Are tumor incidence rates from chronic bioassays telling us what we need to know about carcinogens?

Regulatory Toxicology and Pharmacology

Volumn 41, Issue 2, 2005, Pages 128-133

  Gaylor, David W ^a  

^a Gaylor and Associates LLC   (United States)

Author keywords

Benchmark dose; Bioassay; Cancer risk assessment; Cytotoxicity; Maximum tolerated dose; Regenerative cell replication

Indexed keywords

CARCINOGEN; CYTOTOXIN;

ANIMAL MODEL; ARTICLE; BIOASSAY; CANCER CENTER; CANCER INCIDENCE; CANCER RISK; CARCINOGENICITY; CELL DIVISION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; FEMALE; GENOTOXICITY; LABORATORY DIAGNOSIS; MALE; MAXIMUM TOLERATED DOSE; METHODOLOGY; MOUSE; MUTAGENIC ACTIVITY; NONHUMAN; PRIORITY JOURNAL; RAT; RISK ASSESSMENT; SAMPLE SIZE; SCREENING; SENSITIVITY ANALYSIS; STATISTICAL SIGNIFICANCE; WEIGHT GAIN;

ANIMALS; BENCHMARKING; CARCINOGENICITY TESTS; CARCINOGENS; DOSE-RESPONSE RELATIONSHIP, DRUG; FALSE NEGATIVE REACTIONS; FEMALE; MALE; MICE; NEOPLASMS; PREDICTIVE VALUE OF TESTS; RATS; RISK ASSESSMENT; XENOBIOTICS;

ANIMALIA; RODENTIA;

EID: 13244286533     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yrtph.2004.11.001     Document Type: Article

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