메뉴 건너뛰기




Volumn 31, Issue 6, 2010, Pages 220-227

TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CD8 ANTIGEN; CHEMOKINE; NEUTRALIZING ANTIBODY; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEIN;

EID: 77953023274     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.it.2010.04.002     Document Type: Review
Times cited : (804)

References (86)
  • 1
    • 33745515023 scopus 로고    scopus 로고
    • Tumour microenvironment : TGFβ: the molecular Jekyll and Hyde of cancer
    • Bierie B., and Moses H.L. Tumour microenvironment : TGFβ: the molecular Jekyll and Hyde of cancer. Nat. Rev. Cancer 6 7 (2006) 506-520
    • (2006) Nat. Rev. Cancer , vol.6 , Issue.7 , pp. 506-520
    • Bierie, B.1    Moses, H.L.2
  • 2
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in Cancer
    • Massague J. TGFbeta in Cancer. Cell 134 2 (2008) 215-230
    • (2008) Cell , vol.134 , Issue.2 , pp. 215-230
    • Massague, J.1
  • 3
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • Derynck R., and Zhang Y.E. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425 6958 (2003) 577-584
    • (2003) Nature , vol.425 , Issue.6958 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 4
    • 0030611757 scopus 로고    scopus 로고
    • Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling
    • Nakao A., et al. Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling. Nature 389 6651 (1997) 631-635
    • (1997) Nature , vol.389 , Issue.6651 , pp. 631-635
    • Nakao, A.1
  • 5
    • 0031587828 scopus 로고    scopus 로고
    • The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling
    • Hayashi H., et al. The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling. Cell 89 7 (1997) 1165-1173
    • (1997) Cell , vol.89 , Issue.7 , pp. 1165-1173
    • Hayashi, H.1
  • 6
    • 0035501062 scopus 로고    scopus 로고
    • TGF-beta signaling in cancer-a double-edged sword
    • Akhurst R.J., and Derynck R. TGF-beta signaling in cancer-a double-edged sword. Trends Cell Biol. 11 11 (2001) S44-S51
    • (2001) Trends Cell Biol. , vol.11 , Issue.11
    • Akhurst, R.J.1    Derynck, R.2
  • 7
    • 0029066689 scopus 로고
    • Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability
    • Markowitz S., et al. Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science 268 5215 (1995) 1336-1338
    • (1995) Science , vol.268 , Issue.5215 , pp. 1336-1338
    • Markowitz, S.1
  • 8
    • 0037081179 scopus 로고    scopus 로고
    • Alterations of Smad signaling in human breast carcinoma are associated with poor outcome: a tissue microarray study
    • Xie W., et al. Alterations of Smad signaling in human breast carcinoma are associated with poor outcome: a tissue microarray study. Cancer Res. 62 2 (2002) 497-505
    • (2002) Cancer Res. , vol.62 , Issue.2 , pp. 497-505
    • Xie, W.1
  • 9
    • 56449127197 scopus 로고    scopus 로고
    • Transforming growth factor beta: tumor suppressor or promoter? Are host immune cells the answer?
    • Yang L., and Moses H.L. Transforming growth factor beta: tumor suppressor or promoter? Are host immune cells the answer?. Cancer Res. 68 22 (2008) 9107-9111
    • (2008) Cancer Res. , vol.68 , Issue.22 , pp. 9107-9111
    • Yang, L.1    Moses, H.L.2
  • 10
    • 37549046846 scopus 로고    scopus 로고
    • Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice
    • Pangas S.A., et al. Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice. Mol. Cell Biol. 28 1 (2008) 248-257
    • (2008) Mol. Cell Biol. , vol.28 , Issue.1 , pp. 248-257
    • Pangas, S.A.1
  • 11
    • 35148832173 scopus 로고    scopus 로고
    • Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia
    • Guasch G., et al. Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia. Cancer Cell 12 4 (2007) 313-327
    • (2007) Cancer Cell , vol.12 , Issue.4 , pp. 313-327
    • Guasch, G.1
  • 12
    • 0035912144 scopus 로고    scopus 로고
    • Molecular predictors of survival after adjuvant chemotherapy for colon cancer
    • Watanabe T., et al. Molecular predictors of survival after adjuvant chemotherapy for colon cancer. N. Engl. J. Med. 344 16 (2001) 1196-1206
    • (2001) N. Engl. J. Med. , vol.344 , Issue.16 , pp. 1196-1206
    • Watanabe, T.1
  • 13
    • 33846821916 scopus 로고    scopus 로고
    • High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene
    • Bruna A., et al. High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene. Cancer Cell 11 2 (2007) 147-160
    • (2007) Cancer Cell , vol.11 , Issue.2 , pp. 147-160
    • Bruna, A.1
  • 14
    • 30644467227 scopus 로고    scopus 로고
    • Inhibition of TGFbeta signaling in cancer therapy
    • Arteaga C.L. Inhibition of TGFbeta signaling in cancer therapy. Curr. Opin. Genet. Dev. 16 1 (2006) 30-37
    • (2006) Curr. Opin. Genet. Dev. , vol.16 , Issue.1 , pp. 30-37
    • Arteaga, C.L.1
  • 15
    • 0036675220 scopus 로고    scopus 로고
    • Metastasis to bone: causes, consequences and therapeutic opportunities
    • Mundy G.R. Metastasis to bone: causes, consequences and therapeutic opportunities. Nat. Rev. Cancer 2 8 (2002) 584-593
    • (2002) Nat. Rev. Cancer , vol.2 , Issue.8 , pp. 584-593
    • Mundy, G.R.1
  • 16
    • 0142250340 scopus 로고    scopus 로고
    • Transforming growth factor-beta in osteolytic breast cancer bone metastases
    • Guise T.A., and Chirgwin J.M. Transforming growth factor-beta in osteolytic breast cancer bone metastases. Clin. Orthop. Relat. Res. 415 Suppl (2003) S32-38
    • (2003) Clin. Orthop. Relat. Res. , vol.415 SUPPL
    • Guise, T.A.1    Chirgwin, J.M.2
  • 17
    • 0042307513 scopus 로고    scopus 로고
    • The two faces of transforming growth factor beta in carcinogenesis
    • Roberts A.B., and Wakefield L.M. The two faces of transforming growth factor beta in carcinogenesis. Proc. Natl. Acad. Sci. U. S. A. 100 15 (2003) 8621-8623
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , Issue.15 , pp. 8621-8623
    • Roberts, A.B.1    Wakefield, L.M.2
  • 18
    • 70350231912 scopus 로고    scopus 로고
    • Gain or loss of TGFbeta signaling in mammary carcinoma cells can promote metastasis
    • Bierie B., and Moses H.L. Gain or loss of TGFbeta signaling in mammary carcinoma cells can promote metastasis. Cell Cycle 8 20 (2009) 3319-3327
    • (2009) Cell Cycle , vol.8 , Issue.20 , pp. 3319-3327
    • Bierie, B.1    Moses, H.L.2
  • 19
    • 41149157649 scopus 로고    scopus 로고
    • TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4
    • Padua D., et al. TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell 133 1 (2008) 66-77
    • (2008) Cell , vol.133 , Issue.1 , pp. 66-77
    • Padua, D.1
  • 20
    • 63049136592 scopus 로고    scopus 로고
    • A mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis
    • Adorno M., et al. A mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis. Cell 137 1 (2009) 87-98
    • (2009) Cell , vol.137 , Issue.1 , pp. 87-98
    • Adorno, M.1
  • 21
    • 58149093172 scopus 로고    scopus 로고
    • FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination
    • Dupont S., et al. FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination. Cell 136 1 (2009) 123-135
    • (2009) Cell , vol.136 , Issue.1 , pp. 123-135
    • Dupont, S.1
  • 22
    • 58749089988 scopus 로고    scopus 로고
    • TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch
    • Liu I.M., et al. TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch. EMBO J. 28 2 (2009) 88-98
    • (2009) EMBO J. , vol.28 , Issue.2 , pp. 88-98
    • Liu, I.M.1
  • 23
    • 33646164362 scopus 로고    scopus 로고
    • Transforming growth factor-beta regulation of immune responses
    • Li M.O., et al. Transforming growth factor-beta regulation of immune responses. Annu. Rev. Immunol. 24 (2006) 99-146
    • (2006) Annu. Rev. Immunol. , vol.24 , pp. 99-146
    • Li, M.O.1
  • 24
    • 0036372440 scopus 로고    scopus 로고
    • Transforming growth factor-beta in T-cell biology
    • Gorelik L., and Flavell R.A. Transforming growth factor-beta in T-cell biology. Nat. Rev. Immunol. 2 1 (2002) 46-53
    • (2002) Nat. Rev. Immunol. , vol.2 , Issue.1 , pp. 46-53
    • Gorelik, L.1    Flavell, R.A.2
  • 25
    • 48449086316 scopus 로고    scopus 로고
    • TGF-beta: a master of all T cell trades
    • Li M.O., and Flavell R.A. TGF-beta: a master of all T cell trades. Cell 134 3 (2008) 392-404
    • (2008) Cell , vol.134 , Issue.3 , pp. 392-404
    • Li, M.O.1    Flavell, R.A.2
  • 26
    • 33748756028 scopus 로고    scopus 로고
    • TGF-beta: a mobile purveyor of immune privilege
    • Wahl S.M., et al. TGF-beta: a mobile purveyor of immune privilege. Immunol. Rev. 213 (2006) 213-227
    • (2006) Immunol. Rev. , vol.213 , pp. 213-227
    • Wahl, S.M.1
  • 27
    • 0034770605 scopus 로고    scopus 로고
    • Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells
    • Gorelik L., and Flavell R.A. Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells. Nat. Med. 7 10 (2001) 1118-1122
    • (2001) Nat. Med. , vol.7 , Issue.10 , pp. 1118-1122
    • Gorelik, L.1    Flavell, R.A.2
  • 28
    • 27644457376 scopus 로고    scopus 로고
    • TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance
    • Thomas D.A., and Massague J. TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance. Cancer Cell 8 5 (2005) 369-380
    • (2005) Cancer Cell , vol.8 , Issue.5 , pp. 369-380
    • Thomas, D.A.1    Massague, J.2
  • 29
    • 27644589700 scopus 로고    scopus 로고
    • The dual adverse effects of TGF-beta secretion on tumor progression
    • Trapani J.A. The dual adverse effects of TGF-beta secretion on tumor progression. Cancer Cell 8 5 (2005) 349-350
    • (2005) Cancer Cell , vol.8 , Issue.5 , pp. 349-350
    • Trapani, J.A.1
  • 30
    • 0035801335 scopus 로고    scopus 로고
    • Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta
    • Nakamura K., et al. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J. Exp. Med. 194 5 (2001) 629-644
    • (2001) J. Exp. Med. , vol.194 , Issue.5 , pp. 629-644
    • Nakamura, K.1
  • 31
    • 26844464792 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner
    • Ghiringhelli F., et al. CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner. J. Exp. Med. 202 8 (2005) 1075-1085
    • (2005) J. Exp. Med. , vol.202 , Issue.8 , pp. 1075-1085
    • Ghiringhelli, F.1
  • 32
    • 65549136983 scopus 로고    scopus 로고
    • Mechanisms of foxp3+ T regulatory cell-mediated suppression
    • Shevach E.M. Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity 30 5 (2009) 636-645
    • (2009) Immunity , vol.30 , Issue.5 , pp. 636-645
    • Shevach, E.M.1
  • 33
    • 34248572345 scopus 로고    scopus 로고
    • T(H)-17 cells in the circle of immunity and autoimmunity
    • Bettelli E., et al. T(H)-17 cells in the circle of immunity and autoimmunity. Nat. Immunol. 8 4 (2007) 345-350
    • (2007) Nat. Immunol. , vol.8 , Issue.4 , pp. 345-350
    • Bettelli, E.1
  • 34
    • 61949463911 scopus 로고    scopus 로고
    • IL-17 and Th17 cells
    • Korn T., et al. IL-17 and Th17 cells. Annu. Rev. Immunol. 27 (2009) 485-517
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 485-517
    • Korn, T.1
  • 35
    • 33646560950 scopus 로고    scopus 로고
    • Transforming growth factor-beta induces development of the T(H)17 lineage
    • Mangan P.R., et al. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 441 7090 (2006) 231-234
    • (2006) Nature , vol.441 , Issue.7090 , pp. 231-234
    • Mangan, P.R.1
  • 36
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen M., et al. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24 2 (2006) 179-189
    • (2006) Immunity , vol.24 , Issue.2 , pp. 179-189
    • Veldhoen, M.1
  • 37
    • 34547232503 scopus 로고    scopus 로고
    • IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells
    • Korn T., et al. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 448 7152 (2007) 484-487
    • (2007) Nature , vol.448 , Issue.7152 , pp. 484-487
    • Korn, T.1
  • 38
    • 12244285937 scopus 로고    scopus 로고
    • Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo
    • Chen M.L., et al. Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc. Natl. Acad. Sci. U. S. A. 102 2 (2005) 419-424
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , Issue.2 , pp. 419-424
    • Chen, M.L.1
  • 39
    • 33745578957 scopus 로고    scopus 로고
    • Smad4 signalling in T cells is required for suppression of gastrointestinal cancer
    • Kim B.G., et al. Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. Nature 441 7096 (2006) 1015-1019
    • (2006) Nature , vol.441 , Issue.7096 , pp. 1015-1019
    • Kim, B.G.1
  • 40
    • 0037388134 scopus 로고    scopus 로고
    • Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells
    • Castriconi R., et al. Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells. Proc. Natl. Acad. Sci. U. S. A. 100 7 (2003) 4120-4125
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , Issue.7 , pp. 4120-4125
    • Castriconi, R.1
  • 41
    • 2942588777 scopus 로고    scopus 로고
    • Elevated TGF-beta1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients
    • Lee J.C., et al. Elevated TGF-beta1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients. J. Immunol. 172 12 (2004) 7335-7340
    • (2004) J. Immunol. , vol.172 , Issue.12 , pp. 7335-7340
    • Lee, J.C.1
  • 42
    • 20644472421 scopus 로고    scopus 로고
    • Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma
    • Laouar Y., et al. Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma. Nat. Immunol. 6 6 (2005) 600-607
    • (2005) Nat. Immunol. , vol.6 , Issue.6 , pp. 600-607
    • Laouar, Y.1
  • 43
    • 70350244537 scopus 로고    scopus 로고
    • Platelet-derived transforming growth factor-beta down-regulates NKG2D thereby inhibiting natural killer cell antitumor reactivity
    • Kopp H.G., et al. Platelet-derived transforming growth factor-beta down-regulates NKG2D thereby inhibiting natural killer cell antitumor reactivity. Cancer Res. 69 19 (2009) 7775-7783
    • (2009) Cancer Res. , vol.69 , Issue.19 , pp. 7775-7783
    • Kopp, H.G.1
  • 44
    • 5644248080 scopus 로고    scopus 로고
    • RNA interference targeting transforming growth factor-beta enhances NKG2D-mediated antiglioma immune response, inhibits glioma cell migration and invasiveness, and abrogates tumorigenicity in vivo
    • Friese M.A., et al. RNA interference targeting transforming growth factor-beta enhances NKG2D-mediated antiglioma immune response, inhibits glioma cell migration and invasiveness, and abrogates tumorigenicity in vivo. Cancer Res. 64 20 (2004) 7596-7603
    • (2004) Cancer Res. , vol.64 , Issue.20 , pp. 7596-7603
    • Friese, M.A.1
  • 45
    • 0025780301 scopus 로고
    • Transforming growth factor-beta suppresses human B lymphocyte Ig production by inhibiting synthesis and the switch from the membrane form to the secreted form of Ig mRNA
    • Kehrl J.H., et al. Transforming growth factor-beta suppresses human B lymphocyte Ig production by inhibiting synthesis and the switch from the membrane form to the secreted form of Ig mRNA. J. Immunol. 146 11 (1991) 4016-4023
    • (1991) J. Immunol. , vol.146 , Issue.11 , pp. 4016-4023
    • Kehrl, J.H.1
  • 46
    • 0033697670 scopus 로고    scopus 로고
    • TGF-beta receptor controls B cell responsiveness and induction of IgA in vivo
    • Cazac B.B., and Roes J. TGF-beta receptor controls B cell responsiveness and induction of IgA in vivo. Immunity 13 4 (2000) 443-451
    • (2000) Immunity , vol.13 , Issue.4 , pp. 443-451
    • Cazac, B.B.1    Roes, J.2
  • 47
    • 33747880415 scopus 로고    scopus 로고
    • Inhibitory effects of B cells on antitumor immunity
    • Inoue S., et al. Inhibitory effects of B cells on antitumor immunity. Cancer Res. 66 15 (2006) 7741-7747
    • (2006) Cancer Res. , vol.66 , Issue.15 , pp. 7741-7747
    • Inoue, S.1
  • 48
    • 37849044394 scopus 로고    scopus 로고
    • The 'short' history of regulatory B cells
    • Mauri C., and Ehrenstein M.R. The 'short' history of regulatory B cells. Trends Immunol. 29 1 (2008) 34-40
    • (2008) Trends Immunol. , vol.29 , Issue.1 , pp. 34-40
    • Mauri, C.1    Ehrenstein, M.R.2
  • 49
    • 43049156086 scopus 로고    scopus 로고
    • A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses
    • Yanaba K., et al. A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity 28 5 (2008) 639-650
    • (2008) Immunity , vol.28 , Issue.5 , pp. 639-650
    • Yanaba, K.1
  • 50
    • 19344365408 scopus 로고    scopus 로고
    • De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent
    • de Visser K.E., et al. De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent. Cancer Cell 7 5 (2005) 411-423
    • (2005) Cancer Cell , vol.7 , Issue.5 , pp. 411-423
    • de Visser, K.E.1
  • 51
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • Gabrilovich D.I., and Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat. Rev. Immunol. 9 3 (2009) 162-174
    • (2009) Nat. Rev. Immunol. , vol.9 , Issue.3 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 52
    • 43249130187 scopus 로고    scopus 로고
    • Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T-cell suppressive activity
    • Movahedi K., et al. Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T-cell suppressive activity. Blood 111 8 (2008) 4233-4244
    • (2008) Blood , vol.111 , Issue.8 , pp. 4233-4244
    • Movahedi, K.1
  • 53
    • 37349100945 scopus 로고    scopus 로고
    • Abrogation of TGFbeta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis
    • Yang L., et al. Abrogation of TGFbeta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell 13 1 (2008) 23-35
    • (2008) Cancer Cell , vol.13 , Issue.1 , pp. 23-35
    • Yang, L.1
  • 54
    • 5444225991 scopus 로고    scopus 로고
    • Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis
    • Yang L., et al. Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. Cancer Cell 6 4 (2004) 409-421
    • (2004) Cancer Cell , vol.6 , Issue.4 , pp. 409-421
    • Yang, L.1
  • 55
    • 31044433663 scopus 로고    scopus 로고
    • Macrophages: obligate partners for tumor cell migration, invasion, and metastasis
    • Condeelis J., and Pollard J.W. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 124 2 (2006) 263-266
    • (2006) Cell , vol.124 , Issue.2 , pp. 263-266
    • Condeelis, J.1    Pollard, J.W.2
  • 56
    • 33845524204 scopus 로고    scopus 로고
    • Role of tumor-associated macrophages in tumor progression and invasion
    • Mantovani A., et al. Role of tumor-associated macrophages in tumor progression and invasion. Cancer Metastasis Rev. 25 3 (2006) 315-322
    • (2006) Cancer Metastasis Rev. , vol.25 , Issue.3 , pp. 315-322
    • Mantovani, A.1
  • 57
    • 47949096781 scopus 로고    scopus 로고
    • Cancer-related inflammation
    • Mantovani A., et al. Cancer-related inflammation. Nature 454 7203 (2008) 436-444
    • (2008) Nature , vol.454 , Issue.7203 , pp. 436-444
    • Mantovani, A.1
  • 58
    • 63149088164 scopus 로고    scopus 로고
    • Trophic macrophages in development and disease
    • Pollard J.W. Trophic macrophages in development and disease. Nat. Rev. Immunol. 9 4 (2009) 259-270
    • (2009) Nat. Rev. Immunol. , vol.9 , Issue.4 , pp. 259-270
    • Pollard, J.W.1
  • 59
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • Joyce J.A., and Pollard J.W. Microenvironmental regulation of metastasis. Nat. Rev. Cancer 9 4 (2009) 239-252
    • (2009) Nat. Rev. Cancer , vol.9 , Issue.4 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 60
    • 33344460032 scopus 로고    scopus 로고
    • A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kB and enhanced IRF-3/STAT1 activation)
    • Biswas S.K., et al. A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kB and enhanced IRF-3/STAT1 activation). Blood 107 5 (2006) 2112-2122
    • (2006) Blood , vol.107 , Issue.5 , pp. 2112-2122
    • Biswas, S.K.1
  • 61
    • 69249222379 scopus 로고    scopus 로고
    • Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN
    • Fridlender Z.G., et al. Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN. Cancer Cell 16 3 (2009) 183-194
    • (2009) Cancer Cell , vol.16 , Issue.3 , pp. 183-194
    • Fridlender, Z.G.1
  • 62
    • 69249242897 scopus 로고    scopus 로고
    • The yin-yang of tumor-associated neutrophils
    • Mantovani A. The yin-yang of tumor-associated neutrophils. Cancer Cell 16 3 (2009) 173-174
    • (2009) Cancer Cell , vol.16 , Issue.3 , pp. 173-174
    • Mantovani, A.1
  • 63
    • 10744220561 scopus 로고    scopus 로고
    • Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: abrogation prevents tumor recurrence
    • Terabe M., et al. Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: abrogation prevents tumor recurrence. J. Exp. Med. 198 11 (2003) 1741-1752
    • (2003) J. Exp. Med. , vol.198 , Issue.11 , pp. 1741-1752
    • Terabe, M.1
  • 64
    • 39849102836 scopus 로고    scopus 로고
    • HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
    • Du R., et al. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 13 3 (2008) 206-220
    • (2008) Cancer Cell , vol.13 , Issue.3 , pp. 206-220
    • Du, R.1
  • 65
    • 39749114978 scopus 로고    scopus 로고
    • Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability
    • Bristow R.G., and Hill R.P. Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability. Nat. Rev. Cancer 8 3 (2008) 180-192
    • (2008) Nat. Rev. Cancer , vol.8 , Issue.3 , pp. 180-192
    • Bristow, R.G.1    Hill, R.P.2
  • 66
    • 40949144957 scopus 로고    scopus 로고
    • Transforming growth factor-beta regulates mammary carcinoma cell survival and interaction with the adjacent microenvironment
    • Bierie B., et al. Transforming growth factor-beta regulates mammary carcinoma cell survival and interaction with the adjacent microenvironment. Cancer Res. 68 6 (2008) 1809-1819
    • (2008) Cancer Res. , vol.68 , Issue.6 , pp. 1809-1819
    • Bierie, B.1
  • 67
    • 67651005826 scopus 로고    scopus 로고
    • Abrogation of TGF-beta signaling enhances chemokine production and correlates with prognosis in human breast cancer
    • Bierie B., et al. Abrogation of TGF-beta signaling enhances chemokine production and correlates with prognosis in human breast cancer. J. Clin. Invest. 119 6 (2009) 1571-1582
    • (2009) J. Clin. Invest. , vol.119 , Issue.6 , pp. 1571-1582
    • Bierie, B.1
  • 68
    • 34047138860 scopus 로고    scopus 로고
    • SMAD4-deficient intestinal tumors recruit CCR1(+) myeloid cells that promote invasion
    • Kitamura T., et al. SMAD4-deficient intestinal tumors recruit CCR1(+) myeloid cells that promote invasion. Nat. Genet. 39 4 (2007) 467-475
    • (2007) Nat. Genet. , vol.39 , Issue.4 , pp. 467-475
    • Kitamura, T.1
  • 69
    • 33646537475 scopus 로고    scopus 로고
    • Loss of transforming growth factor-beta type II receptor promotes metastatic head-and-neck squamous cell carcinoma
    • Lu S.L., et al. Loss of transforming growth factor-beta type II receptor promotes metastatic head-and-neck squamous cell carcinoma. Genes Dev. 20 10 (2006) 1331-1342
    • (2006) Genes Dev. , vol.20 , Issue.10 , pp. 1331-1342
    • Lu, S.L.1
  • 70
    • 0037112436 scopus 로고    scopus 로고
    • Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice
    • Engle S.J., et al. Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice. Cancer Res. 62 22 (2002) 6362-6366
    • (2002) Cancer Res. , vol.62 , Issue.22 , pp. 6362-6366
    • Engle, S.J.1
  • 71
    • 3042778716 scopus 로고    scopus 로고
    • Overexpression of transforming growth factor beta1 in head and neck epithelia results in inflammation, angiogenesis, and epithelial hyperproliferation
    • Lu S.L., et al. Overexpression of transforming growth factor beta1 in head and neck epithelia results in inflammation, angiogenesis, and epithelial hyperproliferation. Cancer Res. 64 13 (2004) 4405-4410
    • (2004) Cancer Res. , vol.64 , Issue.13 , pp. 4405-4410
    • Lu, S.L.1
  • 72
    • 0842288323 scopus 로고    scopus 로고
    • TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
    • Bhowmick N.A., et al. TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science 303 5659 (2004) 848-851
    • (2004) Science , vol.303 , Issue.5659 , pp. 848-851
    • Bhowmick, N.A.1
  • 73
    • 1042266673 scopus 로고    scopus 로고
    • A failure of transforming growth factor-beta1 negative regulation maintains sustained NF-kappaB activation in gut inflammation
    • Monteleone G., et al. A failure of transforming growth factor-beta1 negative regulation maintains sustained NF-kappaB activation in gut inflammation. J. Biol. Chem. 279 6 (2004) 3925-3932
    • (2004) J. Biol. Chem. , vol.279 , Issue.6 , pp. 3925-3932
    • Monteleone, G.1
  • 74
    • 31544465904 scopus 로고    scopus 로고
    • Helicobacter infection is required for inflammation and colon cancer in SMAD3-deficient mice
    • Maggio-Price L., et al. Helicobacter infection is required for inflammation and colon cancer in SMAD3-deficient mice. Cancer Res. 66 2 (2006) 828-838
    • (2006) Cancer Res. , vol.66 , Issue.2 , pp. 828-838
    • Maggio-Price, L.1
  • 75
    • 34248384441 scopus 로고    scopus 로고
    • Dose-dependent cross-talk between the transforming growth factor-beta and interleukin-1 signaling pathways
    • Lu T., et al. Dose-dependent cross-talk between the transforming growth factor-beta and interleukin-1 signaling pathways. Proc. Natl. Acad. Sci. U. S. A. 104 11 (2007) 4365-4370
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , Issue.11 , pp. 4365-4370
    • Lu, T.1
  • 76
    • 4644335311 scopus 로고    scopus 로고
    • Cancer: an inflammatory link
    • Balkwill F., and Coussens L.M. Cancer: an inflammatory link. Nature 431 7007 (2004) 405-406
    • (2004) Nature , vol.431 , Issue.7007 , pp. 405-406
    • Balkwill, F.1    Coussens, L.M.2
  • 77
    • 33751504690 scopus 로고    scopus 로고
    • Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis
    • Hiratsuka S., et al. Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis. Nat. Cell Biol. 8 12 (2006) 1369-1375
    • (2006) Nat. Cell Biol. , vol.8 , Issue.12 , pp. 1369-1375
    • Hiratsuka, S.1
  • 78
    • 57749107585 scopus 로고    scopus 로고
    • Systemic blockade of transforming growth factor-beta signaling augments the efficacy of immunogene therapy
    • Kim S., et al. Systemic blockade of transforming growth factor-beta signaling augments the efficacy of immunogene therapy. Cancer Res. 68 24 (2008) 10247-10256
    • (2008) Cancer Res. , vol.68 , Issue.24 , pp. 10247-10256
    • Kim, S.1
  • 79
    • 70350738483 scopus 로고    scopus 로고
    • Synergistic enhancement of CD8+ T cell-mediated tumor vaccine efficacy by an anti-transforming growth factor-beta monoclonal antibody
    • Terabe M., et al. Synergistic enhancement of CD8+ T cell-mediated tumor vaccine efficacy by an anti-transforming growth factor-beta monoclonal antibody. Clin. Cancer Res. 15 21 (2009) 6560-6569
    • (2009) Clin. Cancer Res. , vol.15 , Issue.21 , pp. 6560-6569
    • Terabe, M.1
  • 80
    • 34248185926 scopus 로고    scopus 로고
    • Inhibition of TGF-beta with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression
    • Biswas S., et al. Inhibition of TGF-beta with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression. J. Clin. Invest. 117 5 (2007) 1305-1313
    • (2007) J. Clin. Invest. , vol.117 , Issue.5 , pp. 1305-1313
    • Biswas, S.1
  • 81
    • 45549085803 scopus 로고    scopus 로고
    • An anti-transforming growth factor beta antibody suppresses metastasis via cooperative effects on multiple cell compartments
    • Nam J.S., et al. An anti-transforming growth factor beta antibody suppresses metastasis via cooperative effects on multiple cell compartments. Cancer Res. 68 10 (2008) 3835-3843
    • (2008) Cancer Res. , vol.68 , Issue.10 , pp. 3835-3843
    • Nam, J.S.1
  • 82
    • 45549088943 scopus 로고    scopus 로고
    • Transforming growth factor beta subverts the immune system into directly promoting tumor growth through interleukin-17
    • Nam J.S., et al. Transforming growth factor beta subverts the immune system into directly promoting tumor growth through interleukin-17. Cancer Res. 68 10 (2008) 3915-3923
    • (2008) Cancer Res. , vol.68 , Issue.10 , pp. 3915-3923
    • Nam, J.S.1
  • 83
    • 67449136111 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-beta-mediated immunosuppression in tumor-draining lymph nodes augments antitumor responses by various immunologic cell types
    • Fujita T., et al. Inhibition of transforming growth factor-beta-mediated immunosuppression in tumor-draining lymph nodes augments antitumor responses by various immunologic cell types. Cancer Res. 69 12 (2009) 5142-5150
    • (2009) Cancer Res. , vol.69 , Issue.12 , pp. 5142-5150
    • Fujita, T.1
  • 84
    • 0034125451 scopus 로고    scopus 로고
    • Clinical significance of defective dendritic cell differentiation in cancer
    • Almand B., et al. Clinical significance of defective dendritic cell differentiation in cancer. Clin. Cancer Res. 6 5 (2000) 1755-1766
    • (2000) Clin. Cancer Res. , vol.6 , Issue.5 , pp. 1755-1766
    • Almand, B.1
  • 85
    • 33747029250 scopus 로고    scopus 로고
    • Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment
    • Budhu A., et al. Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment. Cancer Cell 10 2 (2006) 99-111
    • (2006) Cancer Cell , vol.10 , Issue.2 , pp. 99-111
    • Budhu, A.1
  • 86
    • 33749319703 scopus 로고    scopus 로고
    • Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    • Galon J., et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313 5795 (2006) 1960-1964
    • (2006) Science , vol.313 , Issue.5795 , pp. 1960-1964
    • Galon, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.