TNIK inhibition abrogates colorectal cancer stemness

Nature Communications

Volumn 7, Issue , 2016, Pages

  Masuda, Mari ^a   Uno, Yuko ^b   Ohbayashi, Naomi ^c   Ohata, Hirokazu ^a   Mimata, Ayako ^a   Kukimoto Niino, Mutsuko ^c   Moriyama, Hideki ^b   Kashimoto, Shigeki ^b   Inoue, Tomoko ^b   Goto, Naoko ^a   Okamoto, Koji ^a   Shirouzu, Mikako ^c   Sawa, Masaaki ^b   Yamada, Tesshi ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b 1 5 5 Minatojima Minamimachi   (Japan)

^c RIKEN   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; AZOXYMETHANE; NCB 0846; T CELL FACTOR 4; T CELL FACTOR PROTEIN; TRAF2 AND NCK INTERACTING KINASE; TUMOR PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; ADENOMATOUS POLYPOSIS COLI PROTEIN, MOUSE; APC PROTEIN; BETA CATENIN; CTNNB1 PROTEIN, MOUSE; GERMINAL CENTER KINASES; IMIDAZOLE DERIVATIVE; PROTEIN BINDING; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; QUINAZOLINE DERIVATIVE; RECOMBINANT PROTEIN; TNIK PROTEIN, MOUSE; UBIQUITIN PROTEIN LIGASE;

CANCER; CELLS AND CELL COMPONENTS; ENZYME ACTIVITY; GENE EXPRESSION; ORGANIC COMPOUND; PROTEIN; RODENT; TUMOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER CELL LINE; CANCER INHIBITION; CANCER STEM CELL; COLORECTAL CANCER; CONFORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; TRANSCRIPTION REGULATION; X RAY ANALYSIS; AGED; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; C57BL MOUSE; CARCINOGENESIS; CELL PROLIFERATION; CELL TRANSFORMATION; CHEMICALLY INDUCED; CHEMISTRY; COLORECTAL TUMOR; DRUG EFFECT; DRUG SCREENING; FEMALE; GENETICS; KNOCKOUT MOUSE; METABOLISM; MIDDLE AGED; MUTATION; NUDE MOUSE; ORAL DRUG ADMINISTRATION; PATHOLOGY; TUMOR CELL LINE; WNT SIGNALING; X RAY CRYSTALLOGRAPHY;

MUS;

ADENOMATOUS POLYPOSIS COLI PROTEIN; ADMINISTRATION, ORAL; AGED; ANIMALS; AZOXYMETHANE; BETA CATENIN; CARCINOGENESIS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; COLORECTAL NEOPLASMS; CRYSTALLOGRAPHY, X-RAY; FEMALE; HUMANS; IMIDAZOLES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, NUDE; MIDDLE AGED; MUTATION; NEOPLASTIC STEM CELLS; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; QUINAZOLINES; RECOMBINANT PROTEINS; UBIQUITIN-PROTEIN LIGASES; WNT PROTEINS; WNT SIGNALING PATHWAY; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84984612126     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms12586     Document Type: Article

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