Food for thought... on validation;Vor- und Nachdenkliches... zur Validierung

Altex

Volumn 24, Issue 2, 2007, Pages 67-80

  Hartung, Thomas ^a  

^a JOINT RESEARCH CENTRE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL TESTING ALTERNATIVE; ANIMAL WELFARE; CLINICAL PROTOCOL; DRUG RESEARCH; EDITORIAL; EVIDENCE BASED MEDICINE; FEEDBACK SYSTEM; MEDICAL RESEARCH; NONHUMAN; PUBLICATION; QUALITY CONTROL; RELIABILITY; REPRODUCIBILITY; SAFETY; SCIENTIFIC LITERATURE; STANDARDIZATION; STATISTICAL SIGNIFICANCE; TOXICOLOGY; VALIDATION PROCESS;

ANIMAL TESTING ALTERNATIVES; ANIMALS; HUMANS; REPRODUCIBILITY OF RESULTS;

EID: 34249915306     PISSN: 09467785     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Editorial

References (18)

1. Balls, M., Amcoff, P., Bremer, S., et al. (2006). The Principles of weight of evidence validation of test methods and testing strategies. The report and recommendations of ECVAM workshop 58a. ATLA - Altern. Lab. Anim. 34, 603-620.
2. Bremer, S., Pellizzer, C., Hoffmann, S. et al. (2007). The development of new concepts for assessing reproductive toxicity applicable to large scale toxicological programmes. Current Pharmaceutical Design, invited.
3. Coecke, S., Balls, M., Bowe, G., et al. (2005). Guidance on good cell culture practice. ATLA - Altern. Lab. Anim. 33, 261-287.
4. Corvi, R., Ahr, H.-J., Albertini, S. et al. (2006). Validation of toxicogenomics-based test systems: ECVAM-ICCVAM/NICEATM considerations for regulatory use. Environ. Health Persp. 114, 420-429.
5. Fisher, E., Jones, J. and von Schomberg, R. (eds) (2006). Implementing the precautionary principle: perspectives and prospects. Cheltenham, UK and Northampton, MA, USA: Edward Elgar
6. Goldberg, A. and Hartung, T. (2006). Not just for the rabbits. Scientific American 294, 84-91.
7. Gruber, F. P. and Hartung, T. (2004). Alternatives to animal experimentation in basic research. ALTEX 21 Suppl. 1, 3-31.
8. Hartung, T. (2002). Three Rs potential in the development and quality control of pharmaceuticals, ALTEX 18, (Suppl. ],), 3-11.
9. Hartung, T. und Spielmann, H. (1995). Der lange Weg zur validierten Ersatzmethode. ALTEX 12, 98-103.
10. Hartung, T., Bremer, S., Casati, S., et al. (2004). Modular approach to the ECVAM principles on test validity. ATLA - Altern. Lab. Anim. 32, 467-72.
11. Hoffmann, S. and Hartung, T. (2005). Diagnosis: Toxic! - Trying to apply approaches of clinical diagnostics and prevalence in toxicology considerations. Tox. Sci. 85, 422-428.
12. Hoffmann, S. and Hartung, T. (2006a). Designing validation studies more efficiently according to the modular approach: retrospective analysis of the EPISKIN test for skin corrosion. ATLA - Altern. Lab. Anim. 34, 177-191.
13. Hoffmann, S. and Hartung, T. (2006b). Towards an evidence-based toxicology. Human Exp. Toxicol. 25, 497-513.
14. Kirkland, D., Aardema, M., Henderson, L. and Muller, L. (2005). Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens I. Sensitivity, specificity and relative predictivity. Mutat. Res. 584, 1-256
15. Kirkland, D., Pfuhler, S., Tweats, D. et al. (2007). How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop. Mutat. Res. 628, 31-55.
16. Prieto, P., Baird, A. W., Blaauboer, B. J. et al. (2006). The assessment of repeated dose toxicity in vitro: a proposed approach. ATLA - Altern. Lab. Anim. 34, 315-341.
17. Worth, A. P., Hartung, T. and Van Leeuwen, C. J. (2004). The role of the European centre for the validation of alternative methods (ECVAM) in the validation of (Q)SARs. SAR QSAR Environ. Res. 15, 345-358.
18. Worth, A. P., Van Leeuwen, C. J. and Hartung, T. (2004). The prospects for using (Q)SARs in a changing political environment - high expectations and a key role for the European Commission's joint research centre. SAR QSAR Environ. Res. 15, 331-343.