Erratum: Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens I. Sensitivity, specificity and relative predictivity (Mutation Research - Genetic Toxicology and Environmental Mutagenesis (2005) 584 (1-256) DOI: 10.1016/j.mrgentox.2005.02.004);Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens: I. Sensitivity, specificity and relative predictivity

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 584, Issue 1-2, 2005, Pages 1-256

  Kirkland, David ^a   Aardema, Marilyn ^b   Henderson, Leigh ^c,e   Müller, Lutz ^d  

^a UK   (United Kingdom)

^b PROCTER AND GAMBLE COMPANY   (United States)

^c Henderson Scientific Consultancy   (United Kingdom)

^d F HOFFMANN LA ROCHE LTD   (Switzerland)

^e FSANZ   (New Zealand)

Author keywords

Carcinogenicity; Genotoxicity; In vitro tests; Prediction

Indexed keywords

ACETONITRILE DERIVATIVE; AMITROLE; AMPICILLIN; ANTHRAQUINONE; BENZOIN; CAPROLACTAM; CARBAMIC ACID METHYL ESTER; CARCINOGEN; CYCLOHEXANONE; DIETHANOLAMINE; DIOXANE; DIPHENYLNITROSAMINE; ERYTHROMYCIN STEARATE; ETHIONINE; ETODOLAC; MELAMINE; N,N DIMETHYLFORMAMIDE; NITRILOTRIACETIC ACID; PEROXISOME PROLIFERATOR; PROGESTERONE; PYRIDINE; PYRIMETHAMINE; RESERPINE; SUCCINIC ANHYDRIDE; TERT BUTYL ALCOHOL; TETRACHLOROETHANE; TITANIUM DIOXIDE; TOLBUTAMIDE; TOLUIDINE DERIVATIVE; XYLENE;

AMES TEST; ARTICLE; CARCINOGENIC ACTIVITY; CARCINOGENICITY; CHROMOSOME ABERRATION; DATA BASE; GENE EXPRESSION; GENETIC TRAIT; GENOTOXICITY; HUMAN; MICRONUCLEUS TEST; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY;

ANIMALIA; MAMMALIA; RODENTIA;

EID: 21544473568     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2005.10.002     Document Type: Erratum

References (200)

1. R.W. Tennant, B.H. Margolin, M.D. Shelby, E. Zeiger, J.K. Haseman, J. Spalding, W. Caspary, M. Resnick, S. Stasiewicz, B. Anderson, R. Minor, Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays, Science 236 (1987) 933-941.
2. E. Zeiger, J.K. Haseman, M.D. Shelby, B.H. Margolin, R.W. Tennant, Evaluation of four in vitro genetic toxicity tests for predicting rodent carcinogenicity: confirmation of earlier results with 41 additional chemicals, Environ. Mol. Mutagen. 16 (suppl. 18) (1990) 1-14.
3. J.K. Haseman, E. Zeiger, M. Shelby, B. Margolin, R. Tennant, Predicting rodent carcinogenicity from four in vitro genetic toxicity assays: an evaluation of 114 chemicals studied by the National Toxicology Program, J. Am. Stat. Assoc. 85 (1990) 964-971.
4. E. Zeiger, Identification of rodent carcinogens and noncarcinogens using genetic toxicity tests: premises, promises and performance, Regul. Toxicol. Pharm. 28 (1998) 85-95.
5. G. Brambilla, A. Martelli, Failure of the standard battery of short-term tests in detecting some rodent and human genotoxic carcinogens, Toxicology 196 (2003) 1-19.
6. L. Müller, Y. Kikuchi, G. Probst, L. Schechtman, H. Shimada, T. Sofuni, D. Tweats, ICH-harmonised guidances on genotoxicity testing of pharmaceuticals: evolution, reasoning and impact, Mutat. Res. 436 (1999) 195-225.
7. M. Kirsch-Volders, T. Sofuni, M. Aardema, S. Albertini, D. Eastmond, M. Fenech, M. Ishidate Jr., S. Kirchner, E. Lorge, T. Morita, H. Norppa, J. Surrallés, A. Vanhauwaert, A. Wakata, Report from the in vitro micronucleus assay working group, Mutat. Res. 540 (2003) 153-163.
8. OECD, Guidelines for the Testing of Chemicals: Genotoxicity, Organisation for Economic Cooperation and Development, Paris, Revised and new guidelines adopted 1997.
9. L.S. Gold, The carcinogenic potency project. http://potency.berkeley.edu/ cpdb.html, 2004.
10. S. Nesnow, M. Argus, H. Bergman, K. Chu, C. Frith, T. Helmes, R. McGaughy, V. Ray, T.J. Slaga, R. Tennant, E. Weisburger, Chemical carcinogens. A review and analysis of the literature of selected chemicals and the establishment of the Gene-Tox Carcinogen Data Base. A report of the U.S. Environmental Protection Agency Gene-Tox Program, Mutat. Res. 185 (1986) 1-195.
11. J.K. Haseman, A.-M. Clark, Carcinogenicity results for 114 laboratory animal studies used to assess the predictivity of four in vitro genetic toxicity assays for rodent carcinogenicity, Environ. Mol. Mutagen. 16 (suppl. 18) (1990) 15-31.
12. PDR, Physician's Desk Reference, 55 ed., Medical Economics Co. Inc., Montvale, New Jersey, USA, 2001.
13. E. Zeiger, Genotoxicity database, in: L.S. Gold, E. Zeiger (Eds.), Handbook of Carcinogenic Potency and Genotoxicity Databases, CRC Press Inc., Boca Raton, 1997, pp. 687-729.
14. L.S. Gold, T.H. Slone, B.R. Stern, L. Bernstein, Comparison of target organs of carcinogenicity for mutagenic and nonmutagenic chemicals, Mutat. Res. 286 (1993) 75-100.
15. NTP, NTP website at http://ntp-server.niehs.nih.gov.
16. L.D. Kier, D.J. Brusick, A.E. Auletta, E.S. Von Halle, M.M. Brown, V.F. Simmon, V. Dunkel, J. McCann, K. Mortelmans, M. Prival, T.K. Rao, V. Ray, The Salmonella typhimurium/mammalian microsomal assay. A report of the U.S. Environmental Protection Agency Gene-Tox Program, Mutat. Res. 168 (1986) 69-240.
17. D.J. Brusick, Implications for treatment-condition-induced genotoxicity for chemical screening and data interpretation, Mutat. Res. 189 (1987) 1-6.
18. +/- cells, Mutat. Res. 189 (1987) 39-46.
19. S.M. Galloway, D.A. Deasy, C.L. Bean, A.R. Kraynak, M.J. Armstrong, M.O. Bradley, Effects of high osmotic strength on chromosome aberrations, sister-chromatid exchanges and DNA strand breaks, and the relation to toxicity, Mutat. Res. 189 (1987) 15-25.
20. +/- mouse lymphoma specific gene and chromosomal mutation assay. Aphase III report of the U.S. Environmental Protection Agency Gene-Tox Program, Mutat. Res. 394 (1997) 177-303.
21. T. Matsushima, M. Hayashi, A. Matsuoka, M. Ishidate Jr., K.F. Miura, H. Shimizu, Y. Suzuki, K. Morimoto, H. Ogura, K. Mure, K. Koshi, T. Sofuni, Validation of the in vitro micronucleus test in a Chinese hamster lung cell line (CHL/IU), Mutagenesis 14 (1999) 569-580.
22. B. Miller, F. Pötter-Locher, A. Seelbach, H. Stopper, D. Utesch, S. Madle, Evaluation of the in vitro micronucleus test as an alternative to the in vitro chromosomal aberration assay: position of the GUM working group on the in vitro micronucleus test, Mutat. Res. 410 (1998) 81-116.
23. K. Müller-Tegethoff, B. Kersten, P. Kasper, L. Müller, Application of the in vitro rat hepatocyte micronucleus assay in genetic toxicology testing, Mutat. Res. 392 (1997) 125-138.
24. E. Lorge, V. Thybaud, M. Aardema, J. Oliver, A. Wakata, G. Lorenzon, D. Marzin, SFTG International Collaborative Study on the In Vitro Micronucleus Test. I. General conditions and overall conclusions of the study. Mutat. Res., in press.
25. M. Ishidate Jr., M. Harnois, T. Sofuni, A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures, Mutat. Res. 195 (1988) 151-213.
26. S.M. Galloway, M.J. Armstrong, C. Reuben, S. Colman, B. Brown, C. Cannon, A.D. Bloom, F. Nakamura, M. Ahmed, S. Duk, J. Rimpo, B.H. Margolin, M.A. Resnick, B. Anderson, E. Zeiger, Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals, Environ. Mol. Mutagen. 10 (suppl. 10) (1987) 1-175.
27. K.S. Loveday, M.H. Lugo, M.A. Resnick, B.E. Anderson, E. Zeiger, Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro: II. Results with 20 chemicals, Environ. Mol. Mutagen. 13 (1989) 60-94.
28. K.S. Loveday, B.E. Anderson, M.A. Resnick, E. Zeiger, Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. V: results with 46 chemicals, Environ. Mol. Mutagen. 16 (1990) 272-303.
29. B.E. Anderson, E. Zeiger, M.D. Shelby, M.A. Resnick, D.K. Gulati, J.L. Ivett, K.S. Loveday, Chromosome aberration and sister chromatid exchange test results with 42 chemicals, Environ. Mol. Mutagen. 16 (suppl. 18) (1990) 55-137.
30. D.J. Kirkland, L. Müller, Interpretation of the biological relevance of genotoxicity test results: the importance of thresholds, Mutat. Res. 464 (2000) 137-147.
31. L. Müller, P. Kasper, Human biological relevance and the use of threshold-arguments in regulatory genotoxicity assessment: experience with pharmaceuticals, Mutat. Res. 464 (2000) 19-34.
32. C.A. Hilliard, M.J. Armstrong, C.I. Bradt, R.B. Hill, S.K. Greenwood, S.M. Galloway, Chromosome aberrations in vitro related to cytotoxicity of nonmutagenic chemicals and metabolic poisons, Environ. Mol. Mutagen. 31 (1998) 316-326.
33. COM, Guidance on a strategy for testing of chemicals for mutagenicity. Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment (COM), UK Department of Health, December 2000, www.advisorybodies. doh.gov.uk/com/.
34. B. Silva Lima, J.W. Van der Laan, Mechanisms of nongenotoxic carcinogenesis and assessment of the human hazard, Regul. Toxicol. Pharm. 32 (2000) 135-143.
35. R.S. Krauss, T.E. Eling, Macromolecular binding of the thyroid carcinogens 3-amino-1,2,4-triazole (amitrole) catalyzed by prostaglandin H synthase, lactoperoxidase and thyroid peroxidase, Carcinogenesis 8 (1987) 659-664.
36. J.D. Cirvello, A. Radovsky, J.E. Heath, D.R. Farnell, C. Lindamood, Toxicity and carcinogenicity of t-butyl alcohol in rats and mice following chronic exposure in drinking water, Toxicol. Ind. Health 11 (1995) 151-165.
37. California EPA, Evidence on the carcinogenicity of 5-chloroo-toluidine and its strong acid salts. Reproductive and Cancer Hazard Assessment Section, Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, 1997.
38. M. Miyagawa, H. Takasawa, A. Sugiyama, Y. Inoue, T. Murata, Y. Uno, K. Yoshikawa, The in vivo-in vitro replicative DNA synthesis (RDS) test with hepatocytes prepared from male B6C3F1 mice as an early prediction assay for putative nongenotoxic (Ames-negative) mouse hepatocarcinogens, Mutat. Res. 343 (1995) 157-183.
39. J.E. Huff, S.L. Eustis, J.K. Haseman, Occurrence and relevance of chemically induced benign neoplasms in longterm carcinogenicity studies, Cancer Metastasis Rev. 8 (1989) 1-22.
40. L.D. Lehman-McKeeman, E.A. Gamsky, S.M. Hicks, J.D. Vassallo, M.-H. Mar, S.H. Zeisel, Diethanolamine induces hepatic choline deficiency in mice, Toxicol. Sci. 67 (2002) 38-45.
41. P.M. Newberne, Choline deficiency associated with diethanolamine carcinogenicity, Toxicol. Sci. 67 (2002) 1-3.
42. M.A. Jackson, H.F. Stack, M.D. Waters, The genetic toxicology of putative nongenotoxic carcinogens, Mutat. Res. 296 (1993) 241-277.
43. J.A. Stickney, S.L. Sager, J.R. Clarkson, L.A. Smith, B.J. Locey, M.J. Bock, R. Hartung, S.F. Olp, An updated evaluation of the carcinogenic potential of 1,4-dioxane, Regul. Toxicol. Pharm. 38 (2003) 183-195.
44. Y. Uno, H. Takasawa, M. Miyagawa, Y. Inoue, T. Murata, K. Yoshikawa, An in vivo-in vitro replicative DNA synthesis (RDS) test using rat hepatocytes as an early prediction assay for nongenotoxic hepatocarcinogens: screening of 22 known positives and 25 noncarcinogens, Mutat. Res. 320 (1994) 189-205.
45. H.J. Hacker, P. Steinberg, I. Toshkov, F. Oesch, P. Bannasch, Persistence of the cholangiocellular and hepatocellular lesions observed in rats fed a choline-deficient/dl-ethioninesupplemented diet, Carcinogenesis 13 (1992) 271-276.
46. Y.M. Ioannou, J.M. Sanders, H.B. Matthews, Methyl carbamate. Species-dependent variations in metabolism and clearance in rats and mice, Drug Metab. Dispos. 16 (1988) 435-440.
47. F.P. Guengerich, D.H. Kim, Enzymatic oxidation of ethyl carbamate to vinyl carbamate and its role as an intermediate in the formation of 1,N6-ethenoadenosine, Chem. Res. Toxicol. 4 (1991) 413-421.
48. K-K. Park, A. Liem, B.C. Stewart, J.A. Miller, Vinyl carbamate epoxide, a major strong electrophilic, mutagenic and carcinogenic metabolite of vinyl carbamate and ethyl carbamate (urethane), Carcinogenesis 14 (1993) 441-450.
49. K-K. Park, Y-J. Surgh, J.A. Miller, Chemoprotective properties of chlorophyllin against vinyl carbamate, p-nitrophenyl vinyl ether and their electrophilic epoxides, Cancer Lett. 94 (1995) 33-40.
50. D. McGregor, The genetic toxicology of Nnitrosodiphenylamine, Mutat. Res. 317 (1994) 195-211.
51. I.F.H. Purchase, D.B. Clayson, R. Preussman, L. Tomatis, Activity of 42 compounds in animal carcinogenicity studies, in: F.J. de Serres, J. Ashby (Eds.), Progress in Mutation Research, vol. 1, Elsevier, North Holland, New York-Amsterdam-Oxford, 1981, pp. 21-32.
52. +/- and Tg·AC to agents tested in conventional carcinogenicity bioassays, Toxicol. Sci. 53 (2000) 213-223.
53. J.C. O'Connor, J.C. Cook, S.C. Craven, C.S. Van Pelt, J.D. Obourn, An in vivo battery for identifying endocrine modulators that are estrogenic or dopamine regulators, Fund. Appl. Toxicol. 33 (1996) 182-195.
54. D.B. Carlson, G.H. Perdew, A dynamic role for the Ah receptor in cell signalling? Insights from a divers group of Ah receptor interacting proteins, J. Biochem. Mol. Toxicol. 16 (2002) 317-325.
55. A.M. Tritscher, G.C. Clark, G.W. Lucier, Dose-response effects of dioxins. Species comparison and implication for risk assessment, in: A. Schechter (Ed.), Dioxins and Health, Plenum Press, New York, 1994, pp. 227-247.
56. A. Colacci, S. Grilli, G. Lattanzi, G. Prodi, M.P. Turina, G.C. Forti, M. Mazzullo, The covalent binding of 1,1,2,2-tetrachloroethane to macromolecules of rat and mouse organs, Terato. Carcino. Mutagen. 7 (1987) 465-474.
57. P.J. Borm, R.P. Schins, C. Albrecht, Inhaled particles and lung cancer, part B: paradigms and risk assessment, Int. J. Cancer 110 (2004) 3-14.
58. J.M. Parry, E.M. Parry, R. Bourner, A. Doherty, S. Ellard, J. O'Donovan, B. Hoebee, J.M. de Stoppelaar, G.R. Mohn, A. Önfelt, A. Renglin, N. Schultz, C. Söderpalm-Berndes, K.G. Jensen, M. Kirsch-Volders, A. Elhajouji, P. Van Hummelen, F. Degrassi, A. Antoccia, D. Cimini, M. Izzo, C. Tanzarella, I.-D. Adler, U. Kliesch, G. Schriever-Schwemmer, P. Gasser, R. Crebelli, A. Carere, C. Andreoli, R. Benigni, P. Leopardi, F. Marcon, Z. Zinjo, A.T. Natarajan, J.J.W.A. Boei, A. Kappas, G. Voutsinas, F.E. Zarani, A. Patrinelli, F. Pachierotti, C. Tiveron, P. Hess, The detection and evaluation of aneugenic chemicals, Mutat. Res. 353 (1996) 11-46.
59. R. Canonero, G.B. Campart, F. Mattioli, L. Robbiano, A. Martelli, Testing of p-dichlorobenzene and hexachlorobenzene for their ability to induce DNA damage and micronucleus formation in primary cultures of rat and human hepatocytes, Mutagenesis 12 (1997) 35-39.
60. F. Nesslany, D. Marzin, A micromethod for the in vitro micronucleus assay, Mutagenesis 14 (1999) 403-410.
61. M. Sasaki, K. Sugimura, M.A. Yoshida, S. Abe, Cytogenetic effects of 60 chemicals on cultured human and Chinese hamster cells, Senshokuta (Kromosoma) 20 (1980) 574-584.
62. M.L. Garriott, J.B. Phelps, W.P. Hoffman, A protocol for the in vitro micronucleus test. I. Contributions to the development of a protocol suitable for regulatory submissions from an examination of 16 chemicals with different mechanisms of action and different levels of activity, Mutat. Res. 517 (2002) 123-134.
63. C. Crofton-Sleigh, A. Doherty, S. Ellard, E.M. Parry, S. Venitt, Micronucleus assays using cytochalasin-blocked MCL-5 cells, a proprietary human cell line expressing five human cytochromes P-450 and microsomal epoxide hydrolase, Mutagenesis 8 (1993) 363-372.
64. A. Brams, C. de Meester, Mutagenic potency of heterocyclic amines towards Salmonella typhimurium; possible causes of variability in the results observed, Mutat. Res. 280 (1992) 103-107.
65. H.-U. Aeschbacher, R.J. Turesky, Mammalian cell mutagenicity and metabolism of heterocyclic aromatic amines, Mutat. Res. 259 (1991) 235-250.
66. S. Knasmüller, C.E. Schwab, S.J. Land, C.Y. Wang, R. Sanyal, M. Kundi, P. Parzefall, F. Darroudi, Genotoxic effects of heterocyclic amines in human derived hepatoma (HepG2) cells, Mutagenesis 14 (1999) 533-539.
67. M.A. Malfatti, N.H. Shen, R.W. Wu, K.W. Turteltaub, J.S. Felton, A correlation of Salmonella mutagenicity with DNA adducts induced by the cooked-food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, Mutagenesis 10 (1995) 425-431.
68. M. Ishidate Jr., S. Odashima, Chromosome tests with 134 compounds on Chinese hamster cells in vitro-a screening test for chemical carcinogens, Mutat. Res. 48 (1977) 337-354.
69. G. Robisch, O. Schimmer, W. Göggelmann, Aristolochic acid is a direct mutagen in Salmonella typhimurium, Mutat. Res. 105 (1982) 201-204.
70. U. Mengs, W. Lang, J.-A. Poch, The carcinogenic action of aristolochic acid in rats, Arch. Toxicol. 51 (1982) 107-119.
71. K. Athanasiou, S.H. Constantopoulos, E. Rivedal, D.J. Fitzgerald, H. Yamasaki, Metsovo-tremolite asbestos fibres: in vitro effects on mutation, chromosome aberration, cell transformation and intercellular communication, Mutagenesis 7 (1992) 343-347.
72. H. Bartsch, C. Malaveille, A.M. Camus, G. Martel-Planche, G. Brun, A. Hautefeuille, N. Sabadie, A. Barbin, Validation and comparative studies on 180 chemicals with S. typhimurium strains and V79 Chinese hamster cells in the presence of various metabolizing systems, Mutat. Res. 76 (1980) 1-50.
73. M.B. Lioi, M.R. Scarfi, A. Santoro, R. Barbieri, O. Zeni, F. Salvemini, D. Di Berardino, M.V. Ursini, Cytogenetic damage and induction of pro-oxidant state in human lymphocytes exposed in vitro to gliphosphate, vinclozolin, atrazine, and DPX-E9636, Environ. Mol. Mutagen. 32 (1998) 39-46.
74. Y. Oshiro, C.E. Piper, M.L. Garriott, P.S. Balwierz, S.G. Soelter, E. Rohbacher, Genetic toxicology studies with a tumor promoter, J. Appl. Toxicol. 13 (1993) 91-101.
75. S.C. Gad, E. Burton, C.P. Chengeles, S. Levin, C.E. Piper, Y. Oshiro, D.E. Semler, Promotional activities of the nongenotoxic carcinogen Bemitradine (SC-33643), J. Appl. Toxicol. 12 (1992) 157-164.
76. N.E. McCarroll, A. Protzel, Y. Ioannou, H.F. Stack, M.A. Jackson, M.D. Waters, K.L. Dearfield, A survey of EPA/OPP and open literature on selected pesticide chemicals. III. Mutagenicity and carcinogenicity of benomyl and carbendazim, Mutat. Res. 512 (2002) 1-35.
77. D.B. McGregor, A.G. Brown, S. Howgate, D. McBride, C. Riach, W.J. Caspary, Responses of the L5178Y mouse lymphoma cell forward mutation assay. V: 27 coded chemicals, Environ. Mol. Mutagen. 17 (1991) 196-219.
78. W. von der Hude, S. Kalweit, G. Engelhardt, S. McKiernan, P. Kasper, R. Slacik-Erben, H.G. Miltenburger, N. Honarvar, R. Fahrig, B. Görlitz, S. Albertini, S. Kirchner, D. Utesch, F. Pötter-Locher, H. Stopper, S. Madle, In vitro micronucleus assay with Chinese hamster V79 cells-results of a collaborative study with in situ exposure to 26 chemical substances, Mutat. Res. 468 (2000) 137-163.
79. A. Matsuoka, K. Yamakage, H. Kusakabe, S. Wakuri, M. Asakura, T. Noguchi, T. Sugiyama, H. Shimada, S. Nakayama, Y. Kasahara, Y. Takahashi, K.F. Miura, M. Hatanaka, M. Ishidate Jr., T. Morita, K. Watanabe, M. Hara, K. Odawara, N. Tanaka, M. Hayashi, T. Sofuni, Re-evaluation of chromosomal aberration induction on nine mouse lymphoma assay "unique positive" NTP carcinogens, Mutat. Res. 369 (1996) 243-252.
80. W. Lijinsky, Chronic bioassay of benzyl chloride in F344 rats and (C57BL/6J x BALB/c)F1 mice, J. Natl. Cancer Inst. 76 (1986) 1231-1236.
81. A. Nakamura, N. Tateno, S. Kojima, M.-A. Kaniwa, T. Kawamura, The mutagenicity of halogenated alkanols and their phosphoric acid esters for Salmonella typhimurium, Mutat. Res. 66 (1979) 373-380.
82. A. Matsuoka, A. Matsui, N. Miyata, T. Sofuni, M. Ishidate Jr., Mutagenicity of 3-tert-butyl-4-hydroxyanisole (BHA) and its metabolites in short-term tests in vitro, Mutat. Res. 241 (1990) 125-132.
83. R. Mandel, H. Ryser, Mutagenicity of cadmium in Salmonella typhimurium and its synergism with two nitrosamines, Mutat. Res. 138 (1984) 9-16.
84. HSDB, Hazardous Substances Data Bank, http://toxnet.nlm.nih.gov/cgi-bin/ sis/htmlgen?HSDB.
85. M. Nagabhushan, S.V. Bhide, Mutagenicity of chilli extract and capsaicin in short-term tests, Environ. Mutagen. 7 (1985) 881-888.
86. +/- -3.7.2C mouse lymphoma cells, Mutat. Res. 413 (1998) 265-276.
87. A. Seelbach, B. Fissler, S. Madle, Further evaluation of a modified micronucleus assay with V79 cells for detection of aneugenic effects, Mutat. Res. 303 (1993) 163-169.
88. J.M. Gauthier, H. Dubeau, E. Rassart, Induction of micronuclei in vitro by organochlorine compounds in beluga whale skin fibroblasts, Mutat. Res. 439 (1999) 87-95.
89. V.F. Simmon, K. Kauhanen, R.G. Tardiff, Mutagenic activity of chemicals identified in drinking water, Dev. Toxicol. Environ. Sci. 2 (1977) 249-258.
90. J.F. Contrera, A.C. Jacobs, J.J. DeGeorge, Carcinogenicity testing and the evaluation of regulatory requirements for pharmaceuticals, Regul. Toxicol. Pharm. 25 (1997) 130-145.
91. H. Reisenbichler, P.M. Eckl, Genotoxic effects of selected peroxisome proliferators, Mutat. Res. 286 (1993) 135-144.
92. K. Müller, P. Kasper, L. Müller, An assessment of the in vitro hepatocyte micronucleus assay, Mutat. Res. 292 (1993) 213-224.
93. S. Krivobok, F. Seigle-Murandi, R. Steiman, D.R. Marzin, V. Betina, Mutagenicity of substituted anthraquinones in the Ames/Salmonella microsome system, Mutat. Res. 279 (1992) 1-8.
94. K. Watanabe, T. Sasaki, K. Kawakami, Comparisons of chemically-induced mutation among four bacterial strains, Salmonella typhimurium TA102 and TA2638, and Escherichia coli WP2/pKM101 and WP2 uvrA/pKM101: collaborative study III and evaluation of the usefulness of these strains, Mutat. Res. 416 (1998) 169-181.
95. A. Seelbach, B. Fissler, A. Strohbusch, S. Madle, Development of a modified micronucleus assay in vitro for the detection of aneugenic effects, Toxicol. In Vitro 7 (1993) 185-193.
96. D.M. DeMarini, E. Perry, M.L. Shelton, Dichloroacetic acid and related compounds: induction of prophage in E. coli and mutagenicity and mutation spectrum in Salmonella TA100, Mutagenesis 9 (1994) 429-437.
97. G.H. Ingerowski, M. Scheutwinkel-Reich, H-J. Stan, Mutagenicity studies on veterinary anabolic drugs with the Salmonella/microsome test, Mutat. Res. 91 (1981) 93-98.
98. M. Taningher, R. Pasquini, S. Bonatti, Genotoxicity analysis of N,N-dimethylaniline and N,N-dimethyl-p-toluidine, Environ. Mol. Mutagen. 21 (1993) 349-356.
99. C. Malaveille, A. Croisy, G. Brun, H. Bartsch, Hydroxylation, nitroreduction are required to activate dimethylnitramine into alkylating and mutagenic agents, Carcinogenesis 4 (1983) 1477-1481.
100. F. Muniz, E. Houston, R. Schneider, M. Nusyowitz, Chromosomal effects of diphenylhydantoins, Clin. Res. 17 (1969) 28 (Abstract).
101. A. Leonard, C. de Meester, L. Fabry, L. de Saint-Georges, P. Dumont, Lack of mutagenicity of diphenylhydantoin in in vitro short-term tests, Mutat. Res. 137 (1984) 79-88.
102. D. Kindig, M.L. Garriott, J.W. Parton, J.D. Brunny, J.E. Beyers, Diphenylhydantoin is not genotoxic in a battery of shortterm cytogenetic assays, Terato. Carcino. Mutagen. 12 (1992) 43-50.
103. N. Banduhn, G. Obe, Mutagenicity of methyl 2-benzimidazolecarbamate, diethylstilbestrol and estradiol: Structural chromosomal aberrations, sister-chromatid exchanges, C-mitoses, polyploidies and micronuclei, Mutat. Res. 156 (1985) 199-218.
104. R. Reimann, S. Kalweit, R. Lang, Studies for a genotoxic potential of some endogenous and exogenous sex steroids. II. Communication: examination for the induction of cytogenetic damage using the chromosomal aberration assay on human lymphocytes in vitro and the mouse bone marrow micronucleus test in vivo, Environ. Mol. Mutagen. 28 (1996) 133-144.
105. A.T. Natarajan, A.C. van Kesteren-van Leeuwen, Mutagenic activity of 20 coded compounds in chromosome aberration/sister chromatid exchanges assay using Chinese hamster ovary (CHO) cells, in: F.J. de Serres, J. Ashby (Eds.), Progress in Mutation Research, vol. 1, Elsevier/North Holland, New York-Amsterdam- Oxford, 1981, pp. 551-559.
106. M. Honma, M. Hayashi, H. Shimada, N. Tanaka, S. Wakuri, T. Awogi, K.I. Yamamoto, N-U. Kodani, Y. Nishi, M. Nakadate, T. Sofuni, Evaluation of the mouse lymphoma tk assay (microwell method) as an alternative to the in vitro chromosomal aberration test, Mutagenesis 14 (1999) 5-22.
107. R.L. Robison, W. Suter, R.H. Cox, Carcinogenicity and mutagenicity studies with fluvastatin, a new, entirely synthetic HMG-CoA reductase inhibitor, Fund. Appl. Toxicol. 23 (1994) 9-20.
108. J. Wangenheim, G. Bolcsfoldi, Mouse lymphoma L5178Y thymidine kinase locus assay of 50 compounds, Mutagenesis 3 (1988) 193-205.
109. J.A. Quest, K.L. Hamernik, R. Engler, W.L. Burnham, P.A. Fenner-Crisp, Evaluation of the carcinogenic potential of pesticides, Regul. Toxicol. Pharm. 14 (1991) 3-11.
110. S. Knasmüller, N. Bresgen, F. Kassie, V. Mersch-Sundermann, W. Gelderblom, E. Zöhrer, P.M. Eckl, Genotoxic effects of three Fusarium mycotoxins, fumonisin B1, moniliformin and vomitoxin in bacteria and in primary cultures of rat hepatocytes, Mutat. Res. 13 (1997) 39-48.
111. H. van den Berghe, Clastogenic effects of haloperidol in vivo and of haloperidol, droperidol and pipamperone in vitro, Arzneim. Forsch. 24 (1974) 2055-2058.
112. M.A. Rexroat, T.J. Oberly, B.J. Brewsey, M.L. Garriott, The gradient plate assay: a modified Ames assay used to prescreen for the identification of bacterial mutagens, Mutat. Res. 341 (1995) 185-192.
113. H. Ogura, T. Toru, K. Morimoto, A comparison of the 8-hydroxyguanosine, chromosome aberrations and micronucleus techniques for the assessment of the genotoxicity of mercury compounds in human blood lymphocytes, Mutat. Res. 340 (1996) 175-182.
114. C. Betti, T. Davini, R. Barale, Genotoxic activity of methyl mercury chloride and dimethyl mercury in human lymphocytes, Mutat. Res. 281 (1992) 255-260.
115. J. Ashby, R.D. Callander, D. Paton, E. Zeiger, F. Ratpan, Weak and unexpected mutagenicity to Salmonella of the rat hepatocarcinogen methapyrilene, Environ. Mutagen. 12 (1988) 243-252.
116. R. Lippens, M. Claeys, C. Wildemauwe, N. Van Larebeke, Mutagenicity studies on 10 pesticides, on trichloroethane and on diaminobenzidine, Mutat. Res. 113 (1983) 277-278 (Abstract).
117. B.L. Kaul, Cytogenetic activity of some common antioxidants and their interaction with X-rays, Mutat. Res. 67 (1979) 239-247.
118. T.F. McMahon, M.L. Cunningham, Mutagenicity of methylazoxymethanol acetate in the presence of alcohol dehydrogenase, aldehyde dehydrogenase, and rat liver microsomes in Salmonella typhimurium his G46, Environ. Mol. Mutagen. 18 (1991) 151-156.
119. C.R. Mackerer, F.A. Angelosanto, G.R. Blackburn, C.A. Schreiner, Identification of formaldehyde as the metabolite responsible for the mutagenicity of methyl tertiary-butyl ether in the activated mouse lymphoma assay, Proc. Soc. Exp. Biol. Med. 212 (1996) 338-341.
120. M.D. Mudry, M. Carballo, M. Labal de Vinuesa, M. Gonzalez Cid, I. Larripa, Mutagenic bioassay of certain pharmacological drugs: III Metronidazole (MTZ), Mutat. Res. 305 (1994) 127-132.
121. M.M. Lopéz Nigro, A.M. Palermo, M.D. Mudry, M.A. Carballo, Cytogenetic evaluation of two nitroimidazole derivatives, Toxicol. In Vitro 17 (2003) 35-40.
122. S. Albertini, A.-A. Chételat, B. Miller, W. Muster, E. Pujadas, R. Strobel, E. Gocke, Genotoxicity of 17 gyrase- and four mammalian topoisomerase II-poisons in prokaryotic and eukaryotic test systems, Mutagenesis 4 (1995) 343-351.
123. D.P. Gibson, X. Ma, A.G. Switzer, V.A. Murphy, M.J. Aardema, Comparative genotoxicity of quinolone and quinolonyl-lactam antibacterials in the in vitro micronucleus assay in Chinese hamster ovary cells, Environ. Mol. Mutagen. 31 (1998) 345-351.
124. J.C. Sasaki, J. Arey, D.A. Eastmond, K.K. Parks, A.J. Grosovsky, Genotoxicity induced in human lymphoblasts by atmospheric reaction products of naphthalene and phenanthrene, Mutat. Res. 393 (1997) 23-35.
125. S. Toyokuni, J.L. Sagripanti, V.M. Hitchins, Cytotoxic and mutagenic effects of ferric nitrilotriacetate on L5178Y mouse lymphoma cells, Cancer Lett. 27 (1995) 157-162.
126. D. Modesti, C. Tanzarella, F. Degrassi, Genotoxic activity of nitriloacetic acid in Chinese hamster cells, Mutat. Res. 343 (1995) 1-6.
127. Q-G. Huang, L-R. Kong, Y-B. Liu, L-S. Wang, Relationships between molecular structure and chromosomal aberrations in in vitro human lymphocytes induced by substituted nitrobenzenes, Bull. Environ. Contam. Toxicol. 57 (1996) 349-353.
128. T. Sugimura, S. Takayama, Biological actions of nitroarenes in short-term tests on Salmonella, cultured mammalian cells and cultured human tracheal tissues: possible basis for regulatory control, Environ. Health Perspect. 47 (1983) 171-176.
129. A. Matsuoka, T. Sofuni, N. Miyata, M. Ishidate Jr., Clastogenicity of 1-nitropyrene, dinitropyrenes, fluorene and mononitrofluorenes in cultured Chinese hamster cells, Mutat. Res. 259 (1991) 103-110.
130. J.B. Phelps, M.L. Garriott, W.P. Hoffman, Aprotocol for the in vitro micronucleus test. II. Contributions to the validation of a protocol suitable for regulatory submissions from an examination of 10 chemicals with different mechanisms of action and different levels of activity, Mutat. Res. 521 (2002) 103-112.
131. E. Zeiger, A.T. Sheldon, The mutagenicity of heterocyclic N-nitrosamines for Salmonella typhimurium, Mutat. Res. 57 (1978) 1-10.
132. A. Balbi, G. Muscettola, N. Staiano, G. Martire, F.D. Lorenzo, Psychotropic drugs: evaluation of mutagenic effect, Pharmacol. Res. Commun. 12 (1980) 423-431.
133. H. Stopper, C. Körber, D.L. Spencer, S. Kirchner, W.J. Caspary, D. Schiffmann, An investigation of micronucleus and mutation induction by oxazepam in mammalian cells, Mutagenesis 8 (1993) 449-455.
134. F.L. Fort, Mutagenicity of quinolone antibacterials, Drug Safe. 7 (1992) 214-222.
135. K. Victorin, Review of the genotoxicity of ozone, Mutat. Res. 277 (1992) 221-238.
136. - mouse lymphoma cell forward mutation assay to coded chemicals. I: Results for nine compounds, Environ. Mutagen. 9 (1987) 143-160.
137. M.E. Bishop, A. Aidoo, O.E. Domon, S.M. Morris, D.A. Casciano, Phenolphthalein induces micronuclei in transgenic human lymphoblastoid cells, Environ. Mol. Mutagen. 32 (1998) 286-288.
138. U. Egeli, G. Erdogan, The clastogenic effect of pyrimethamine (Daraprim) on human chromosomes in lymphocyte cultures, Cell Biol. Toxicol. 7 (1991) 347-356.
139. H. Yamanaka, M. Nagao, T. Sugimura, Mutagenicity of pyrrolizidine alkaloids in the Salmonella/mammalianmicrosome test, Mutat. Res. 68 (1979) 211-216.
140. J. McCann, E. Choi, E. Yamasaki, B.N. Ames, Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals, Proc. Natl. Acad. Sci. U.S.A. 72 (1975) 5135-5139.
141. E. Astrup, O. Iversen, The tumorigenic and carcinogenic effect of 12-O-tetradecanoyl 13-acetate when applied to the skin of BALB/cA and hairless (hr/hr) mice, Acta Pathol. Microbiol. Immunol. Scand. 91 (1983) 103-113.
142. B.M. Miller, E. Pujadas, E. Gocke, Evaluation of the micronucleus test in vitro using Chinese hamster cells: results of four chemicals weakly positive in the in vivo micronucleus test, Environ. Mol. Mutagen. 26 (1995) 240-247.
143. J.M. Mackay, V. Fox, K. Griffiths, D.A. Fox, C.A. Howard, C. Coutts, I. Wyatt, J.A. Styles, Trichloroacetic acid: investigation into the mechanism of chromosomal damage in the in vitro human lymphocyte cytogenetic assay and mouse bone marrow micronucleus test, Carcinogenesis 16 (1995) 1127-1133.
144. S.R. Sirianni, Further studies on cytogenetic effects of folpet, Mutat. Res. 53 (1978) 64-265 (Abstract).
145. E. Janik-Spiechowicz, K. Wyszynska, E. Dziubaltowska, Genotoxicity evaluation of trimethylbenzenes, Mutat. Res. 412 (1998) 299-305.
146. D.A. Wink, K.S. Kasprzak, C.M. Maragos, R.K. Elespuru, M. Misra, T.M. Dunams, T.A. Cebula, W.H. Koch, A.W. Andrews, J.S. Allen, L.K. Keefer, DNA deaminating ability and genotoxicity of nitric oxide and its progenitors, Science 254 (1991) 1001-1003.
147. P. Ramäirez, D.A. Eastmond, J.P. Laclette, P. Ostrosky-Wegman, Disruption of microtubule assembly and spindle formation as a mechanism for the induction of aneuploid cells by sodium arsenite and vanadium pentoxide, Mutat. Res. 386 (1997) 291-298.
148. M. Ishidate Jr., T. Nohmi, M. Matsui, in: M. Ishidate Jr., T. Nohmi, M. Matsui (Eds.), Mutagenicity Databook: Bacterial Mutation Assays, Life Science Information Center, Tokyo, 1991.
149. M.D. Shelby, S. Stasiewicz, Chemicals showing no evidence of carcinogenicity in long-term, two-species rodent studies: the need for short-term test data, Environ. Mutagen. 6 (1984) 871-878.
150. T.L. Dunn, R.A. Gardiner, G.J. Seymour, M.F. Lavin, Genotoxicity of analgesic compounds assess by an in vitro micronucleus assay, Mutat. Res. 189 (1987) 299-306.
151. M. Moriya, T. Ohta, K. Watanabe, T. Miyazawa, K. Kato, Y. Shirasu, Further mutagenicity studies on pesticides in bacterial reversion assay systems, Mutat. Res. 116 (1982) 185-216.
152. V.F. Garry, R.L. Nelson, J. Griffith, M. Harkins, Preparation for human study of pesticide applicators: sister chromatid exchanges and chromosome aberrations in cultured human lymphocytes exposed to selected fumigants, Terato. Carcino. Mutagen. 10 (1990) 21-29.
153. W.J. Caspary, D. Spencer Daston, B.C. Myhr, A.D. Mitchell, C.J. Rudd, P.S. Lee, Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: interlaboratory reproducibility and assessment, Environ. Mol. Mutagen. 12 (Suppl. 13) (1988) 195-229.
154. E. Longstaff, D.B. McGregor, Mutagenicity of halocarbon refrigerant monochlorodifluoromethane (R-22) in Salmonella typhimurium, Toxicol. Lett. 2 (1978) 1-4.
155. Y. Oshiro, C.E. Piper, P.S. Balwierz, S.G. Soelter, Chinese hamster ovary cell assays for mutation and chromosome damage: data from non-carcinogens, J. Appl. Toxicol. 11 (1991) 167-177.
156. TSCATS, US Environmental Protection Agency database on Toxic Substances Control Act Test Submissions, http://www.rtknet.org/datadoc/tscats.html.
157. EPA, California Environmental Protection Agency Department of Pesticide Regulation, Medical Toxicology Branch. Summary of Toxicological Data, http://www.cdpr.ca.gov/docs/toxsums/pdfs/3010.pdf.
158. D.K. Gulati, K. Witt, B. Anderson, E. Zeiger, M.D. Shelby, Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro: results with 27 chemicals, Environ. Mol. Mutagen. 13 (1989) 133-193.
159. A. Bianchi-Santamaria, M. Gobbi, M. Cembran, A. Arnaboldi, Human lymphocyte micronucleus test with mixtures of phytochemicals in environmental concentrations, Mutat. Res. 388 (1997) 27-32.
160. A. Araki, T. Noguchi, F. Kato, T. Matsushima, Improved method for mutagenicity testing of gaseous compounds by using a gas sampling bag, Mutat. Res. 307 (1994) 335-344.
161. S. Monarca, R. Rizzi, R. Pasquini, B.L. Pool, R. De Fusco, D. Biscardi, M. Gervasoni, E. Piatti, Studies on genotoxic properties of precursors of polyethyleneterephthalate plastics, Mutat. Res. 216 (1989) 314-315 (Abstract).
162. G.S. Probst, C.Z. Thompson, S.B. Neal, S.M. Rinzel, J.K. Epp, B.J. Bewsey, Genotoxicity of some antihistamines in a battery of short-term tests, Environ. Mutagen. 3 (1981) 326 (Abstract).
163. S.M. Galloway, T. Sofuni, M.D. Shelby, A. Thilagar, V. Kumaroo, P. Kaur, D. Gulati, D.L. Putman, H. Murli, R. Marshall, N. Tanaka, B. Anderson, E. Zeiger, M. Ishidate Jr., Multilaboratory comparison of in vitro tests for chromosome aberrations in CHO and CHL cells tested under the same protocols, Environ. Mol. Mutagen. 29 (1997) 189-207.
164. - mouse lymphoma cell forward mutation assay: III. 72 coded chemicals, Environ. Mol. Mutagen. 12 (1988) 85-154.
165. M. Ishidate Jr., T. Sofuni, K. Yoshikawa, M. Hayashi, T. Nohmi, M. Sawada, A. Matsuoka, Primary mutagenicity screening of food additives currently used in Japan, Food Chem. Toxicol. 22 (1984) 623-636.
166. R.D. Snyder, J.W. Green, A review of the genotoxicity of marketed pharmaceuticals, Mutat. Res. 488 (2001) 151-169.
167. T.P. Cameron, T.J. Hughes, P.E. Kirby, V.A. Fung, V.C. Dunkel, Mutagenic activity of 27 dyes and related chemicals in the Salmonella/microsome and mouse lymphoma TK +/- assay, Mutat. Res. 189 (1987) 223-262.
168. G.Hy. Lin, D.J. Brusick, Mutagenicity studies on FD&C Red No. 3, Mutagenesis 1 (1986) 253-260.
169. J.L. Ivett, B.M. Brown, C. Rodgers, B.E. Anderson, M.A. Resnick, E. Zeiger, Chromosomal aberrations and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. IV. Results with 15 chemicals, Environ. Mol. Mutagen. 14 (1989) 165-187.
170. M.V.U. Rani, M.S. Rao, In vitro effect of fenthion on human lymphocytes, Bull. Environ. Contam. Toxicol. 47 (1991) 316-323.
171. A. Herrera, E. Laborda, Mutagenic activity in synthetic pyrethroids in Salmonella typhimurium, Mutagenesis 3 (1988) 509-514.
172. J. Surralles, E. Carbonell, M. Puig, N. Xamena, A. Creus, R. Marcos, Induction of mitotic micronuclei by the pyrethroid insecticide fenvalerate in cultured human lymphocytes, Toxicol. Lett. 54 (1990) 151-155.
173. C. Caballo, A. Herrara, C. Barrueco, A. Santa-Maria, F. Sanz, E. de la Plena, Analysis of cytogenetic damage induced in CHO cells by the pyrethroid insecticide fenvalerate, Terato. Carcino. Mutagen. 12 (1992) 243-249.
174. M.J. Armstrong, C.L. Bean, S.M. Galloway, A quantitative assessment of the cytotoxicity associated with chromosomal aberration detection in Chinese hamster ovary cells, Mutat. Res. 265 (1992) 45-60.
175. FAO, Pesticide residues in food. Chlorpropham. Toxicological evaluations, Food and Agriculture Organisation of the World Health Organisation working groups, 2000 pp. 3-59.
176. S.M. Galloway, J.E. Miller, M.J. Armstrong, C.L. Bean, T.R. Skopek, W.W. Nichols, DNA synthesis inhibition as an indirect mechanism of chromosome aberrations: comparison of DNA-reactive and non-DNA-reactive clastogens, Mutat. Res. 400 (1998) 169-186.
177. N. Titenko-Holland, G. Windham, P. Kolachana, F. Reinisch, S. Parvatham, A.M. Osorio, M.T. Smith, Genotoxicity of malathion in human lymphocytes assessed using the micronucleus assay in vitro and in vivo: A study of malathion-exposed workers, Mutat. Res. 388 (1997) 85-95.
178. G. Ribas, J. Surralles, E. Carbonell, N. Xamena, A. Creus, R. Marcos, Genotoxicity of the herbicides alachlor and maleic hydrazide in cultured human lymphocytes, Mutagenesis 11 (1996) 221-227.
179. M. De Meo, M. Laget, M. Castegnaro, G. Dumenil, Genotoxic activity of potassium permanganate in acidic solutions, Mutat. Res. 260 (1991) 295-306.
180. M. Sawada, T. Sofuni, M. Ishidate Jr., Cytogenetic studies on 1,1-dichloroethylene and its two isomers in mammalian cells in vitro and in vivo, Mutat. Res. 187 (1987) 157-163.
181. S. Ohshima, Induction of genetic instability and chromosomal instability by nickel sulfate in V79 Chinese hamster cells, Mutagenesis 18 (2003) 133-137.
182. A. Martelli, F. Mattioli, E. Mereto, G. Brambilla Campart, D. Sini, G. Bergamaschi, G. Brambilla, Evaluation of omeprazole genotoxicity in a battery of in vitro and in vivo assays, Toxicology 130 (1998) 29-41.
183. G. Tsushimoto, T. Shibahara, T. Awogi, E. Kaneko, S. Sutuo, K. Yamamoto, H. Shirakawa, DNA-damaging, mutagenic, clastogenic and cell-cell communication inhibitory properties of gamma oryzanol, J. Toxicol. Sci. 16 (1991) 191-202.
184. L.K.N. Okine, C. Ioannides, D.V. Parke, Studies on the possible mutagenicity of beta-adrenergic blocker drugs, Toxicol. Lett. 16 (1983) 167-174.
185. G. Stemp, S. Pascoe, D. Gatehouse, In vitro and in vivo cytogenetic studies of three β-lactam antibiotics (penicillin VK, ampicillin and carbenicillin), Mutagenesis 4 (1989) 439-445.
186. T. Sofuni, A. Matsuoka, M. Sawada, M. Ishidate Jr., E. Zeiger, M.D. Shelby, A comparison of chromosome aberration induction by 25 compounds tested by two Chinese hamster cell (CHL and CHO) systems in culture, Mutat. Res. 241 (1990) 175-213.
187. T.S. L'vova, Study of the mutagenic effect of five promising pesticides on mouse bone marrow, cultured human peripheral blood lymphocytes, and Saccharomyctes, Cytol. Genet. (Engl. Ed.) 18 (1984) 57-60.
188. R.D. Snyder, A review and investigation into the mechanistic basis of the genotoxicity of antihistamines, Mutat. Res. 411 (1998) 235-248.
189. A. Guadano, A. Gonzalez-Coloma, E. de la Pena, Investigation of the insecticide rotenone in cultured human lymphocytes, Mutat. Res. 414 (1998) 1-7.
190. D.B. McGregor, A.G. Brown, P. Cattanach, I. Edwards, D. McBride, C. Riach, W. Shepherd, W.J. Caspary, Responses of the L5178Y mouse lymphoma forward mutation assay: V. Gases and vapors, Environ. Mol. Mutagen. 17 (1991) 122-129.
191. M. Hayashi, M. Kishi, T. Sofuni, M. Ishidate Jr., Micronucleus tests in mice on 39 food additives and eight miscellaneous chemicals, Food Chem. Toxicol. 26 (1988) 485-500.
192. M. Ishidate Jr., in: M. Ishidate Jr. (Ed.), Data Book of Chromosomal Aberration Test In Vitro, LIC, Tokyo, 1987.
193. B.C. Myhr, W.J. Caspary, Chemical mutagenesis at the thymidine kinase locus in L5178Y mouse lymphoma cells: results for 31 coded compounds in the National Toxicology Program, Environ. Mol. Mutagen. 18 (1991) 51-83.
194. B. Myhr, D. McGregor, L. Bowers, C. Riach, A.G. Brown, I. Edwards, D. McBride, R. Martin, W.J. Caspary, L5178Y mouse lymphoma mutation assay results with 41 compounds, Environ. Mol. Mutagen. 16 (Suppl. 18) (1990) 138-167.
195. M. Zdzienicka, M. Zielenska, B. Tudek, T. Szymczyk, Mutagenic activity of thiram in Ames tester strains of Salmonella typhimurium, Mutat. Res. 68 (1979) 9-13.
196. J.A. Heddle, M. Hite, B. Kirkhart, K. Mavournin, J.T. MacGregor, G.W. Newell, M.F. Salamone, The induction of micronuclei as a measure of genotoxicity: A report of the US Environmental Protection Agency Gene-Tox Program, Mutat. Res. 123 (1983) 61-118.
197. T. Sofuni, in: T. Sofuni (Ed.), Data Book for Chromosomal aberration Test on Chemicals In Vitro, LIC, Tokyo, 1999.
198. A.D. Mitchell, C.J. Rudd, W.J. Caspary, Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: intralaboratory results for sixty-three coded chemicals tested at SRI International, Environ. Mol. Mutagen. 12 (Suppl. 13) (1988) 37-101.
199. B.C. Myhr, W.J. Caspary, Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc, Environ. Mol. Mutagen. 12 (Suppl. 13) (1988) 103-194.
200. R.A. LeBoeuf, G.A. Kerckaert, M.J. Aardema, D.P. Gibson, R. Brauninger, R. Isfort, The pH 6.7 Syrian hamster embryo cell transformation assay for assessing the carcinogenic potential of chemicals, Mutat. Res. 356 (1996) 85-127.