introduction to predictive carcinogenicity. In Issues in Toxicology No. 28 Toxicogenomics in Predictive Carcinogenicity (Waters MD and Thomas RS, eds). Cambridge, UK: Royal Society of Chemistry. doi:10.1039/9781782624059-00001
-
(2016)
Issues in Toxicology No. 28 Toxicogenomics in Predictive Carcinogenicity
-
-
Waters, M. D.1
-
218
-
-
85032345063
-
Fitting tissue chips and microphysiological systems into the grand scheme of medicine, biology, pharmacology, and toxicology
-
Watson, D. E., Hunziker, R. and Wikswo, J. P. (2017). Fitting tissue chips and microphysiological systems into the grand scheme of medicine, biology, pharmacology, and toxicology. Exp Biol Med 242, 1559-1572. doi:10.1177/1535370217732765
-
(2017)
Exp Biol Med
, vol.242
, pp. 1559-1572
-
-
Watson, D. E.1
Hunziker, R.2
Wikswo, J. P.3
-
219
-
-
77954819352
-
Zebrafish teratogenicity test with metabolic activation (mDarT): Effects of phase I activation of acetaminophen on zebrafish Danio rerio embryos
-
Weigt, S., Huebler, N., Braunbeck, T. et al. (2010). Zebrafish teratogenicity test with metabolic activation (mDarT): Effects of phase I activation of acetaminophen on zebrafish Danio rerio embryos. Toxicology 275, 36-49. doi:10.1016/j. tox.2010.05.012
-
(2010)
Toxicology
, vol.275
, pp. 36-49
-
-
Weigt, S.1
Huebler, N.2
Braunbeck, T.3
-
220
-
-
84937760941
-
-
JRC Report 26797
-
Worth, A., Barroso, J. F., Bremer, S. et al. (2014). Alternative Methods for Regulatory Toxicology – A State-of-the-art Review, 470pp. JRC Report 26797. https://bit.ly/2q91DiM
-
(2014)
Alternative Methods for Regulatory Toxicology – A State-of-the-art Review, 470pp
-
-
Worth, A.1
Barroso, J. F.2
Bremer, S.3
|