Ten questions about systems biology

Journal of Physiology

Volumn 589, Issue 5, 2011, Pages 1017-1030

  Joyner, Michael J ^a   Pedersen, Bente K ^b  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ATHEROSCLEROSIS; BIOMEDICINE; CORONARY ARTERY BLOOD FLOW; DOG; ENVIRONMENTAL FACTOR; GENE EXPRESSION; GENETIC RISK; GENETIC VARIABILITY; GENOME ANALYSIS; GENOTYPE ENVIRONMENT INTERACTION; HOMEOSTASIS; HUMAN; HUMAN GENOME; INTEGRATIVE MEDICINE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OPTIMISM; OXYGEN CONSUMPTION; PRIORITY JOURNAL; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMS BIOLOGY; TRANSLATIONAL RESEARCH;

ANIMALS; GENETIC VARIATION; POLYMORPHISM, SINGLE NUCLEOTIDE; SYSTEMS BIOLOGY;

EID: 79951963979     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2010.201509     Document Type: Review

References (94)

1. Alibegovic AC, Sonne MP, Højbjerre L, Hansen T, Pedersen O, van Hall G et al (2010). The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest. Diabetes 59, 836-843.
2. Auffray C & Noble D (2009). Origins of systems biology in William Harvey's masterpiece on the movement of the heart and the blood in animals. Int J Mol Sci 10, 1658-1669.
3. Bassett DR Jr, Schneider PL & Huntington GE (2004). Physical activity in an old order Amish community. Med Sci Sports Exerc 36, 79-85.
4. Black J (1989). Drugs from emasculated hormones: the principle of syntopic antagonism. Science 245, 486-493.
5. Blair SN & Morris JN (2009). Healthy hearts - and the universal benefits of being physically active: physical activity and health. Ann Epidemiol 19, 253-256.
6. Bock G, Chittilapilly E, Basu R, Toffolo G, Cobelli C, Chandramouli V et al (2007). Contribution of hepatic and extrahepatic insulin resistance to the pathogenesis of impaired fasting glucose. Role of increased rates of gluconeogenesis. Diabetes 56, 1703-1711.
7. Brook RH (2010). Medical leadership in an increasingly complex world. JAMA 304, 465-466.
8. Bunton SA (2006). Recent trends in basic science department reorganizations. Analysis in Brief, AAMC, Vol. 6, No. 1. Available at.
9. Cannon WB (1941). The body physiologic and the body politic. Science 93, 1-10.
10. Chakravarthy MV & Booth FW (2004). Eating, exercise, and "thrifty" genotypes: connecting the dots toward an evolutionary understanding of modern chronic diseases. J Appl Physiol 96, 3-10.
11. Collins FS (2001). Contemplating the end of the beginning. Genome Res 11, 641-643.
12. Collins FS (1992). Cystic fibrosis: molecular biology and therapeutic implications. Science 256, 774-779.
13. Collins FS (1999). The human genome project and the future of medicine. Ann NY Acad Sci 882, 42-55.
14. Comroe JH Jr & Dripps RD (1974). Ben Franklin and open heart surgery. Circ Res 35, 661-669.
15. Cowley AW Jr, Liard JF & Guyton AC (1973). Role of the baroreceptor reflex in daily control of arterial blood pressure and other variables in dogs. Circ Res 32, 564-576.
16. Csete ME & Doyle JC (2002). Reverse engineering of biological complexity. Science 295, 1664-1669.
17. Curb JD & Marcus EB (1991). Body fat and obesity in Japanese Americans. Am J Clin Nutr 53, 1552S-1555S.
18. Diabetes Prevention Program Research Group (2002). Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346, 393-403.
19. DiBona GF & Esler M (2010). Translational medicine: the antihypertensive effect of renal denervation. Am J Physiol Regul Integr Comp Physiol 298, R245-R253.
20. Dill J (2009). Bicycling for transportation and health: the role of infrastructure. J Public Health Policy 30, S95-S110.
21. Donald DE, Milburn SE & Shepherd JT (1964). Effect of cardiac denervation on the maximal capacity for exercise in the racing greyhound. J Appl Physiol 19, 849-852.
22. Donaldson SH & Boucher RC (2007). Sodium channels and cystic fibrosis. Chest 132, 1631-1636.
23. Dougherty ER (2009). Translational science: epistemology and the investigative process. Curr Genomics 10, 102-109.
24. Duncker DJ & Bache RJ (2008). Regulation of coronary blood flow during exercise. Physiol Rev 88, 1009-1086.
25. Dupuy A & Simon RM (2007). Critical review of published microarray studies for cancer outcome and guidelines on statistical analysis and reporting. J Natl Cancer Inst 99, 147-157.
26. Ehsani AA, Heath GW, Hagberg JM, Sobel BE & Holloszy JO (1981). Effects of 12 months of intense exercise training on ischemic ST-segment depression in patients with coronary artery disease. Circulation 64, 1116-1124.
27. Enattah NS, Jensen TGK, Nielsen M, Lewinski R, Kuokkanen M, Rasinpera H et al (2008). Independent introduction of two lactase-persistence alleles into human populations reflects different history of adaptation to milk culture. Am J Hum Genet 82, 57-72.
28. Esquível M & González C (2010). Excess weight and adiposity in children and adolescents in Havana, Cuba: prevalence and trends, 1972 to 2005. MEDICC Rev 12, 13-18.
29. Felder RB, Francis J, Weiss RM, Zhang Z-H, Wei S-G & Johnson AK (2002). Neurohumoral regulation in ischemia-induced heart failure. Role of the forebrain. Ann NY Acad Sci USA 940, 444-453.
30. Fields S (2004). The fat of the land: do agricultural subsidies foster poor health? Environ Health Perspect 112, A820-A823.
31. Folkow B (1995). Integration of hypertension research in the era of molecular biology: G.W. Pickering Memorial Lecture (Dublin 1994). J Hypertens 13, 5-18.
32. Fraser GE & Shavlik DJ (2001). Ten years of life. Is it a matter of choice? Arch Intern Med 161, 1645-1652.
33. Furchgott RF (1996). The discovery of endothelium-derived relaxing factor and its importance in the identification of nitric oxide. JAMA 276, 1186-1188.
34. Gibson G (2007). Human evolution: thrifty genes and the Dairy Queen. Curr Biol 17, R295-R296.
35. Gleiberman L (2009). Sodium, blood pressure, and ethnicity: what have we learned? Am J Human Biol 21, 679-686.
36. Golub TR (2010). Counterpoint: Data first. Nature 464, 679.
37. Henderson LJ (1941). The study of man. Science 94, 1-10.
38. Henriksen EJ (2002). Invited review: Effects of acute exercise and exercise training on insulin resistance. J Appl Physiol 93, 788-796.
39. Heron M, Hoyert DL, Murphy SL, Xu J, Kochanek KD & Tejada-Vera B (2009). Deaths: Final data for 2006. National vital statistics reports; vol. 57, no. 14, pp. 1-117. National Center for Health Statistics, Hyattsville, MD.
40. Hester RL, Iliescu R, Summers R & Coleman TG (2011). Systems biology and integrative physiological modelling. J Physiol 589, 1053-1060.
41. Hillenmeyer ME, Fung E, Wildenhain J, Pierce SE, Hoon S, Lee W et al (2008). The chemical genomic portrait of yeast: uncovering a phenotype for all genes. Science 320, 362-365.
42. Ingram CJE, Mulcare CA, Itan Y, Thomas MG & Swallow DM (2009). Lactose digestion and the evolutionary genetics of lactase persistence. Hum Genet 124, 579-591.
43. James WPT (2008). The fundamental driers of the obesity epidemic. Obesity Rev 9, 6-13.
44. Joyner MJ, Charkoudian N & Wallin BG (2010). Sympathetic nervous system and blood pressure in humans. Individualized patterns of regulation and their implications. Hypertension 56, 10-16.
45. Joyner MJ, Freund BJ, Jilka SM, Hetrick GA, Martinez E, Ewy GA & Wilmore JH (1986). Effects of beta-blockade on exercise capacity of trained and untrained men: a hemodynamic comparison. J Appl Physiol 60, 1429-1434.
46. Kell DB & Oliver SG (2004). Here is the evidence, now what is the hypothesis? The complementary roles of inductive and hypothesis-driven science in the post-genomic era. BioEssays 26, 99-105.
47. Kohl P, Crampin EJ, Quinn TA & Noble D (2010). Systems biology: an approach. Clin Pharmacol Ther 88, 25-33.
48. Koscielny S (2008). Critical review of microarray-based prognostic tests and trials in breast cancer. Curr Opin Obstet Gynecol 20, 47-50.
49. Krebs JR (2009). The gourmet ape: evolution and human food preferences. Am J Clin Nutr 90, 707S-711S.
50. Krogh A (1939). The teaching of physiology. Science 89, 545-547.
51. Kyle UG & Pichard C (2006). The Dutch famine of 1944-1945: a pathophysiological model of long-term consequences of wasting disease. Curr Opin Clin Nutr Metab Care 9, 388-394.
52. Ley TJ & Rosenberg LE (2005). The physician-scientist career pipeline in 2005: build it, and they will come. JAMA 294, 1343-1351.
53. Libby P (2001). What have we learned about the biology of atherosclerosis? The role of inflammation. Am J Cardiol 88, 3J-6J.
54. Lindström J, Ilanne-Parikka P, Peltonen M, Aunola S, Eriksson JG, Hemiö K et al (2006). Sustained reduction in the incidence of type 2 diabetes by ifestyle intervention: follow-up of the Finnish Diabetes Prevention Study. Lancet 368, 1673-1679.
55. Ma P & Zemmel R (2002). Value of novelty? Nat Rev 1, 571-572.
56. Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ et al (2009). Finding the missing heritability of complex diseases. Nature 461, 747-753.
57. Marmot MG (2006). Status syndrome: a challenge to medicine. JAMA 295, 1304-1307.
58. Marmot MG & Syme SL (1976). Acculturation and coronary heart disease in Japanese-Americans. Am J Epidemiol 104, 225-247.
59. Marmot MG, Syme SL, Kagan A, Kato H, Cohen JB & Belsky J (1975). Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California: prevalence of coronary and hypertensive heart disease and associated risk factors. Am J Epidemiol 102, 514-525.
60. Mitchell GS & Babb TG (2006). Layers of exercise hyperpnea: modulation and plasticity. Respir Physiol Neurobiol 151, 251-266.
61. Murray CJL, Kulkarni SC, Michaud C, Tomijima N, Bulzaccheli MT, Iandiorio TJ & Ezzati M (2006). Eight Americas: investigating mortality disparities across races, counties, and race-counties in the United States. PLoS Med 3, e260.
62. Nelson RR, Gobel FL, Jorgensen CR, Wang K, Wang Y & Taylor HL (1974). Hemodynamic predictors of myocardial oxygen consumption during static and dynamic exercise. Circulation 50, 1179-1189.
63. NHTSA (2010). An Analysis of the Significant Decline in Motor Vehicle Traffic Fatalities in 2008. National Highway Traffic Safety Administration, Washington, DC.
64. Noble D (2007). Clade Bernard, the first systems biologist, and the future of physiology. Exp Physiol 93, 16-26.
65. Noble D (2008). Genes and causation. Phil Trans R Soc A 366, 3001-3015.
66. Nolte E, Shkolnikov V & McKee M (2000). Changing mortality patterns in East and West Germany and Poland. I: long term trends (1960-1997). J Epidemiol Community Health 54, 890-898.
67. Olsen RH, Krogh-Madsen R, Thomsen C, Booth FW & Pedersen BK (2008). Metabolic responses to reduced daily steps in healthy nonexercising men. JAMA 299, 1261-1263.
68. Ornish D, Schwerwitz LW, Billings JH, Brown SE, Gould KL, Merritt TA et al (1998). Intensive lifestyle changes for reversal of coronary heart disease. JAMA 280, 2001-2007.
69. Ouchi N, Higuchi A, Ohashi K, Oshima Y, Gokce N, Shibata R et al (2010). Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity. Science 329, 454-457.
70. Paynter NP, Chasman DI, Pare G, Buring JE, Cook NR, Miletich JP & Ridker PM (2010). Association between a literature-based genetic risk score and cardiovascular events in women. JAMA 303, 631-637.
71. Pearson H (2009). One gene, twenty years. Nature 460, 165-169.
72. Pedersen BK & Febbraio MA (2008). Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol Rev 88, 1379-1406.
73. Pedersen NL (2010). Reaching the limits of genome-wide significance in Alzheimer disease: back to the environment. JAMA 303, 1864-1865.
74. Pereira NL & Weinshilboum RM (2009). Cardiovascular pharmacogenomics and individualized drug therapy. Nat Rev Cardiol 6, 632-638.
75. Powell LM, Han E & Chaloupka FJ (2010). Economic contextual factors, food consumption, and obesity among U.S. adolescents. J Nutr 140, 1175-1180.
76. Rajagopal S, Rajagopal K & Lefkowitz RJ (2010). Teaching old receptors new tricks: biasing seven-transmembrane receptors. Nat Rev 9, 373-386.
77. Rizza RA (2010). Pathogenesis of fasting and postprandial hyperglycemia in type 2 diabetes: implications for therapy. Diabetes 59, 2697-2707.
78. Rodríguez-Ojea A, Berdasco JS & Esquível M (2002). The nutrition transition in Cuba in the nineties: an overview. Public Health Nutr 5, 129-133.
79. Rogers MA, Yamamoto C, King DS, Hagberg JM, Ehsani AA & Holloszy JO (1988). Improvement in glucose tolerance after 1 wk of exercise in patients with mild NIDDM. Diabetes Care 11, 613-618.
80. Rosenberg LE (1999). The physician-scientist: an essential-and fragile-link in the medical research chain. J Clin Invest 103, 1621-1626.
81. Schroth W, Goetz MP, Hamann U, Fasching PA, Schmidt M, Winter S et al (2009). Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen. JAMA 302, 1429-1436.
82. Seshadri S, Fitzpatrick AL, Ikram MA, DeStefano AL, Gudnason V, Boada M et al (2010). Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA 303, 1832-1840.
83. Simonson TS, Yang Y, Huff CD, Yun H, Qin G, Witherspoon DJ et al (2010). Genetic evidence for high-altitude adaptation in Tibet. Science 329, 72-75.
84. Sorensen KD & Orntoft TF (2010). Discovery of prostate cancer biomarkers by microarray gene expression profiling. Expert Rev Mol Diagn 10, 49-64.
85. Talmud PJ, Hingorani AD, Cooper JA, Marmot MG, Brunner EJ, Kumari M et al (2010). Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study. Br Med J 340, b4838.
86. + channels, nitric oxide, and adenosine are not required for local metabolic coronary vasodilation. Am J Physiol Heart Circ Physiol 280, H868-H875.
87. Van Der Vegt, de Bock GH, Hollema H & Wesseling J (2009). Microarray methods to identify factors determining breast cancer progression: potentials, limitations, and challenges. Crit Rev Oncol Hematol 70, 1-11.
88. Varki A & Rosenberg LE (2002). Emerging opportunities and career paths for the young physician-scientist. Nat Med 8, 437-439.
89. Verkman AS & Galietta LJV (2009). Chloride channels as drug targets. Nat Rev 8, 153-171.
90. Weedon MN & Frayling TM (2008). Reaching new heights: insights into the genetics of human stature. Trends Genet 24, 595-603.
91. Weinberg RA (2010). Point: Hypotheses first. Nature 464, 678.
92. Wishnow RM & Steinfeld JL (1976). The conquest of the major infectious diseases in the United States: A bicentennial retrospect. Ann Rev Microbiol 30, 427-450.
93. Yi X, Liang Y, Huerta-Sanchez E, Jin X, Cuo ZXP, Pool JE et al (2010). Sequencing of 50 human exomes reveals adaptation to high altitude. Science 329, 75-78.
94. Zhang L, Zhang W & Chen K (2010). Search for cancer risk factors with microarray-based genome-wide association studies. Technol Cancer Res Treat 9, 107-121.