Zebrafish for drug toxicity screening: Bridging the in vitro cell-based models and in vivo mammalian models

Expert Opinion on Drug Metabolism and Toxicology

Volumn 7, Issue 5, 2011, Pages 579-589

  Sukardi, Hendrian ^a   Chng, Hui Ting ^a   Chan, Eric Chun Yong ^a   Gong, Zhiyuan ^a   Lam, Siew Hong ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

cardiotoxicity; drug toxicity screening; high throughput phenotype based screening; neuro sensory organ toxicity; omics applications; safety pharmacology; teratogenicity; zebrafish

Indexed keywords

CIMETIDINE; CISAPRIDE; CYCLOSPORIN A; ERYTHROMYCIN; PENTAMIDINE; PROPANTHELINE BROMIDE; RHODAMINE B; TERFENADINE;

CARDIOTOXICITY; DRUG METABOLISM; DRUG SCREENING; DRUG TRANSFORMATION; EMBRYO DEVELOPMENT; EXPERIMENTAL MODEL; HIGH THROUGHPUT SCREENING; IC 50; IN VITRO STUDY; IN VIVO STUDY; MAMMAL; MEDICAL TECHNOLOGY; NEUROTOXICITY; NONHUMAN; OTOTOXICITY; QT PROLONGATION; REVIEW; TERATOGENICITY; TORSADE DES POINTES; TOXICITY TESTING; ZEBRA FISH;

ANIMALS; DRUG DESIGN; DRUG TOXICITY; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MODELS, ANIMAL; PHARMACEUTICAL PREPARATIONS; TOXICITY TESTS; ZEBRAFISH;

DANIO RERIO; MAMMALIA;

EID: 79955107544     PISSN: 17425255     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425255.2011.562197     Document Type: Review

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