메뉴 건너뛰기




Volumn 16, Issue 6, 2015, Pages 13610-13632

Colorectal cancer classification and cell heterogeneity: A systems oncology approach

Author keywords

Cancer systems biology; Classification; Colorectal cancer; Heterogeneity; Molecular pathology; Precision medicine; Targeted therapy

Indexed keywords

B RAF KINASE; BEVACIZUMAB; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN; OXALIPLATIN; PANITUMUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN MLH1; RAS PROTEIN; WNT PROTEIN;

EID: 84934978026     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms160613610     Document Type: Review
Times cited : (51)

References (119)
  • 1
    • 84874354257 scopus 로고    scopus 로고
    • The implications of clonal genome evolution for cancer medicine
    • Aparicio, S.; Caldas, C. The implications of clonal genome evolution for cancer medicine. N. Engl. J. Med. 2013, 368, 842–851.
    • (2013) N. Engl. J. Med. , vol.368 , pp. 842-851
    • Aparicio, S.1    Caldas, C.2
  • 2
    • 84860214990 scopus 로고    scopus 로고
    • Intra-tumour heterogeneity: A looking glass for cancer?
    • Marusyk, A.; Almendro, V.; Polyak, K. Intra-tumour heterogeneity: A looking glass for cancer? Nat. Rev. Cancer 2012, 12, 323–334.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 323-334
    • Marusyk, A.1    Almendro, V.2    Polyak, K.3
  • 3
    • 84867121875 scopus 로고    scopus 로고
    • Intratumor heterogeneity: Evolution through space and time
    • Swanton, C. Intratumor heterogeneity: Evolution through space and time. Cancer Res. 2012, 72, 4875–4882.
    • (2012) Cancer Res , vol.72 , pp. 4875-4882
    • Swanton, C.1
  • 4
    • 84884365015 scopus 로고    scopus 로고
    • The causes and consequences of genetic heterogeneity in cancer evolution
    • Burrell, R.A.; McGranahan, N.; Bartek, J.; Swanton, C. The causes and consequences of genetic heterogeneity in cancer evolution. Nature 2013, 501, 338–345.
    • (2013) Nature , vol.501 , pp. 338-345
    • Burrell, R.A.1    McGranahan, N.2    Bartek, J.3    Swanton, C.4
  • 5
    • 84919384591 scopus 로고    scopus 로고
    • The evolution of our molecular understanding of colorectal cancer: What we are doing now, what the future holds, and how tumor profiling is just the beginning
    • Dienstmann, R.; Salazar, R.; Tabernero, J. The evolution of our molecular understanding of colorectal cancer: What we are doing now, what the future holds, and how tumor profiling is just the beginning. Am. Soc. Clin. Oncol. Educ. Book 2014, 34, 91–99.
    • (2014) Am. Soc. Clin. Oncol. Educ. Book , vol.34 , pp. 91-99
    • Dienstmann, R.1    Salazar, R.2    Tabernero, J.3
  • 6
    • 84890472864 scopus 로고    scopus 로고
    • Molecular pathways involved in colorectal cancer: Implications for disease behavior and prevention
    • Colussi, D.; Brandi, G.; Bazzoli, F.; Ricciardiello, L. Molecular pathways involved in colorectal cancer: Implications for disease behavior and prevention. Int. J. Mol. Sci. 2013, 14, 16365–16385.
    • (2013) Int. J. Mol. Sci , vol.14 , pp. 16365-16385
    • Colussi, D.1    Brandi, G.2    Bazzoli, F.3    Ricciardiello, L.4
  • 8
    • 72449176846 scopus 로고    scopus 로고
    • Molecular origins of cancer: Molecular basis of colorectal cancer
    • Markowitz, S.D.; Bertagnolli, M.M. Molecular origins of cancer: Molecular basis of colorectal cancer. N. Engl. J. Med. 2009, 361, 2449–2460.
    • (2009) N. Engl. J. Med , vol.361 , pp. 2449-2460
    • Markowitz, S.D.1    Bertagnolli, M.M.2
  • 9
    • 84858166365 scopus 로고    scopus 로고
    • Molecular pathways: Microsatellite instability in colorectal cancer: Prognostic, predictive, and therapeutic implications
    • Sinicrope, F.A.; Sargent, D.J. Molecular pathways: Microsatellite instability in colorectal cancer: Prognostic, predictive, and therapeutic implications. Clin. Cancer Res. 2012, 18, 1506–1512.
    • (2012) Clin. Cancer Res , vol.18 , pp. 1506-1512
    • Sinicrope, F.A.1    Sargent, D.J.2
  • 14
    • 84864436663 scopus 로고    scopus 로고
    • A comprehensive characterization of genome-wide copy number aberrations in colorectal cancer reveals novel oncogenes and patterns of alterations
    • Xie, T.; d’ Ario, G.; Lamb, J.R.; Martin, E.; Wang, K.; Tejpar, S.; Delorenzi, M.; Bosman, F.T.; Roth, A.D.; Yan, P., et al. A comprehensive characterization of genome-wide copy number aberrations in colorectal cancer reveals novel oncogenes and patterns of alterations. PLoS ONE 2012, 7, 1–9.
    • (2012) Plos ONE , vol.7 , pp. 1-9
    • Xie, T.1    D’Ario, G.2    Lamb, J.R.3    Martin, E.4    Wang, K.5    Tejpar, S.6    Delorenzi, M.7    Bosman, F.T.8    Roth, A.D.9    Yan, P.10
  • 15
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • The Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature 2012, 487, 330–337.
    • (2012) Nature , vol.487 , pp. 330-337
  • 17
    • 84878822005 scopus 로고    scopus 로고
    • Epigenetics and colorectal cancer pathogenesis
    • Bardhan, K.; Liu, K. Epigenetics and colorectal cancer pathogenesis. Cancers 2013, 5, 676–713.
    • (2013) Cancers , vol.5 , pp. 676-713
    • Bardhan, K.1    Liu, K.2
  • 21
    • 84887119057 scopus 로고    scopus 로고
    • Functional heterogeneity of cancer-associated fibroblasts from human colon tumors shows specific prognostic gene expression signature
    • Herrera, M.; Islam, A.B.M.M.K.; Herrera, A.; Martín, P.; García, V.; Silva, J.; Garcia, J.M.; Salas, C.; Casal, I.; de Herreros, A.G., et al. Functional heterogeneity of cancer-associated fibroblasts from human colon tumors shows specific prognostic gene expression signature. Clin. Cancer Res. 2013, 19, 5914–5926.
    • (2013) Clin. Cancer Res , vol.19 , pp. 5914-5926
    • Herrera, M.1    Islam, A.2    Herrera, A.3    Martín, P.4    García, V.5    Silva, J.6    Garcia, J.M.7    Salas, C.8    Casal, I.9    De Herreros, A.G.10
  • 22
    • 84908505808 scopus 로고    scopus 로고
    • Differences between CAFs and their paired NCF from adjacent colonic mucosa reveal functional heterogeneity of CAFs, providing prognostic information
    • Berdiel-Acer, M.; Sanz-Pamplona, R.; Calon, A.; Cuadras, D.; Berenguer, A.; Sanjuan, X.; Paules, M.J.; Salazar, R.; Moreno, V.; Batlle, E., et al. Differences between CAFs and their paired NCF from adjacent colonic mucosa reveal functional heterogeneity of CAFs, providing prognostic information. Mol. Oncol. 2014, 8, 1290–1305.
    • (2014) Mol. Oncol , vol.8 , pp. 1290-1305
    • Berdiel-Acer, M.1    Sanz-Pamplona, R.2    Calon, A.3    Cuadras, D.4    Berenguer, A.5    Sanjuan, X.6    Paules, M.J.7    Salazar, R.8    Moreno, V.9    Batlle, E.10
  • 23
    • 84862668532 scopus 로고    scopus 로고
    • Dietary fibre intake and risks of cancers of the colon and rectum in the European prospective investigation into cancer and nutrition (EPIC)
    • Murphy, N.; Norat, T.; Ferrari, P.; Jenab, M.; Bueno-de-Mesquita, B.; Skeie, G.; Dahm, C.C.; Overvad, K.; Olsen, A.; Tjønneland, A., et al. Dietary fibre intake and risks of cancers of the colon and rectum in the European prospective investigation into cancer and nutrition (EPIC). PLoS ONE 2012, 7, doi:10.1371/journal.pone.0039361.
    • (2012) Plos ONE , vol.7
    • Murphy, N.1    Norat, T.2    Ferrari, P.3    Jenab, M.4    Bueno-De-Mesquita, B.5    Skeie, G.6    Dahm, C.C.7    Overvad, K.8    Olsen, A.9    Tjønneland, A.10
  • 24
    • 77449124028 scopus 로고    scopus 로고
    • Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations: A nested case-control study
    • Jenab, M.; Bueno-de-Mesquita, H.B.; Ferrari, P.; van Duijnhoven, F.J.B.; Norat, T.; Pischon, T.; Jansen, E.H.J.M.; Slimani, N.; Byrnes, G.; Rinaldi, S., et al. Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations: A nested case-control study. BMJ 2010, 340, b5500, doi:10.1136/bmj.b5500.
    • (2010) BMJ , vol.340
    • Jenab, M.1    Bueno-De-Mesquita, H.B.2    Ferrari, P.3    Van Duijnhoven, F.4    Norat, T.5    Pischon, T.6    Jansen, E.7    Slimani, N.8    Byrnes, G.9    Rinaldi, S.10
  • 27
    • 84922479931 scopus 로고    scopus 로고
    • Television viewing and time spent sedentary in relation to cancer risk: A meta-analysis
    • Schmid, D.; Leitzmann, M.F. Television viewing and time spent sedentary in relation to cancer risk: A meta-analysis. J. Natl. Cancer Inst. 2014, 106, 1–19.
    • (2014) J. Natl. Cancer Inst. , vol.106 , pp. 1-19
    • Schmid, D.1    Leitzmann, M.F.2
  • 28
    • 84864579906 scopus 로고    scopus 로고
    • How many molecular subtypes? Implications of the unique tumor principle in personalized medicine
    • Ogino, S.; Fuchs, C.S.; Giovannucci, E. How many molecular subtypes? Implications of the unique tumor principle in personalized medicine. Expert Rev. Mol. Diagn. 2012, 12, 621–628.
    • (2012) Expert Rev. Mol. Diagn , vol.12 , pp. 621-628
    • Ogino, S.1    Fuchs, C.S.2    Giovannucci, E.3
  • 29
    • 79955562970 scopus 로고    scopus 로고
    • Consensus pathways implicated in prognosis of colorectal cancer identified through systematic enrichment analysis of gene expression profiling studies
    • Lascorz, J.; Chen, B.; Hemminki, K.; Försti, A. Consensus pathways implicated in prognosis of colorectal cancer identified through systematic enrichment analysis of gene expression profiling studies. PLoS ONE 2011, 6, e18867.
    • (2011) Plos ONE , vol.6
    • Lascorz, J.1    Chen, B.2    Hemminki, K.3    Försti, A.4
  • 32
    • 78650966622 scopus 로고    scopus 로고
    • Somatic mutation profiles of MSI and MSS colorectal cancer identified by whole exome next generation sequencing and bioinformatics analysis
    • Timmermann, B.; Kerick, M.; Roehr, C.; Fischer, A.; Isau, M.; Boerno, S.T.; Wunderlich, A.; Barmeyer, C.; Seemann, P.; Koenig, J., et al. Somatic mutation profiles of MSI and MSS colorectal cancer identified by whole exome next generation sequencing and bioinformatics analysis. PLoS ONE 2010, 5, e15661.
    • (2010) Plos ONE , vol.5
    • Timmermann, B.1    Kerick, M.2    Roehr, C.3    Fischer, A.4    Isau, M.5    Boerno, S.T.6    Wunderlich, A.7    Barmeyer, C.8    Seemann, P.9    Koenig, J.10
  • 33
    • 84865012891 scopus 로고    scopus 로고
    • Prognostic gene expression signature associated with two molecularly distinct subtypes of colorectal cancer
    • Oh, S.C.; Park, Y.-Y.; Park, E.S.; Lim, J.Y.; Kim, S.M.; Kim, S.-B.; Kim, J.; Kim, S.C.; Chu, I.-S.; Smith, J.J., et al. Prognostic gene expression signature associated with two molecularly distinct subtypes of colorectal cancer. Gut 2012, 61, 1291–1298.
    • (2012) Gut , vol.61 , pp. 1291-1298
    • Oh, S.C.1    Park, Y.-Y.2    Park, E.S.3    Lim, J.Y.4    Kim, S.M.5    Kim, S.-B.6    Kim, J.7    Kim, S.C.8    Chu, I.-S.9    Smith, J.J.10
  • 34
    • 41549166455 scopus 로고    scopus 로고
    • Meta-analysis of colorectal cancer gene expression profiling studies identifies consistently reported candidate biomarkers
    • Chan, S.K.; Griffith, O.L.; Tai, I.T.; Jones, S.J.M. Meta-analysis of colorectal cancer gene expression profiling studies identifies consistently reported candidate biomarkers. Cancer Epidemiol. Biomark. Prev. 2008, 17, 543–552.
    • (2008) Cancer Epidemiol. Biomark. Prev , vol.17 , pp. 543-552
    • Chan, S.K.1    Griffith, O.L.2    Tai, I.T.3    Jones, S.4
  • 41
    • 84879471309 scopus 로고    scopus 로고
    • Biologic determinants of tumor recurrence in stage II colon cancer: Validation study of the 12-gene recurrence score in cancer and leukemia group B (CALGB) 9581
    • Venook, A.P.; Niedzwiecki, D.; Lopatin, M.; Ye, X.; Lee, M.; Friedman, P.N.; Frankel, W.; Clark-Langone, K.; Millward, C.; Shak, S., et al. Biologic determinants of tumor recurrence in stage II colon cancer: Validation study of the 12-gene recurrence score in cancer and leukemia group B (CALGB) 9581. J. Clin. Oncol. 2013, 31, 1775–1781.
    • (2013) J. Clin. Oncol. , vol.31 , pp. 1775-1781
    • Venook, A.P.1    Niedzwiecki, D.2    Lopatin, M.3    Ye, X.4    Lee, M.5    Friedman, P.N.6    Frankel, W.7    Clark-Langone, K.8    Millward, C.9    Shak, S.10
  • 46
    • 84884377472 scopus 로고    scopus 로고
    • Tumour heterogeneity and cancer cell plasticity
    • Meacham, C.E.; Morrison, S.J. Tumour heterogeneity and cancer cell plasticity. Nature 2013, 501, 328–337.
    • (2013) Nature , vol.501 , pp. 328-337
    • Meacham, C.E.1    Morrison, S.J.2
  • 48
    • 84862757952 scopus 로고    scopus 로고
    • Evolutionary dynamics of carcinogenesis and why targeted therapy does not work
    • Gillies, R.J.; Verduzco, D.; Gatenby, R.A. Evolutionary dynamics of carcinogenesis and why targeted therapy does not work. Nat. Rev. Cancer 2012, 12, 487–493.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 487-493
    • Gillies, R.J.1    Verduzco, D.2    Gatenby, R.A.3
  • 51
    • 77953718827 scopus 로고    scopus 로고
    • Hard and “soft” lesions underlying the HLA class I alterations in cancer cells: Implications for immunotherapy
    • Garrido, F.; Cabrera, T.; Aptsiauri, N. “Hard” and “soft” lesions underlying the HLA class I alterations in cancer cells: Implications for immunotherapy. Int. J. Cancer 2010, 127, 249–256.
    • (2010) Int. J. Cancer , vol.127 , pp. 249-256
    • Garrido, F.1    Cabrera, T.2    Aptsiauri, N.3
  • 52
    • 79959763400 scopus 로고    scopus 로고
    • Leukocyte infiltrate in gastrointestinal adenocarcinomas is strongly associated with tumor microsatellite instability but not with tumor immunogenicity
    • Bernal, M.; Concha, A.; Sáenz-López, P.; Rodríguez, A.I.; Cabrera, T.; Garrido, F.; Ruiz-Cabello, F. Leukocyte infiltrate in gastrointestinal adenocarcinomas is strongly associated with tumor microsatellite instability but not with tumor immunogenicity. Cancer Immunol. Immunother. 2011, 60, 869–882.
    • (2011) Cancer Immunol. Immunother , vol.60 , pp. 869-882
    • Bernal, M.1    Concha, A.2    Sáenz-López, P.3    Rodríguez, A.I.4    Cabrera, T.5    Garrido, F.6    Ruiz-Cabello, F.7
  • 53
    • 84862318326 scopus 로고    scopus 로고
    • Genome-wide differential genetic profiling characterizes colorectal cancers with genetic instability and specific routes to HLA class I loss and immune escape
    • Bernal, M.; García-Alcalde, F.; Concha, A.; Cano, C.; Blanco, A.; Garrido, F.; Ruiz-Cabello, F. Genome-wide differential genetic profiling characterizes colorectal cancers with genetic instability and specific routes to HLA class I loss and immune escape. Cancer Immunol. Immunother. 2012, 61, 803–816.
    • (2012) Cancer Immunol. Immunother , vol.61 , pp. 803-816
    • Bernal, M.1    García-Alcalde, F.2    Concha, A.3    Cano, C.4    Blanco, A.5    Garrido, F.6    Ruiz-Cabello, F.7
  • 57
    • 79952156460 scopus 로고    scopus 로고
    • TNM staging in colorectal cancer: T is for T Cell and M is for memory
    • Broussard, E.K.; Disis, M.L. TNM staging in colorectal cancer: T is for T Cell and M is for memory. J. Clin. Oncol. 2011, 29, 601–603.
    • (2011) J. Clin. Oncol , vol.29 , pp. 601-603
    • Broussard, E.K.1    Disis, M.L.2
  • 58
    • 79961208848 scopus 로고    scopus 로고
    • Initial steps of metastasis: Cell invasion and endothelial transmigration
    • Van Zijl, F.; Krupitza, G.; Mikulits, W. Initial steps of metastasis: Cell invasion and endothelial transmigration. Mutat. Res.-Rev. Mutat. Res. 2011, 728, 23–34.
    • (2011) Mutat. Res.-Rev. Mutat. Res , vol.728 , pp. 23-34
    • Van Zijl, F.1    Krupitza, G.2    Mikulits, W.3
  • 60
    • 84885915873 scopus 로고    scopus 로고
    • Epithelial-mesenchymal plasticity in carcinoma metastasis
    • Tsai, J.H.; Yang, J. Epithelial-mesenchymal plasticity in carcinoma metastasis. Genes Dev. 2013, 27, 2192–2206.
    • (2013) Genes Dev , vol.27 , pp. 2192-2206
    • Tsai, J.H.1    Yang, J.2
  • 66
    • 79960435101 scopus 로고    scopus 로고
    • Increased detection sensitivity for KRAS mutations enhances the prediction of anti-EGFR monoclonal antibody resistance in metastatic colorectal cancer
    • Molinari, F.; Felicioni, L.; Buscarino, M.; de Dosso, S.; Buttitta, F.; Malatesta, S.; Movilia, A.; Luoni, M.; Boldorini, R.; Alabiso, O., et al. Increased detection sensitivity for KRAS mutations enhances the prediction of anti-EGFR monoclonal antibody resistance in metastatic colorectal cancer. Clin. Cancer Res. 2011, 17, 4901–4914.
    • (2011) Clin. Cancer Res , vol.17 , pp. 4901-4914
    • Molinari, F.1    Felicioni, L.2    Buscarino, M.3    De Dosso, S.4    Buttitta, F.5    Malatesta, S.6    Movilia, A.7    Luoni, M.8    Boldorini, R.9    Alabiso, O.10
  • 68
    • 84879903169 scopus 로고    scopus 로고
    • Colorectal cancer patients with low abundance of KRAS mutation may benefit from EGFR antibody therapy
    • Yu, S.; Xiao, X.; Lu, J.; Qian, X.; Liu, B.; Feng, J. Colorectal cancer patients with low abundance of KRAS mutation may benefit from EGFR antibody therapy. PLoS ONE 2013, 8, e68022.
    • (2013) Plos ONE , vol.8
    • Yu, S.1    Xiao, X.2    Lu, J.3    Qian, X.4    Liu, B.5    Feng, J.6
  • 70
    • 41649100689 scopus 로고    scopus 로고
    • Mining the plasma proteome for cancer biomarkers
    • Hanash, S.M.; Pitteri, S.J.; Faca, V.M. Mining the plasma proteome for cancer biomarkers. Nature 2008, 452, 571–579.
    • (2008) Nature , vol.452 , pp. 571-579
    • Hanash, S.M.1    Pitteri, S.J.2    Faca, V.M.3
  • 71
    • 84896974769 scopus 로고    scopus 로고
    • Proteomics, genomics and transcriptomics: Their emerging roles in the discovery and validation of colorectal cancer biomarkers
    • Wang, K.; Huang, C.; Nice, E.C. Proteomics, genomics and transcriptomics: Their emerging roles in the discovery and validation of colorectal cancer biomarkers. Expert Rev. Proteomics 2014, 11, 179–205.
    • (2014) Expert Rev. Proteomics , vol.11 , pp. 179-205
    • Wang, K.1    Huang, C.2    Nice, E.C.3
  • 78
    • 84923013251 scopus 로고    scopus 로고
    • Concordant analysis of KRAS, BRAF, PIK3CA mutations, and PTEN expression between primary colorectal cancer and matched metastases
    • Mao, C.; Wu, X.; Yang, Z.; Threapleton, D.E.; Yuan, J.; Yu, Y.; Tang, J. Concordant analysis of KRAS, BRAF, PIK3CA mutations, and PTEN expression between primary colorectal cancer and matched metastases. Sci. Rep. 2015, 5, doi:10.1038/srep08065.
    • (2015) Sci. Rep , vol.5
    • Mao, C.1    Wu, X.2    Yang, Z.3    Threapleton, D.E.4    Yuan, J.5    Yu, Y.6    Tang, J.7
  • 81
    • 84927537664 scopus 로고    scopus 로고
    • Comparative analysis of primary tumour and matched metastases in colorectal cancer patients: Evaluation of concordance between genomic and transcriptional profiles
    • Vignot, S.; Lefebvre, C.; Frampton, G.M.; Meurice, G.; Yelensky, R.; Palmer, G.; Capron, F.; Lazar, V.; Hannoun, L.; Miller, V.A., et al. Comparative analysis of primary tumour and matched metastases in colorectal cancer patients: Evaluation of concordance between genomic and transcriptional profiles. Eur. J. Cancer 2015, 51, 791–799.
    • (2015) Eur. J. Cancer , vol.51 , pp. 791-799
    • Vignot, S.1    Lefebvre, C.2    Frampton, G.M.3    Meurice, G.4    Yelensky, R.5    Palmer, G.6    Capron, F.7    Lazar, V.8    Hannoun, L.9    Miller, V.A.10
  • 84
    • 84873488599 scopus 로고    scopus 로고
    • Down-regulation of the miRNA-200 family at the invasive front of colorectal cancers with degraded basement membrane indicates EMT is involved in cancer progression
    • Paterson, E.L.; Kazenwadel, J.; Bert, A.G.; Khew-Goodall, Y.; Ruszkiewicz, A.; Goodall, G.J. Down-regulation of the miRNA-200 family at the invasive front of colorectal cancers with degraded basement membrane indicates EMT is involved in cancer progression. Neoplasia 2013, 15, 180–191.
    • (2013) Neoplasia , vol.15 , pp. 180-191
    • Paterson, E.L.1    Kazenwadel, J.2    Bert, A.G.3    Khew-Goodall, Y.4    Ruszkiewicz, A.5    Goodall, G.J.6
  • 85
    • 70349939382 scopus 로고    scopus 로고
    • Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer
    • Siena, S.; Sartore-Bianchi, A.; di Nicolantonio, F.; Balfour, J.; Bardelli, A. Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer. J. Natl. Cancer Inst. 2009, 101, 1308–1324.
    • (2009) J. Natl. Cancer Inst , vol.101 , pp. 1308-1324
    • Siena, S.1    Sartore-Bianchi, A.2    Di Nicolantonio, F.3    Balfour, J.4    Bardelli, A.5
  • 86
    • 79957523828 scopus 로고    scopus 로고
    • KRAS, BRAF, PIK3CA, and PTEN mutations: Implications for targeted therapies in metastatic colorectal cancer
    • De Roock, W.; de Vriendt, V.; Normanno, N.; Ciardiello, F.; Tejpar, S. KRAS, BRAF, PIK3CA, and PTEN mutations: Implications for targeted therapies in metastatic colorectal cancer. Lancet Oncol. 2011, 12, 594–603.
    • (2011) Lancet Oncol , vol.12 , pp. 594-603
    • De Roock, W.1    De Vriendt, V.2    Normanno, N.3    Ciardiello, F.4    Tejpar, S.5
  • 87
    • 79960932729 scopus 로고    scopus 로고
    • BRAF V600E mutation and resistance to anti-EGFR monoclonal antibodies in patients with metastatic colorectal cancer: A meta-analysis
    • Mao, C.; Liao, R.-Y.; Qiu, L.-X.; Wang, X.-W.; Ding, H.; Chen, Q. BRAF V600E mutation and resistance to anti-EGFR monoclonal antibodies in patients with metastatic colorectal cancer: A meta-analysis. Mol. Biol. Rep. 2011, 38, 2219–2223.
    • (2011) Mol. Biol. Rep , vol.38 , pp. 2219-2223
    • Mao, C.1    Liao, R.-Y.2    Qiu, L.-X.3    Wang, X.-W.4    Ding, H.5    Chen, Q.6
  • 91
    • 84909606346 scopus 로고    scopus 로고
    • Timing and heterogeneity of mutations associated with drug resistance in metastatic cancers
    • Bozic, I.; Nowak, M.A. Timing and heterogeneity of mutations associated with drug resistance in metastatic cancers. Proc. Natl. Acad. Sci. USA 2014, 111, 15964–15968.
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 15964-15968
    • Bozic, I.1    Nowak, M.A.2
  • 92
    • 84870490913 scopus 로고    scopus 로고
    • Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer
    • Montagut, C.; Dalmases, A.; Bellosillo, B.; Crespo, M.; Pairet, S.; Iglesias, M.; Salido, M.; Gallen, M.; Marsters, S.; Tsai, S.P., et al. Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer. Nat. Med. 2012, 18, 1445–1445.
    • (2012) Nat. Med , vol.18
    • Montagut, C.1    Dalmases, A.2    Bellosillo, B.3    Crespo, M.4    Pairet, S.5    Iglesias, M.6    Salido, M.7    Gallen, M.8    Marsters, S.9    Tsai, S.P.10
  • 95
    • 84862026304 scopus 로고    scopus 로고
    • Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: Pooled analysis of the CRYSTAL and OPUS randomised clinical trials
    • Bokemeyer, C.; van Cutsem, E.; Rougier, P.; Ciardiello, F.; Heeger, S.; Schlichting, M.; Celik, I.; Köhne, C.-H. Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: Pooled analysis of the CRYSTAL and OPUS randomised clinical trials. Eur. J. Cancer 2012, 48, 1466–1475.
    • (2012) Eur. J. Cancer , vol.48 , pp. 1466-1475
    • Bokemeyer, C.1    Van Cutsem, E.2    Rougier, P.3    Ciardiello, F.4    Heeger, S.5    Schlichting, M.6    Celik, I.7    Köhne, C.-H.8
  • 96
    • 84906846009 scopus 로고    scopus 로고
    • Clinical activity of FOLFIRI plus cetuximab according to extended gene mutation status by next generation sequencing: Findings from the CAPRI-GOIM trial
    • Ciardiello, F.; Normanno, N.; Maiello, E.; Martinelli, E.; Troiani, T.; Pisconti, S.; Giuliani, F.; Barone, C.; Cartenì, G.; Rachiglio, A.M., et al. Clinical activity of FOLFIRI plus cetuximab according to extended gene mutation status by next generation sequencing: Findings from the CAPRI-GOIM trial. Ann. Oncol. 2014, 25, 1756–1761.
    • (2014) Ann. Oncol , vol.25 , pp. 1756-1761
    • Ciardiello, F.1    Normanno, N.2    Maiello, E.3    Martinelli, E.4    Troiani, T.5    Pisconti, S.6    Giuliani, F.7    Barone, C.8    Cartenì, G.9    Rachiglio, A.M.10
  • 97
    • 84909606012 scopus 로고    scopus 로고
    • Mismatch repair status and BRAF mutation status in metastatic colorectal cancer patients: A pooled analysis of the CAIRO, CAIRO2, COIN and FOCUS studies
    • Venderbosch, S.; Nagtegaal, I.D.; Maughan, T.S.; Smith, C.G.; Cheadle, J.P.; Fisher, D.; Kaplan, R.; Quirke, P.; Seymour, M.T.; Richman, S., et al. Mismatch repair status and BRAF mutation status in metastatic colorectal cancer patients: A pooled analysis of the CAIRO, CAIRO2, COIN and FOCUS studies. Clin. Cancer Res. 2014, 20, 5322–5331.
    • (2014) Clin. Cancer Res , vol.20 , pp. 5322-5331
    • Venderbosch, S.1    Nagtegaal, I.D.2    Maughan, T.S.3    Smith, C.G.4    Cheadle, J.P.5    Fisher, D.6    Kaplan, R.7    Quirke, P.8    Seymour, M.T.9    Richman, S.10
  • 99
    • 84929141867 scopus 로고    scopus 로고
    • Extended RAS mutations and anti-EGFR monoclonal antibody survival benefit in metastatic colorectal cancer: A meta-analysis of randomized controlled trials
    • Sorich, M.J.; Wiese, M.D.; Rowland, A.; Kichenadasse, G.; McKinnon, R.A.; Karapetis, C.S. Extended RAS mutations and anti-EGFR monoclonal antibody survival benefit in metastatic colorectal cancer: A meta-analysis of randomized controlled trials. Ann. Oncol. 2014, 26, 1–27.
    • (2014) Ann. Oncol , vol.26 , pp. 1-27
    • Sorich, M.J.1    Wiese, M.D.2    Rowland, A.3    Kichenadasse, G.4    McKinnon, R.A.5    Karapetis, C.S.6
  • 100
    • 75749102647 scopus 로고    scopus 로고
    • Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: Results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial
    • Roth, A.D.; Tejpar, S.; Delorenzi, M.; Yan, P.; Fiocca, R.; Klingbiel, D.; Dietrich, D.; Biesmans, B.; Bodoky, G.; Barone, C., et al. Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: Results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial. J. Clin. Oncol. 2010, 28, 466–474.
    • (2010) J. Clin. Oncol. , vol.28 , pp. 466-474
    • Roth, A.D.1    Tejpar, S.2    Delorenzi, M.3    Yan, P.4    Fiocca, R.5    Klingbiel, D.6    Dietrich, D.7    Biesmans, B.8    Bodoky, G.9    Barone, C.10
  • 102
    • 73349114941 scopus 로고    scopus 로고
    • KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: Results from the MRC FOCUS trial
    • Richman, S.D.; Seymour, M.T.; Chambers, P.; Elliott, F.; Daly, C.L.; Meade, A.M.; Taylor, G.; Barrett, J.H.; Quirke, P. KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: Results from the MRC FOCUS trial. J. Clin. Oncol. 2009, 27, 5931–5937.
    • (2009) J. Clin. Oncol , vol.27 , pp. 5931-5937
    • Richman, S.D.1    Seymour, M.T.2    Chambers, P.3    Elliott, F.4    Daly, C.L.5    Meade, A.M.6    Taylor, G.7    Barrett, J.H.8    Quirke, P.9
  • 104
    • 14544300998 scopus 로고    scopus 로고
    • Systematic review of microsatellite instability and colorectal cancer prognosis
    • Popat, S.; Hubner, R.; Houlston, R.S. Systematic review of microsatellite instability and colorectal cancer prognosis. J. Clin. Oncol. 2005, 23, 609–618.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 609-618
    • Popat, S.1    Hubner, R.2    Houlston, R.S.3
  • 106
    • 66949113291 scopus 로고    scopus 로고
    • Does microsatellite instability predict the efficacy of adjuvant chemotherapy in colorectal cancer? A systematic review with meta-analysis
    • Des Guetz, G.; Schischmanoff, O.; Nicolas, P.; Perret, G.-Y.; Morere, J.-F.; Uzzan, B. Does microsatellite instability predict the efficacy of adjuvant chemotherapy in colorectal cancer? A systematic review with meta-analysis. Eur. J. Cancer 2009, 45, 1890–1896.
    • (2009) Eur. J. Cancer , vol.45 , pp. 1890-1896
    • Des Guetz, G.1    Schischmanoff, O.2    Nicolas, P.3    Perret, G.-Y.4    Morere, J.-F.5    Uzzan, B.6
  • 110
    • 64649096900 scopus 로고    scopus 로고
    • Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia Group B Protocol 89803
    • Bertagnolli, M.M.; Niedzwiecki, D.; Compton, C.C.; Hahn, H.P.; Hall, M.; Damas, B.; Jewell, S.D.; Mayer, R.J.; Goldberg, R.M.; Saltz, L.B., et al. Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia Group B Protocol 89803. J. Clin. Oncol. 2009, 27, 1814–1821.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 1814-1821
    • Bertagnolli, M.M.1    Niedzwiecki, D.2    Compton, C.C.3    Hahn, H.P.4    Hall, M.5    Damas, B.6    Jewell, S.D.7    Mayer, R.J.8    Goldberg, R.M.9    Saltz, L.B.10
  • 112
    • 84860634396 scopus 로고    scopus 로고
    • PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wild-type metastatic colorectal cancer: A systematic review and meta-analysis
    • Mao, C.; Yang, Z.Y.; Hu, X.F.; Chen, Q.; Tang, J.L. PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wild-type metastatic colorectal cancer: A systematic review and meta-analysis. Ann. Oncol. 2012, 23, 1518–1525.
    • (2012) Ann. Oncol , vol.23 , pp. 1518-1525
    • Mao, C.1    Yang, Z.Y.2    Hu, X.F.3    Chen, Q.4    Tang, J.L.5
  • 115
    • 84874167463 scopus 로고    scopus 로고
    • EGFR gene copy number as a prognostic marker in colorectal cancer patients treated with cetuximab or panitumumab: A systematic review and meta analysis
    • Jiang, Z.; Li, C.; Li, F.; Wang, X. EGFR gene copy number as a prognostic marker in colorectal cancer patients treated with cetuximab or panitumumab: A systematic review and meta analysis. PLoS ONE 2013, 8, e56205.
    • (2013) Plos ONE , vol.8
    • Jiang, Z.1    Li, C.2    Li, F.3    Wang, X.4
  • 117
    • 84896705997 scopus 로고    scopus 로고
    • Cancer systems biology: A peek into the future of patient care
    • Werner, H.M.J.; Mills, G.B.; Ram, P.T. Cancer systems biology: A peek into the future of patient care? Nat. Rev. Clin. Oncol. 2014, 11, 167–176.
    • (2014) Nat. Rev. Clin. Oncol , vol.11 , pp. 167-176
    • Werner, H.1    Mills, G.B.2    Ram, P.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.