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Volumn 37, Issue 2, 2009, Pages 219-225

A modular approach to the extended one-generation reproduction toxicity study

(14)  Moore, Nigel a   Bremer, Susanne b   Carmichael, Neil c   Daston, George d   Dent, Matt e   Gaoua Chapelle, Wassila f   Hallmark, Nina g   Hartung, Thomas b,l   Holzum, Beate h   Hübel, Ulrich i   Meisters, Marie Louise j   Schneider, Steffen k   Van Ravenzwaay, Bennard k   Hennes, Christa c  

f ARKEMA   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AGRICULTURAL CHEMICAL; INDUSTRIAL CHEMICAL;

EID: 67649586930     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119290903700211     Document Type: Conference Paper
Times cited : (11)

References (18)
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    • Document No. 45, 51pp. Brussels, Belgium: European Centre for Ecotoxicology & Toxicology of Chemicals. Available at: (Accessed 10.03.09)
    • ECETOC (2008). Triggering and Waiving Criteria for the Extended One-generation Reproduction Toxicity Study. Document No. 45, 51pp. Brussels, Belgium: European Centre for Ecotoxicology & Toxicology of Chemicals. Available at: http://www.ecetoc.org/technical-documents (Accessed 10.03.09).
    • (2008) Triggering and Waiving Criteria for the Extended One-generation Reproduction Toxicity Study
  • 4
    • 77249164989 scopus 로고    scopus 로고
    • Corrigendum to Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive
    • European Union
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    • (2007) Official Journal of the European Union , vol.L136 , pp. 3-280
  • 6
    • 34447265983 scopus 로고    scopus 로고
    • A retrospective analysis of the two-generation study: What is the added value of the second generation?
    • DOI 10.1016/j.reprotox.2007.04.068, PII S0890623807001621, Includes a Special Issue Section on the 35th Annual Conference of the European Teratology Society
    • Janer, G., Hakkert, B.C., Slob, W., Vermehre, T. & Piersma, A.H. (2007). A retrospective analysis of the two-generation study: What is the added value of the second generation? Reproductive Toxicology 24, 97-102. (Pubitemid 47042355)
    • (2007) Reproductive Toxicology , vol.24 , Issue.1 , pp. 97-102
    • Janer, G.1    Hakkert, B.C.2    Slob, W.3    Vermeire, T.4    Piersma, A.H.5
  • 7
    • 67649597143 scopus 로고    scopus 로고
    • Unpublished data. Washington, DC, USA: US Environmental Protection Agency, Office of Pesticide Programs, Health Effects Division. Cited in (8)
    • Makris, S.L. (2004). Unpublished data. Washington, DC, USA: US Environmental Protection Agency, Office of Pesticide Programs, Health Effects Division. Cited in (8).
    • (2004)
    • Makris, S.L.1
  • 10
    • 34249879680 scopus 로고    scopus 로고
    • The development of new concepts for assessing reproductive toxicity applicable to large scale toxicological programmes
    • DOI 10.2174/138161207782110462
    • Bremer, S., Pellizzer, C., Hoffmann, S., Seidle, T. & Hartung, T. (2007). The development of new concepts for assessing reproductive toxicity applicable to large scale toxicological programs. Current Pharmaceutical Design 13, 3047-3058. (Pubitemid 350130970)
    • (2007) Current Pharmaceutical Design , vol.13 , Issue.29 , pp. 3047-3058
    • Bremer, S.1    Pellizzer, C.2    Hoffmann, S.3    Seidle, T.4    Hartung, T.5
  • 13
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    • Council Directive of 24 November 1986 on the approximation of laws, regulations and administrative provisions of the Member States regarding the protection of animals used for experimental and other scientific purposes
    • European Union
    • European Union (1986). Council Directive of 24 November 1986 on the approximation of laws, regulations and administrative provisions of the Member States regarding the protection of animals used for experimental and other scientific purposes. Official Journal of the European Communities, L358, 1-28.
    • (1986) Official Journal of the European Communities , vol.L358 , pp. 1-28
  • 14
    • 67649608820 scopus 로고    scopus 로고
    • Detection of Toxicity to Reproduction for Medicinal Products and Toxicity to Male Fertility S5 (R2)
    • ICH Geneva, Switzerland: International Conference on Harmonisation of Technical Requirements for Registrations of Pharmaceuticals for Human Use
    • ICH (2005). Detection of Toxicity to Reproduction for Medicinal Products and Toxicity to Male Fertility S5 (R2). ICH Harmonised Tripartite Guideline, 24pp. Geneva, Switzerland: International Conference on Harmonisation of Technical Requirements for Registrations of Pharmaceuticals for Human Use.
    • (2005) ICH Harmonised Tripartite Guideline
  • 15
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    • An analysis of the results from two-generation reproduction toxicity studies to assess the value of mating animals of the second (F1) generation for the detection of adverse treatment-related effects on reproductive performance
    • Myers, D.P., Willoughby, C.R., Bottomley, A.M. & Buschmann, J. (2008). An analysis of the results from two-generation reproduction toxicity studies to assess the value of mating animals of the second (F1) generation for the detection of adverse treatment-related effects on reproductive performance. Reproductive Toxicology 26, 47-50.
    • (2008) Reproductive Toxicology , vol.26 , pp. 47-50
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  • 18
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    • (1997) Regulatory Toxicology and Pharmacology , vol.25 , Issue.1 , pp. 1-5
    • Klimisch, H.-J.1    Andreae, M.2    Tillmann, U.3


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