Comparative lesion sequencing provides insights into tumor evolution

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 11, 2008, Pages 4283-4288

  Jones, Siân ^a   Chen, Wei Dong ^b,c,d   Parmigiani, Giovanni ^a   Diehl, Frank ^a   Beerenwinkel, Niko ^e,g   Antal, Tibor ^g   Traulsen, Arne ^f,g   Nowak, Martin A ^g   Siegel, Christopher ^b   Velculescu, Victor E ^a   Kinzler, Kenneth W ^a   Vogelstein, Bert ^a   Willis, Joseph ^b,c   Markowitz, Sanford D ^b,c,d  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e ETH ZURICH   (Switzerland)

^f MAX PLANCK INSTITUTE FOR EVOLUTIONARY BIOLOGY   (Germany)

^g HARVARD UNIVERSITY   (United States)

Author keywords

Cancer genetics; Colorectal cancer; Metastasis; Stem cells

Indexed keywords

ADULT; ADVANCED CANCER; AGED; ARTICLE; BENIGN TUMOR; CARCINOGENESIS; CELL CULTURE; CELL POPULATION; CELL TRANSFORMATION; COLORECTAL TUMOR; DISEASE COURSE; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; INVASIVE CARCINOMA; MALE; METASTASIS; MUTATIONAL ANALYSIS; POINT MUTATION; PRIORITY JOURNAL; TUMOR CELL; TUMOR GROWTH; ADENOMA; ANIMAL; CANCER STAGING; COLON TUMOR; COMPARATIVE STUDY; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETICS; KINETICS; MIDDLE AGED; MOUSE; MUTATION; NUCLEOTIDE SEQUENCE; NUDE MOUSE; PATHOLOGY; TUMOR CELL LINE;

DNA;

ADENOMA; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; BASE SEQUENCE; CELL LINE, TUMOR; COLONIC NEOPLASMS; DNA; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KINETICS; MALE; MICE; MICE, NUDE; MIDDLE AGED; MUTATION; NEOPLASM METASTASIS; NEOPLASM STAGING; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 41949139438     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0712345105     Document Type: Article

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