Sequential cancer mutations in cultured human intestinal stem cells

Nature

Volumn 521, Issue 7550, 2015, Pages 43-47

  Drost, Jarno ^a   Van Jaarsveld, Richard H ^a   Ponsioen, Bas ^a   Zimberlin, Cheryl ^a,b   Van Boxtel, Ruben ^a   Buijs, Arjan ^c   Sachs, Norman ^a   Overmeer, René M ^a   Offerhaus, G Johan ^c   Begthel, Harry ^a   Korving, Jeroen ^a   Van De Wetering, Marc ^a,d   Schwank, Gerald ^a   Logtenberg, Meike ^a   Cuppen, Edwin ^a   Snippert, Hugo J ^a   Medema, Jan Paul ^a,b   Kops, Geert J P L ^a   Clevers, Hans ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c Molecular Cancer Research Centre for Molecular Medicine UMC Utrecht ^*  (Netherlands)

^d Foundation Hubrecht Organoid Technology (HUB)   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; CRISPR ASSOCIATED PROTEIN; GROWTH FACTOR; K RAS PROTEIN; NUTLIN 3; PROTEIN P53; IMIDAZOLE DERIVATIVE; KRAS PROTEIN, HUMAN; PIPERAZINE DERIVATIVE; PROTEIN P21; SIGNAL PEPTIDE; SMAD4 PROTEIN; SMAD4 PROTEIN, HUMAN;

CANCER; CELL ORGANELLE; GENE EXPRESSION; GENETICALLY MODIFIED ORGANISM; MUTATION; PHENOTYPE; POLYPLOIDY; RODENT; TUMOR;

ANEUPLOIDY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLON; COLORECTAL CANCER; CONTROLLED STUDY; CULTURE MEDIUM; CYTOPLASM; GENE MUTATION; GENE TARGETING; HUMAN; HUMAN CELL; INTESTINAL STEM CELL; INVASIVE CARCINOMA; LIVER; MOUSE; MUTANT; NONHUMAN; PANCREAS; PRIORITY JOURNAL; SMALL INTESTINE; STEM CELL CULTURE; TUMOR GENE; TUMOR GROWTH; XENOTRANSPLANTATION; ANIMAL; CANCER TRANSPLANTATION; CHILD; COLORECTAL TUMOR; CRISPR CAS SYSTEM; DEFICIENCY; FEMALE; GENETICS; INTESTINE; METABOLISM; MIDDLE AGED; MUTATION; PATHOLOGY; PHYSIOLOGY; PRESCHOOL CHILD; SITE DIRECTED MUTAGENESIS; STEM CELL; STEM CELL NICHE; TUMOR INVASION; TUMOR SUPPRESSOR GENE; XENOGRAFT;

MUS;

ANEUPLOIDY; ANIMALS; CHILD; CHILD, PRESCHOOL; COLORECTAL NEOPLASMS; CRISPR-CAS SYSTEMS; FEMALE; GENES, APC; GENES, P53; HETEROGRAFTS; HUMANS; IMIDAZOLES; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTESTINES; MICE; MIDDLE AGED; MUTAGENESIS, SITE-DIRECTED; MUTATION; NEOPLASM INVASIVENESS; NEOPLASM TRANSPLANTATION; ORGANOIDS; PIPERAZINES; PROTO-ONCOGENE PROTEINS P21(RAS); SMAD4 PROTEIN; STEM CELL NICHE; STEM CELLS;

EID: 84929103936     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14415     Document Type: Article

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