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Volumn 11, Issue 1, 2017, Pages 97-119

Determinants of metastatic competency in colorectal cancer

Author keywords

Cancer immunology; Cancer stem cells; Clonal diversity; Combination therapy; Dormancy; Heterogeneity; Immunotherapy; Stroma; TGF beta; Tumour microenvironment Correspondence

Indexed keywords

ADAPTIVE IMMUNITY; CANCER ASSOCIATED FIBROBLAST; CANCER IMMUNOTHERAPY; CANCER PATIENT; CANCER PROGNOSIS; CANCER STEM CELL; CELL INVASION; COLON CARCINOGENESIS; ENDOTHELIUM CELL; HUMAN; IMMUNOCOMPETENT CELL; INNATE IMMUNITY; INTESTINE MUCOSA; METASTATIC COLORECTAL CANCER; NONHUMAN; PRIORITY JOURNAL; REVIEW; TUMOR MICROENVIRONMENT; ANIMAL; CARCINOGENESIS; COLON; COLORECTAL TUMOR; IMMUNOLOGY; IMMUNOTHERAPY; METASTASIS; MOLECULARLY TARGETED THERAPY; PATHOLOGY; PROCEDURES; PROGNOSIS; RECTUM;

EID: 85021111135     PISSN: 15747891     EISSN: 18780261     Source Type: Journal    
DOI: 10.1002/1878-0261.12018     Document Type: Review
Times cited : (174)

References (194)
  • 1
    • 84866985855 scopus 로고    scopus 로고
    • Targeting the TGFbeta signalling pathway in disease
    • Akhurst RJ and Hata A (2012) Targeting the TGFbeta signalling pathway in disease. Nat Rev Drug Discov 11, 790-811.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 790-811
    • Akhurst, R.J.1    Hata, A.2
  • 2
    • 84871846692 scopus 로고    scopus 로고
    • WNT signalling pathways as therapeutic targets in cancer
    • Anastas JN and Moon RT (2012) WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer 13, 11-26.
    • (2012) Nat Rev Cancer , vol.13 , pp. 11-26
    • Anastas, J.N.1    Moon, R.T.2
  • 3
    • 67650315187 scopus 로고    scopus 로고
    • Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial
    • Andrè T, Boni C, Navarro M, Tabernero J, Hickish T, Topham C, Bonetti A, Clingan P, Bridgewater J, Rivera F et al. (2009) Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial. J Clin Oncol 27, 3109-3116.
    • (2009) J Clin Oncol , vol.27 , pp. 3109-3116
    • Andrè, T.1    Boni, C.2    Navarro, M.3    Tabernero, J.4    Hickish, T.5    Topham, C.6    Bonetti, A.7    Clingan, P.8    Bridgewater, J.9    Rivera, F.10
  • 4
    • 11144357346 scopus 로고    scopus 로고
    • Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway
    • Bao S, Ouyang G, Bai X, Huang Z, Ma C, Liu M, Shao R, Anderson RM, Rich JN and Wang XF (2004) Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. Cancer Cell 5, 329-339.
    • (2004) Cancer Cell , vol.5 , pp. 329-339
    • Bao, S.1    Ouyang, G.2    Bai, X.3    Huang, Z.4    Ma, C.5    Liu, M.6    Shao, R.7    Erson, R.M.8    Rich, J.N.9    Wang, X.F.10
  • 9
    • 84901499648 scopus 로고    scopus 로고
    • Epidemiological transition of colorectal cancer in developing countries: Environmental factors, molecular pathways, and opportunities for prevention
    • Bishehsari F, Mahdavinia M, Vacca M, Malekzadeh R and Mariani-Costantini R (2014) Epidemiological transition of colorectal cancer in developing countries: environmental factors, molecular pathways, and opportunities for prevention. World J Gastroenterol 20, 6055-6072.
    • (2014) World J Gastroenterol , vol.20 , pp. 6055-6072
    • Bishehsari, F.1    Mahdavinia, M.2    Vacca, M.3    Malekzadeh, R.4    Mariani-Costantini, R.5
  • 11
    • 24944450679 scopus 로고    scopus 로고
    • Somatic evolution of cancer cells
    • Boland CR and Goel A (2005) Somatic evolution of cancer cells. Semin Cancer Biol 15, 436-450.
    • (2005) Semin Cancer Biol , vol.15 , pp. 436-450
    • Boland, C.R.1    Goel, A.2
  • 12
    • 0031727409 scopus 로고    scopus 로고
    • Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front
    • Brabletz T, Jung A, Hermann K, Gunther K, Hohenberger W and Kirchner T (1998) Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front. Pathol Res Pract 194, 701-704.
    • (1998) Pathol Res Pract , vol.194 , pp. 701-704
    • Brabletz, T.1    Jung, A.2    Hermann, K.3    Gunther, K.4    Hohenberger, W.5    Kirchner, T.6
  • 13
    • 84940911278 scopus 로고    scopus 로고
    • The delicate balance of macrophages in colorectal cancer; their role in tumour development and therapeutic potential
    • Braster R, Bogels M, Beelen RHJ and van Egmond M (2015) The delicate balance of macrophages in colorectal cancer; their role in tumour development and therapeutic potential. Immunobiology 222, 21-30.
    • (2015) Immunobiology , vol.222 , pp. 21-30
    • Braster, R.1    Bogels, M.2    Beelen, R.3    Van Egmond, M.4
  • 16
    • 75149149879 scopus 로고    scopus 로고
    • Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors
    • Butler JM, Kobayashi H and Rafii S (2010) Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors. Nat Rev Cancer 10, 138-146.
    • (2010) Nat Rev Cancer , vol.10 , pp. 138-146
    • Butler, J.M.1    Kobayashi, H.2    Rafii, S.3
  • 17
    • 84930640786 scopus 로고    scopus 로고
    • Cancer vaccines
    • Butterfield LH (2015) Cancer vaccines. BMJ 350, h988.
    • (2015) BMJ , vol.350
    • Butterfield, L.H.1
  • 20
    • 84897556892 scopus 로고    scopus 로고
    • TGF-beta in CAF-mediated tumor growth and metastasis
    • Calon A, Tauriello DVF and Batlle E (2014) TGF-beta in CAF-mediated tumor growth and metastasis. Semin Cancer Biol 25, 15-22.
    • (2014) Semin Cancer Biol , vol.25 , pp. 15-22
    • Calon, A.1    Tauriello, D.2    Batlle, E.3
  • 21
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • Cancer Genome Atlas Network (2012) Comprehensive molecular characterization of human colon and rectal cancer. Nature 487, 330-337.
    • (2012) Nature , vol.487 , pp. 330-337
  • 24
    • 84937519151 scopus 로고    scopus 로고
    • CCL2 promotes colorectal carcinogenesis by enhancing polymorphonuclear myeloid-derived suppressor cell population and function
    • Chun E, Lavoie S, Michaud M, Gallini CA, Kim J, Soucy G, Odze R, Glickman JN and Garrett WS (2015) CCL2 promotes colorectal carcinogenesis by enhancing polymorphonuclear myeloid-derived suppressor cell population and function. Cell Rep 12, 244-257.
    • (2015) Cell Rep , vol.12 , pp. 244-257
    • Chun, E.1    Lavoie, S.2    Michaud, M.3    Gallini, C.A.4    Kim, J.5    Soucy, G.6    Odze, R.7    Glickman, J.N.8    Garrett, W.S.9
  • 25
    • 84880548336 scopus 로고    scopus 로고
    • The intestinal crypt, a prototype stem cell compartment
    • Clevers H (2013) The intestinal crypt, a prototype stem cell compartment. Cell 154, 274-284.
    • (2013) Cell , vol.154 , pp. 274-284
    • Clevers, H.1
  • 26
  • 30
    • 84942984617 scopus 로고    scopus 로고
    • Molecular and pathogenetic aspects of tumor budding in colorectal cancer
    • Dawson H and Lugli A (2015) Molecular and pathogenetic aspects of tumor budding in colorectal cancer. Front Med (Lausanne) 2, 11.
    • (2015) Front Med (Lausanne) , vol.2 , pp. 11
    • Dawson, H.1    Lugli, A.2
  • 33
    • 84946825075 scopus 로고    scopus 로고
    • PD-1 blockade in tumors with mismatch-repair deficiency
    • Diaz LA Jr and Le DT (2015) PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med 373, 1979.
    • (2015) N Engl J Med , vol.373 , pp. 1979
    • Diaz, L.A.1    Le, D.T.2
  • 36
    • 0034712536 scopus 로고    scopus 로고
    • Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicentre randomised trial
    • Douillard J, Cunningham D, Roth A, Navarro M, James R, Karasek P, Jandik P, Iveson T, Carmichael J, Alakl M et al. (2000) Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. Lancet 355, 1041-1047.
    • (2000) Lancet , vol.355 , pp. 1041-1047
    • Douillard, J.1    Cunningham, D.2    Roth, A.3    Navarro, M.4    James, R.5    Karasek, P.6    Jandik, P.7    Iveson, T.8    Carmichael, J.9    Alakl, M.10
  • 39
    • 84857118418 scopus 로고    scopus 로고
    • Expression of tumour-specific antigens underlies cancer immunoediting
    • DuPage M, Mazumdar C, Schmidt LM, Cheung AF and Jacks T (2012) Expression of tumour-specific antigens underlies cancer immunoediting. Nature 482, 405-409.
    • (2012) Nature , vol.482 , pp. 405-409
    • Dupage, M.1    Mazumdar, C.2    Schmidt, L.M.3    Cheung, A.F.4    Jacks, T.5
  • 40
    • 77953225810 scopus 로고    scopus 로고
    • Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma
    • Eyles J, Puaux AL, Wang X, Toh B, Prakash C, Hong M, Tan TG, Zheng L, Ong LC, Jin Y et al. (2010) Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma. J Clin Invest 120, 2030-2039.
    • (2010) J Clin Invest , vol.120 , pp. 2030-2039
    • Eyles, J.1    Puaux, A.L.2    Wang, X.3    Toh, B.4    Prakash, C.5    Hong, M.6    Tan, T.G.7    Zheng, L.8    Ong, L.C.9    Jin, Y.10
  • 41
    • 84882619034 scopus 로고    scopus 로고
    • Targeting the tumor microenvironment: From understanding pathways to effective clinical trials
    • Fang H and Declerck YA (2013) Targeting the tumor microenvironment: from understanding pathways to effective clinical trials. Cancer Res 73, 4965-4977.
    • (2013) Cancer Res , vol.73 , pp. 4965-4977
    • Fang, H.1    Declerck, Y.A.2
  • 42
    • 79751489596 scopus 로고    scopus 로고
    • Molecular genetics of colorectal cancer
    • Fearon ER (2011) Molecular genetics of colorectal cancer. Annu Rev Pathol 6, 479-507.
    • (2011) Annu Rev Pathol , vol.6 , pp. 479-507
    • Fearon, E.R.1
  • 43
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon ER and Vogelstein B (1990) A genetic model for colorectal tumorigenesis. Cell 61, 759-767.
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 45
    • 84954569855 scopus 로고    scopus 로고
    • Ten years of anti-vascular endothelial growth factor therapy
    • Ferrara N and Adamis AP (2016) Ten years of anti-vascular endothelial growth factor therapy. Nat Rev Drug Discov 15, 385-403.
    • (2016) Nat Rev Drug Discov , vol.15 , pp. 385-403
    • Ferrara, N.1    Adamis, A.P.2
  • 49
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • Gabrilovich DI and Nagaraj S (2009) Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 9, 162-174.
    • (2009) Nat Rev Immunol , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 52
    • 84925669716 scopus 로고    scopus 로고
    • Metastasis prevention by targeting the dormant niche
    • Ghajar CM (2015) Metastasis prevention by targeting the dormant niche. Nat Rev Cancer 15, 238-247.
    • (2015) Nat Rev Cancer , vol.15 , pp. 238-247
    • Ghajar, C.M.1
  • 53
    • 84887981252 scopus 로고    scopus 로고
    • Mechanisms governing metastatic dormancy and reactivation
    • Giancotti FG (2013) Mechanisms governing metastatic dormancy and reactivation. Cell 155, 750-764.
    • (2013) Cell , vol.155 , pp. 750-764
    • Giancotti, F.G.1
  • 57
    • 84856013431 scopus 로고    scopus 로고
    • Clonal evolution in cancer
    • Greaves M and Maley CC (2012) Clonal evolution in cancer. Nature 481, 306-313.
    • (2012) Nature , vol.481 , pp. 306-313
    • Greaves, M.1    Maley, C.C.2
  • 61
    • 64049092886 scopus 로고    scopus 로고
    • The localization and density of immune cells in primary tumors of human metastatic colorectal cancer shows an association with response to chemotherapy
    • Halama N, Michel S, Kloor M, Zoernig I, Pommerencke T, Doeberitz MVK, Schirmacher P, Weitz J, Grabe N and Jager D (2009) The localization and density of immune cells in primary tumors of human metastatic colorectal cancer shows an association with response to chemotherapy. Cancer Immun 9, 1.
    • (2009) Cancer Immun , vol.9 , pp. 1
    • Halama, N.1    Michel, S.2    Kloor, M.3    Zoernig, I.4    Pommerencke, T.5    Doeberitz, M.6    Schirmacher, P.7    Weitz, J.8    Grabe, N.9    Jager, D.10
  • 63
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: Functions of cells recruited to the tumor microenvironment
    • Hanahan D and Coussens LM (2012) Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell 21, 309-322.
    • (2012) Cancer Cell , vol.21 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 64
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D and Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144, 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 65
    • 84945948733 scopus 로고    scopus 로고
    • Detection and clinical significance of circulating tumor cells in colorectal cancer-20 years of progress
    • Hardingham JE, Grover P, Winter M, Hewett PJ, Price TJ and Thierry B (2015) Detection and clinical significance of circulating tumor cells in colorectal cancer-20 years of progress. Mol Med 21(Suppl 1), S25-S31.
    • (2015) Mol Med , vol.21 , pp. S25-S31
    • Hardingham, J.E.1    Grover, P.2    Winter, M.3    Hewett, P.J.4    Price, T.J.5    Thierry, B.6
  • 69
    • 84991063920 scopus 로고    scopus 로고
    • Direct targeting of b-catenin by a small molecule stimulates proteasomal degradation and suppresses oncogenic Wnt/b-catenin signaling
    • Hwang S-Y, Deng X, Byun S, Lee C, Lee S-J, Suh H, Zhang J, Kang Q, Zhang T, Westover KD et al. (2016) Direct targeting of b-catenin by a small molecule stimulates proteasomal degradation and suppresses oncogenic Wnt/b-catenin signaling. Cell Rep 16, 28-36.
    • (2016) Cell Rep , vol.16 , pp. 28-36
    • Hwang, S.-Y.1    Deng, X.2    Byun, S.3    Lee, C.4    Lee, S.-J.5    Suh, H.6    Zhang, J.7    Kang, Q.8    Zhang, T.9    Westover, K.D.10
  • 70
    • 79955030814 scopus 로고    scopus 로고
    • Clinical significance of circulating tumor cells, including cancer stem-like cells, in peripheral blood for recurrence and prognosis in patients with dukes’ stage B and C colorectal cancer
    • Iinuma H, Watanabe T, Mimori K, Adachi M, Hayashi N, Tamura J, Matsuda K, Fukushima R, Okinaga K, Sasako M et al. (2011) Clinical significance of circulating tumor cells, including cancer stem-like cells, in peripheral blood for recurrence and prognosis in patients with dukes’ stage B and C colorectal cancer. J Clin Oncol 29, 1547-1555.
    • (2011) J Clin Oncol , vol.29 , pp. 1547-1555
    • Iinuma, H.1    Watanabe, T.2    Mimori, K.3    Adachi, M.4    Hayashi, N.5    Tamura, J.6    Matsuda, K.7    Fukushima, R.8    Okinaga, K.9    Sasako, M.10
  • 75
    • 23444460271 scopus 로고    scopus 로고
    • Antiangiogenic therapy for cancer: Current and emerging concepts
    • Jain RK (2005) Antiangiogenic therapy for cancer: current and emerging concepts. Oncology (Williston Park) 19, 7-16.
    • (2005) Oncology (Williston Park) , vol.19 , pp. 7-16
    • Jain, R.K.1
  • 78
    • 84903767326 scopus 로고    scopus 로고
    • Can we safely target the WNT pathway?
    • Kahn M (2014) Can we safely target the WNT pathway? Nat Rev Drug Discov 13, 513-532.
    • (2014) Nat Rev Drug Discov , vol.13 , pp. 513-532
    • Kahn, M.1
  • 79
    • 84984694266 scopus 로고    scopus 로고
    • The biology and function of fibroblasts in cancer
    • Kalluri R (2016) The biology and function of fibroblasts in cancer. Nat Rev Cancer 16, 582-598.
    • (2016) Nat Rev Cancer , vol.16 , pp. 582-598
    • Kalluri, R.1
  • 82
    • 77955640339 scopus 로고    scopus 로고
    • Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model
    • Kitamura T, Fujishita T, Loetscher P, Revesz L, Hashida H, Kizaka-Kondoh S, Aoki M and Taketo MM (2010) Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model. Proc Natl Acad Sci USA 107, 13063-13068.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 13063-13068
    • Kitamura, T.1    Fujishita, T.2    Loetscher, P.3    Revesz, L.4    Hashida, H.5    Kizaka-Kondoh, S.6    Aoki, M.7    Taketo, M.M.8
  • 84
    • 77955487514 scopus 로고    scopus 로고
    • Immune evasion of microsatellite unstable colorectal cancers
    • Kloor M, Michel S and von Knebel Doeberitz M (2010) Immune evasion of microsatellite unstable colorectal cancers. Int J Cancer 127, 1001-1010.
    • (2010) Int J Cancer , vol.127 , pp. 1001-1010
    • Kloor, M.1    Michel, S.2    Von Knebel Doeberitz, M.3
  • 85
    • 84961843547 scopus 로고    scopus 로고
    • The immune biology of microsatellite-unstable cancer
    • Kloor M and von Knebel Doeberitz M (2016) The immune biology of microsatellite-unstable cancer. Trends Cancer 2, 121-133.
    • (2016) Trends Cancer , vol.2 , pp. 121-133
    • Kloor, M.1    Von Knebel Doeberitz, M.2
  • 89
    • 84896125494 scopus 로고    scopus 로고
    • Evolution of the cancer stem cell model
    • Kreso A and Dick JE (2014) Evolution of the cancer stem cell model. Cell Stem Cell 14, 275-291.
    • (2014) Cell Stem Cell , vol.14 , pp. 275-291
    • Kreso, A.1    Dick, J.E.2
  • 91
    • 84900459331 scopus 로고    scopus 로고
    • IL-22+ CD4+ T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L
    • Kryczek I, Lin Y, Nagarsheth N, Peng D, Zhao L, Zhao E, Vatan L, Szeliga W, Dou Y, Owens S et al. (2014) IL-22+ CD4+ T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L. Immunity 40, 772-784.
    • (2014) Immunity , vol.40 , pp. 772-784
    • Kryczek, I.1    Lin, Y.2    Nagarsheth, N.3    Peng, D.4    Zhao, L.5    Zhao, E.6    Vatan, L.7    Szeliga, W.8    Dou, Y.9    Owens, S.10
  • 93
    • 84866307571 scopus 로고    scopus 로고
    • Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 Signaling
    • Li HJ, Reinhardt F, Herschman HR and Weinberg RA (2012) Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 Signaling. Cancer Discov 2, 840-855.
    • (2012) Cancer Discov , vol.2 , pp. 840-855
    • Li, H.J.1    Reinhardt, F.2    Herschman, H.R.3    Weinberg, R.A.4
  • 96
    • 84907519671 scopus 로고    scopus 로고
    • PDGF receptor-a promotes TGF-b signaling in hepatic stellate cells via transcriptional and posttranscriptional regulation of TGF-b receptors
    • Liu C, Li J, Xiang X, Guo L, Tu K, Liu Q, Shah VH and Kang N (2014) PDGF receptor-a promotes TGF-b signaling in hepatic stellate cells via transcriptional and posttranscriptional regulation of TGF-b receptors. Am J Physiol Gastrointest Liver Physiol 307, G749-G759.
    • (2014) Am J Physiol Gastrointest Liver Physiol , vol.307 , pp. G749-G759
    • Liu, C.1    Li, J.2    Xiang, X.3    Guo, L.4    Tu, K.5    Liu, Q.6    Shah, V.H.7    Kang, N.8
  • 103
    • 84928226005 scopus 로고    scopus 로고
    • The interaction of anticancer therapies with tumor-associated macrophages
    • Mantovani A and Allavena P (2015) The interaction of anticancer therapies with tumor-associated macrophages. J Exp Med 212, 435-445.
    • (2015) J Exp Med , vol.212 , pp. 435-445
    • Mantovani, A.1    Allavena, P.2
  • 104
    • 65049084189 scopus 로고    scopus 로고
    • Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation
    • Mantovani A, Sica A, Allavena P, Garlanda C and Locati M (2009) Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation. Hum Immunol 70, 325-330.
    • (2009) Hum Immunol , vol.70 , pp. 325-330
    • Mantovani, A.1    Sica, A.2    Allavena, P.3    Garlanda, C.4    Locati, M.5
  • 106
    • 84955515590 scopus 로고    scopus 로고
    • Metastatic colonization by circulating tumour cells
    • Massague J and Obenauf AC (2016) Metastatic colonization by circulating tumour cells. Nature 529, 298-306.
    • (2016) Nature , vol.529 , pp. 298-306
    • Massague, J.1    Obenauf, A.C.2
  • 109
    • 84898876965 scopus 로고    scopus 로고
    • Hallmarks in colorectal cancer: Angiogenesis and cancer stem-like cells
    • Mathonnet M (2014) Hallmarks in colorectal cancer: angiogenesis and cancer stem-like cells. World J Gastroenterol 20, 4189.
    • (2014) World J Gastroenterol , vol.20 , pp. 4189
    • Mathonnet, M.1
  • 114
    • 84893768750 scopus 로고    scopus 로고
    • Lgr5+ stem cells are indispensable for radiationinduced intestinal regeneration
    • Metcalfe C, Kljavin NM, Ybarra R and de Sauvage FJ (2014) Lgr5+ stem cells are indispensable for radiationinduced intestinal regeneration. Cell Stem Cell 14, 149-159.
    • (2014) Cell Stem Cell , vol.14 , pp. 149-159
    • Metcalfe, C.1    Kljavin, N.M.2    Ybarra, R.3    De Sauvage, F.J.4
  • 118
    • 0032529466 scopus 로고    scopus 로고
    • CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer
    • Naito Y, Saito K, Shiiba K, Ohuchi A, Saigenji K, Nagura H and Ohtani H (1998) CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer. Cancer Res 58, 3491-3494.
    • (1998) Cancer Res , vol.58 , pp. 3491-3494
    • Naito, Y.1    Saito, K.2    Shiiba, K.3    Ohuchi, A.4    Saigenji, K.5    Nagura, H.6    Ohtani, H.7
  • 120
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell PC (1976) The clonal evolution of tumor cell populations. Science 194, 23-28.
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1
  • 121
    • 84955461015 scopus 로고    scopus 로고
    • Surviving at a distance: Organ-specific metastasis
    • Obenauf AC and Massague J (2015) Surviving at a distance: organ-specific metastasis. Trends Cancer 1, 76-91.
    • (2015) Trends Cancer , vol.1 , pp. 76-91
    • Obenauf, A.C.1    Massague, J.2
  • 122
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    • O’Brien CA, Pollett A, Gallinger S and Dick JE (2007) A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445, 106-110.
    • (2007) Nature , vol.445 , pp. 106-110
    • O’Brien, C.A.1    Pollett, A.2    Gallinger, S.3    Dick, J.E.4
  • 124
    • 84896113460 scopus 로고    scopus 로고
    • Metastatic stem cells: Sources, niches, and vital pathways
    • Oskarsson T, Batlle E and Massague J (2014) Metastatic stem cells: sources, niches, and vital pathways. Cell Stem Cell 14, 306-321.
    • (2014) Cell Stem Cell , vol.14 , pp. 306-321
    • Oskarsson, T.1    Batlle, E.2    Massague, J.3
  • 125
    • 41149157649 scopus 로고    scopus 로고
    • TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4
    • Padua D, Zhang XH, Wang Q, Nadal C, Gerald WL, Gomis RR and Massague J (2008) TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell 133, 66-77.
    • (2008) Cell , vol.133 , pp. 66-77
    • Padua, D.1    Zhang, X.H.2    Wang, Q.3    Nadal, C.4    Gerald, W.L.5    Gomis, R.R.6    Massague, J.7
  • 126
    • 84960422665 scopus 로고    scopus 로고
    • The basis of oncoimmunology
    • Palucka AK and Coussens LM (2016) The basis of oncoimmunology. Cell 164, 1233-1247.
    • (2016) Cell , vol.164 , pp. 1233-1247
    • Palucka, A.K.1    Coussens, L.M.2
  • 127
    • 84888639681 scopus 로고    scopus 로고
    • The roles of TGFbeta in the tumour microenvironment
    • Pickup M, Novitskiy S and Moses HL (2013) The roles of TGFbeta in the tumour microenvironment. Nat Rev Cancer 13, 788-799.
    • (2013) Nat Rev Cancer , vol.13 , pp. 788-799
    • Pickup, M.1    Novitskiy, S.2    Moses, H.L.3
  • 128
    • 0023946119 scopus 로고
    • Tumors as caricatures of the process of tissue renewal: Prospects for therapy by directing differentiation
    • Pierce GB and Speers WC (1988) Tumors as caricatures of the process of tissue renewal: prospects for therapy by directing differentiation. Cancer Res 48, 1996-2004.
    • (1988) Cancer Res , vol.48 , pp. 1996-2004
    • Pierce, G.B.1    Speers, W.C.2
  • 132
    • 84887444879 scopus 로고    scopus 로고
    • Microenvironmental regulation of tumor progression and metastasis
    • Quail DF and Joyce JA (2013) Microenvironmental regulation of tumor progression and metastasis. Nat Med 19, 1423-1437.
    • (2013) Nat Med , vol.19 , pp. 1423-1437
    • Quail, D.F.1    Joyce, J.A.2
  • 136
    • 84920962202 scopus 로고    scopus 로고
    • Molecular and genetic properties of tumors associated with local immune cytolytic activity
    • Rooney MS, Shukla SA, Wu CJ, Getz G and Hacohen N (2015) Molecular and genetic properties of tumors associated with local immune cytolytic activity. Cell 160, 48-61.
    • (2015) Cell , vol.160 , pp. 48-61
    • Rooney, M.S.1    Shukla, S.A.2    Wu, C.J.3    Getz, G.4    Hacohen, N.5
  • 137
    • 0030787373 scopus 로고    scopus 로고
    • Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer
    • Ropponen KM, Eskelinen MJ, Lipponen PK, Alhava E and Kosma V-M (1997) Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer. J Pathol 182, 318-324.
    • (1997) J Pathol , vol.182 , pp. 318-324
    • Ropponen, K.M.1    Eskelinen, M.J.2    Lipponen, P.K.3    Alhava, E.4    Kosma, V.-M.5
  • 142
    • 79953151458 scopus 로고    scopus 로고
    • Cancer immunoediting: Integrating immunity’s roles in cancer suppression and promotion
    • Schreiber RD, Old LJ and Smyth MJ (2011) Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion. Science 331, 1565-1570.
    • (2011) Science , vol.331 , pp. 1565-1570
    • Schreiber, R.D.1    Old, L.J.2    Smyth, M.J.3
  • 145
    • 84928774156 scopus 로고    scopus 로고
    • The future of immune checkpoint therapy
    • Sharma P and Allison JP (2015) The future of immune checkpoint therapy. Science 348, 56-61.
    • (2015) Science , vol.348 , pp. 56-61
    • Sharma, P.1    Allison, J.P.2
  • 147
    • 84871365780 scopus 로고    scopus 로고
    • Stroma-directed imatinib therapy impairs the tumor-promoting effect of bone marrow-derived mesenchymal stem cells in an orthotopic transplantation model of colon cancer
    • Shinagawa K, Kitadai Y, Tanaka M, Sumida T, Onoyama M, Ohnishi M, Ohara E, Higashi Y, Tanaka S, Yasui W et al. (2013) Stroma-directed imatinib therapy impairs the tumor-promoting effect of bone marrow-derived mesenchymal stem cells in an orthotopic transplantation model of colon cancer. Int J Cancer 132, 813-823.
    • (2013) Int J Cancer , vol.132 , pp. 813-823
    • Shinagawa, K.1    Kitadai, Y.2    Tanaka, M.3    Sumida, T.4    Onoyama, M.5    Ohnishi, M.6    Ohara, E.7    Higashi, Y.8    Tanaka, S.9    Yasui, W.10
  • 148
    • 84865787544 scopus 로고    scopus 로고
    • Molecular pathways: Targeting the TGF-beta pathway for cancer therapy
    • Smith AL, Robin TP and Ford HL (2012) Molecular pathways: targeting the TGF-beta pathway for cancer therapy. Clin Cancer Res 18, 4514-4521.
    • (2012) Clin Cancer Res , vol.18 , pp. 4514-4521
    • Smith, A.L.1    Robin, T.P.2    Ford, H.L.3
  • 152
    • 84906937205 scopus 로고    scopus 로고
    • Mechanisms of disseminated cancer cell dormancy: An awakening field
    • Sosa MS, Bragado P and Aguirre-Ghiso JA (2014) Mechanisms of disseminated cancer cell dormancy: an awakening field. Nat Rev Cancer 14, 611-622.
    • (2014) Nat Rev Cancer , vol.14 , pp. 611-622
    • Sosa, M.S.1    Bragado, P.2    Aguirre-Ghiso, J.A.3
  • 154
    • 77955268790 scopus 로고    scopus 로고
    • Transmission of donor melanoma by organ transplantation
    • Strauss DC and Thomas JM (2010) Transmission of donor melanoma by organ transplantation. Lancet Oncol 11, 790-796.
    • (2010) Lancet Oncol , vol.11 , pp. 790-796
    • Strauss, D.C.1    Thomas, J.M.2
  • 156
    • 84863923651 scopus 로고    scopus 로고
    • Increased frequency and clinical significance of myeloid-derived suppressor cells in human colorectal carcinoma
    • Sun H-L, Zhou X, Xue Y-F, Wang K, Shen Y-F, Mao J-J, Guo H-F and Miao Z-N (2012) Increased frequency and clinical significance of myeloid-derived suppressor cells in human colorectal carcinoma. World J Gastroenterol 18, 3303-3309.
    • (2012) World J Gastroenterol , vol.18 , pp. 3303-3309
    • Sun, H.-L.1    Zhou, X.2    Xue, Y.-F.3    Wang, K.4    Shen, Y.-F.5    Mao, J.-J.6    Guo, H.-F.7    Miao, Z.-N.8
  • 157
    • 84867121875 scopus 로고    scopus 로고
    • Intratumor heterogeneity: Evolution through space and time
    • Swanton C (2012) Intratumor heterogeneity: evolution through space and time. Cancer Res 72, 4875-4882.
    • (2012) Cancer Res , vol.72 , pp. 4875-4882
    • Swanton, C.1
  • 158
    • 84901606669 scopus 로고    scopus 로고
    • Serum levels of hepatocyte growth factor and epiregulin are associated with the prognosis on anti-EGFR antibody treatment in KRAS wild-type metastatic colorectal cancer
    • Takahashi N, Yamada Y, Furuta K, Honma Y, Iwasa S, Takashima A, Kato K, Hamaguchi T and Shimada Y (2014) Serum levels of hepatocyte growth factor and epiregulin are associated with the prognosis on anti-EGFR antibody treatment in KRAS wild-type metastatic colorectal cancer. Br J Cancer 110, 2716-2727.
    • (2014) Br J Cancer , vol.110 , pp. 2716-2727
    • Takahashi, N.1    Yamada, Y.2    Furuta, K.3    Honma, Y.4    Iwasa, S.5    Takashima, A.6    Kato, K.7    Hamaguchi, T.8    Shimada, Y.9
  • 159
    • 60449084008 scopus 로고    scopus 로고
    • Role of bone marrow-derived cells in colon cancer: Lessons from mouse model studies
    • Taketo MM (2009) Role of bone marrow-derived cells in colon cancer: lessons from mouse model studies. J Gastroenterol 44, 93-102.
    • (2009) J Gastroenterol , vol.44 , pp. 93-102
    • Taketo, M.M.1
  • 160
    • 84989964522 scopus 로고    scopus 로고
    • Trends in cancer targeting the microenvironment in advanced colorectal cancer
    • Tauriello DVF and Batlle E (2016) Trends in cancer targeting the microenvironment in advanced colorectal cancer. Trends Cancer 2, 495-504.
    • (2016) Trends Cancer , vol.2 , pp. 495-504
    • Tauriello, D.1    Batlle, E.2
  • 163
    • 84921629064 scopus 로고    scopus 로고
    • Plasticity within stem cell hierarchies in mammalian epithelia
    • Tetteh PW, Farin HF and Clevers H (2015) Plasticity within stem cell hierarchies in mammalian epithelia. Trends Cell Biol 25, 100-108.
    • (2015) Trends Cell Biol , vol.25 , pp. 100-108
    • Tetteh, P.W.1    Farin, H.F.2    Clevers, H.3
  • 164
    • 27644457376 scopus 로고    scopus 로고
    • TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance
    • Thomas DA and Massague J (2005) TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance. Cancer Cell 8, 369-380.
    • (2005) Cancer Cell , vol.8 , pp. 369-380
    • Thomas, D.A.1    Massague, J.2
  • 169
    • 84979872943 scopus 로고    scopus 로고
    • Relationship between hypoxia and response to antiangiogenic therapy in metastatic colorectal cancer
    • Ulivi P, Marisi G, Passardi A, Ulivi P, Marisi G and Passardi A (2016) Relationship between hypoxia and response to antiangiogenic therapy in metastatic colorectal cancer. Oncotarget 7, 46678-46691.
    • (2016) Oncotarget , vol.7 , pp. 46678-46691
    • Ulivi, P.1    Marisi, G.2    Passardi, A.3    Ulivi, P.4    Marisi, G.5    Passardi, A.6
  • 171
    • 80054686286 scopus 로고    scopus 로고
    • Tumor metastasis: Molecular insights and evolving paradigms
    • Valastyan S and Weinberg RA (2011) Tumor metastasis: molecular insights and evolving paradigms. Cell 147, 275-292.
    • (2011) Cell , vol.147 , pp. 275-292
    • Valastyan, S.1    Weinberg, R.A.2
  • 175
    • 84867047384 scopus 로고    scopus 로고
    • Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen
    • Van Cutsem E, Tabernero J, Lakomy R, Prenen H, Prausova J, Macarulla T, Ruff P, van Hazel GA, Moiseyenko V, Ferry D et al. (2012) Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen. J Clin Oncol 30, 3499-3506.
    • (2012) J Clin Oncol , vol.30 , pp. 3499-3506
    • Van Cutsem, E.1    Tabernero, J.2    Lakomy, R.3    Prenen, H.4    Prausova, J.5    Macarulla, T.6    Ruff, P.7    Van Hazel, G.A.8    Moiseyenko, V.9    Ferry, D.10
  • 177
    • 84921797416 scopus 로고    scopus 로고
    • The role of tumour budding in predicting survival in patients with primary operable colorectal cancer: A systematic review
    • van Wyk HC, Park J, Roxburgh C, Horgan P, Foulis A and McMillan DC (2015) The role of tumour budding in predicting survival in patients with primary operable colorectal cancer: a systematic review. Cancer Treat Rev 41, 151-159.
    • (2015) Cancer Treat Rev , vol.41 , pp. 151-159
    • Van Wyk, H.C.1    Park, J.2    Roxburgh, C.3    Horgan, P.4    Foulis, A.5    McMillan, D.C.6
  • 183
    • 84943427644 scopus 로고    scopus 로고
    • Humanized anti-hepatocyte growth factor (HGF) antibody suppresses innate irinotecan (CPT-11) resistance induced by fibroblast-derived HGF
    • Woo JK, Kang JH, Kim B, Park BH, Shin KJ, Song SW, Kim JJ, Kim HM, Lee SJ and Oh SH (2015) Humanized anti-hepatocyte growth factor (HGF) antibody suppresses innate irinotecan (CPT-11) resistance induced by fibroblast-derived HGF. Oncotarget 6, 24047-24060.
    • (2015) Oncotarget , vol.6 , pp. 24047-24060
    • Woo, J.K.1    Kang, J.H.2    Kim, B.3    Park, B.H.4    Shin, K.J.5    Song, S.W.6    Kim, J.J.7    Kim, H.M.8    Lee, S.J.9    Oh, S.H.10
  • 185
  • 187
    • 77953023274 scopus 로고    scopus 로고
    • TGF-beta and immune cells: An important regulatory axis in the tumor microenvironment and progression
    • Yang L, Pang Y and Moses HL (2010) TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression. Trends Immunol 31, 220-227.
    • (2010) Trends Immunol , vol.31 , pp. 220-227
    • Yang, L.1    Pang, Y.2    Moses, H.L.3
  • 188
    • 25444491756 scopus 로고    scopus 로고
    • Absence of smooth muscle actin-positive pericyte coverage of tumor vessels correlates with hematogenous metastasis and prognosis of colorectal cancer patients
    • Yonenaga Y, Mori A, Onodera H, Yasuda S, Oe H, Fujimoto A, Tachibana T and Imamura M (2005) Absence of smooth muscle actin-positive pericyte coverage of tumor vessels correlates with hematogenous metastasis and prognosis of colorectal cancer patients. Oncology 69, 159-166.
    • (2005) Oncology , vol.69 , pp. 159-166
    • Yonenaga, Y.1    Mori, A.2    Onodera, H.3    Yasuda, S.4    Oe, H.5    Fujimoto, A.6    Tachibana, T.7    Imamura, M.8
  • 189
    • 35948945337 scopus 로고    scopus 로고
    • Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts
    • Zeisberg EM, Potenta S, Xie L, Zeisberg M and Kalluri R (2007) Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts. Cancer Res 67, 10123-10128.
    • (2007) Cancer Res , vol.67 , pp. 10123-10128
    • Zeisberg, E.M.1    Potenta, S.2    Xie, L.3    Zeisberg, M.4    Kalluri, R.5
  • 190
    • 85002369621 scopus 로고    scopus 로고
    • IL-33 promotes growth and liver metastasis of colorectal cancer in mice by remodeling the tumor microenvironment and inducing angiogenesis
    • Zhang Y, Davis C, Shah S, Hughes D, Ryan JC, Altomare D and Pena MMO (2016) IL-33 promotes growth and liver metastasis of colorectal cancer in mice by remodeling the tumor microenvironment and inducing angiogenesis. Mol Carcinog 56, 272-287.
    • (2016) Mol Carcinog , vol.56 , pp. 272-287
    • Zhang, Y.1    Davis, C.2    Shah, S.3    Hughes, D.4    Ryan, J.C.5    Altomare, D.6    Pena, M.7
  • 191
    • 20144387943 scopus 로고    scopus 로고
    • Adoptive transfer of tumor-reactive transforming growth factor-beta-insensitive CD8+ T cells: Eradication of autologous mouse prostate cancer
    • Zhang Q, Yang X, Pins M, Javonovic B, Kuzel T, Kim S-J, Parijs L Van, Greenberg NM, Liu V, Guo Y et al. (2005) Adoptive transfer of tumor-reactive transforming growth factor-beta-insensitive CD8+ T cells: eradication of autologous mouse prostate cancer. Cancer Res 65, 1761-1769.
    • (2005) Cancer Res , vol.65 , pp. 1761-1769
    • Zhang, Q.1    Yang, X.2    Pins, M.3    Javonovic, B.4    Kuzel, T.5    Kim, S.-J.6    Van, P.L.7    Greenberg, N.M.8    Liu, V.9    Guo, Y.10
  • 192
    • 84880747672 scopus 로고    scopus 로고
    • Mechanism of action of conventional and targeted anticancer therapies: Reinstating immunosurveillance
    • Zitvogel L, Galluzzi L, Smyth MJ and Kroemer G (2013) Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. Immunity 39, 74-88.
    • (2013) Immunity , vol.39 , pp. 74-88
    • Zitvogel, L.1    Galluzzi, L.2    Smyth, M.J.3    Kroemer, G.4
  • 193
    • 79958003343 scopus 로고    scopus 로고
    • Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: Tumor budding as oncotarget
    • Zlobec I, Lugli A, Zlobec I and Lugli A (2010) Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: tumor budding as oncotarget. Oncotarget 1, 651-661.
    • (2010) Oncotarget , vol.1 , pp. 651-661
    • Zlobec, I.1    Lugli, A.2    Zlobec, I.3    Lugli, A.4
  • 194
    • 84929966392 scopus 로고    scopus 로고
    • Immunotherapy of metastatic colorectal cancer: Prevailing challenges and new perspectives
    • Zumwalt TJ and Goel A (2015) Immunotherapy of metastatic colorectal cancer: prevailing challenges and new perspectives. Curr Colorectal Cancer Rep 11, 125-140.
    • (2015) Curr Colorectal Cancer Rep , vol.11 , pp. 125-140
    • Zumwalt, T.J.1    Goel, A.2


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