IFNα gene/cell therapy curbs colorectal cancer colonization of the liver by acting on the hepatic microenvironment

EMBO Molecular Medicine

Volumn 8, Issue 2, 2016, Pages 155-170

  Catarinella, Mario ^a,b   Monestiroli, Andrea ^a   Escobar, Giulia ^b,c   Fiocchi, Amleto ^a   Tran, Ngoc Lan ^a   Aiolfi, Roberto ^a,d   Marra, Paolo ^a,b   Esposito, Antonio ^a,b   Cipriani, Federica ^a   Aldrighetti, Luca ^a   Iannacone, Matteo ^a,b   Naldini, Luigi ^b,c   Guidotti, Luca G ^a   Sitia, Giovanni ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^c SAN RAFFAELE SCIENTIFIC INSTITUTE   (Italy)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Colorectal cancer; Gene therapy; Interferon alpha; Liver metastases; Tumor microenvironment

Indexed keywords

ALPHA INTERFERON; LENTIVIRUS VECTOR; MICRORNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL THERAPY; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE COURSE; GENE TRANSFER; HEMATOPOIETIC STEM CELL; IMMUNE RESPONSE; IMMUNOCOMPETENCE; IN VITRO STUDY; LIVER METASTASIS; LIVER PARENCHYMA; MACROPHAGE; METASTASIS; MICROENVIRONMENT; MONOCYTE; MORTALITY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; ANIMAL; BIOLOGICAL THERAPY; COLORECTAL NEOPLASMS; COMPLICATION; DISEASE MODEL; GENE THERAPY; HUMAN; LIVER NEOPLASMS; METABOLISM; NEOPLASM METASTASIS; PROCEDURES; SURVIVAL ANALYSIS;

ANIMALS; CELL- AND TISSUE-BASED THERAPY; COLORECTAL NEOPLASMS; DISEASE MODELS, ANIMAL; GENETIC THERAPY; HUMANS; INTERFERON-ALPHA; LIVER NEOPLASMS; MICE; NEOPLASM METASTASIS; SURVIVAL ANALYSIS;

EID: 84957937575     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.15252/emmm.201505395     Document Type: Article

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