Development and Validation of a Computational Model for Androgen Receptor Activity

Chemical Research in Toxicology

Volumn 30, Issue 4, 2017, Pages 946-964

  Kleinstreuer, Nicole C ^a   Ceger, Patricia ^b   Watt, Eric D ^c   Martin, Matthew ^c   Houck, Keith ^c   Browne, Patience ^d   Thomas, Russell S ^c   Casey, Warren M ^a   Dix, David J ^c   Allen, David ^b   Sakamuru, Srilatha ^e   Xia, Menghang ^e   Huang, Ruili ^e   Judson, Richard ^c  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b INTEGRATED LABORATORY SYSTEMS   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^d OECD   (France)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; ANDROGEN RECEPTOR; ANDROGEN RECEPTOR AGONIST; ANDROGEN RECEPTOR ANTAGONIST; ANDROSTANOLONE; BICALUTAMIDE; CLOMIFENE CITRATE; CORTICOSTERONE; CYPROTERONE; CYPROTERONE ACETATE; DEXAMETHASONE; ESTRADIOL; FENITROTHION; FLUOXYMESTERONE; FLUTAMIDE; GENISTEIN; HORMONE RECEPTOR STIMULATING AGENT; HYDROXYFLUTAMIDE; LINURON; METHOXYCHLOR; METRIBOLONE; MIBOLERONE; NORGESTREL; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PROCYMIDONE; PROGESTERONE; PROTEIN; TESTOSTERONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINCLOZOLIN; ANDROGEN; PROTEIN BINDING;

ACCURACY; AREA UNDER THE CURVE; ARTICLE; AUTOMATION; CELLS BY BODY ANATOMY; COMPUTATIONAL TOXICOLOGY; CONTROLLED STUDY; CYTOTOXICITY; DRUG ANTAGONISM; DRUG DETERMINATION; DRUG RECEPTOR BINDING; GENETIC TRANSCRIPTION; HIGH THROUGHPUT SCREENING; HUMAN; IC50; IN VITRO STUDY; NONHUMAN; ONTOLOGY; PROTEIN DATABASE; PROTEIN SYNTHESIS; RECEPTOR BINDING; SIGNAL TRANSDUCTION; STANDARDIZATION; TOXICITY TESTING; TOXICOLOGY; TRANSACTIVATION; VALIDATION STUDY; CHEMISTRY; DRUG EFFECTS; GENETICS; METABOLISM; RECEIVER OPERATING CHARACTERISTIC; THEORETICAL MODEL; TRANSCRIPTION INITIATION;

ANDROGEN RECEPTOR ANTAGONISTS; ANDROGENS; AREA UNDER CURVE; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MODELS, THEORETICAL; PROTEIN BINDING; RECEPTORS, ANDROGEN; ROC CURVE; TRANSCRIPTIONAL ACTIVATION;

EID: 85018493200     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/acs.chemrestox.6b00347     Document Type: Article

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