-
1
-
-
0023449617
-
The int-1 proto-oncogene products are glycoproteins that appear to enter the secretory pathway
-
Papkoff, J., Brown, A. M. & Varmus, H. E. The int-1 proto-oncogene products are glycoproteins that appear to enter the secretory pathway. Mol. Cell. Biol. 7, 3978-3984 (1987).
-
(1987)
Mol. Cell. Biol
, vol.7
, pp. 3978-3984
-
-
Papkoff, J.1
Brown, A.M.2
Varmus, H.E.3
-
2
-
-
0020216124
-
Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome
-
Nusse, R. & Varmus, H. E. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell 31, 99-109 (1982).
-
(1982)
Cell
, vol.31
, pp. 99-109
-
-
Nusse, R.1
Varmus, H.E.2
-
3
-
-
0021270667
-
Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15
-
Nusse, R., Van Ooyen, A., Cox, D., Fung, Y. K. & Varmus, H. Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15. Nature 307, 131-136 (1984).
-
(1984)
Nature
, vol.307
, pp. 131-136
-
-
Nusse, R.1
Van Ooyen, A.2
Cox, D.3
Fung, Y.K.4
Varmus, H.5
-
4
-
-
0024162530
-
Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice
-
Tsukamoto, A. S., Grosschedl, R., Guzman, R. C., Parslow, T. & Varmus, H. E. Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. Cell 55, 619-625 (1988).
-
(1988)
Cell
, vol.55
, pp. 619-625
-
-
Tsukamoto, A.S.1
Grosschedl, R.2
Guzman, R.C.3
Parslow, T.4
Varmus, H.E.5
-
5
-
-
0029920839
-
Wnt-1 regulates free pools of catenins and stabilizes APC-catenin complexes
-
Papkoff, J., Rubinfeld, B., Schryver, B. & Polakis, P. Wnt-1 regulates free pools of catenins and stabilizes APC-catenin complexes. Mol. Cell. Biol. 16, 2128-2134 (1996).
-
(1996)
Mol. Cell. Biol
, vol.16
, pp. 2128-2134
-
-
Papkoff, J.1
Rubinfeld, B.2
Schryver, B.3
Polakis, P.4
-
6
-
-
0030975671
-
Constitutive transcriptional activation by a β-catenin-Tcf complex in APC?/? colon carcinoma
-
Korinek, V. et al. Constitutive transcriptional activation by a β-catenin-Tcf complex in APC?/? colon carcinoma. Science 275, 1784-1787 (1997).
-
(1997)
Science
, vol.275
, pp. 1784-1787
-
-
Korinek, V.1
-
7
-
-
0030949463
-
Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC
-
Morin, P. J. et al. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science 275, 1787-1790 (1997).
-
(1997)
Science
, vol.275
, pp. 1787-1790
-
-
Morin, P.J.1
-
8
-
-
0030592517
-
Lessons from hereditary colorectal cancer
-
Kinzler, K. W. & Vogelstein, B. Lessons from hereditary colorectal cancer. Cell 87, 159-170 (1996).
-
(1996)
Cell
, vol.87
, pp. 159-170
-
-
Kinzler, K.W.1
Vogelstein, B.2
-
9
-
-
33845373278
-
Colorectal cancer and genetic alterations in the Wnt pathway
-
Segditsas, S. & Tomlinson, I. Colorectal cancer and genetic alterations in the Wnt pathway. Oncogene 25, 7531-7537 (2006).
-
(2006)
Oncogene
, vol.25
, pp. 7531-7537
-
-
Segditsas, S.1
Tomlinson, I.2
-
10
-
-
67649470380
-
Proximal events in Wnt signal transduction
-
Angers, S. & Moon, R. T. Proximal events in Wnt signal transduction. Nature Rev. Mol. Cell. Biol. 10, 468-477 (2009).
-
(2009)
Nature Rev. Mol. Cell. Biol
, vol.10
, pp. 468-477
-
-
Angers, S.1
Moon, R.T.2
-
11
-
-
24644499046
-
Wnt and calcium signaling: β-catenin-independent pathways
-
Kohn, A. D. & Moon, R. T. Wnt and calcium signaling: β-catenin-independent pathways. Cell Calcium 38, 439-446 (2005).
-
(2005)
Cell Calcium
, vol.38
, pp. 439-446
-
-
Kohn, A.D.1
Moon, R.T.2
-
12
-
-
84863922124
-
Comprehensive molecular characterization of human colon and rectal cancer
-
Cancer Genome Atlas Network
-
Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature 487, 330-337 (2012).
-
(2012)
Nature
, vol.487
, pp. 330-337
-
-
-
13
-
-
80053385552
-
Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion
-
Bass, A. J. et al. Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion. Nature Genet. 43, 964-968 (2011).
-
(2011)
Nature Genet
, vol.43
, pp. 964-968
-
-
Bass, A.J.1
-
14
-
-
33745532794
-
Genetics of hepatocellular tumors
-
Laurent-Puig, P. & Zucman-Rossi, J. Genetics of hepatocellular tumors. Oncogene 25, 3778-3786 (2006).
-
(2006)
Oncogene
, vol.25
, pp. 3778-3786
-
-
Laurent-Puig, P.1
Zucman-Rossi, J.2
-
15
-
-
33745552897
-
Dysregulation of growth factor signaling in human hepatocellular carcinoma
-
Breuhahn, K., Longerich, T. & Schirmacher, P. Dysregulation of growth factor signaling in human hepatocellular carcinoma. Oncogene 25, 3787-3800 (2006).
-
(2006)
Oncogene
, vol.25
, pp. 3787-3800
-
-
Breuhahn, K.1
Longerich, T.2
Schirmacher, P.3
-
16
-
-
0032030894
-
Sporadic medulloblastomas contain oncogenic β-catenin mutations
-
Zurawel, R. H., Chiappa, S. A., Allen, C. & Raffel, C. Sporadic medulloblastomas contain oncogenic β-catenin mutations. Cancer Res. 58, 896-899 (1998).
-
(1998)
Cancer Res
, vol.58
, pp. 896-899
-
-
Zurawel, R.H.1
Chiappa, S.A.2
Allen, C.3
Raffel, C.4
-
17
-
-
0032054206
-
Mutations in the β-catenin gene (CTNNB1) in endometrioid ovarian carcinomas
-
Palacios, J. & Gamallo, C. Mutations in the β-catenin gene (CTNNB1) in endometrioid ovarian carcinomas. Cancer Res. 58, 1344-1347 (1998).
-
(1998)
Cancer Res
, vol.58
, pp. 1344-1347
-
-
Palacios, J.1
Gamallo, C.2
-
18
-
-
15044348490
-
The links between axin and carcinogenesis
-
Salahshor, S. & Woodgett, J. R. The links between axin and carcinogenesis. J. Clin. Pathol. 58, 225-236 (2005).
-
(2005)
J. Clin. Pathol
, vol.58
, pp. 225-236
-
-
Salahshor, S.1
Woodgett, J.R.2
-
19
-
-
0034088858
-
AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1
-
Satoh, S. et al. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nature Genet. 24, 245-250 (2000).
-
(2000)
Nature Genet
, vol.24
, pp. 245-250
-
-
Satoh, S.1
-
20
-
-
33847656105
-
LRP6 mutation in a family with early coronary disease and metabolic risk factors
-
Mani, A. et al. LRP6 mutation in a family with early coronary disease and metabolic risk factors. Science 315, 1278-1282 (2007).
-
(2007)
Science
, vol.315
, pp. 1278-1282
-
-
Mani, A.1
-
21
-
-
0036789449
-
Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy
-
Robitaille, J. et al. Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy. Nature Genet. 32, 326-330 (2002).
-
(2002)
Nature Genet
, vol.32
, pp. 326-330
-
-
Robitaille, J.1
-
22
-
-
34547191230
-
Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease
-
De Ferrari, G. V. et al. Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease. Proc. Natl Acad. Sci. USA 104, 9434-9439 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 9434-9439
-
-
De Ferrari, G.V.1
-
23
-
-
36349013133
-
Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma
-
Chim, C. S., Pang, R., Fung, T. K., Choi, C. L. & Liang, R. Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma. Leukemia 21, 2527-2536 (2007).
-
(2007)
Leukemia
, vol.21
, pp. 2527-2536
-
-
Chim, C.S.1
Pang, R.2
Fung, T.K.3
Choi, C.L.4
Liang, R.5
-
24
-
-
47149097853
-
Epigenetic gene silencing in the Wnt pathway in breast cancer
-
Klarmann, G. J., Decker, A. & Farrar, W. L. Epigenetic gene silencing in the Wnt pathway in breast cancer. Epigenetics 3, 59-63 (2008).
-
(2008)
Epigenetics
, vol.3
, pp. 59-63
-
-
Klarmann, G.J.1
Decker, A.2
Farrar, W.L.3
-
25
-
-
33745765883
-
Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer
-
Aguilera, O. et al. Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer. Oncogene 25, 4116-4121 (2006).
-
(2006)
Oncogene
, vol.25
, pp. 4116-4121
-
-
Aguilera, O.1
-
26
-
-
65249167488
-
Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice
-
Kansara, M. et al. Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice. J. Clin. Invest. 119, 837-851 (2009).
-
(2009)
J. Clin. Invest
, vol.119
, pp. 837-851
-
-
Kansara, M.1
-
27
-
-
11144355980
-
MUC1 and nuclear β-catenin are coexpressed at the invasion front of colorectal carcinomas and are both correlated with tumor prognosis
-
Baldus, S. E. et al. MUC1 and nuclear β-catenin are coexpressed at the invasion front of colorectal carcinomas and are both correlated with tumor prognosis. Clin. Cancer Res. 10, 2790-2796 (2004).
-
(2004)
Clin. Cancer Res
, vol.10
, pp. 2790-2796
-
-
Baldus, S.E.1
-
28
-
-
0034636153
-
β-catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression
-
Lin, S. Y. et al. β-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proc. Natl Acad. Sci. USA 97, 4262-4266 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 4262-4266
-
-
Lin, S.Y.1
-
29
-
-
0037114729
-
A survival-stratification model of human colorectal carcinomas with β-catenin and p27kip1
-
Cheah, P. Y., Choo, P. H., Yao, J., Eu, K. W. & Seow-Choen, F. A survival-stratification model of human colorectal carcinomas with β-catenin and p27kip1. Cancer 95, 2479-2486 (2002).
-
(2002)
Cancer
, vol.95
, pp. 2479-2486
-
-
Cheah, P.Y.1
Choo, P.H.2
Yao, J.3
Eu, K.W.4
Seow-Choen, F.5
-
30
-
-
0031727409
-
Nuclear overexpression of the oncoprotein β-catenin in colorectal cancer is localized predominantly at the invasion front
-
Brabletz, T. et al. Nuclear overexpression of the oncoprotein β-catenin in colorectal cancer is localized predominantly at the invasion front. Pathol. Res. Pract. 194, 701-704 (1998).
-
(1998)
Pathol. Res. Pract
, vol.194
, pp. 701-704
-
-
Brabletz, T.1
-
31
-
-
80355145628
-
Nuclear β-catenin overexpression in metastatic sentinel lymph node is associated with synchronous liver metastasis in colorectal cancer
-
Cheng, H., Liang, H., Qin, Y. & Liu, Y. Nuclear β-catenin overexpression in metastatic sentinel lymph node is associated with synchronous liver metastasis in colorectal cancer. Diagn. Pathol. 6, 109 (2011).
-
(2011)
Diagn. Pathol
, vol.6
, Issue.109
-
-
Cheng, H.1
Liang, H.2
Qin, Y.3
Liu, Y.4
-
32
-
-
0035674997
-
Tissue microarray analysis of β-catenin in colorectal cancer shows nuclear phospho-β-catenin is associated with a better prognosis
-
Chung, G. G. et al. Tissue microarray analysis of β-catenin in colorectal cancer shows nuclear phospho-β-catenin is associated with a better prognosis. Clin. Cancer Res. 7, 4013-4020 (2001).
-
(2001)
Clin. Cancer Res
, vol.7
, pp. 4013-4020
-
-
Chung, G.G.1
-
33
-
-
0031825010
-
E-cadherin and α-β-and γ-catenin protein expression in relation to metastasis in human breast carcinoma
-
Bukholm, I. K., Nesland, J. M., Kresen, R., Jacobsen, U. & Brresen-Dale, A. L. E-cadherin and α-, β-, and γ-catenin protein expression in relation to metastasis in human breast carcinoma. J. Pathol. 185, 262-266 (1998).
-
(1998)
J. Pathol
, vol.185
, pp. 262-266
-
-
Bukholm, I.K.1
Nesland, J.M.2
Kresen, R.3
Jacobsen, U.4
Brresen-Dale, A.L.5
-
34
-
-
77953183234
-
Wnt/β-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome
-
Khramtsov, A. I. et al. Wnt/β-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome. Am. J. Pathol. 176, 2911-2920 (2010).
-
(2010)
Am. J. Pathol
, vol.176
, pp. 2911-2920
-
-
Khramtsov, A.I.1
-
35
-
-
74549167752
-
Cytoplasmic localization of β-catenin is a marker of poor outcome in breast cancer patients
-
Lσpez-Knowles, E. et al. Cytoplasmic localization of β-catenin is a marker of poor outcome in breast cancer patients. Cancer Epidemiol. Biomarkers Prev. 19, 301-309 (2010).
-
(2010)
Cancer Epidemiol. Biomarkers Prev
, vol.19
, pp. 301-309
-
-
Lpez-Knowles, E.1
-
36
-
-
65849356587
-
β-catenin status in paediatric medulloblastomas: Correlation of immunohistochemical expression with mutational status, genetic profiles, and clinical characteristics
-
Fattet, S. et al. β-catenin status in paediatric medulloblastomas: correlation of immunohistochemical expression with mutational status, genetic profiles, and clinical characteristics. J. Pathol. 218, 86-94 (2009).
-
(2009)
J. Pathol
, vol.218
, pp. 86-94
-
-
Fattet, S.1
-
37
-
-
32944461274
-
β-catenin status predicts a favorable outcome in childhood medulloblastoma: The United Kingdom Children's Cancer Study Group Brain Tumour Committee
-
Ellison, D. W. et al. β-catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee. J. Clin. Oncol. 23, 7951-7957 (2005).
-
(2005)
J. Clin. Oncol
, vol.23
, pp. 7951-7957
-
-
Ellison, D.W.1
-
38
-
-
19944382766
-
Lower levels of nuclear β-catenin predict for a poorer prognosis in localized prostate cancer
-
Horvath, L. G. et al. Lower levels of nuclear β-catenin predict for a poorer prognosis in localized prostate cancer. Int. J. Cancer 113, 415-422 (2005).
-
(2005)
Int. J. Cancer
, vol.113
, pp. 415-422
-
-
Horvath, L.G.1
-
39
-
-
0032813907
-
β-catenin expression pattern in stage i and II ovarian carcinomas: Relationship with β-catenin gene mutations, clinicopathological features, and clinical outcome
-
Gamallo, C. et al. β-catenin expression pattern in stage I and II ovarian carcinomas: relationship with β-catenin gene mutations, clinicopathological features, and clinical outcome. Am. J. Pathol. 155, 527-536 (1999).
-
(1999)
Am. J. Pathol
, vol.155
, pp. 527-536
-
-
Gamallo, C.1
-
40
-
-
59049101982
-
Activated Wnt/β-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model
-
Chien, A. J. et al. Activated Wnt/β-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model. Proc. Natl Acad. Sci. USA 106, 1193-1198 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 1193-1198
-
-
Chien, A.J.1
-
41
-
-
0034601455
-
Molecular classification of cutaneous malignant melanoma by gene expression profiling
-
Bittner, M. et al. Molecular classification of cutaneous malignant melanoma by gene expression profiling. Nature 406, 536-540 (2000).
-
(2000)
Nature
, vol.406
, pp. 536-540
-
-
Bittner, M.1
-
42
-
-
0036528247
-
Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma
-
Weeraratna, A. T. et al. Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma. Cancer Cell 1, 279-288 (2002).
-
(2002)
Cancer Cell
, vol.1
, pp. 279-288
-
-
Weeraratna, A.T.1
-
43
-
-
53249090604
-
WNT5A expression increases during melanoma progression and correlates with outcome
-
Da Forno, P. D. et al. WNT5A expression increases during melanoma progression and correlates with outcome. Clin. Cancer Res. 14, 5825-5832 (2008).
-
(2008)
Clin. Cancer Res
, vol.14
, pp. 5825-5832
-
-
Da Forno, P.D.1
-
44
-
-
33751295132
-
Expression of Wnt-5a is correlated with aggressiveness of gastric cancer by stimulating cell migration and invasion
-
Kurayoshi, M. et al. Expression of Wnt-5a is correlated with aggressiveness of gastric cancer by stimulating cell migration and invasion. Cancer Res. 66, 10439-10448 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 10439-10448
-
-
Kurayoshi, M.1
-
45
-
-
0028902359
-
Wnt5a cloning, expression, and up-regulation in human primary breast cancers
-
Lejeune, S., Huguet, E. L., Hamby, A., Poulsom, R. & Harris, A. L. Wnt5a cloning, expression, and up-regulation in human primary breast cancers. Clin. Cancer Res. 1, 215-222 (1995).
-
(1995)
Clin. Cancer Res
, vol.1
, pp. 215-222
-
-
Lejeune, S.1
Huguet, E.L.2
Hamby, A.3
Poulsom, R.4
Harris, A.L.5
-
46
-
-
27144450534
-
Wnt-5a protein expression in primary dukes B colon cancers identifies a subgroup of patients with good prognosis
-
Dejmek, J., Dejmek, A., Säfholm, A., Sjölander, A. & Andersson, T. Wnt-5a protein expression in primary dukes B colon cancers identifies a subgroup of patients with good prognosis. Cancer Res. 65, 9142-9146 (2005).
-
(2005)
Cancer Res
, vol.65
, pp. 9142-9146
-
-
Dejmek, J.1
Dejmek, A.2
Säfholm, A.3
Sjölander, A.4
Andersson, T.5
-
47
-
-
0027965236
-
Differential transformation of mammary epithelial cells by Wnt genes
-
Wong, G. T., Gavin, B. J. & McMahon, A. P. Differential transformation of mammary epithelial cells by Wnt genes. Mol. Cell. Biol. 14, 6278-6286 (1994).
-
(1994)
Mol. Cell. Biol
, vol.14
, pp. 6278-6286
-
-
Wong, G.T.1
Gavin, B.J.2
McMahon, A.P.3
-
48
-
-
0031456662
-
Transformation by Wnt family proteins correlates with regulation of β-catenin
-
Shimizu, H. et al. Transformation by Wnt family proteins correlates with regulation of β-catenin. Cell Growth Differ. 8, 1349-1358 (1997).
-
(1997)
Cell Growth Differ
, vol.8
, pp. 1349-1358
-
-
Shimizu, H.1
-
49
-
-
0033919506
-
Retroviral expression of Wnt-1 and Wnt-7b produces different effects in mouse mammary epithelium
-
Naylor, S. et al. Retroviral expression of Wnt-1 and Wnt-7b produces different effects in mouse mammary epithelium. J. Cell. Sci. 113, 2129-2138 (2000).
-
(2000)
J. Cell. Sci
, vol.113
, pp. 2129-2138
-
-
Naylor, S.1
-
50
-
-
0037434982
-
Wnt signaling in B-cell neoplasia
-
Qiang, Y.-W., Endo, Y., Rubin, J. S. & Rudikoff, S. Wnt signaling in B-cell neoplasia. Oncogene 22, 1536-1545 (2003).
-
(2003)
Oncogene
, vol.22
, pp. 1536-1545
-
-
Qiang, Y.-W.1
Endo, Y.2
Rubin, J.S.3
Rudikoff, S.4
-
51
-
-
11144355390
-
Illegitimate WNT signaling promotes proliferation of multiple myeloma cells
-
Derksen, P. W. B. Illegitimate WNT signaling promotes proliferation of multiple myeloma cells. Proc. Natl Acad. Sci. 101, 6122-6127 (2004).
-
(2004)
Proc. Natl Acad. Sci
, vol.101
, pp. 6122-6127
-
-
Derksen, P.W.B.1
-
52
-
-
10844230334
-
Wnt3a growth factor induces androgen receptor-mediated transcription and enhances cell growth in human prostate cancer cells
-
Verras, M., Brown, J., Li, X., Nusse, R. & Sun, Z. Wnt3a growth factor induces androgen receptor-mediated transcription and enhances cell growth in human prostate cancer cells. Cancer Res. 64, 8860-8866 (2004).
-
(2004)
Cancer Res
, vol.64
, pp. 8860-8866
-
-
Verras, M.1
Brown, J.2
Li, X.3
Nusse, R.4
Sun, Z.5
-
53
-
-
58149215849
-
Prostate tumor progression is mediated by a paracrine TGF-β/Wnt3a signaling axis
-
Li, X. et al. Prostate tumor progression is mediated by a paracrine TGF-β/Wnt3a signaling axis. Oncogene 27, 7118-7130 (2008).
-
(2008)
Oncogene
, vol.27
, pp. 7118-7130
-
-
Li, X.1
-
54
-
-
58249105729
-
K-ras and Wnt Signaling synergize to accelerate prostate tumorigenesis in the mouse
-
Pearson, H. B., Phesse, T. J. & Clarke, A. R. K-ras and Wnt Signaling synergize to accelerate prostate tumorigenesis in the mouse. Cancer Res. 69, 94-101 (2009).
-
(2009)
Cancer Res
, vol.69
, pp. 94-101
-
-
Pearson, H.B.1
Phesse, T.J.2
Clarke, A.R.3
-
55
-
-
79955479314
-
Wnt/β-Catenin activation promotes prostate tumor progression in a mouse model
-
Yu, X., Wang, Y., DeGraff, D. J., Wills, M. L. & Matusik, R. J. Wnt/β-Catenin activation promotes prostate tumor progression in a mouse model. Oncogene 30, 1868-1879 (2010).
-
(2010)
Oncogene
, vol.30
, pp. 1868-1879
-
-
Yu, X.1
Wang, Y.2
Degraff, D.J.3
Wills, M.L.4
Matusik, R.J.5
-
56
-
-
84855696067
-
Wnt/β-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma
-
Biechele, T. L. et al. Wnt/β-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma. Sci. Signal. 5, ra3 (2012).
-
(2012)
Sci. Signal
, vol.5
-
-
Biechele, T.L.1
-
57
-
-
84858605181
-
WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/β-catenin pathway
-
Yoshioka, S. et al. WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/β-catenin pathway. Mol. Cancer Res. 10, 469-482 (2012).
-
(2012)
Mol. Cancer Res
, vol.10
, pp. 469-482
-
-
Yoshioka, S.1
-
58
-
-
84858076616
-
Peripheral T-lymphocytes express WNT7A and its restoration in leukemia-derived lymphoblasts inhibits cell proliferation
-
Ochoa-Hernαndez, A. B. et al. Peripheral T-lymphocytes express WNT7A and its restoration in leukemia-derived lymphoblasts inhibits cell proliferation. BMC Cancer 12, 60 (2012).
-
(2012)
BMC Cancer
, vol.12
, Issue.60
-
-
Ochoa-Hernndez, A.B.1
-
59
-
-
50349095325
-
Secreted frizzled-related protein 4 regulates two Wnt7a signaling pathways and inhibits proliferation in endometrial cancer cells
-
Carmon, K. S. & Loose, D. S. Secreted frizzled-related protein 4 regulates two Wnt7a signaling pathways and inhibits proliferation in endometrial cancer cells. Mol. Cancer Res. 6, 1017-1028 (2008).
-
(2008)
Mol. Cancer Res
, vol.6
, pp. 1017-1028
-
-
Carmon, K.S.1
Loose, D.S.2
-
60
-
-
84861553906
-
Mechanism of β-catenin-mediated transcriptional regulation of epidermal growth factor receptor expression in glycogen synthase kinase 3β-inactivated prostate cancer cells
-
Guturi, K. K. N. et al. Mechanism of β-catenin-mediated transcriptional regulation of epidermal growth factor receptor expression in glycogen synthase kinase 3β-inactivated prostate cancer cells. J. Biol. Chem. 287, 18287-18296 (2012).
-
(2012)
J. Biol. Chem
, vol.287
, pp. 18287-18296
-
-
Guturi, K.K.N.1
-
61
-
-
80053361798
-
Wnt5a suppresses epithelial ovarian cancer by promoting cellular senescence
-
Bitler, B. G. et al. Wnt5a suppresses epithelial ovarian cancer by promoting cellular senescence. Cancer Res. 71, 6184-6194 (2011).
-
(2011)
Cancer Res
, vol.71
, pp. 6184-6194
-
-
Bitler, B.G.1
-
62
-
-
16444372007
-
Wnt-5a has tumor suppressor activity in thyroid carcinoma
-
Kremenevskaja, N. et al. Wnt-5a has tumor suppressor activity in thyroid carcinoma. Oncogene 24, 2144-2154 (2005).
-
(2005)
Oncogene
, vol.24
, pp. 2144-2154
-
-
Kremenevskaja, N.1
-
63
-
-
0345356929
-
Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue
-
Liang, H. et al. Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue. Cancer Cell 4, 349-360 (2003).
-
(2003)
Cancer Cell
, vol.4
, pp. 349-360
-
-
Liang, H.1
-
64
-
-
67449156114
-
Phenylmethimazole decreases toll-like receptor 3 and noncanonical Wnt5a expression in pancreatic cancer and melanoma together with tumor cell growth and migration
-
Schwartz, A. L. et al. Phenylmethimazole decreases toll-like receptor 3 and noncanonical Wnt5a expression in pancreatic cancer and melanoma together with tumor cell growth and migration. Clin. Cancer Res. 15, 4114-4122 (2009).
-
(2009)
Clin. Cancer Res
, vol.15
, pp. 4114-4122
-
-
Schwartz, A.L.1
-
65
-
-
42949121156
-
Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a
-
Fukuda, T. et al. Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a. Proc. Natl Acad. Sci. 105, 3047-3052 (2008).
-
(2008)
Proc. Natl Acad. Sci
, vol.105
, pp. 3047-3052
-
-
Fukuda, T.1
-
66
-
-
39449106321
-
Persistence of CD133+ cells in human and mouse glioma cell lines: Detailed characterization of GL261 glioma cells with cancer stem cell-like properties
-
Wu, A. et al. Persistence of CD133+ cells in human and mouse glioma cell lines: detailed characterization of GL261 glioma cells with cancer stem cell-like properties. Stem Cells Dev. 17, 173-184 (2008).
-
(2008)
Stem Cells Dev
, vol.17
, pp. 173-184
-
-
Wu, A.1
-
67
-
-
84856209607
-
Frizzled7 as an emerging target for cancer therapy
-
King, T. D., Zhang, W., Suto, M. J. & Li, Y. Frizzled7 as an emerging target for cancer therapy. Cell. Signal. 24, 846-851 (2012).
-
(2012)
Cell. Signal
, vol.24
, pp. 846-851
-
-
King, T.D.1
Zhang, W.2
Suto, M.J.3
Li, Y.4
-
68
-
-
80055040407
-
FZD7 has a critical role in cell proliferation in triple negative breast cancer
-
Yang, L. et al. FZD7 has a critical role in cell proliferation in triple negative breast cancer. Oncogene 30, 4437-4446 (2011).
-
(2011)
Oncogene
, vol.30
, pp. 4437-4446
-
-
Yang, L.1
-
69
-
-
79751531916
-
Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin
-
Wei, W., Chua, M.-S., Grepper, S. & So, S. K. Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin. Mol. Cancer 10, 16 (2011).
-
(2011)
Mol. Cancer
, vol.10
, Issue.16
-
-
Wei, W.1
Chua, M.-S.2
Grepper, S.3
So, S.K.4
-
70
-
-
81155125694
-
Enhancement of canonical Wnt/β-catenin signaling activity by HCV core protein promotes cell growth of hepatocellular carcinoma cells
-
Liu, J. et al. Enhancement of canonical Wnt/β-catenin signaling activity by HCV core protein promotes cell growth of hepatocellular carcinoma cells. PLoS ONE 6, e27496 (2011).
-
(2011)
PLoS ONE
, vol.6
-
-
Liu, J.1
-
71
-
-
84863384604
-
NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma
-
Yamaguchi, T. et al. NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma. Cancer Cell 21, 348-361 (2012).
-
(2012)
Cancer Cell
, vol.21
, pp. 348-361
-
-
Yamaguchi, T.1
-
72
-
-
84863251015
-
ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth
-
Zhang, S. et al. ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth. PLoS ONE 7, e31127 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Zhang, S.1
-
73
-
-
79954622199
-
Ror1 is a pseudokinase that is crucial for Met-driven tumorigenesis
-
Gentile, A., Lazzari, L., Benvenuti, S., Trusolino, L. & Comoglio, P. M. Ror1 is a pseudokinase that is crucial for Met-driven tumorigenesis. Cancer Res. 71, 3132-3141 (2011).
-
(2011)
Cancer Res
, vol.71
, pp. 3132-3141
-
-
Gentile, A.1
Lazzari, L.2
Benvenuti, S.3
Trusolino, L.4
Comoglio, P.M.5
-
74
-
-
67650429679
-
Ror2, a developmentally regulated kinase, promotes tumor growth potential in renal cell carcinoma
-
Wright, T. M. et al. Ror2, a developmentally regulated kinase, promotes tumor growth potential in renal cell carcinoma. Oncogene 28, 2513-2523 (2009).
-
(2009)
Oncogene
, vol.28
, pp. 2513-2523
-
-
Wright, T.M.1
-
75
-
-
84862808809
-
ROR2 is a novel prognostic biomarker and a potential therapeutic target in leiomyosarcoma and gastrointestinal stromal tumour
-
Edris, B. et al. ROR2 is a novel prognostic biomarker and a potential therapeutic target in leiomyosarcoma and gastrointestinal stromal tumour. J. Pathol. 227, 223-233 (2012).
-
(2012)
J. Pathol
, vol.227
, pp. 223-233
-
-
Edris, B.1
-
76
-
-
40449138006
-
Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation
-
Schlange, T., Matsuda, Y., Lienhard, S., Huber, A. & Hynes, N. E. Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation. Breast Cancer Res. 9, R63 (2007).
-
(2007)
Breast Cancer Res
, vol.9
-
-
Schlange, T.1
Matsuda, Y.2
Lienhard, S.3
Huber, A.4
Hynes, N.E.5
-
77
-
-
74049105681
-
WNT signaling enhances breast cancer cell motility and blockade of the WNT pathway by sFRP1 suppresses MDA-MB-231 xenograft growth
-
Matsuda, Y., Schlange, T., Oakeley, E. J., Boulay, A. & Hynes, N. E. WNT signaling enhances breast cancer cell motility and blockade of the WNT pathway by sFRP1 suppresses MDA-MB-231 xenograft growth. Breast Cancer Res. 11, R32 (2009).
-
(2009)
Breast Cancer Res
, vol.11
-
-
Matsuda, Y.1
Schlange, T.2
Oakeley, E.J.3
Boulay, A.4
Hynes, N.E.5
-
78
-
-
67650496215
-
A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer
-
DiMeo, T. A. et al. A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer. Cancer Res. 69, 5364-5373 (2009).
-
(2009)
Cancer Res
, vol.69
, pp. 5364-5373
-
-
Dimeo, T.A.1
-
79
-
-
10744233346
-
Membranous expression of secreted frizzled-related protein 4 predicts for good prognosis in localized prostate cancer and inhibits PC3 cellular proliferation in vitro
-
Horvath, L. G. et al. Membranous expression of secreted frizzled-related protein 4 predicts for good prognosis in localized prostate cancer and inhibits PC3 cellular proliferation in vitro. Clin. Cancer Res. 10, 615-625 (2004).
-
(2004)
Clin. Cancer Res
, vol.10
, pp. 615-625
-
-
Horvath, L.G.1
-
80
-
-
27544496133
-
Expression of Frzb/secreted Frizzled-related protein 3, a secreted Wnt antagonist, in human androgen-independent prostate cancer PC-3 cells suppresses tumor growth and cellular invasiveness
-
Zi, X. et al. Expression of Frzb/secreted Frizzled-related protein 3, a secreted Wnt antagonist, in human androgen-independent prostate cancer PC-3 cells suppresses tumor growth and cellular invasiveness. Cancer Res. 65, 9762-9770 (2005).
-
(2005)
Cancer Res
, vol.65
, pp. 9762-9770
-
-
Zi, X.1
-
81
-
-
28544445306
-
Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancer
-
Joesting, M. S. et al. Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancer. Cancer Res. 65, 10423-10430 (2005).
-
(2005)
Cancer Res
, vol.65
, pp. 10423-10430
-
-
Joesting, M.S.1
-
82
-
-
77953695990
-
The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition
-
Yee, D. S. et al. The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition. Mol. Cancer 9, 162 (2010).
-
(2010)
Mol. Cancer
, vol.9
, Issue.162
-
-
Yee, D.S.1
-
83
-
-
80052773858
-
The Wnt inhibitory factor 1 (WIF1) is targeted in glioblastoma and has a tumor suppressing function potentially by induction of senescence
-
Lambiv, W. L. et al. The Wnt inhibitory factor 1 (WIF1) is targeted in glioblastoma and has a tumor suppressing function potentially by induction of senescence. Neuro Oncol. 13, 736-747 (2011).
-
(2011)
Neuro Oncol
, vol.13
, pp. 736-747
-
-
Lambiv, W.L.1
-
84
-
-
84861660394
-
Wnt inhibitory factor 1 induces apoptosis and inhibits cervical cancer growth, invasion and angiogenesis in vivo
-
Ramachandran, I. et al. Wnt inhibitory factor 1 induces apoptosis and inhibits cervical cancer growth, invasion and angiogenesis in vivo. Oncogene 31, 2725-2737 (2011).
-
(2011)
Oncogene
, vol.31
, pp. 2725-2737
-
-
Ramachandran, I.1
-
85
-
-
77949667984
-
Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma
-
Rubin, E. M. et al. Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma. Mol. Cancer Ther. 9, 731-741 (2010).
-
(2010)
Mol. Cancer Ther
, vol.9
, pp. 731-741
-
-
Rubin, E.M.1
-
86
-
-
84856226651
-
Cancer stem cells: An evolving concept
-
Nguyen, L. V., Vanner, R., Dirks, P. & Eaves, C. J. Cancer stem cells: an evolving concept. Nature Rev. Cancer 12, 133-143 (2012).
-
(2012)
Nature Rev. Cancer
, vol.12
, pp. 133-143
-
-
Nguyen, L.V.1
Vanner, R.2
Dirks, P.3
Eaves, C.J.4
-
87
-
-
78650003931
-
β-catenin mediates the establishment and drug resistance of MLL leukemic stem cells
-
Yeung, J. et al.β-catenin mediates the establishment and drug resistance of MLL leukemic stem cells. Cancer Cell 18, 606-618 (2010).
-
(2010)
Cancer Cell
, vol.18
, pp. 606-618
-
-
Yeung, J.1
-
88
-
-
3943088431
-
Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
-
Jamieson, C. H. M. et al. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N. Engl. J. Med. 351, 657-667 (2004).
-
(2004)
N. Engl. J. Med
, vol.351
, pp. 657-667
-
-
Jamieson, C.H.M.1
-
89
-
-
36649002031
-
Loss of β-catenin impairs the renewal of normal and CML stem cells in vivo
-
Zhao, C. et al. Loss of β-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell 12, 528-541 (2007).
-
(2007)
Cancer Cell
, vol.12
, pp. 528-541
-
-
Zhao, C.1
-
90
-
-
77950287628
-
The Wnt/β-catenin pathway is required for the development of leukemia stem cells in AML
-
Wang, Y. et al. The Wnt/β-catenin pathway is required for the development of leukemia stem cells in AML. Science 327, 1650-1653 (2010).
-
(2010)
Science
, vol.327
, pp. 1650-1653
-
-
Wang, Y.1
-
91
-
-
59049106578
-
Crypt stem cells as the cells-of-origin of intestinal cancer
-
Barker, N. et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 457, 608-611 (2009).
-
(2009)
Nature
, vol.457
, pp. 608-611
-
-
Barker, N.1
-
92
-
-
18644373146
-
The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
-
Van de Wetering, M. et al. The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 111, 241-250 (2002).
-
(2002)
Cell
, vol.111
, pp. 241-250
-
-
Van De Wetering, M.1
-
93
-
-
77955747501
-
Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas
-
Deka, J. et al. Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas. Cancer Res. 70, 6619-6628 (2010).
-
(2010)
Cancer Res
, vol.70
, pp. 6619-6628
-
-
Deka, J.1
-
94
-
-
84856534355
-
Stem cell pathways contribute to clinical chemoresistance in ovarian cancer
-
Steg, A. D. et al. Stem cell pathways contribute to clinical chemoresistance in ovarian cancer. Clin. Cancer Res. 18, 869-881 (2011).
-
(2011)
Clin. Cancer Res
, vol.18
, pp. 869-881
-
-
Steg, A.D.1
-
95
-
-
9144269759
-
Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells
-
Li, Y. et al. Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proc. Natl Acad. Sci. USA 100, 15853-15858 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 15853-15858
-
-
Li, Y.1
-
96
-
-
30144433093
-
Generation of a functional mammary gland from a single stem cell
-
Shackleton, M. et al. Generation of a functional mammary gland from a single stem cell. Nature 439, 84-88 (2006).
-
(2006)
Nature
, vol.439
, pp. 84-88
-
-
Shackleton, M.1
-
97
-
-
84859032134
-
Small molecule antagonists of the Wnt/β-catenin signaling pathway target breast tumor-initiating cells in a Her2/Neu mouse model of breast cancer
-
Hallett, R. M. et al. Small molecule antagonists of the Wnt/β-catenin signaling pathway target breast tumor-initiating cells in a Her2/Neu mouse model of breast cancer. PLoS ONE 7, e33976 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Hallett, R.M.1
-
98
-
-
77956628008
-
Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture
-
Zeng, Y. A. & Nusse, R. Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture. Cell Stem Cell 6, 568-577 (2010).
-
(2010)
Cell Stem Cell
, vol.6
, pp. 568-577
-
-
Zeng, Y.A.1
Nusse, R.2
-
99
-
-
79958265710
-
Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast
-
Scheel, C. et al. Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell 145, 926-940 (2011).
-
(2011)
Cell
, vol.145
, pp. 926-940
-
-
Scheel, C.1
-
100
-
-
34447343780
-
Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells
-
Ye, X. et al. Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells. Mol. Cell 27, 183-196 (2007).
-
(2007)
Mol. Cell
, vol.27
, pp. 183-196
-
-
Ye, X.1
-
101
-
-
84861813696
-
Interference of Frizzled 1 (FZD1) reverses multidrug resistance in breast cancer cells through the Wnt/β-catenin pathway
-
Zhang, H. et al. Interference of Frizzled 1 (FZD1) reverses multidrug resistance in breast cancer cells through the Wnt/β-catenin pathway. Cancer Lett. 323, 106-113 (2012).
-
(2012)
Cancer Lett
, vol.323
, pp. 106-113
-
-
Zhang, H.1
-
102
-
-
67349198077
-
Activation of Wnt/β-catenin signalling pathway induces chemoresistance to interferon-α/5-fluorouracil combination therapy for hepatocellular carcinoma
-
Noda, T. et al. Activation of Wnt/β-catenin signalling pathway induces chemoresistance to interferon-α/5-fluorouracil combination therapy for hepatocellular carcinoma. Br. J. Cancer 100, 1647-1658 (2009).
-
(2009)
Br. J. Cancer
, vol.100
, pp. 1647-1658
-
-
Noda, T.1
-
103
-
-
67349153325
-
The Wnt receptor FZD1 mediates chemoresistance in neuroblastoma through activation of the Wnt/β-catenin pathway
-
Flahaut, M. et al. The Wnt receptor FZD1 mediates chemoresistance in neuroblastoma through activation of the Wnt/β-catenin pathway. Oncogene 28, 2245-2256 (2009).
-
(2009)
Oncogene
, vol.28
, pp. 2245-2256
-
-
Flahaut, M.1
-
104
-
-
80555146643
-
A switch from canonical to noncanonical Wnt signaling mediates drug resistance in colon cancer cells
-
Bordonaro, M., Tewari, S., Cicco, C. E., Atamna, W. & Lazarova, D. L. A switch from canonical to noncanonical Wnt signaling mediates drug resistance in colon cancer cells. PLoS ONE 6, e27308 (2011).
-
(2011)
PLoS ONE
, vol.6
-
-
Bordonaro, M.1
Tewari, S.2
Cicco, C.E.3
Atamna, W.4
Lazarova, D.L.5
-
105
-
-
0031870862
-
Up-regulation of human secreted frizzled homolog in apoptosis and its down-regulation in breast tumors
-
Zhou, Z., Wang, J., Han, X., Zhou, J. & Linder, S. Up-regulation of human secreted frizzled homolog in apoptosis and its down-regulation in breast tumors. Int. J. Cancer 78, 95-99 (1998).
-
(1998)
Int. J. Cancer
, vol.78
, pp. 95-99
-
-
Zhou, Z.1
Wang, J.2
Han, X.3
Zhou, J.4
Linder, S.5
-
106
-
-
85047699343
-
Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA
-
Shou, J. et al. Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. Oncogene 21, 878-889 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 878-889
-
-
Shou, J.1
-
107
-
-
24044490922
-
Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis
-
Mazieres, J. et al. Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis. Oncogene 24, 5396-5400 (2005).
-
(2005)
Oncogene
, vol.24
, pp. 5396-5400
-
-
Mazieres, J.1
-
108
-
-
79951986031
-
Wnt antagonist DKK1 acts as a tumor suppressor gene that induces apoptosis and inhibits proliferation in human renal cell carcinoma
-
Hirata, H. et al. Wnt antagonist DKK1 acts as a tumor suppressor gene that induces apoptosis and inhibits proliferation in human renal cell carcinoma. Int. J. Cancer 128, 1793-1803 (2011).
-
(2011)
Int. J. Cancer
, vol.128
, pp. 1793-1803
-
-
Hirata, H.1
-
109
-
-
1642341682
-
A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells
-
He, B. et al. A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells. Neoplasia 6, 7-14 (2004).
-
(2004)
Neoplasia
, vol.6
, pp. 7-14
-
-
He, B.1
-
110
-
-
20444419344
-
Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance
-
MacKeigan, J. P., Murphy, L. O. & Blenis, J. Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance. Nature Cell Biol. 7, 591-600 (2005).
-
(2005)
Nature Cell Biol
, vol.7
, pp. 591-600
-
-
MacKeigan, J.P.1
Murphy, L.O.2
Blenis, J.3
-
111
-
-
77958519836
-
Silencing of ROR1 and FMOD with siRNA results in apoptosis of CLL cells
-
Choudhury, A. et al. Silencing of ROR1 and FMOD with siRNA results in apoptosis of CLL cells. Br. J. Haematol. 151, 327-335 (2010).
-
(2010)
Br. J. Haematol
, vol.151
, pp. 327-335
-
-
Choudhury, A.1
-
112
-
-
70349975727
-
Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells
-
Ueno, K. et al. Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells. Br. J. Cancer 101, 1374-1381 (2009).
-
(2009)
Br. J. Cancer
, vol.101
, pp. 1374-1381
-
-
Ueno, K.1
-
113
-
-
45849134073
-
Frizzled-7 as a potential therapeutic target in colorectal cancer
-
Ueno, K. et al. Frizzled-7 as a potential therapeutic target in colorectal cancer. Neoplasia 10, 697-705 (2008).
-
(2008)
Neoplasia
, vol.10
, pp. 697-705
-
-
Ueno, K.1
-
114
-
-
23944524848
-
Wnts induce migration and invasion of myeloma plasma cells
-
Qiang, Y.-W. Wnts induce migration and invasion of myeloma plasma cells. Blood 106, 1786-1793 (2005).
-
(2005)
Blood
, vol.106
, pp. 1786-1793
-
-
Qiang, Y.-W.1
-
115
-
-
33645774667
-
Wnt 5a signaling is critical for macrophage-induced invasion of breast cancer cell lines
-
Pukrop, T. Wnt 5a signaling is critical for macrophage-induced invasion of breast cancer cell lines. Proc. Natl Acad. Sci. 103, 5454-5459 (2006).
-
(2006)
Proc. Natl Acad. Sci
, vol.103
, pp. 5454-5459
-
-
Pukrop, T.1
-
116
-
-
42949110059
-
Frizzled-1 is down-regulated in follicular thyroid tumours and modulates growth and invasiveness
-
Ulivieri, A. et al. Frizzled-1 is down-regulated in follicular thyroid tumours and modulates growth and invasiveness. J. Pathol. 215, 87-96 (2008).
-
(2008)
J. Pathol
, vol.215
, pp. 87-96
-
-
Ulivieri, A.1
-
117
-
-
80655149144
-
Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/β-catenin signalling pathway
-
Fu, L. et al. Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/β-catenin signalling pathway. Gut 60, 1635-1643 (2011).
-
(2011)
Gut
, vol.60
, pp. 1635-1643
-
-
Fu, L.1
-
118
-
-
33751514601
-
A Wnt-Axin2-GSK3β cascade regulates Snail1 activity in breast cancer cells
-
Yook, J. I. et al. A Wnt-Axin2-GSK3β cascade regulates Snail1 activity in breast cancer cells. Nature Cell Biol. 8, 1398-1406 (2006).
-
(2006)
Nature Cell Biol
, vol.8
, pp. 1398-1406
-
-
Yook, J.I.1
-
119
-
-
33244463813
-
Complex networks orchestrate epithelial-mesenchymal transitions
-
Thiery, J. P. & Sleeman, J. P. Complex networks orchestrate epithelial-mesenchymal transitions. Nature Rev. Mol. Cell. Biol. 7, 131-142 (2006).
-
(2006)
Nature Rev. Mol. Cell. Biol
, vol.7
, pp. 131-142
-
-
Thiery, J.P.1
Sleeman, J.P.2
-
120
-
-
24944577909
-
Cdc42 and Par6-PKCζ regulate the spatially localized association of Dlg1 and APC to control cell polarization
-
Etienne-Manneville, S., Manneville, J.-B., Nicholls, S., Ferenczi, M. A. & Hall, A. Cdc42 and Par6-PKCζ regulate the spatially localized association of Dlg1 and APC to control cell polarization. J. Cell Biol. 170, 895-901 (2005).
-
(2005)
J. Cell Biol
, vol.170
, pp. 895-901
-
-
Etienne-Manneville, S.1
Manneville, J.-B.2
Nicholls, S.3
Ferenczi, M.A.4
Hall, A.5
-
121
-
-
34547604466
-
Cdc42 and noncanonical Wnt signal transduction pathways cooperate to promote cell polarity
-
Schlessinger, K., McManus, E. J. & Hall, A. Cdc42 and noncanonical Wnt signal transduction pathways cooperate to promote cell polarity. J. Cell Biol. 178, 355-361 (2007).
-
(2007)
J. Cell Biol
, vol.178
, pp. 355-361
-
-
Schlessinger, K.1
McManus, E.J.2
Hall, A.3
-
122
-
-
67649662201
-
WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis
-
Nguyen, D. X. et al. WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Cell 138, 51-62 (2009).
-
(2009)
Cell
, vol.138
, pp. 51-62
-
-
Nguyen, D.X.1
-
123
-
-
77952324704
-
Activation of β-catenin by hypoxia in hepatocellular carcinoma contributes to enhanced metastatic potential and poor prognosis
-
Liu, L. et al. Activation of β-catenin by hypoxia in hepatocellular carcinoma contributes to enhanced metastatic potential and poor prognosis. Clin. Cancer Res. 16, 2740-2750 (2010).
-
(2010)
Clin. Cancer Res
, vol.16
, pp. 2740-2750
-
-
Liu, L.1
-
124
-
-
80755138384
-
In melanoma, β-catenin is a suppressor of invasion
-
Arozarena, I. et al. In melanoma, β-catenin is a suppressor of invasion. Oncogene 30, 4531-4543 (2011).
-
(2011)
Oncogene
, vol.30
, pp. 4531-4543
-
-
Arozarena, I.1
-
125
-
-
84876903398
-
β-catenin inhibits melanocyte migration but induces melanoma metastasis
-
4 Jun doi:10.1038/onc.2012.229
-
Gallagher, S. J. et al. β-catenin inhibits melanocyte migration but induces melanoma metastasis. Oncogene 4 Jun 2012 (doi:10.1038/onc.2012.229).
-
(2012)
Oncogene
-
-
Gallagher, S.J.1
-
126
-
-
83455171909
-
β-catenin signaling controls metastasis in braf-activated pten-deficient melanomas
-
Damsky, W. E. et al.β-catenin signaling controls metastasis in braf-activated pten-deficient melanomas. Cancer Cell 20, 741-754 (2011).
-
(2011)
Cancer Cell
, vol.20
, pp. 741-754
-
-
Damsky, W.E.1
-
127
-
-
84855425160
-
Interactions between cancer stem cells and their niche govern metastatic colonization
-
Malanchi, I. et al. Interactions between cancer stem cells and their niche govern metastatic colonization. Nature 481, 85-89 (2012).
-
(2012)
Nature
, vol.481
, pp. 85-89
-
-
Malanchi, I.1
-
128
-
-
80055047246
-
Elevated level of Wnt5a protein in localized prostate cancer tissue is associated with better outcome
-
Syed Khaja, A. S. et al. Elevated level of Wnt5a protein in localized prostate cancer tissue is associated with better outcome. PLoS ONE 6, e26539 (2011).
-
(2011)
PLoS ONE
, vol.6
-
-
Syed Khaja, A.S.1
-
129
-
-
33645789040
-
A formylated hexapeptide ligand mimics the ability of Wnt-5a to impair migration of human breast epithelial cells
-
Sδfholm, A. et al. A formylated hexapeptide ligand mimics the ability of Wnt-5a to impair migration of human breast epithelial cells. J. Biol. Chem. 281, 2740-2749 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 2740-2749
-
-
Sfholm, A.1
-
130
-
-
42349093195
-
Wnt5a control of cell polarity and directional movement by polarized redistribution of adhesion receptors
-
Witze, E. S., Litman, E. S., Argast, G. M., Moon, R. T. & Ahn, N. G. Wnt5a control of cell polarity and directional movement by polarized redistribution of adhesion receptors. Science 320, 365-369 (2008).
-
(2008)
Science
, vol.320
, pp. 365-369
-
-
Witze, E.S.1
Litman, E.S.2
Argast, G.M.3
Moon, R.T.4
Ahn, N.G.5
-
131
-
-
34147094240
-
The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: Regulation of Rho GTPase recruitment to the leading edge
-
Dow, L. E. et al. The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge. Oncogene 26, 2272-2282 (2007).
-
(2007)
Oncogene
, vol.26
, pp. 2272-2282
-
-
Dow, L.E.1
-
132
-
-
84864956480
-
A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration, and is associated with breast cancer progression
-
Anastas, J. N. et al. A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration, and is associated with breast cancer progression. Oncogene 31, 3696-3708 (2012).
-
(2012)
Oncogene
, vol.31
, pp. 3696-3708
-
-
Anastas, J.N.1
-
133
-
-
3042659106
-
KAI1 COOH-terminal interacting tetraspanin (KITENIN), a member of the tetraspanin family, interacts with KAI1, a tumor metastasis suppressor, and enhances metastasis of cancer
-
Lee, J. H. et al. KAI1 COOH-terminal interacting tetraspanin (KITENIN), a member of the tetraspanin family, interacts with KAI1, a tumor metastasis suppressor, and enhances metastasis of cancer. Cancer Res. 64, 4235-4243 (2004).
-
(2004)
Cancer Res
, vol.64
, pp. 4235-4243
-
-
Lee, J.H.1
-
134
-
-
84864106172
-
The cytosolic domain of PTK7, generated from sequential cleavage by ADAM17 and γ-secretase, enhances cell proliferation and migration in colon cancer cells
-
Na, H.-W., Shin, W.-S., Ludwig, A. & Lee, S.-T. The cytosolic domain of PTK7, generated from sequential cleavage by ADAM17 and γ-secretase, enhances cell proliferation and migration in colon cancer cells. J. Biol. Chem. 287, 25001-25009 (2012).
-
(2012)
J. Biol. Chem
, vol.287
, pp. 25001-25009
-
-
Na, H.-W.1
Shin, W.-S.2
Ludwig, A.3
Lee, S.-T.4
-
135
-
-
78149234115
-
The Wnt/planar cell polarity (PCP) protein tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase (MT1-MMP): Implications in cancer and embryogenesis
-
Golubkov, V. S. et al. The Wnt/planar cell polarity (PCP) protein tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase (MT1-MMP): implications in cancer and embryogenesis. J. Biol. Chem. 285, 35740-35749 (2010).
-
(2010)
J. Biol. Chem
, vol.285
, pp. 35740-35749
-
-
Golubkov, V.S.1
-
136
-
-
79751515852
-
Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2
-
Gao, B. et al. Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2. Dev. Cell 20, 163-176 (2011).
-
(2011)
Dev. Cell
, vol.20
, pp. 163-176
-
-
Gao, B.1
-
137
-
-
73849123750
-
The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma
-
O'Connell, M. P. et al. The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma. Oncogene 29, 34-44 (2010).
-
(2010)
Oncogene
, vol.29
, pp. 34-44
-
-
O'Connell, M.P.1
-
138
-
-
70349101267
-
Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling
-
Enomoto, M. et al. Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling. Oncogene 28, 3197-3208 (2009).
-
(2009)
Oncogene
, vol.28
, pp. 3197-3208
-
-
Enomoto, M.1
-
139
-
-
0037055583
-
Molecular genetic analysis of malignant melanomas for aberrations of the WNT signaling pathway genes CTNNB1, APC, ICAT and BTRC
-
Reifenberger, J. et al. Molecular genetic analysis of malignant melanomas for aberrations of the WNT signaling pathway genes CTNNB1, APC, ICAT and BTRC. Int. J. Cancer 100, 549-556 (2002).
-
(2002)
Int. J. Cancer
, vol.100
, pp. 549-556
-
-
Reifenberger, J.1
-
140
-
-
75349094058
-
The role of APC in mitosis and in chromosome instability
-
Caldwell, C. M. & Kaplan, K. B. The role of APC in mitosis and in chromosome instability. Adv. Exp. Med. Biol. 656, 51-64 (2009).
-
(2009)
Adv. Exp. Med. Biol
, vol.656
, pp. 51-64
-
-
Caldwell, C.M.1
Kaplan, K.B.2
-
141
-
-
0035972159
-
Δn89β-catenin induces precocious development, differentiation, and neoplasia in mammary gland
-
Imbert, A., Eelkema, R., Jordan, S., Feiner, H. & Cowin, P. ΔN89β-catenin induces precocious development, differentiation, and neoplasia in mammary gland. J. Cell Biol. 153, 555-568 (2001).
-
(2001)
J. Cell Biol
, vol.153
, pp. 555-568
-
-
Imbert, A.1
Eelkema, R.2
Jordan, S.3
Feiner, H.4
Cowin, P.5
-
142
-
-
84887212573
-
MMTV-Wnt1 and-ΔN89β-catenin induce canonical signaling in distinct progenitors and differentially activate Hedgehog signaling within mammary tumors
-
Teissedre, B. et al. MMTV-Wnt1 and-ΔN89β-catenin induce canonical signaling in distinct progenitors and differentially activate Hedgehog signaling within mammary tumors. PLoS ONE 4, e4537 (2009).
-
(2009)
PLoS ONE
, vol.4
-
-
Teissedre, B.1
-
143
-
-
0037071903
-
Stabilization of β-catenin induces lesions reminiscent of prostatic intraepithelial neoplasia, but terminal squamous transdifferentiation of other secretory epithelia
-
Gounari, F. et al. Stabilization of β-catenin induces lesions reminiscent of prostatic intraepithelial neoplasia, but terminal squamous transdifferentiation of other secretory epithelia. Oncogene 21, 4099-4107 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 4099-4107
-
-
Gounari, F.1
-
144
-
-
0032482198
-
Effects of forced expression of an NH2-terminal truncated β-Catenin on mouse intestinal epithelial homeostasis
-
Wong, M. H., Rubinfeld, B. & Gordon, J. I. Effects of forced expression of an NH2-terminal truncated β-Catenin on mouse intestinal epithelial homeostasis. J. Cell Biol. 141, 765-777 (1998).
-
(1998)
J. Cell Biol
, vol.141
, pp. 765-777
-
-
Wong, M.H.1
Rubinfeld, B.2
Gordon, J.I.3
-
145
-
-
0035801388
-
Deregulated β-catenin induces a p53-and ARF-dependent growth arrest and cooperates with Ras in transformation
-
Damalas, A., Kahan, S., Shtutman, M., Ben-Ze'ev, A. & Oren, M. Deregulated β-catenin induces a p53-and ARF-dependent growth arrest and cooperates with Ras in transformation. EMBO J. 20, 4912-4922 (2001).
-
(2001)
EMBO J
, vol.20
, pp. 4912-4922
-
-
Damalas, A.1
Kahan, S.2
Shtutman, M.3
Ben-Ze'Ev, A.4
Oren, M.5
-
146
-
-
0034724315
-
Tumorigenesis in the multiple intestinal neoplasia mouse: Redundancy of negative regulators and specificity of modifiers
-
Halberg, R. B. et al. Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers. Proc. Natl Acad. Sci. USA 97, 3461-3466 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 3461-3466
-
-
Halberg, R.B.1
-
147
-
-
79955496473
-
Wnt/β-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium
-
Pacheco-Pinedo, E. C. et al. Wnt/β-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium. J. Clin. Invest. 121, 1935-1945 (2011).
-
(2011)
J. Clin. Invest
, vol.121
, pp. 1935-1945
-
-
Pacheco-Pinedo, E.C.1
-
148
-
-
36249026528
-
β-Catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development
-
Delmas, V. et al. β-Catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development. Genes Dev. 21, 2923-2935 (2007).
-
(2007)
Genes Dev
, vol.21
, pp. 2923-2935
-
-
Delmas, V.1
-
149
-
-
80455129710
-
β-catenin accelerates human papilloma virus type-16 mediated cervical carcinogenesis in transgenic mice
-
Bulut, G. et al.β-catenin accelerates human papilloma virus type-16 mediated cervical carcinogenesis in transgenic mice. PLoS ONE 6, e27243 (2011).
-
(2011)
PLoS ONE
, vol.6
-
-
Bulut, G.1
-
150
-
-
0034057928
-
The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cells: Evidence of different mechanisms of action
-
Smith, M. L., Hawcroft, G. & Hull, M. A. The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cells: evidence of different mechanisms of action. Eur. J. Cancer 36, 664-674 (2000).
-
(2000)
Eur. J. Cancer
, vol.36
, pp. 664-674
-
-
Smith, M.L.1
Hawcroft, G.2
Hull, M.A.3
-
151
-
-
0035252741
-
The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate β-catenin/TCF-4 signaling
-
Dihlmann, S., Siermann, A. & Von Knebel Doeberitz, M. The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate β-catenin/TCF-4 signaling. Oncogene 20, 645-653 (2001).
-
(2001)
Oncogene
, vol.20
, pp. 645-653
-
-
Dihlmann, S.1
Siermann, A.2
Von Knebel Doeberitz, M.3
-
152
-
-
39449084394
-
Cyclooxygenase-2 inhibition inhibits c-Met kinase activity and Wnt activity in colon cancer
-
Tuynman, J. B. et al. Cyclooxygenase-2 inhibition inhibits c-Met kinase activity and Wnt activity in colon cancer. Cancer Res. 68, 1213-1220 (2008).
-
(2008)
Cancer Res
, vol.68
, pp. 1213-1220
-
-
Tuynman, J.B.1
-
153
-
-
0025834849
-
Sulindac causes regression of rectal polyps in familial adenomatous polyposis
-
Labayle, D. et al. Sulindac causes regression of rectal polyps in familial adenomatous polyposis. Gastroenterology 101, 635-639 (1991).
-
(1991)
Gastroenterology
, vol.101
, pp. 635-639
-
-
Labayle, D.1
-
154
-
-
0027197062
-
Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis
-
Giardiello, F. M. et al. Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. N. Engl. J. Med. 328, 1313-1316 (1993).
-
(1993)
N. Engl. J. Med
, vol.328
, pp. 1313-1316
-
-
Giardiello, F.M.1
-
155
-
-
0036114348
-
A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase 2 inhibitor, on duodenal polyposis in familial adenomatous polyposis
-
Phillips, R. K. S. et al. A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase 2 inhibitor, on duodenal polyposis in familial adenomatous polyposis. Gut 50, 857-860 (2002).
-
(2002)
Gut
, vol.50
, pp. 857-860
-
-
Phillips, R.K.S.1
-
156
-
-
17744418769
-
The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis
-
Steinbach, G. et al. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N. Engl. J. Med. 342, 1946-1952 (2000).
-
(2000)
N. Engl. J. Med
, vol.342
, pp. 1946-1952
-
-
Steinbach, G.1
-
157
-
-
58249122326
-
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
-
Chen, B. et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature Chem. Biol. 5, 100-107 (2009).
-
(2009)
Nature Chem. Biol
, vol.5
, pp. 100-107
-
-
Chen, B.1
-
158
-
-
77958171338
-
Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α
-
Thorne, C. A. et al. Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α. Nature Chem. Biol. 6, 829-836 (2010).
-
(2010)
Nature Chem. Biol
, vol.6
, pp. 829-836
-
-
Thorne, C.A.1
-
159
-
-
70349695861
-
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
-
Huang, S.-M. A. et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature 461, 614-620 (2009).
-
(2009)
Nature
, vol.461
, pp. 614-620
-
-
Huang, S.-M.A.1
-
160
-
-
79955046668
-
An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway
-
Gonsalves, F. C. et al. An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proc. Natl Acad. Sci. USA 108, 5954-5963 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 5954-5963
-
-
Gonsalves, F.C.1
-
161
-
-
79955613593
-
A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/β-catenin signaling and colon cancer cell tumorigenesis
-
Wang, W., Liu, H., Wang, S., Hao, X. & Li, L. A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/β-catenin signaling and colon cancer cell tumorigenesis. Cell Res. 21, 730-740 (2011).
-
(2011)
Cell Res
, vol.21
, pp. 730-740
-
-
Wang, W.1
Liu, H.2
Wang, S.3
Hao, X.4
Li, L.5
-
162
-
-
1642512639
-
Small-molecule antagonists of the oncogenic Tcf/β-catenin protein complex
-
Lepourcelet, M. et al. Small-molecule antagonists of the oncogenic Tcf/β-catenin protein complex. Cancer Cell 5, 91-102 (2004).
-
(2004)
Cancer Cell
, vol.5
, pp. 91-102
-
-
Lepourcelet, M.1
-
163
-
-
84862916465
-
Structure-based discovery of a novel inhibitor targeting the β-catenin/Tcf4 interaction
-
Tian, W. et al. Structure-based discovery of a novel inhibitor targeting the β-catenin/Tcf4 interaction. Biochemistry 51, 724-731 (2012).
-
(2012)
Biochemistry
, vol.51
, pp. 724-731
-
-
Tian, W.1
-
164
-
-
28244496603
-
Identification of a specific inhibitor of the dishevelled PDZ domain
-
Shan, J., Shi, D.-L., Wang, J. & Zheng, J. Identification of a specific inhibitor of the dishevelled PDZ domain. Biochemistry 44, 15495-15503 (2005).
-
(2005)
Biochemistry
, vol.44
, pp. 15495-15503
-
-
Shan, J.1
Shi, D.-L.2
Wang, J.3
Zheng, J.4
-
165
-
-
33846673934
-
An antagonist of dishevelled protein-protein interaction suppresses β-catenin-dependent tumor cell growth
-
Fujii, N. et al. An antagonist of dishevelled protein-protein interaction suppresses β-catenin-dependent tumor cell growth. Cancer Res. 67, 573-579 (2007).
-
(2007)
Cancer Res
, vol.67
, pp. 573-579
-
-
Fujii, N.1
-
166
-
-
67650266967
-
Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled
-
Grandy, D. et al. Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled. J. Biol. Chem. 284, 16256-16263 (2009).
-
(2009)
J. Biol. Chem
, vol.284
, pp. 16256-16263
-
-
Grandy, D.1
-
167
-
-
62649175248
-
Inhibition of Wnt signaling by Dishevelled PDZ peptides
-
Zhang, Y. et al. Inhibition of Wnt signaling by Dishevelled PDZ peptides. Nature Chem. Biol. 5, 217-219 (2009).
-
(2009)
Nature Chem. Biol
, vol.5
, pp. 217-219
-
-
Zhang, Y.1
-
168
-
-
78751578854
-
Pharmacological inhibition of Frizzled-7 displays anti-tumor properties in hepatocellular carcinoma
-
Nambotin, S. B. et al. Pharmacological inhibition of Frizzled-7 displays anti-tumor properties in hepatocellular carcinoma. J. Hepatol. 54, 288-299 (2011).
-
(2011)
J. Hepatol
, vol.54
, pp. 288-299
-
-
Nambotin, S.B.1
-
169
-
-
0037737728
-
A role for Wnt signalling in self-renewal of haematopoietic stem cells
-
Reya, T. et al. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 423, 409-414 (2003).
-
(2003)
Nature
, vol.423
, pp. 409-414
-
-
Reya, T.1
-
170
-
-
0037737726
-
Wnt proteins are lipid-modified and can act as stem cell growth factors
-
Willert, K. et al. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 423, 448-452 (2003).
-
(2003)
Nature
, vol.423
, pp. 448-452
-
-
Willert, K.1
-
171
-
-
0035825119
-
Wnt-1 signaling inhibits apoptosis by activating β-catenin/T cell factor-mediated transcription
-
Chen, S. et al. Wnt-1 signaling inhibits apoptosis by activating β-catenin/T cell factor-mediated transcription. J. Cell Biol. 152, 87-96 (2001).
-
(2001)
J. Cell Biol
, vol.152
, pp. 87-96
-
-
Chen, S.1
-
172
-
-
26844569797
-
Efficacy of Wnt-1 monoclonal antibody in sarcoma cells
-
Mikami, I. et al. Efficacy of Wnt-1 monoclonal antibody in sarcoma cells. BMC Cancer 5, 53 (2005).
-
(2005)
BMC Cancer
, vol.5
, pp. 53
-
-
Mikami, I.1
-
173
-
-
79953795334
-
Resistance or sensitivity of Wilms' tumor to anti-FZD7 antibody highlights the Wnt pathway as a possible therapeutic target
-
Pode-Shakked, N. et al. Resistance or sensitivity of Wilms' tumor to anti-FZD7 antibody highlights the Wnt pathway as a possible therapeutic target. Oncogene 30, 1664-1680 (2011).
-
(2011)
Oncogene
, vol.30
, pp. 1664-1680
-
-
Pode-Shakked, N.1
-
174
-
-
77957266335
-
Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies
-
Ettenberg, S. A. et al. Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies. Proc. Natl Acad. Sci. USA 107, 15473-15478 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 15473-15478
-
-
Ettenberg, S.A.1
-
175
-
-
78649461928
-
The B-cell tumor-associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor
-
Hudecek, M. et al. The B-cell tumor-associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor. Blood 116, 4532-4541 (2010).
-
(2010)
Blood
, vol.116
, pp. 4532-4541
-
-
Hudecek, M.1
-
176
-
-
79958776633
-
Therapeutic potential and challenges of targeting receptor tyrosine kinase ROR1 with monoclonal antibodies in B-cell malignancies
-
Yang, J. et al. Therapeutic potential and challenges of targeting receptor tyrosine kinase ROR1 with monoclonal antibodies in B-cell malignancies. PLoS ONE 6, e21018 (2011).
-
(2011)
PLoS ONE
, vol.6
-
-
Yang, J.1
-
177
-
-
79251634676
-
Blocking Wnt signaling by SFRP-like molecules inhibits in vivo cell proliferation and tumor growth in cells carrying active β-catenin
-
Lavergne, E. et al. Blocking Wnt signaling by SFRP-like molecules inhibits in vivo cell proliferation and tumor growth in cells carrying active β-catenin. Oncogene 30, 423-433 (2011).
-
(2011)
Oncogene
, vol.30
, pp. 423-433
-
-
Lavergne, E.1
-
178
-
-
58149190789
-
The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility
-
Sδfholm, A. et al. The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility. Clin. Cancer Res. 14, 6556-6563 (2008).
-
(2008)
Clin. Cancer Res
, vol.14
, pp. 6556-6563
-
-
Sfholm, A.1
-
179
-
-
34347254641
-
The soluble wnt receptor Frizzled8CRD-hFc inhibits the growth of teratocarcinomas in vivo
-
DeAlmeida, V. I. et al. The soluble wnt receptor Frizzled8CRD-hFc inhibits the growth of teratocarcinomas in vivo. Cancer Res. 67, 5371-5379 (2007).
-
(2007)
Cancer Res
, vol.67
, pp. 5371-5379
-
-
Dealmeida, V.I.1
-
180
-
-
84863543371
-
Structural basis of Wnt recognition by frizzled
-
Janda, C. Y., Waghray, D., Levin, A. M., Thomas, C. & Garcia, K. C. Structural basis of Wnt recognition by frizzled. Science 337, 59-64 (2012).
-
(2012)
Science
, vol.337
, pp. 59-64
-
-
Janda, C.Y.1
Waghray, D.2
Levin, A.M.3
Thomas, C.4
Garcia, K.C.5
-
181
-
-
10144237223
-
Inhibition of Wnt signaling downregulates Akt activity and induces chemosensitivity in PTEN-mutated prostate cancer cells
-
Ohigashi, T., Mizuno, R., Nakashima, J., Marumo, K. & Murai, M. Inhibition of Wnt signaling downregulates Akt activity and induces chemosensitivity in PTEN-mutated prostate cancer cells. Prostate 62, 61-68 (2005).
-
(2005)
Prostate
, vol.62
, pp. 61-68
-
-
Ohigashi, T.1
Mizuno, R.2
Nakashima, J.3
Marumo, K.4
Murai, M.5
-
182
-
-
79956116022
-
Wnt5a as a predictor in poor clinical outcome of patients and a mediator in chemoresistance of ovarian cancer
-
Peng, C., Zhang, X., Yu, H., Wu, D. & Zheng, J. Wnt5a as a predictor in poor clinical outcome of patients and a mediator in chemoresistance of ovarian cancer. Int. J. Gynecol. Cancer 21, 280-288 (2011).
-
(2011)
Int. J. Gynecol. Cancer
, vol.21
, pp. 280-288
-
-
Peng, C.1
Zhang, X.2
Yu, H.3
Wu, D.4
Zheng, J.5
-
183
-
-
33846846541
-
Differential effects of inactivated Axin1 and activated β-catenin mutations in human hepatocellular carcinomas
-
Zucman-Rossi, J. et al. Differential effects of inactivated Axin1 and activated β-catenin mutations in human hepatocellular carcinomas. Oncogene 26, 774-780 (2007).
-
(2007)
Oncogene
, vol.26
, pp. 774-780
-
-
Zucman-Rossi, J.1
-
184
-
-
33845355511
-
Diversity of LEF/TCF action in development and disease
-
Arce, L., Yokoyama, N. N. & Waterman, M. L. Diversity of LEF/TCF action in development and disease. Oncogene 25, 7492-7504 (2006).
-
(2006)
Oncogene
, vol.25
, pp. 7492-7504
-
-
Arce, L.1
Yokoyama, N.N.2
Waterman, M.L.3
-
185
-
-
47749089779
-
A genome-wide RNAi screen for Wnt/β-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer
-
Tang, W. et al. A genome-wide RNAi screen for Wnt/β-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. Proc. Natl Acad. Sci. USA 105, 9697-9702 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 9697-9702
-
-
Tang, W.1
-
186
-
-
0034283030
-
β-catenin affects androgen receptor transcriptional activity and ligand specificity
-
Truica, C. I., Byers, S. & Gelmann, E. P. β-catenin affects androgen receptor transcriptional activity and ligand specificity. Cancer Res. 60, 4709-4713 (2000).
-
(2000)
Cancer Res
, vol.60
, pp. 4709-4713
-
-
Truica, C.I.1
Byers, S.2
Gelmann, E.P.3
-
187
-
-
18344389705
-
3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of β-catenin signaling
-
Pαlmer, H. G. et al. Vitamin D3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of β-catenin signaling. J. Cell Biol. 154, 369-387 (2001).
-
(2001)
J. Cell Biol
, vol.154
, pp. 369-387
-
-
Plmer, H.G.1
-
188
-
-
0033518310
-
Cross-regulation of β-catenin-LEF/TCF and retinoid signaling pathways
-
Easwaran, V., Pishvaian, M., Salimuddin & Byers, S. Cross-regulation of β-catenin-LEF/TCF and retinoid signaling pathways. Curr. Biol. 9, 1415-1418 (1999).
-
(1999)
Curr. Biol
, vol.9
, pp. 1415-1418
-
-
Easwaran, V.1
Salimuddin, P.M.2
Byers, S.3
-
189
-
-
0037192870
-
Linking β-catenin to androgen-signaling pathway
-
Yang, F. et al. Linking β-catenin to androgen-signaling pathway. J. Biol. Chem. 277, 11336-11344 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 11336-11344
-
-
Yang, F.1
-
190
-
-
33644850904
-
The molecular basis of vitamin D receptor and β-catenin crossregulation
-
Shah, S. et al. The molecular basis of vitamin D receptor and β-catenin crossregulation. Mol. Cell 21, 799-809 (2006).
-
(2006)
Mol. Cell
, vol.21
, pp. 799-809
-
-
Shah, S.1
-
191
-
-
44449144396
-
Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis
-
Yang, J. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev. Cell 14, 818-829 (2008).
-
(2008)
Dev. Cell
, vol.14
, pp. 818-829
-
-
Yang, J.1
-
192
-
-
67449106155
-
Wnt-5a-CKIα signaling promotes β-catenin/E-cadherin complex formation and intercellular adhesion in human breast epithelial cells
-
Medrek, C., Landberg, G., Andersson, T. & Leandersson, K. Wnt-5a-CKIα signaling promotes β-catenin/E-cadherin complex formation and intercellular adhesion in human breast epithelial cells. J. Biol. Chem. 284, 10968-10979 (2009).
-
(2009)
J. Biol. Chem
, vol.284
, pp. 10968-10979
-
-
Medrek, C.1
Landberg, G.2
Andersson, T.3
Leandersson, K.4
-
193
-
-
84862783300
-
Dickkopf-1 inhibits epithelial-mesenchymal transition of colon cancer cells and contributes to colon cancer suppression
-
Qi, L. et al. Dickkopf-1 inhibits epithelial-mesenchymal transition of
-
(2012)
Cancer Sci
, vol.103
, pp. 828-835
-
-
Qi, L.1
-
194
-
-
79951896236
-
Critical role of Wnt5a-Ror2 signaling in motility and invasiveness of carcinoma cells following Snail-mediated epithelial-mesenchymal transition
-
Ren, D., Minami, Y. & Nishita, M. Critical role of Wnt5a-Ror2 signaling in motility and invasiveness of carcinoma cells following Snail-mediated epithelial-mesenchymal transition. Genes Cells 16, 304-315 (2011).
-
(2011)
Genes Cells
, vol.16
, pp. 304-315
-
-
Ren, D.1
Minami, Y.2
Nishita, M.3
-
195
-
-
0033868542
-
Role of frizzled 7 in the regulation of convergent extension movements during gastrulation in Xenopus laevis
-
Djiane, A., Riou, J., Umbhauer, M., Boucaut, J. & Shi, D. Role of frizzled 7 in the regulation of convergent extension movements during gastrulation in Xenopus laevis. Development 127, 3091-3100 (2000).
-
(2000)
Development
, vol.127
, pp. 3091-3100
-
-
Djiane, A.1
Riou, J.2
Umbhauer, M.3
Boucaut, J.4
Shi, D.5
-
196
-
-
0035966322
-
Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1
-
Habas, R., Kato, Y. & He, X. Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. Cell 107, 843-854 (2001).
-
(2001)
Cell
, vol.107
, pp. 843-854
-
-
Habas, R.1
Kato, Y.2
He, X.3
-
197
-
-
0037439138
-
Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation
-
Habas, R., Dawid, I. B. & He, X. Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation. Genes Dev. 17, 295-309 (2003).
-
(2003)
Genes Dev
, vol.17
, pp. 295-309
-
-
Habas, R.1
Dawid, I.B.2
He, X.3
-
198
-
-
79951630375
-
The planar cell polarity pathway in vertebrate development
-
Wansleeben, C. & Meijlink, F. The planar cell polarity pathway in vertebrate development. Dev. Dyn. 240, 616-626 (2011).
-
(2011)
Dev. Dyn
, vol.240
, pp. 616-626
-
-
Wansleeben, C.1
Meijlink, F.2
-
199
-
-
67649109026
-
Wnt/Fz signaling and the cytoskeleton: Potential roles in tumorigenesis
-
Lai, S.-L., Chien, A. J. & Moon, R. T. Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis. Cell Res. 19, 532-545 (2009).
-
(2009)
Cell Res
, vol.19
, pp. 532-545
-
-
Lai, S.-L.1
Chien, A.J.2
Moon, R.T.3
-
200
-
-
70350439474
-
Wnt-5a-induced phosphorylation of DARPP-32 inhibits breast cancer cell migration in a CREB-dependent manner
-
Hansen, C. et al. Wnt-5a-induced phosphorylation of DARPP-32 inhibits breast cancer cell migration in a CREB-dependent manner. J. Biol. Chem. 284, 27533-27543 (2009).
-
(2009)
J. Biol. Chem
, vol.284
, pp. 27533-27543
-
-
Hansen, C.1
|