Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids

Nature Medicine

Volumn 21, Issue 3, 2015, Pages 256-262

  Matano, Mami ^a   Date, Shoichi ^a,b   Shimokawa, Mariko ^a   Takano, Ai ^a   Fujii, Masayuki ^a,c   Ohta, Yuki ^a   Watanabe, Toshiaki ^c   Kanai, Takanori ^a   Sato, Toshiro ^a  

^a KEIO UNIVERSITY   (Japan)

^b OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; PROTEIN KINASE B; PROTEIN P53; SMAD4 PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PIK3CA PROTEIN, HUMAN; SMAD4 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ENGINEERING; CELL GROWTH; CHROMOSOMAL INSTABILITY; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; COLON MUCOSA; COLORECTAL CANCER; CONTROLLED STUDY; GENE MUTATION; GENETIC STABILITY; HISTOPATHOLOGY; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INDEL MUTATION; INTESTINE EPITHELIUM; INTESTINE EPITHELIUM CELL; MICROARRAY ANALYSIS; MICROMETASTASIS; MOUSE; NONHUMAN; ONCOGENE K RAS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SEQUENCE ANALYSIS; SOUTHERN BLOTTING; UPREGULATION; WESTERN BLOTTING; ADENOCARCINOMA; ADENOMA; ANIMAL; COLORECTAL TUMOR; CYTOPLASM; GENE EXPRESSION REGULATION; GENETICS; INTESTINE MUCOSA; MUTATION; ONCOGENE RAS; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; ADENOMA; ANIMALS; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; COLORECTAL NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, APC; GENES, P53; GENES, RAS; HUMANS; IN VITRO TECHNIQUES; INTESTINAL MUCOSA; MICE; MUTATION; ORGANOIDS; PHOSPHATIDYLINOSITOL 3-KINASES; SMAD4 PROTEIN;

EID: 84924422753     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3802     Document Type: Article

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