A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens

Archives of Toxicology

Volumn 89, Issue 12, 2015, Pages 2413-2427

  Schaap, Mirjam M ^a,b   Wackers, Paul F K ^a,c,d   Zwart, Edwin P ^a   Huijskens, Ilse ^e   Jonker, Martijs J ^c,f   Hendriks, Giel ^b   Breit, Timo M ^c,f   van Steeg, Harry ^a,b   van de Water, Bob ^e   Luijten, Mirjam ^a,b  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d ERASMUS MEDICAL CENTER   (Netherlands)

^e LEIDEN UNIVERSITY   (Netherlands)

^f NETHERLANDS BIOINFORMATICS CENTRE   (Netherlands)

Author keywords

Comparison approach; Gene expression profiles; Mode of action; Mouse embryonic stem cells; Non genotoxic carcinogens; Primary mouse hepatocytes; Safety assessment of chemicals

Indexed keywords

1,1,1 TRICHLOROETHANE; 1,4 BIS(3,5 DICHLORO 2 PYRIDYLOXY)BENZENE; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 4,4' ISOPROPYLIDENEDIPHENOL; AROCLOR 1254; ARSENITE SODIUM; BETA HEXACHLOROCYCLOHEXANE; BIS(TRIBUTYLTIN) OXIDE; CALYCULIN A; CARBON TETRACHLORIDE; CARCINOGEN; CISPLATIN; CLOFIBRATE; CYCLOSPORIN A; DIISODECYL PHTHALATE; ETOPOSIDE; HEPTACHLOR EPOXIDE; LEAD ACETATE; MALEIC ACID DIETHYL ESTER; MANNITOL; MENADIONE; METHYLNITROSOUREA; MITOMYCIN; NON GENOTOXIC CARCINOGEN; OKADAIC ACID; PHENOBARBITAL; TACROLIMUS; UNCLASSIFIED DRUG; WYETH 14643; MUTAGENIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARCINOGENICITY; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; EMBRYONIC STEM CELL; GENE EXPRESSION PROFILING; GENOMICS; GENOTOXICITY; IN VITRO STUDY; LIVER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TOXICOGENOMICS; TOXICOLOGY; UPREGULATION; ANIMAL; C57BL MOUSE; DRUG EFFECTS; PATHOLOGY; PROCEDURES; TOXICOGENETICS;

ANIMALS; CARCINOGENS; DOWN-REGULATION; EMBRYONIC STEM CELLS; GENE EXPRESSION PROFILING; HEPATOCYTES; MALE; MICE; MICE, INBRED C57BL; MUTAGENS; TOXICOGENETICS; UP-REGULATION;

EID: 84949293901     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1368-6     Document Type: Article

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