A retrospective analysis of the two-generation study: What is the added value of the second generation?

Reproductive Toxicology

Volumn 24, Issue 1, 2007, Pages 97-102

  Janer, Gemma ^a   Hakkert, Betty C ^a   Slob, Wout ^a   Vermeire, Theo ^a   Piersma, Aldert H ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

Classification and labeling; Developmental toxicity; Fertility; NOAEL; One generation study; Reproductive toxicity; Risk assessment; Two generation study

Indexed keywords

TOXIC SUBSTANCE;

ARTICLE; DEVELOPMENTAL DISORDER; INFERTILITY; NONHUMAN; ONE GENERATION STUDY; PROGENY; REPRODUCTIVE TOXICITY; RETROSPECTIVE STUDY; RISK ASSESSMENT; TOXICITY TESTING; TWO GENERATION STUDY;

ANIMALS; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO IMPLANTATION; ENVIRONMENTAL POLLUTANTS; EPIDIDYMIS; FEMALE; FERTILITY; GERM CELLS; GROWTH AND DEVELOPMENT; LITTER SIZE; MALE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PESTICIDES; POPULATION DYNAMICS; REPRODUCTION; RETROSPECTIVE STUDIES; RISK ASSESSMENT; SPERMATOZOA; TIME FACTORS; TOXICITY TESTS, CHRONIC;

ANIMALIA;

EID: 34447265983     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2007.04.068     Document Type: Article

References (4)

1. Van der Jagt K, Munn S, Tørsløv J, de Bruijn J. Alternative approaches can reduce the use of test animals under REACH. European Commission Report EUR 21405 EN; 2004.
2. Cooper R.L., Lamb J.C., Barlow S.M., Bentley K., Brady A.M., Doerrer N.G., et al. A tiered approach to life stages testing for agricultural chemical safety assessment. Crit Rev Toxicol 36 (2006) 69-98
3. McKee R.H., Pavkov K.L., Timmer G.W., Keller L.H., and Stump D.G. An assessment of the potential developmental and reproductive toxicity of di-isoheptyl phthalate in rodents. Reprod Toxicol 21 (2006) 241-252
4. Nagymajtényi L., Shulz H., and Dési I. Behavioural and functional neurotoxicological changes caused by cadmium in a three-generation study in rats. Hum Exp Toxicol 16 (1997) 691-699