Correlation of chemical structure with reproductive and developmental toxicity as it relates to the use of the threshold of toxicological concern

Regulatory Toxicology and Pharmacology

Volumn 62, Issue 1, 2012, Pages 160-182

  Laufersweiler, Michael C ^a   Gadagbui, Bernard ^b   Baskerville Abraham, Irene M ^b   Maier, Andrew ^b   Willis, Alison ^b   Scialli, Anthony R ^c   Carr, Gregory J ^a   Felter, Susan P ^a   Blackburn, Karen ^a   Daston, George ^a  

^a PROCTER AND GAMBLE COMPANY   (United States)

^b Toxicology Excellence for Risk Assessment   (United States)

^c TETRA TECH INC   (United States)

Author keywords

Chemical structure; Cramer Class; Developmental toxicity; Reproductive toxicity; Threshold of toxicological concern

Indexed keywords

CHEMICAL COMPOUND;

ANALYTIC METHOD; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CORRELATION ANALYSIS; DEVELOPMENTAL DISORDER; DEVELOPMENTAL TOXICITY; FERTILITY; HUMAN; POPULATION EXPOSURE; PRIORITY JOURNAL; REPRODUCTIVE TOXICITY; RISK ASSESSMENT; THRESHOLD OF TOXICOLOGICAL CONCERN; TOXICITY TESTING;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYONIC DEVELOPMENT; FETAL DEVELOPMENT; HAZARDOUS SUBSTANCES; HUMANS; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PHARMACEUTICAL PREPARATIONS; REPRODUCTION; RISK ASSESSMENT; TOXICITY TESTS;

EID: 84856225029     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2011.09.004     Document Type: Article

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225. NTP (National Toxicology Program), 1990. Peri/postnatal evaluation of hexachloro-1,-butadiene (HCBD) (CAS# 87-68-3) toxicity in CD rats. Abstract for T0166 - hexachloro-1,-butadiene (HCBD) (CASRN 87-68-3). NTP Study: T0166. Available online at: http://ntp.niehs.nih.gov/index.cfm?objectid=072FB355-0493-DA1D-4E87FC7629C47E45.
226. NTP (National Toxicology Program), 1991a. Developmental toxicity of methacrylamide (CAS No. 79-39-0) in CD-1® Swiss mice. Abstract for TER90007 - methacrylamide (CASRN 79-39-0). NTP Study: TER90007. Available online at: http://ntp.niehs.nih.gov/index.cfm?objectid=07308C60-BC2A-92C2-100425EB72BEF266.
227. NTP (National Toxicology Program), 1991b. Developmental Toxicity of Mono(2-ethylhexyl)phthalate (MEHP) (CAS No. 4376-20-9) in CD-1 Swiss Mice NTP. NTP Study: TER90002. Available online at: http://ntp.niehs.nih.gov/index.cfm?objectid=07307C72-AD2F-33AC-704CB9D1B31AC3ED.
228. NTP (National Toxicology Program), 1992a. Developmental toxicity of d-camphor (CAS No. 464-49-3) in New Zealand white (NZW) rabbits. Abstract for TER91019 - d-camphor (CASRN 464-49-3). NTP Study: TER91019. Available online at: http://ntp.niehs.nih.gov/index.cfm?objectid=0730BBCC-EEDA-B6DF-A9A2C0915FF88637.
229. NTP (National Toxicology Program), 1992b. Technical report on the toxicology and cancerogenesis studies of monochloroacetic acid (Cas No. 79-11-8) in F344/N rats and B6C3F1 mice (gavage studies), NTP TR 396, NIH publication No. 90-2851.
230. NTP (National Toxicology Program), 1992c. Developmental toxicity of dipropylene glycol (CAS No. 25265-71-8) in New Zealand white rabbits. Abstract for TER90014 - dipropylene glycol (CASRN 25265-71-8). NTP Study: TER90014. Available online at: http://ntp.niehs.nih.gov/index.cfm?objectid=07309549-F9FF-CD32-CC5AD89B0F4E7AF2.
231. NTP (National Toxicology Program), 1992d. Developmental toxicity evaluation of N,N'-methylenebisacrylamide (CAS No. 110-26-9) in Swiss (CD-1®) mice. Abstract for TER90008 - N,N'-methylenebisacrylamide (CASRN 110-26-9) Final study report. NTP Study: TER90008. Available online at: http://ntp.niehs.nih.gov/index.cfm?objectid=07308E25-CB19-2813-FB73F302947ED02F.
232. NTP (National Toxicology Program), 1992e. Developmental toxicity of naphthalene (CAS No. 91-20-3) in New Zealand white (NZW) rabbits. Abstract for TER91021 - naphthalene (CASRN 91-20-3). NTP Study: TER91021. Available online at: http://ntp-server.niehs.nih.gov/index.cfm?objectid=0730C4E5-F71E-FC4D-645A7709088C7037.
233. NTP (National Toxicology Program), 1992f. Developmental toxicology of polyoxyethylene sorbitan monooleate (CAS #9005-65-6) in Sprague-Dawley CD® Rats. Abstract for TER91009 - polyoxyethylene sorbitan monooleate (CASRN 9005-65-6). NTP Study: TER91009. Available online at: http://ntp.niehs.nih.gov/index.cfm?objectid=0730AFC6-AB6F-8A04-CFF2C1037A209CB8.
234. NTP (National Toxicology Program),1992g. Reproductive, developmental and general toxicity study of 2',3'-dideoxycytidine (ddC) (CAS No. 7481-89-2) in CD-1 mice. Abstract for RACB92122 - 2',3'-dideoxycytidine (ddC) (CASRN 7481-89-2). Available online at: http://ntp.niehs.nih.gov/index.cfm?objectid=EEF0D7DF-F1F6-975E-7C92E6283BC7FC2F.
235. NTP (National Toxicology Program), 1993a. Developmental toxicity of glyoxal trimeric dihydrate, (CAS No. 4405-13-4) in New Zealand white (NZW) rabbits. Abstract for TER92121 - glyoxal trimeric dihydrate, (CASRN 4405-13-4). NTP Study: TER92121. Available online at: http://ntp-server.niehs.nih.gov/index.cfm?objectid=0730DDAC-92E9-FAC9-16500C9B60489662.
236. NTP (National Toxicology Program), 1993b. Developmental toxicity studies of ethylenediamine (CAS No. 107-15-3) in New Zealand white rabbits. Abstract for TER92020 - ethylenediamine (CASRN 107-15-3). NTP Study: TER92020. Available online at: http://ntp.niehs.nih.gov/go/12989.
237. NTP (National Toxicology Program), 1993c. Developmental Toxicity of Methylene Blue Trihydrate (CAS No. 7220-79-3) in Sprague-Dawley (CD®) Rats. Abstract for TER92124 - Methylene Blue Trihydrate (CASRN 7220-79-3). NTP Study: TER92124. Available online at: http://ntp-server.niehs.nih.gov/index.cfm?objectid=0730DFA0-E886-A42E-EC5B04D11413A174.
238. NTP (National Toxicology Program), 1993d. Developmental toxicity of sodium flouride (CAS No. 7681-49-4) in New Zealand white (NZW) rabbits. Abstract for TER91033 - sodium flouride (CASRN 7681-49-4). NTP Study: TER91033. Available online at: http://ntp.niehs.nih.gov/index.cfm?objectid=0730CD80-B2C2-891D-21C8B0C7154BE4D9.
239. NTP (National Toxicology Program), 1994a. Developmental toxicity of a-cyclodextrin (CAS No. 10016-20-3) in Sprague-Dawley CD® rats NTP Study: TER92136: report date: January, 1994, NTIS# PB94-139953. Available online at: http://ntp.niehs.nih.gov/index.cfm?objectid=0730FAD9-94D6-4411-24AD2972B772426E.
240. NTP (National Toxicology Program), 1994b. Developmental toxicity of thiophenol (CAS No. 108-98-5) in Sprague-Dawley (CD®) rats. Abstract for TER92133 - thiophenol (CASRN 108-98-5). NTP Study: TER92133. Available online at: http://ntp.niehs.nih.gov/index.cfm?objectid=0730E732-CE7E-2885-BA7356C93FF151BB.
241. NTP (National Toxicology Program), 1994c. Developmental toxicity of 1,4-butanediol (CAS No. 110-63-4) in Swiss (CD-1®) mice. Abstract for TER90030 - 1,4-butanediol (CASRN 110-63-4). NTP Study: TER90030. Available online at: http://ntp.niehs.nih.gov/index.cfm?objectid=07309D96-F3FA-B9A8-DB32C567C2378295.
242. NTP (National Toxicology Program), 1994d. Developmental toxicity evaluation of 8-methoxypsoralen (CAS No. 298-81-7) administered by gavage to Spraguw-Dawley (CD®) rats on gestational days 6 through 15. NTP report TER91017. Available online at: http://ntp.niehs.nih.gov/INDEX.CFM?OBJECTID=89BC6F41-F1F6-975E-78235C74E57E43F0.
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246. NTP (National Toxicology Program), 2004b. Developmental toxicity evaluation of 3'-Azido-3'-deoxythymidine (AZT; CAS No. 30516-87-1) and dapsone (CAS No. 80-08-0) administered by gavage to Swiss Albino (CD-1®) mice on gestational days 6 Through 15. NTP Report # RACB98001. Available online at: http://ntp.niehs.nih.gov/index.cfm?objectid=4E0069C7-F1F6-975E-73C21974B4DD7ACF.
247. NTP (National Toxicology Program), 2004c. Developmental toxicity evaluation of 2',3'-Dideoxyinosine (ddI; CAS No. 69655-05-6) and 2',3'-didehydro-3'-deoxythymidine (d4T; CAS No. 3056-17-5) co-administered by gavage to Swiss Albino (CD-1®) mice on gestational days 6 through 16. Abstract for TER20201 - 2',3'-dideoxyinosine (ddI; CASRN 69655-05-6) and 2',3'-didehydro-3'-deoxythymidine (d4T; CASRN 3056-17-5), Final study report. NTP Study: TER20201. Available online at: http://ntp.niehs.nih.gov/index.cfm?objectid=072FBECF-FEE9-D264-6BADBFCDE187B683.
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