Use of High-Throughput In Vitro Toxicity Screening Data in Cancer Hazard Evaluations by IARC Monograph Working Groups

Altex

Volumn 35, Issue 1, 2018, Pages 51-64

  Chiu, Weihsueh A ^a   Guyton, Kathryn Z ^b   Martin, Matthew T ^c   Reif, David M ^d   Rusyn, Ivan ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^d NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

carcinogenicity; high throughput screening; in vitro; mechanisms

Indexed keywords

CARCINOGEN;

ANIMAL; BIOASSAY; CARCINOGEN TESTING; GOVERNMENT; HIGH THROUGHPUT SCREENING; HUMAN; INTERNATIONAL COOPERATION; PROCEDURES; PUBLICATION; UNITED STATES;

ANIMALS; BIOLOGICAL ASSAY; CARCINOGENICITY TESTS; CARCINOGENS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INTERNATIONAL AGENCIES; PUBLICATIONS; UNITED STATES; UNITED STATES ENVIRONMENTAL PROTECTION AGENCY;

EID: 85045209260     PISSN: 1868596X     EISSN: 18688551     Source Type: Journal    
DOI: 10.14573/altex.1703231     Document Type: Article

References (47)

1. Ahrens, L. and Bundschuh, M. (2014). Fate and effects of poly- and perfluoroalkyl substances in the aquatic environment: A review. Environ Toxicol Chem 33, 1921-1929. doi:10.1002/ etc.2663
2. Attene-Ramos, M. S., Miller, N., Huang, R. et al. (2013). The Tox21 robotic platform for the assessment of environmental chemicals – From vision to reality. Drug Discov Today 18, 716-723. doi:10.1016/j.drudis.2013.05.015
3. Auerbach, S., Filer, D., Reif, D. et al. (2016). Prioritizing environmental chemicals for obesity and diabetes outcomes research: A screening approach using toxcast high throughput data. Environ Health Perspect 124, 1141-1154. doi:10.1289/ehp.1510456
4. Benbrahim-Tallaa, L., Lauby-Secretan, B., Loomis, D. et al. (2014). Carcinogenicity of perfluorooctanoic acid, tetrafluoro-ethylene, dichloromethane, 1,2-dichloropropane, and 1,3-pro-pane sultone. Lancet Oncol 15, 924-925. doi:10.1016/S1470-2045(14)70316-X
5. Biegel, L. B., Liu, R. C., Hurtt, M. E. et al. (1995). Effects of ammonium perfluorooctanoate on Leydig cell function: In vitro, in vivo, and ex vivo studies. Toxicol Appl Pharmacol 134, 18-25. doi:10.1006/taap.1995.1164
6. Brouwer, M., Schinasi, L., Beane Freeman, L. E. et al. (2016). Assessment of occupational exposure to pesticides in a pooled analysis of agricultural cohorts within the AGRICOH consortium. Occup Environ Med 73, 359-367. doi:10.1136/ oemed-2015-103319
7. Butenhoff, J., Costa, G., Elcombe, C. et al. (2002). Toxicity of ammonium perfluorooctanoate in male cynomolgus monkeys after oral dosing for 6 months. Toxicol Sci 69, 244-257. doi:10.1093/ toxsci/69.1.244
8. Chappell, G., Pogribny, I. P., Guyton, K. Z. et al. (2016). Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: A systematic literature review. Mutat Res Rev Mutat Res 768, 27-45. doi:10.1016/j. mrrev.2016.03.004
9. Collins, F. S., Gray, G. M. and Bucher, J. R. (2008). Toxicology. Transforming environmental health protection. Science 319, 906-907. doi:10.1126/science.1154619
10. Corton, J. C., Cunningham, M. L., Hummer, B. T. et al. (2014). Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARalpha) as a case study. Crit Rev Toxicol 44, 1-49. doi:10. 3109/10408444.2013.835784
11. Elcombe, C. R., Elcombe, B. M., Foster, J. R. et al. (2010). Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPARalpha and CAR/PXR. Arch Toxicol 84, 787-798. doi:10.1007/s00204-010-0572-2
12. Filer, D., Patisaul, H. B., Schug, T. et al. (2014). Test driving ToxCast: Endocrine profiling for 1858 chemicals included in phase II. Curr Opin Pharmacol 19, 145-152. doi:10.1016/j. coph.2014.09.021
13. Filgo, A. J., Quist, E. M., Hoenerhoff, M. J. et al. (2015). Perfluorooctanoic acid (PFOA)-induced liver lesions in two strains of mice following developmental exposures: PPARalpha is not required. Toxicol Pathol 43, 558-568. doi:10.1177/0192623314558463
14. Gallo, V., Leonardi, G., Genser, B. et al. (2012). Serum perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) concentrations and liver function biomarkers in a population with elevated PFOA exposure. Environ Health Perspect 120, 655-660. doi:10.1289/ehp.1104436
15. Grimm, F. A., Iwata, Y., Sirenko, O. et al. (2016). A chemical-biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives. Green Chem 18, 4407-4419. doi:10.1039/C6GC01147K
16. Grosse, Y., Loomis, D., Guyton, K. Z. et al. (2016). Carcinogenicity of some industrial chemicals. Lancet Oncol 17, 419-420. doi:10.1016/s1470-2045(16)00137-6
17. Guyton, K. Z., Loomis, D., Grosse, Y. et al. (2015). Carcinogenicity of tetrachlorvinphos, parathion, malathion, diazinon, and glyphosate. Lancet Oncol 16, 490-491. doi:10.1016/S1470-2045(15)70134-8
18. Guyton, K. Z., Loomis, D., Grosse, Y. et al. (2016). Carcinogenicity of pentachlorophenol and some related compounds. Lancet Oncol 17, 1637-1638. doi:10.1016/s1470-2045(16)30513-7
19. IARC Monograph Working Group (2006). IARC monographs on the evaluation of carcinogenic risks to humans: Preamble. World Health Organization. http://monographs.iarc.fr/ENG/Preamble/CurrentPreamble.pdf
20. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2008). IARC monographs on the evaluation of carcinogenic risks to humans. 1,3-butadiene, ethylene oxide and vinyl halides (vinyl fluoride, vinyl chloride and vinyl bromide). IARC Monogr Eval Carcinog Risks Hum 97, 3-471.
21. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2016a). IARC monographs on the evaluation of carcinogenic risks to humans. Perfluorooctanoic acid, tetrafluoroethylene, dichloromethane, 1,2-dichloropropane, and 1,3-propane sultone. IARC Monogr Eval Carcinog Risks Hum 110, 1-74.
22. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2016b). IARC monographs on the evaluation of carcinogenic risks to humans. 2,4-dichlorophenoxyacetic acid (2,4-D) and some organochlorine insecticides. IARC Monogr Eval Carcinog Risks Hum 113, in press.
23. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2017). IARC monographs on the evaluation of carcinogenic risks to humans. Some organophosphate insecticides and herbicides. IARC Monogr Eval Carcinog Risks Hum 112, in press.
24. Judson, R. S., Martin, M. T., Reif, D. M. et al. (2010). Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity. Environ Sci Technol 44, 5979-5985. doi:10.1021/es102150z
25. Judson, R., Houck, K., Martin, M. et al. (2016). Editor’s highlight: Analysis of the effects of cell stress and cytotoxicity on in vitro assay activity across a diverse chemical and assay space. Toxicol Sci 152, 323-339. doi:10.1093/toxsci/kfw092
26. Klaunig, J. E., Babich, M. A., Baetcke, K. P. et al. (2003). PPARalpha agonist-induced rodent tumors: Modes of action and human relevance. Crit Rev Toxicol 33, 655-780. doi:10.1080/713608372
27. Klaunig, J. E., Hocevar, B. A. and Kamendulis, L. M. (2012). Mode of action analysis of perfluorooctanoic acid (PFOA) tumorigenicity and human relevance. Reprod Toxicol 33, 410-418. doi:10.1016/j.reprotox.2011.10.014
28. Lauby-Secretan, B., Loomis, D., Baan, R. et al. (2016). Use of mechanistic data in the IARC evaluations of the carcinogenicity of polychlorinated biphenyls and related compounds. Environ Sci Pollut Res Int 23, 2220-2229. doi:10.1007/s11356-015-4829-4
29. Loomis, D., Guyton, K., Grosse, Y. et al. (2015). Carcinogenicity of lindane, DDT, and 2,4-dichlorophenoxyacetic acid. Lancet Oncol 16, 891-892. doi:10.1016/S1470-2045(15)00081-9
30. Loomis, D., Guyton, K. Z., Grosse, Y. et al. (2016). Carcinogenicity of drinking coffee, mate, and very hot beverages. Lancet Oncol 17, 877-878. doi:10.1016/s1470-2045(16)30239-x
31. Martin, M. T., Dix, D. J., Judson, R. S. et al. (2010). Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA’s ToxCast program. Chem Res Toxicol 23, 578-590. doi:10.1021/tx900325g
32. Pearce, N. E., Blair, A., Vineis, P. et al. (2015). IARC monographs: 40 years of evaluating carcinogenic hazards to humans. Environ Health Perspect 123, 507-514. doi:10.1289/ehp.1409149
33. Perez, F., Nadal, M., Navarro-Ortega, A. et al. (2013). Accumulation of perfluoroalkyl substances in human tissues. Environ Int 59, 354-362. doi:10.1016/j.envint.2013.06.004
34. Pham, N., Iyer, S., Hackett, E. et al. (2016). Using ToxCast to explore chemical activities and hazard traits: A case study with ortho-phthalates. Toxicol Sci 151, 286-301. doi:10.1093/toxsci/ kfw049
35. Rager, J. E., Strynar, M. J., Liang, S. et al. (2016). Linking high resolution mass spectrometry data with exposure and toxicity forecasts to advance high-throughput environmental monitoring. Environ Int 88, 269-280. doi:10.1016/j.envint.2015.12.008
36. Reif, D. M., Martin, M. T., Tan, S. W. et al. (2010). Endocrine profiling and prioritization of environmental chemicals using ToxCast data. Environ Health Perspect 118, 1714-1720. doi:10.1289/ehp.1002180
37. Reif, D. M., Sypa, M., Lock, E. F. et al. (2013). ToxPi GUI: An interactive visualization tool for transparent integration of data from diverse sources of evidence. Bioinformatics 29, 402-403. doi:10.1093/bioinformatics/bts686
38. st century toxicology. Chem Res Toxicol 29, 1225-51. doi:10.1021/acs.chemrestox. 6b00135
39. Rosen, M. B., Schmid, J. R., Corton, J. C. et al. (2010). Gene expression profiling in wild-type and PPARalpha-Null mice exposed to perfluorooctane sulfonate reveals PPARalpha-independent effects. PPAR Res 2010. doi:10.1155/2010/794739
40. Sipes, N. S., Martin, M. T., Kothiya, P. et al. (2013). Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays. Chem Res Toxicol 26, 878-895. doi:10.1021/tx400021f
41. Sirenko, O., Cromwell, E. F., Crittenden, C. et al. (2013). Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity. Toxicol Appl Pharmacol 273, 500-507. doi:10.1016/j. taap.2013.09.017
42. Smith, M. T., Guyton, K. Z., Gibbons, C. F. et al. (2016). Key characteristics of carcinogens as a basis for organizing data on mechanisms of carcinogenesis. Environ Health Perspect 124, 713-721. doi:10.1289/ehp.1509912
43. Straif, K., Loomis, D., Guyton, K. et al. (2014). Future priorities for the IARC monographs. Lancet Oncol 15, 683-684. doi:10.1016/S1470-2045(14)70168-8
44. Tice, R. R., Austin, C. P., Kavlock, R. J. et al. (2013). Improving the human hazard characterization of chemicals: A Tox21 update. Environ Health Perspect 121, 756-765. doi:10.1289/ ehp.1205784
45. Yan, S., Wang, J. and Dai, J. (2015). Activation of sterol regulatory element-binding proteins in mice exposed to perfluorooctanoic acid for 28 days. Arch Toxicol 89, 1569-1578. doi:10.1007/ s00204-014-1322-7
46. Zhao, B., Hu, G. X., Chu, Y. et al. (2010a). Inhibition of human and rat 3beta-hydroxysteroid dehydrogenase and 17beta-hy-droxysteroid dehydrogenase 3 activities by perfluoroalkylated substances. Chem Biol Interact 188, 38-43. doi:10.1016/j. cbi.2010.07.001
47. Zhao, Y., Tan, Y. S., Haslam, S. Z. et al. (2010b). Perfluorooctanoic acid effects on steroid hormone and growth factor levels mediate stimulation of peripubertal mammary gland development in C57BL/6 mice. Toxicol Sci 115, 214-224. doi:10.1093/ toxsci/kfq030