Inter-laboratory study of human in vitro toxicogenomics-based tests as alternative methods for evaluating chemical carcinogenicity: a bioinformatics perspective

Archives of Toxicology

Volumn 90, Issue 9, 2016, Pages 2215-2229

  Herwig, R ^a   Gmuender, H ^b   Corvi, R ^c   Bloch, K M ^d   Brandenburg, A ^b   Castell, J ^e   Ceelen, L ^f   Chesne, C ^g   Doktorova, T Y ^f   Jennen, D ^h   Jennings, P ⁱ   Limonciel, A ⁱ   Lock, E A ^d   McMorrow, T ^j   Phrakonkham, P ^c   Radford, R ^j   Slattery, C ^j   Stierum, R ^k   Vilardell, M ^a   Wittenberger, T ^b   Yildirimman, R ^a   Ryan, M ^j   Rogiers, V ^f   Kleinjans, J ^h   more..

^a MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^b GENEDATA AG   (Switzerland)

^c JOINT RESEARCH CENTRE   (Italy)

^d LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^e UNIVERSITY OF VALENCIA   (Spain)

^f VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^g Société Biopredic International   (France)

^h MAASTRICHT UNIVERSITY   (Netherlands)

ⁱ INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^j UNIVERSITY COLLEGE DUBLIN   (Ireland)

^k TNO   (Netherlands)

more..

Author keywords

Bioinformatics; Carcinogenicity; In vitro assays; Inter laboratory assessment; Pre validation; Toxicogenomics

Indexed keywords

DIMETHYL SULFOXIDE; TRANSCRIPTOME; CARCINOGEN;

ARTICLE; BIOINFORMATICS; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; CYTOTOXICITY; EPITHELIUM CELL; GENE EXPRESSION; GENOMICS; HUMAN; HUMAN CELL; IN VITRO STUDY; KIDNEY; KIDNEY CELL; KIDNEY PROXIMAL TUBULE; LABORATORY; LIVER; MTT ASSAY; PRIORITY JOURNAL; REPRODUCIBILITY; TOXICOGENOMICS; WORKFLOW; BIOLOGY; CLASSIFICATION; CLINICAL TRIAL; COMPARATIVE STUDY; DNA MICROARRAY; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENOME-WIDE ASSOCIATION STUDY; GOOD LABORATORY PRACTICE; METABOLISM; MULTICENTER STUDY; OBSERVER VARIATION; PROCEDURES; RISK ASSESSMENT; TIME FACTOR; TOXICOGENETICS; TUMOR CELL LINE;

CARCINOGENS; CELL LINE, TUMOR; COMPUTATIONAL BIOLOGY; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; KIDNEY TUBULES, PROXIMAL; LABORATORY PROFICIENCY TESTING; LIVER; OBSERVER VARIATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; TIME FACTORS; TOXICOGENETICS; TRANSCRIPTOME; WORKFLOW;

EID: 84946114411     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-015-1617-3     Document Type: Article

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