-
1
-
-
36448936383
-
TGFβ-SMAD signal transduction: Molecular specificity and functional flexibility
-
Schmierer, B. & Hill, C. S. TGFβ-SMAD signal transduction: molecular specificity and functional flexibility. Nature Rev. Mol. Cell Biol. 8, 970-982 (2007).
-
(2007)
Nature Rev. Mol. Cell Biol.
, vol.8
, pp. 970-982
-
-
Schmierer, B.1
Hill, C.S.2
-
3
-
-
34548329486
-
Differentiation plasticity regulated by TGF-β family proteins in development and disease
-
Derynck, R. & Akhurst, R. J. Differentiation plasticity regulated by TGF-β family proteins in development and disease. Nature Cell Biol. 9, 1000-1004 (2007).
-
(2007)
Nature Cell Biol.
, vol.9
, pp. 1000-1004
-
-
Derynck, R.1
Akhurst, R.J.2
-
4
-
-
77954951446
-
The polarization of immune cells in the tumour environment by TGFβ
-
Flavell, R. A., Sanjabi, S., Wrzesinski, S. H. & Licona-Limon, P. The polarization of immune cells in the tumour environment by TGFβ. Nature Rev. Immunol. 10, 554-567 (2010).
-
(2010)
Nature Rev. Immunol.
, vol.10
, pp. 554-567
-
-
Flavell, R.A.1
Sanjabi, S.2
Wrzesinski, S.H.3
Licona-Limon, P.4
-
5
-
-
33744483745
-
Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility
-
Mao, J. H. et al. Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility. Proc. Natl Acad. Sci. USA 103, 8125-8130 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 8125-8130
-
-
Mao, J.H.1
-
6
-
-
58149216052
-
Signaling cross-talk between TGF-β/BMP and other pathways
-
Guo, X. & Wang, X. F. Signaling cross-talk between TGF-β/BMP and other pathways. Cell Res. 19, 71-88 (2009).
-
(2009)
Cell Res.
, vol.19
, pp. 71-88
-
-
Guo, X.1
Wang, X.F.2
-
7
-
-
82955203433
-
Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo
-
Conidi, A. et al. Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo. Cytokine Growth Factor Rev. 22, 287-300 (2011).
-
(2011)
Cytokine Growth Factor Rev.
, vol.22
, pp. 287-300
-
-
Conidi, A.1
-
8
-
-
3543037590
-
TGFβ signaling in health and disease
-
Akhurst, R. J. TGFβ signaling in health and disease. Nature Genet. 36, 790-792 (2004).
-
(2004)
Nature Genet.
, vol.36
, pp. 790-792
-
-
Akhurst, R.J.1
-
9
-
-
84872486001
-
Epistatic interactions between Tgfb1 and genetic loci, Tgfbm2 and Tgfbm3, determine susceptibility to an asthmatic stimulus
-
in the press
-
Freimuth, J. et al. Epistatic interactions between Tgfb1 and genetic loci, Tgfbm2 and Tgfbm3, determine susceptibility to an asthmatic stimulus. Proc. Natl Acad. Sci. USA (in the press).
-
Proc. Natl Acad. Sci. USA
-
-
Freimuth, J.1
-
10
-
-
44449179168
-
Small molecular inhibitor of transforming growth factor-β protects against development of radiation-induced lung injury
-
Anscher, M. S. et al. Small molecular inhibitor of transforming growth factor-β protects against development of radiation-induced lung injury. Int. J. Radiat. Oncol. Biol. Phys. 71, 829-837 (2008).
-
(2008)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.71
, pp. 829-837
-
-
Anscher, M.S.1
-
11
-
-
0037373277
-
Dysregulation of TGF-β activation contributes to pathogenesis in Marfan syndrome
-
Neptune, E. R. et al. Dysregulation of TGF-β activation contributes to pathogenesis in Marfan syndrome. Nature Genet. 33, 407-411 (2003).
-
(2003)
Nature Genet.
, vol.33
, pp. 407-411
-
-
Neptune, E.R.1
-
12
-
-
33645672459
-
Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome
-
Habashi, J. P. et al. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science 312, 117-121 (2006).
-
(2006)
Science
, vol.312
, pp. 117-121
-
-
Habashi, J.P.1
-
13
-
-
0042307513
-
The two faces of transforming growth factor β in carcinogenesis
-
Roberts, A. B. & Wakefield, L. M. The two faces of transforming growth factor β in carcinogenesis. Proc. Natl Acad. Sci. USA 100, 8621-8623 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 8621-8623
-
-
Roberts, A.B.1
Wakefield, L.M.2
-
14
-
-
47549090432
-
TGFβ in cancer
-
Massague, J. TGFβ in cancer. Cell 134, 215-230 (2008).
-
(2008)
Cell
, vol.134
, pp. 215-230
-
-
Massague, J.1
-
15
-
-
30944444113
-
Alterations in components of the TGF-β superfamily signaling pathways in human cancer
-
Levy, L. & Hill, C. S. Alterations in components of the TGF-β superfamily signaling pathways in human cancer. Cytokine Growth Factor Rev. 17, 41-58 (2006).
-
(2006)
Cytokine Growth Factor Rev.
, vol.17
, pp. 41-58
-
-
Levy, L.1
Hill, C.S.2
-
16
-
-
79960364782
-
Exploring anti-TGF-β therapies in cancer and fibrosis
-
Hawinkels, L. J. & Ten Dijke, P. Exploring anti-TGF-β therapies in cancer and fibrosis. Growth Factors 29, 140-152 (2011).
-
(2011)
Growth Factors
, vol.29
, pp. 140-152
-
-
Hawinkels, L.J.1
Ten Dijke, P.2
-
17
-
-
33749246730
-
Mutations of TGFβ signaling molecules in human disease
-
Harradine, K. A. & Akhurst, R. J. Mutations of TGFβ signaling molecules in human disease. Ann. Med. 38, 403-414 (2006).
-
(2006)
Ann. Med.
, vol.38
, pp. 403-414
-
-
Harradine, K.A.1
Akhurst, R.J.2
-
18
-
-
0025977578
-
Embryonic gene expression patterns of TGF β1, β2 and β3 suggest different developmental functions in vivo
-
Millan, F. A., Denhez, F., Kondaiah, P. & Akhurst, R. J. Embryonic gene expression patterns of TGF β1, β2 and β3 suggest different developmental functions in vivo. Development 111, 131-143 (1991).
-
(1991)
Development
, vol.111
, pp. 131-143
-
-
Millan, F.A.1
Denhez, F.2
Kondaiah, P.3
Akhurst, R.J.4
-
19
-
-
0027531528
-
Transforming growth factor β1 null mutation in mice causes excessive inflammatory response and early death
-
Kulkarni, A. B. et al. Transforming growth factor β1 null mutation in mice causes excessive inflammatory response and early death. Proc. Natl Acad. Sci. USA 90, 770-774 (1993).
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 770-774
-
-
Kulkarni, A.B.1
-
20
-
-
0026799402
-
Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
-
Shull, M. M. et al. Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease. Nature 359, 693-699 (1992).
-
(1992)
Nature
, vol.359
, pp. 693-699
-
-
Shull, M.M.1
-
21
-
-
0029074681
-
Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice
-
Dickson, M. C. et al. Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice. Development 121, 1845-1854 (1995).
-
(1995)
Development
, vol.121
, pp. 1845-1854
-
-
Dickson, M.C.1
-
22
-
-
0030609894
-
TG F β2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes
-
Sanford, L. P. et al. TG F β2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes. Development 124, 2659-2670 (1997).
-
(1997)
Development
, vol.124
, pp. 2659-2670
-
-
Sanford, L.P.1
-
23
-
-
0028972869
-
Transforming growth factor-β3 is required for secondary palate fusion
-
Proetzel, G. et al. Transforming growth factor-β3 is required for secondary palate fusion. Nature Genet. 11, 409-414 (1995).
-
(1995)
Nature Genet.
, vol.11
, pp. 409-414
-
-
Proetzel, G.1
-
24
-
-
0027967771
-
Thrombospondin binds and activates the small and large forms of latent transforming growth factor-β in a chemically defined system
-
Schultz-Cherry, S., Ribeiro, S., Gentry, L. & Murphy-Ullrich, J. E. Thrombospondin binds and activates the small and large forms of latent transforming growth factor-β in a chemically defined system. J. Biol. Chem. 269, 26775-26782 (1994).
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 26775-26782
-
-
Schultz-Cherry, S.1
Ribeiro, S.2
Gentry, L.3
Murphy-Ullrich, J.E.4
-
25
-
-
0033524949
-
The integrin αvβ6 binds and activates latent TGF β1: A mechanism for regulating pulmonary inflammation and fibrosis
-
Munger, J. S. et al. The integrin αvβ6 binds and activates latent TGF β1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell 96, 319-328 (1999).
-
(1999)
Cell
, vol.96
, pp. 319-328
-
-
Munger, J.S.1
-
26
-
-
79959250326
-
Latent TGF-β structure and activation
-
Shi, M. et al. Latent TGF-β structure and activation. Nature 474, 343-349 (2011).
-
(2011)
Nature
, vol.474
, pp. 343-349
-
-
Shi, M.1
-
27
-
-
0038682002
-
Mechanisms of TGF-β signaling from cell membrane to the nucleus
-
Shi, Y. & Massague, J. Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell 11 3, 685-700 (2003).
-
(2003)
Cell
, vol.11
, pp. 3685-3700
-
-
Shi, Y.1
Massague, J.2
-
28
-
-
79952227351
-
Smad-mediated miRNA processing: A critical role for a conserved RNA sequence
-
Davis-Dusenbery, B. N. & Hata, A. Smad-mediated miRNA processing: a critical role for a conserved RNA sequence. RNA Biol. 8, 71-76 (2011).
-
(2011)
RNA Biol.
, vol.8
, pp. 71-76
-
-
Davis-Dusenbery, B.N.1
Hata, A.2
-
29
-
-
0029662049
-
TGF-β1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells
-
Oft, M. et al. TGF-β1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. Genes Dev. 10, 2462-2477 (1996).
-
(1996)
Genes Dev.
, vol.10
, pp. 2462-2477
-
-
Oft, M.1
-
30
-
-
33646562542
-
The logic of TGFβ signaling
-
Massague, J. & Gomis, R. R. The logic of TGFβ signaling. FEBS Lett. 580, 2811-2820 (2006).
-
(2006)
FEBS Lett.
, vol.580
, pp. 2811-2820
-
-
Massague, J.1
Gomis, R.R.2
-
31
-
-
0034574298
-
How cells read TGF-β signals
-
Massague, J. How cells read TGF-β signals. Nature Rev. Mol. Cell Biol. 1, 169-178 (2000).
-
(2000)
Nature Rev. Mol. Cell Biol.
, vol.1
, pp. 169-178
-
-
Massague, J.1
-
32
-
-
0036965929
-
TGF-β and the Smad signal transduction pathway
-
Mehra, A. & Wrana, J. L. TGF-β and the Smad signal transduction pathway. Biochem. Cell Biol. 80, 605-622 (2002).
-
(2002)
Biochem. Cell Biol.
, vol.80
, pp. 605-622
-
-
Mehra, A.1
Wrana, J.L.2
-
33
-
-
58149236744
-
Roles of TGFβ in metastasis
-
Padua, D. & Massague, J. Roles of TGFβ in metastasis. Cell Res. 19, 89-102 (2009).
-
(2009)
Cell Res.
, vol.19
, pp. 89-102
-
-
Padua, D.1
Massague, J.2
-
34
-
-
63749105896
-
Mechanism of TGF-β signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition
-
Heldin, C. H., Landstrom, M. & Moustakas, A. Mechanism of TGF-β signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition. Curr. Opin. Cell Biol. 21, 166-176 (2009).
-
(2009)
Curr. Opin. Cell Biol.
, vol.21
, pp. 166-176
-
-
Heldin, C.H.1
Landstrom, M.2
Moustakas, A.3
-
35
-
-
84859445823
-
TGF-β in Progression of Liver Disease
-
Dooley, S. & ten Dijke, P. TGF-β in progression of liver disease. Cell Tissue Res. 347, 245-256 (2012).
-
(2012)
Cell Tissue Res.
, vol.347
, pp. 245-256
-
-
Dooley, S.1
Ten Dijke, P.2
-
36
-
-
84856186176
-
TGFβ signaling and cardiovascular diseases
-
Pardali, E. & Te n Dijke, P. TGFβ signaling and cardiovascular diseases. Int. J. Biol. Sci. 8, 195-213 (2012).
-
(2012)
Int. J. Biol. Sci.
, vol.8
, pp. 195-213
-
-
Pardali, E.1
Ten Dijke, P.2
-
37
-
-
0034785348
-
TGF-β signaling in tumor suppression and cancer progression
-
Derynck, R., Akhurst, R. J. & Balmain, A. TGF-β signaling in tumor suppression and cancer progression. Nature Genet. 29, 117-129 (2001).
-
(2001)
Nature Genet.
, vol.29
, pp. 117-129
-
-
Derynck, R.1
Akhurst, R.J.2
Balmain, A.3
-
38
-
-
0023878291
-
Growth modulation of mouse keratinocytes by transforming growth factors
-
Coffey, R. J. Jr. et al. Growth modulation of mouse keratinocytes by transforming growth factors. Cancer Res. 48, 1596-1602 (1988).
-
(1988)
Cancer Res.
, vol.48
, pp. 1596-1602
-
-
Coffey, Jr.R.J.1
-
39
-
-
33748075143
-
A FoxO-Smad synexpression group in human keratinocytes
-
Gomis, R. R. et al. A FoxO-Smad synexpression group in human keratinocytes. Proc. Natl Acad. Sci. USA 103, 12747-12752 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 12747-12752
-
-
Gomis, R.R.1
-
40
-
-
0042316912
-
Mad upregulation and Id2 repression accompany transforming growth factor (TGF)-β-mediated epithelial cell growth suppression
-
Siegel, P. M., Shu, W. & Massague, J. Mad upregulation and Id2 repression accompany transforming growth factor (TGF)-β-mediated epithelial cell growth suppression. J. Biol. Chem. 278, 35444-35450 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 35444-35450
-
-
Siegel, P.M.1
Shu, W.2
Massague, J.3
-
41
-
-
84864413216
-
The paradoxical TGF-β vasculopathies
-
Akhurst, R. J. The paradoxical TGF-β vasculopathies. Nature Genet. 44, 838-839 (2012).
-
(2012)
Nature Genet.
, vol.44
, pp. 838-839
-
-
Akhurst, R.J.1
-
42
-
-
4944266313
-
High interstitial fluid pressure-an obstacle in cancer therapy
-
Heldin, C. H., Rubin, K., Pietras, K. & Ostman, A. High interstitial fluid pressure-an obstacle in cancer therapy. Nature Rev. Cancer 4, 806-813 (2004).
-
(2004)
Nature Rev. Cancer
, vol.4
, pp. 806-813
-
-
Heldin, C.H.1
Rubin, K.2
Pietras, K.3
Ostman, A.4
-
43
-
-
43049165453
-
The epithelial-mesenchymal transition generates cells with properties of stem cells
-
Mani, S. A. et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133, 704-715 (2008).
-
(2008)
Cell
, vol.133
, pp. 704-715
-
-
Mani, S.A.1
-
44
-
-
17144428081
-
Inhibition of TGF-β modulates macrophages and vessel maturation in parallel to a lowering of interstitial fluid pressure in experimental carcinoma
-
Salnikov, A. V. et al. Inhibition of TGF-β modulates macrophages and vessel maturation in parallel to a lowering of interstitial fluid pressure in experimental carcinoma. Lab. Invest. 85, 512-521 (2005).
-
(2005)
Lab. Invest.
, vol.85
, pp. 512-521
-
-
Salnikov, A.V.1
-
45
-
-
17844384822
-
Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-β1: Potential role in idiopathic pulmonary fibrosis
-
Willis, B. C. et al. Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-β1: potential role in idiopathic pulmonary fibrosis. Am. J. Pathol. 166, 1321-1332 (2005).
-
(2005)
Am. J. Pathol.
, vol.166
, pp. 1321-1332
-
-
Willis, B.C.1
-
46
-
-
33748375828
-
Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
-
Kim, K. K. et al. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc. Natl Acad. Sci. USA 103, 13180-13185 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 13180-13185
-
-
Kim, K.K.1
-
47
-
-
63449110274
-
Transforming Growth Factor β-induced Endothelial-to-mesenchymal Transition: A Switch to Cardiac Fibrosis?
-
Goumans, M. J., van Zonneveld, A. J. & ten Dijke, P. Transforming growth factor β-induced endothelial-to-mesenchymal transition: a switch to cardiac fibrosis? Trends Cardiovasc. Med. 18, 293-298 (2008).
-
(2008)
Trends Cardiovasc. Med.
, vol.18
, pp. 293-298
-
-
Goumans, M.J.1
Van Zonneveld, A.J.2
Ten Dijke, P.3
-
48
-
-
0346727324
-
Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
-
Sato, M., Muragaki, Y., Saika, S., Roberts, A. B. & Ooshima, A. Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. J. Clin. Invest. 11 2, 1486-1494 (2003).
-
(2003)
J. Clin. Invest.
, vol.11
, pp. 21486-21494
-
-
Sato, M.1
Muragaki, Y.2
Saika, S.3
Roberts, A.B.4
Ooshima, A.5
-
49
-
-
80052754775
-
Diverse roles of TGF-β/Smads in renal fibrosis and inflammation
-
Lan, H. Y. Diverse roles of TGF-β/Smads in renal fibrosis and inflammation. Int. J. Biol. Sci. 7, 1056-1067 (2011).
-
(2011)
Int. J. Biol. Sci.
, vol.7
, pp. 1056-1067
-
-
Lan, H.Y.1
-
50
-
-
60149106394
-
A pyrrole-imidazole polyamide targeting transforming growth factor-β1 inhibits restenosis and preserves endothelialization in the injured artery
-
Yao, E. H. et al. A pyrrole-imidazole polyamide targeting transforming growth factor-β1 inhibits restenosis and preserves endothelialization in the injured artery. Cardiovasc. Res. 81, 797-804 (2009).
-
(2009)
Cardiovasc. Res.
, vol.81
, pp. 797-804
-
-
Yao, E.H.1
-
51
-
-
68049103323
-
TGF-β through Smad3 signaling stimulates vascular smooth muscle cell proliferation and neointimal formation
-
Tsai, S. et al. TGF-β through Smad3 signaling stimulates vascular smooth muscle cell proliferation and neointimal formation. Am. J. Physiol. Heart Circ. Physiol. 297, H540-H549 (2009).
-
(2009)
Am. J. Physiol. Heart Circ. Physiol.
, vol.297
-
-
Tsai, S.1
-
52
-
-
42249113861
-
SM16, an orally active TGFß type i receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model
-
Fu, K. et al. SM16, an orally active TGFß type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model. Arterioscler. Thromb. Vasc. Biol. 28, 665-671 (2008).
-
(2008)
Arterioscler. Thromb. Vasc. Biol.
, vol.28
, pp. 665-671
-
-
Fu, K.1
-
53
-
-
33745505315
-
5EF1 mediates TGF-ß signaling in vascular smooth muscle cell differentiation
-
Nishimura, G. et al. 5EF1 mediates TGF-ß signaling in vascular smooth muscle cell differentiation. Dev Cell 11, 93-104 (2006).
-
(2006)
Dev Cell
, vol.11
, pp. 93-104
-
-
Nishimura, G.1
-
54
-
-
0029618694
-
Early-onset multifocal inflammation in the transforming growth factor ß 1-null mouse is lymphocyte mediated
-
Diebold, R. J. et al. Early-onset multifocal inflammation in the transforming growth factor ß 1-null mouse is lymphocyte mediated. Proc. Natl Acad. Sci. USA 92, 12215-12219 (1995).
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 12215-12219
-
-
Diebold, R.J.1
-
55
-
-
34249678653
-
TGFß signalling in control of T-cell-mediated self-reactivity
-
Rubtsov, Y. P. & Rudensky, A. Y. TGFß signalling in control of T-cell-mediated self-reactivity. Nature Rev. Immunol. 7, 443-453 (2007).
-
(2007)
Nature Rev. Immunol.
, vol.7
, pp. 443-453
-
-
Rubtsov, Y.P.1
Rudensky, A.Y.2
-
56
-
-
60749137393
-
Transforming growth factor ß (TGFß)-induced apoptosis: The rise and fall of Bim
-
Ramesh, S., Wildey, G. M. & Howe, P. H. Transforming growth factor ß (TGFß)-induced apoptosis: the rise and fall of Bim. Cell Cycle 8, 11-17 (2009).
-
(2009)
Cell Cycle
, vol.8
, pp. 11-17
-
-
Ramesh, S.1
Wildey, G.M.2
Howe, P.H.3
-
57
-
-
78650309487
-
H17 cells by the DNA-binding inhibitor Id3
-
H17 cells by the DNA-binding inhibitor Id3. Nature Immunol. 12, 86-95 (2011).
-
(2011)
Nature Immunol.
, vol.12
, pp. 86-95
-
-
Maruyama, T.1
-
58
-
-
0034770605
-
Immune-mediated eradication of tumors through the blockade of transforming growth factor-ß signaling in T cells
-
Gorelik, L. & Flavell, R. A. Immune-mediated eradication of tumors through the blockade of transforming growth factor-ß signaling in T cells. Nature Med. 7, 1118-1122 (2001).
-
(2001)
Nature Med.
, vol.7
, pp. 1118-1122
-
-
Gorelik, L.1
Flavell, R.A.2
-
59
-
-
0030893704
-
Contrasting effects of TGF-ß 1 and TNF-a on the development of dendritic cells from progenitors in mouse bone marrow
-
Yamaguchi, Y, Tsumura, H., Miwa, M. & Inaba, K. Contrasting effects of TGF-ß 1 and TNF-a on the development of dendritic cells from progenitors in mouse bone marrow. Stem Cells 15, 144-153 (1997).
-
(1997)
Stem Cells
, vol.15
, pp. 144-153
-
-
Yamaguchi, Y.1
Tsumura, H.2
Miwa, M.3
Inaba, K.4
-
60
-
-
0034161681
-
TGF-ß 1 reciprocally controls chemotaxis of human peripheral blood monocyte-derived dendritic cells via chemokine receptors
-
Sato, K. et al. TGF-ß 1 reciprocally controls chemotaxis of human peripheral blood monocyte-derived dendritic cells via chemokine receptors. J. Immunol. 164, 2285-2295 (2000).
-
(2000)
J. Immunol.
, vol.164
, pp. 2285-2295
-
-
Sato, K.1
-
61
-
-
33646577466
-
H17 and regulatory T cells
-
H17 and regulatory T cells. Nature 441, 235-238 (2006).
-
(2006)
Nature
, vol.441
, pp. 235-238
-
-
Bettelli, E.1
-
62
-
-
33646560950
-
H17 lineage
-
H17 lineage. Nature 441, 231-234 (2006).
-
(2006)
Nature
, vol.441
, pp. 231-234
-
-
Mangan, P.R.1
-
63
-
-
79952771167
-
H17 cell differentiation
-
H17 cell differentiation. Immunity 34, 396-408 (2011).
-
(2011)
Immunity
, vol.34
, pp. 396-408
-
-
Gutcher, I.1
-
64
-
-
80052752968
-
Mouse T helper 17 phenotype: Not so different than in man after all
-
Annunziato, F & Romagnani, S. Mouse T helper 17 phenotype: not so different than in man after all. Cytokine 56, 112-115 (2011).
-
(2011)
Cytokine
, vol.56
, pp. 112-115
-
-
Annunziato, F.1
Romagnani, S.2
-
65
-
-
70449711235
-
H17 cell differentiation
-
H17 cell differentiation. J. Exp. Med. 206, 2407-2416 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 2407-2416
-
-
Das, J.1
-
66
-
-
77958584113
-
H17 cells in the absence of TGF-ß signalling
-
H17 cells in the absence of TGF-ß signalling. Nature 467, 967-971 (2010).
-
(2010)
Nature
, vol.467
, pp. 967-971
-
-
Ghoreschi, K.1
-
67
-
-
20644472421
-
Transforming growth factor-ß controls T helper type 1 cell development through regulation of natural killer cell interferon-y
-
Laouar, Y., Sutterwala, F S., Gorelik, L. & Flavell, R. A. Transforming growth factor-ß controls T helper type 1 cell development through regulation of natural killer cell interferon-y. Nature Immunol. 6, 600-607 (2005).
-
(2005)
Nature Immunol.
, vol.6
, pp. 600-607
-
-
Laouar, Y.1
Sutterwala, F.S.2
Gorelik, L.3
Flavell, R.A.4
-
68
-
-
0036839143
-
Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
-
Mantovani, A., Sozzani, S., Locati, M., Allavena, P. & Sica, A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 23, 549-555 (2002).
-
(2002)
Trends Immunol.
, vol.23
, pp. 549-555
-
-
Mantovani, A.1
Sozzani, S.2
Locati, M.3
Allavena, P.4
Sica, A.5
-
69
-
-
69249222379
-
Polarization of Tumor-associated Neutrophil Phenotype by TGF-ß: "n1" versus "n2" TAN
-
Fridlender, Z. G. et al. Polarization of tumor-associated neutrophil phenotype by TGF-ß: "N1" versus "N2" TAN. Cancer Cell 16, 183-194 (2009).
-
(2009)
Cancer Cell
, vol.16
, pp. 183-194
-
-
Fridlender, Z.G.1
-
70
-
-
22044456529
-
Intracerebral and intrathecal infusion of the TGF-ß2-specific antisense phosphorothioate oligonucleotide AP 12009 in rabbits and primates: Toxicology and safety
-
Schlingensiepen, R. et al. Intracerebral and intrathecal infusion of the TGF-ß2-specific antisense phosphorothioate oligonucleotide AP 12009 in rabbits and primates: toxicology and safety Oligonucleotides 15, 94-104 (2005).
-
(2005)
Oligonucleotides
, vol.15
, pp. 94-104
-
-
Schlingensiepen, R.1
-
71
-
-
30944437585
-
Targeted tumor therapy with the TGF-ß2 antisense compound AP 12009
-
Schlingensiepen, K. H. et al. Targeted tumor therapy with the TGF-ß2 antisense compound AP 12009. Cytokine Growth Factor Rev. 17, 129-139 (2006).
-
(2006)
Cytokine Growth Factor Rev.
, vol.17
, pp. 129-139
-
-
Schlingensiepen, K.H.1
-
72
-
-
0027223428
-
The effect of transforming growth factor-ß2-specific phosphorothioate-anti-sense oligodeoxynucleotides in reversing cellular immunosuppression in malignant glioma
-
Jachimczak, P. et al. The effect of transforming growth factor-ß2-specific phosphorothioate-anti-sense oligodeoxynucleotides in reversing cellular immunosuppression in malignant glioma. J. Neurosurg. 78, 944-951 (1993).
-
(1993)
J. Neurosurg.
, vol.78
, pp. 944-951
-
-
Jachimczak, P.1
-
73
-
-
79956217912
-
Transforming growth factor-ß2 gene silencing with trabedersen (AP 12009) in pancreatic cancer
-
Schlingensiepen, K. H. et al. Transforming growth factor-ß2 gene silencing with trabedersen (AP 12009) in pancreatic cancer. Cancer Sci. 102, 1193-1200 (2011).
-
(2011)
Cancer Sci.
, vol.102
, pp. 1193-1200
-
-
Schlingensiepen, K.H.1
-
74
-
-
79951602633
-
Targeted therapy for high-grade glioma with the TGF-β2 inhibitor trabedersen: Results of a randomized and controlled phase IIb study
-
Bogdahn, U. et al. Targeted therapy for high-grade glioma with the TGF-β2 inhibitor trabedersen: results of a randomized and controlled phase IIb study. Neuro Oncol. 13, 132-142 (2011).
-
(2011)
Neuro Oncol.
, vol.13
, pp. 132-142
-
-
Bogdahn, U.1
-
75
-
-
27144458232
-
Topical application of a peptide inhibitor of transforming growth factor-β1 ameliorates bleomycin-induced skin fibrosis
-
Santiago, B. et al. Topical application of a peptide inhibitor of transforming growth factor-β1 ameliorates bleomycin-induced skin fibrosis. J. Invest. Dermatol. 125, 450-455 (2005).
-
(2005)
J. Invest. Dermatol.
, vol.125
, pp. 450-455
-
-
Santiago, B.1
-
76
-
-
70350736109
-
Peptide inhibitors of transforming growth factor-β enhance the efficacy of antitumor immunotherapy
-
Llopiz, D. et al. Peptide inhibitors of transforming growth factor-β enhance the efficacy of antitumor immunotherapy. Int. J. Cancer 125, 2614-2623 (2009).
-
(2009)
Int. J. Cancer
, vol.125
, pp. 2614-2623
-
-
Llopiz, D.1
-
77
-
-
59449111178
-
A synthetic peptide from transforming growth factor-β1 type III receptor prevents myocardial fibrosis in spontaneously hypertensive rats
-
Hermida, N. et al. A synthetic peptide from transforming growth factor-β1 type III receptor prevents myocardial fibrosis in spontaneously hypertensive rats. Cardiovascular Res. 81, 601-609 (2009).
-
(2009)
Cardiovascular Res.
, vol.81
, pp. 601-609
-
-
Hermida, N.1
-
78
-
-
10744230462
-
A synthetic peptide from transforming growth factor β type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury
-
Ezquerro, I. J. et al. A synthetic peptide from transforming growth factor β type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury. Cytokine 22, 12-20 (2003).
-
(2003)
Cytokine
, vol.22
, pp. 12-20
-
-
Ezquerro, I.J.1
-
79
-
-
45549085803
-
An anti-transforming growth factor β antibody suppresses metastasis via cooperative effects on multiple cell compartments
-
Nam, J. S. et al. An anti-transforming growth factor β antibody suppresses metastasis via cooperative effects on multiple cell compartments. Cancer Res. 68, 3835-3843 (2008).
-
(2008)
Cancer Res.
, vol.68
, pp. 3835-3843
-
-
Nam, J.S.1
-
80
-
-
77952609184
-
Targeting the transforming growth factor-β pathway inhibits human basal-like breast cancer metastasis
-
Ganapathy, V. et al. Targeting the transforming growth factor-β pathway inhibits human basal-like breast cancer metastasis. Mol. Cancer 9, 122 (2010).
-
Mol. Cancer
, vol.9
, Issue.122
, pp. 2010
-
-
Ganapathy, V.1
-
81
-
-
80455144497
-
TG F β1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo
-
Bouquet, F. et al. TG F β1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo. Clin. Cancer Res. 17, 6754-6765 (2011).
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 6754-6765
-
-
Bouquet, F.1
-
82
-
-
84862704827
-
First human dose (FHD) study of the oral transforming growth factor-β receptor i kinase inhibitor LY2157299 in patients with treatment-refractory malignant glioma
-
Abstract 3011
-
Rodon Ahnert, J. et al. First human dose (FHD) study of the oral transforming growth factor-β receptor I kinase inhibitor LY2157299 in patients with treatment-refractory malignant glioma. J. Clin. Oncol. 29, Abstract 3011 (2011).
-
(2011)
J. Clin. Oncol.
, vol.29
-
-
Rodon Ahnert, J.1
-
83
-
-
38449103630
-
Antisense therapeutics for tumor treatment: The TGF-β2 inhibitor AP 12009 in clinical development against malignant tumors
-
Schlingensiepen, K. H., Fischer-Blass, B., Schmaus, S. & Ludwig, S. Antisense therapeutics for tumor treatment: the TGF-β2 inhibitor AP 12009 in clinical development against malignant tumors. Recent Results Cancer Res. 177, 137-150 (2008).
-
(2008)
Recent Results Cancer Res.
, vol.177
, pp. 137-150
-
-
Schlingensiepen, K.H.1
Fischer-Blass, B.2
Schmaus, S.3
Ludwig, S.4
-
84
-
-
84864528071
-
Final results of a phase I/II study in patients with pancreatic cancer, malignant melanoma, and colorectal carcinoma with trabedersen
-
Abstract 4034
-
Oettle, H. et al. Final results of a phase I/II study in patients with pancreatic cancer, malignant melanoma, and colorectal carcinoma with trabedersen. J. Clin. Oncol. 30, Abstract 4034 (2012).
-
(2012)
J. Clin. Oncol.
, vol.30
-
-
Oettle, H.1
-
85
-
-
33750586798
-
Phase II study of belagenpumatucel-L, a transforming growth factor β-2 antisense gene-modified allogeneic tumor cell vaccine in non-small-cell lung cancer
-
Nemunaitis, J. et al. Phase II study of belagenpumatucel-L, a transforming growth factor β-2 antisense gene-modified allogeneic tumor cell vaccine in non-small-cell lung cancer. J. Clin. Oncol. 24, 4721-4730 (2006).
-
(2006)
J. Clin. Oncol.
, vol.24
, pp. 4721-4730
-
-
Nemunaitis, J.1
-
86
-
-
67651091694
-
Phase II trial of Belagenpumatucel-L, a TGF-β2 antisense gene modified allogeneic tumor vaccine in advanced non small cell lung cancer (NSCLC) patients
-
Nemunaitis, J. et al. Phase II trial of Belagenpumatucel-L, a TGF-β2 antisense gene modified allogeneic tumor vaccine in advanced non small cell lung cancer (NSCLC) patients. Cancer Gene Ther. 16, 620-624 (2009).
-
(2009)
Cancer Gene Ther.
, vol.16
, pp. 620-624
-
-
Nemunaitis, J.1
-
87
-
-
84872502255
-
Long-term survival in a phase II study of belagenpumatucel-L (antisense TGFβ vaccine) in non small-cell lung cancer (NSCLC)
-
Abstract 5367
-
Bazhenova, L., Carrier, E., Shawler, D. & Fakhrai, H. Long-term survival in a phase II study of belagenpumatucel-L (antisense TGFβ vaccine) in non small-cell lung cancer (NSCLC). Cancer Res. 72, Abstract 5367 (2012).
-
(2012)
Cancer Res.
, vol.72
-
-
Bazhenova, L.1
Carrier, E.2
Shawler, D.3
Fakhrai, H.4
-
88
-
-
0041342109
-
Evaluation of anti-TGF-β2 antibody as a new postoperative anti-scarring agent in glaucoma surgery
-
Mead, A. L., Wong, T. T., Cordeiro, M. F., Anderson, I. K. & Khaw, P. T. Evaluation of anti-TGF-β2 antibody as a new postoperative anti-scarring agent in glaucoma surgery. Invest. Ophthalmol. Vis. Sci. 44, 3394-3401 (2003).
-
(2003)
Invest. Ophthalmol. Vis. Sci.
, vol.44
, pp. 3394-3401
-
-
Mead, A.L.1
Wong, T.T.2
Cordeiro, M.F.3
Anderson, I.K.4
Khaw, P.T.5
-
89
-
-
34748820160
-
CAT-152 trabeculectomy study
-
CAT-152 0201 Trabeculectomy Study Group.
-
CAT-152 0201 Trabeculectomy Study Group. CAT-152 trabeculectomy study. Ophthalmology 11 4, 1950 (2007).
-
(2007)
Ophthalmology
, vol.114
, pp. 1950
-
-
-
90
-
-
33846250366
-
Recombinant human anti-transforming growth factor β1 antibody therapy in systemic sclerosis: A multicenter, randomized, placebo-controlled phase I/II trial of CAT-192
-
Denton, C. P. et al. Recombinant human anti-transforming growth factor β1 antibody therapy in systemic sclerosis: a multicenter, randomized, placebo-controlled phase I/II trial of CAT-192. Arthritis Rheum. 56, 323-333 (2007).
-
(2007)
Arthritis Rheum.
, vol.56
, pp. 323-333
-
-
Denton, C.P.1
-
91
-
-
84855222588
-
Antibody targeting of TGF-β in cancer patients
-
Lonning, S., Mannick, J. & McPherson, J. M. Antibody targeting of TGF-β in cancer patients. Curr. Pharm. Biotechnol. 12, 2176-2189 (2011).
-
(2011)
Curr. Pharm. Biotechnol.
, vol.12
, pp. 2176-2189
-
-
Lonning, S.1
Mannick, J.2
McPherson, J.M.3
-
92
-
-
79956011495
-
A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis
-
Trachtman, H. et al. A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis. Kidney Int. 79, 1236-1243 (2011).
-
(2011)
Kidney Int.
, vol.79
, pp. 1236-1243
-
-
Trachtman, H.1
-
93
-
-
56849115306
-
Phase III Study of GC1008: A Human Anti-transforming Growth Factor-beta (TGFβ) Monoclonal Antibody (MAb) in Patients with Advanced Malignant Melanoma (MM) or renal cell carcinoma (RCC)
-
Abstract 9028
-
Morris, J. C. et al. Phase I/II study of GC1008: a human anti-transforming growth factor-beta (TGFβ) monoclonal antibody (MAb) in patients with advanced malignant melanoma (MM) or renal cell carcinoma (RCC). J. Clin. Oncol. 26, Abstract 9028 (2008).
-
(2008)
J. Clin. Oncol.
, vol.26
-
-
Morris, J.C.1
-
94
-
-
76749102053
-
Anti-transforming growth factor β receptor II antibody has therapeutic efficacy against primary tumor growth and metastasis through multieffects on cancer, stroma, and immune cells
-
Zhong, Z. et al. Anti-transforming growth factor β receptor II antibody has therapeutic efficacy against primary tumor growth and metastasis through multieffects on cancer, stroma, and immune cells. Clin. Cancer Res. 16, 1191-1205 (2010).
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 1191-1205
-
-
Zhong, Z.1
-
95
-
-
39049098274
-
Antibody-mediated blockade of integrin αvβ6 inhibits tumor progression in vivo by a transforming growth factor-β-regulated mechanism
-
Van Aarsen, L. A. et al. Antibody-mediated blockade of integrin αvβ6 inhibits tumor progression in vivo by a transforming growth factor-β-regulated mechanism. Cancer Res. 68, 561-570 (2008).
-
(2008)
Cancer Res.
, vol.68
, pp. 561-570
-
-
Van Aarsen, L.A.1
-
96
-
-
0036086409
-
Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases
-
Muraoka, R. S. et al. Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases. J. Clin. Invest. 109, 1551-1559 (2002).
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 1551-1559
-
-
Muraoka, R.S.1
-
97
-
-
79959473807
-
Blockade of TSP1-dependent TGF-β activity reduces renal injury and proteinuria in a murine model of diabetic nephropathy
-
Lu, A., Miao, M., Schoeb, T. R., Agarwal, A. & Murphy-Ullrich, J. E. Blockade of TSP1-dependent TGF-β activity reduces renal injury and proteinuria in a murine model of diabetic nephropathy. Am. J. Pathol. 178, 2573-2586 (2011).
-
(2011)
Am. J. Pathol.
, vol.178
, pp. 2573-2586
-
-
Lu, A.1
Miao, M.2
Schoeb, T.R.3
Agarwal, A.4
Murphy-Ullrich, J.E.5
-
98
-
-
10444261212
-
Development of TGF-β signalling inhibitors for cancer therapy
-
Yingling, J. M., Blanchard, K. L. & Sawyer, J. S. Development of TGF-β signalling inhibitors for cancer therapy. Nature Rev. Drug Discov. 3, 1011-1022 (2004).
-
(2004)
Nature Rev. Drug Discov.
, vol.3
, pp. 1011-1022
-
-
Yingling, J.M.1
Blanchard, K.L.2
Sawyer, J.S.3
-
99
-
-
71449100603
-
Strategies for TGF-β modulation: A review of recent patents
-
Bonafoux, D. & Lee, W. C. Strategies for TGF-β modulation: a review of recent patents. Expert Opin. Ther. Pat. 19, 1759-1769 (2009).
-
(2009)
Expert Opin. Ther. Pat.
, vol.19
, pp. 1759-1769
-
-
Bonafoux, D.1
Lee, W.C.2
-
101
-
-
33745146191
-
Large-and small-molecule inhibitors of transforming growth factor-beta signaling
-
Akhurst, R. J. Large-and small-molecule inhibitors of transforming growth factor-beta signaling. Curr. Opin. Investig. Drugs 7, 513-521 (2006).
-
(2006)
Curr. Opin. Investig. Drugs
, vol.7
, pp. 513-521
-
-
Akhurst, R.J.1
-
102
-
-
80052822707
-
Transcriptional inhibition of hypertrophic scars by a gene silencer, pyrrole-imidazole polyamide, targeting the TGF-β1 promoter
-
Washio, H. et al. Transcriptional inhibition of hypertrophic scars by a gene silencer, pyrrole-imidazole polyamide, targeting the TGF-β1 promoter. J. Invest. Dermatol. 131, 1987-1995 (2011).
-
(2011)
J. Invest. Dermatol.
, vol.131
, pp. 1987-1995
-
-
Washio, H.1
-
103
-
-
77649269818
-
Pretranscriptional regulation of Tgf-β1 by PI polyamide prevents scarring and accelerates wound healing of the cornea after exposure to alkali
-
Chen, M. et al. Pretranscriptional regulation of Tgf-β1 by PI polyamide prevents scarring and accelerates wound healing of the cornea after exposure to alkali. Mol. Ther. 18, 519-527 (2010).
-
(2010)
Mol. Ther.
, vol.18
, pp. 519-527
-
-
Chen, M.1
-
104
-
-
79551599216
-
The protective role of Smad7 in diabetic kidney disease: Mechanism and therapeutic potential
-
Chen, H. Y. et al. The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potential. Diabetes 60, 590-601 (2011).
-
(2011)
Diabetes
, vol.60
, pp. 590-601
-
-
Chen, H.Y.1
-
105
-
-
54349095411
-
Smad7 gene transfer therapy: Therapeutic applications beyond colonic fibrosis
-
author reply 878-880
-
Kapoor, S. Smad7 gene transfer therapy: therapeutic applications beyond colonic fibrosis. Eur. J. Clin. Invest. 38, 876-877; author reply 878-880 (2008).
-
(2008)
Eur. J. Clin. Invest.
, vol.38
, pp. 876-877
-
-
Kapoor, S.1
-
106
-
-
79751506542
-
Gene therapy finds its niche
-
Sheridan, C. Gene therapy finds its niche. Nature Biotech. 29, 121-128 (2011).
-
(2011)
Nature Biotech.
, vol.29
, pp. 121-128
-
-
Sheridan, C.1
-
107
-
-
55249117972
-
Antitumor activity of EBV-specific T lymphocytes transduced with a dominant negative TGF-β receptor
-
Foster, A. E. et al. Antitumor activity of EBV-specific T lymphocytes transduced with a dominant negative TGF-β receptor. J. Immunother. 31, 500-505 (2008).
-
(2008)
J. Immunother.
, vol.31
, pp. 500-505
-
-
Foster, A.E.1
-
108
-
-
84857115215
-
Immunotherapy targeting HER2 with genetically modified T cells eliminates tumor-initiating cells in osteosarcoma
-
Rainusso, N. et al. Immunotherapy targeting HER2 with genetically modified T cells eliminates tumor-initiating cells in osteosarcoma. Cancer Gene Ther. 19, 212-217 (2012).
-
(2012)
Cancer Gene Ther.
, vol.19
, pp. 212-217
-
-
Rainusso, N.1
-
109
-
-
82955187824
-
PiggyBac-mediated cancer immunotherapy using EBV-specific cytotoxic T-cells expressing HER2-specific chimeric antigen receptor
-
Nakazawa, Y. et al. PiggyBac-mediated cancer immunotherapy using EBV-specific cytotoxic T-cells expressing HER2-specific chimeric antigen receptor. Mol. Ther. 19, 2133-2143 (2011).
-
(2011)
Mol. Ther.
, vol.19
, pp. 2133-2143
-
-
Nakazawa, Y.1
-
110
-
-
74549196076
-
HER2-specific T cells target primary glioblastoma stem cells and induce regression of autologous experimental tumors
-
Ahmed, N. et al. HER2-specific T cells target primary glioblastoma stem cells and induce regression of autologous experimental tumors. Clin. Cancer Res. 16, 474-485 (2010).
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 474-485
-
-
Ahmed, N.1
-
111
-
-
34250844475
-
Regression of experimental medulloblastoma following transfer of HER2-specific T cells
-
Ahmed, N. et al. Regression of experimental medulloblastoma following transfer of HER2-specific T cells. Cancer Res. 67, 5957-5964 (2007).
-
(2007)
Cancer Res.
, vol.67
, pp. 5957-5964
-
-
Ahmed, N.1
-
112
-
-
77957947386
-
Effects of avotermin (transforming growth factor β3) in a clinically relevant pig model of long, full-thickness incisional wounds
-
Laverty, H. G. et al. Effects of avotermin (transforming growth factor β3) in a clinically relevant pig model of long, full-thickness incisional wounds. J. Cutan. Med. Surg. 14, 223-232 (2010).
-
(2010)
J. Cutan. Med. Surg.
, vol.14
, pp. 223-232
-
-
Laverty, H.G.1
-
113
-
-
33846946114
-
Angiotensin II type 1 receptor blockade attenuates TGF-β-induced failure of muscle regeneration in multiple myopathic states
-
Cohn, R. D. et al. Angiotensin II type 1 receptor blockade attenuates TGF-β-induced failure of muscle regeneration in multiple myopathic states. Nature Med. 13, 204-210 (2007).
-
(2007)
Nature Med.
, vol.13
, pp. 204-210
-
-
Cohn, R.D.1
-
114
-
-
84855441194
-
Angiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in mice
-
Podowski, M. et al. Angiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in mice. J. Clin. Invest. 122, 229-240 (2012).
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 229-240
-
-
Podowski, M.1
-
115
-
-
77955300852
-
Angiotensin II sustains brain inflammation in mice via TGF-ß
-
Lanz, T. V. et al. Angiotensin II sustains brain inflammation in mice via TGF-ß. J. Clin. Invest. 120, 2782-2794 (2010).
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 2782-2794
-
-
Lanz, T.V.1
-
116
-
-
25844433805
-
Pirfenidone inhibits obliterative airway disease in mouse tracheal allografts
-
Zhou, H., Latham, C. W., Zander, D. S., Margolin, S. B. & Visner, G. A. Pirfenidone inhibits obliterative airway disease in mouse tracheal allografts. J. Heart Lung Transplant. 24, 1577-1585 (2005).
-
(2005)
J. Heart Lung Transplant.
, vol.24
, pp. 1577-1585
-
-
Zhou, H.1
Latham, C.W.2
Zander, D.S.3
Margolin, S.B.4
Visner, G.A.5
-
117
-
-
79960556065
-
The clinical significance of 5% change in vital capacity in patients with idiopathic pulmonary fibrosis: Extended analysis of the pirfenidone trial
-
Taniguchi, H. et al. The clinical significance of 5% change in vital capacity in patients with idiopathic pulmonary fibrosis: extended analysis of the pirfenidone trial. Respir. Res. 12, 93 (2011).
-
(2011)
Respir. Res.
, vol.12
, pp. 93
-
-
Taniguchi, H.1
-
118
-
-
79956341531
-
Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): Two randomised trials
-
Noble, P. W. et al. Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trials. Lancet 377, 1760-1769 (2011).
-
(2011)
Lancet
, vol.377
, pp. 1760-1769
-
-
Noble, P.W.1
-
119
-
-
0028918825
-
The serum concentration of active transforming growth factor-ß is severely depressed in advanced atherosclerosis
-
Grainger, D. J. et al. The serum concentration of active transforming growth factor-ß is severely depressed in advanced atherosclerosis. Nature Med. 1, 74-79 (1995).
-
(1995)
Nature Med.
, vol.1
, pp. 74-79
-
-
Grainger, D.J.1
-
120
-
-
0030598681
-
TGFß1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice
-
Cui, W. et al. TGFß1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice. Cell 86, 531-542 (1996).
-
(1996)
Cell
, vol.86
, pp. 531-542
-
-
Cui, W.1
-
121
-
-
70350231912
-
Gain or loss of TGFß signaling in mammary carcinoma cells can promote metastasis
-
Bierie, B. & Moses, H. L. Gain or loss of TGFß signaling in mammary carcinoma cells can promote metastasis. Cell Cycle 8, 3319-3327 (2009).
-
(2009)
Cell Cycle
, vol.8
, pp. 3319-3327
-
-
Bierie, B.1
Moses, H.L.2
-
122
-
-
67651005826
-
Abrogation of TGF-ß signaling enhances chemokine production and correlates with prognosis in human breast cancer
-
Bierie, B. et al. Abrogation of TGF-ß signaling enhances chemokine production and correlates with prognosis in human breast cancer. J. Clin. Invest. 119, 1571-1582 (2009).
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 1571-1582
-
-
Bierie, B.1
-
123
-
-
17744397294
-
Abnormal angiogenesis but intact hematopoietic potential in TGF-ß type i receptor-deficient mice
-
Larsson, J. et al. Abnormal angiogenesis but intact hematopoietic potential in TGF-ß type I receptor-deficient mice. EMBO J. 20, 1663-1673 (2001).
-
(2001)
EMBO J.
, vol.20
, pp. 1663-1673
-
-
Larsson, J.1
-
124
-
-
0036084359
-
TGF-ß antagonists: Why suppress a tumor suppressor?
-
Akhurst, R. J. TGF-ß antagonists: why suppress a tumor suppressor? J. Clin. Invest. 109, 1533-1536 (2002).
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 1533-1536
-
-
Akhurst, R.J.1
-
125
-
-
0036087521
-
Lifetime exposure to a soluble TGF-ß antagonist protects mice against metastasis without adverse side effects
-
Yang, Y. A. et al. Lifetime exposure to a soluble TGF-ß antagonist protects mice against metastasis without adverse side effects. J. Clin. Invest. 109, 1607-1615 (2002).
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 1607-1615
-
-
Yang, Y.A.1
-
126
-
-
80053585761
-
Induction of heart valve lesions by small-molecule ALK5 inhibitors
-
Anderton, M. J. et al. Induction of heart valve lesions by small-molecule ALK5 inhibitors. Toxicol. Pathol. 39, 916-924 (2011).
-
(2011)
Toxicol. Pathol.
, vol.39
, pp. 916-924
-
-
Anderton, M.J.1
-
127
-
-
33847775958
-
Inhibition of ALK5 signaling induces physeal dysplasia in rats
-
Frazier, K. et al. Inhibition of ALK5 signaling induces physeal dysplasia in rats. Toxicol. Pathol. 35, 284-295 (2007).
-
(2007)
Toxicol. Pathol.
, vol.35
, pp. 284-295
-
-
Frazier, K.1
-
128
-
-
79953180846
-
Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1
-
Goudie, D. R. et al. Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1. Nature Genet. 43, 365-369 (2011).
-
(2011)
Nature Genet.
, vol.43
, pp. 365-369
-
-
Goudie, D.R.1
-
129
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman, P. B. et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N. Engl. J. Med. 364, 2507-2516 (2011).
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
-
130
-
-
68949094219
-
Keratoacanthomas and squamous cell carcinomas in patients receiving sorafenib
-
Arnault, J. P. et al. Keratoacanthomas and squamous cell carcinomas in patients receiving sorafenib. J. Clin. Oncol. 27, e59-e61 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
-
-
Arnault, J.P.1
-
131
-
-
2342509094
-
Acute development of multiple keratoacanthomas and squamous cell carcinomas after treatment with infliximab
-
Esser, A. C, Abril, A., Fayne, S. & Doyle, J. A. Acute development of multiple keratoacanthomas and squamous cell carcinomas after treatment with infliximab. J. Am. Acad. Dermatol. 50, S75-S77 (2004).
-
(2004)
J. Am. Acad. Dermatol.
, vol.50
-
-
Esser, A.C.1
Abril, A.2
Fayne, S.3
Doyle, J.A.4
-
132
-
-
84862908097
-
RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors
-
Su, F et al. RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors. N. Engl. J. Med. 366, 207-215 (2012).
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 207-215
-
-
Su, F.1
-
133
-
-
84855435059
-
Skin tumors induced by sorafenib; Paradoxic RAS-RAF pathway activation and oncogenic mutations of HRAS, TP53, and TGFBR1
-
Arnault, J. P. et al. Skin tumors induced by sorafenib; paradoxic RAS-RAF pathway activation and oncogenic mutations of HRAS, TP53, and TGFBR1. Clin. Cancer Res. 18, 263-272 (2012).
-
(2012)
Clin. Cancer Res.
, vol.18
, pp. 263-272
-
-
Arnault, J.P.1
-
134
-
-
77956178360
-
EMT, cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer
-
Singh, A. & Settleman, J. EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene 29, 4741-4751 (2010).
-
(2010)
Oncogene
, vol.29
, pp. 4741-4751
-
-
Singh, A.1
Settleman, J.2
-
135
-
-
33847419142
-
Molecular definition of breast tumor heterogeneity
-
Shipitsin, M. et al. Molecular definition of breast tumor heterogeneity. Cancer Cell 11, 259-273 (2007).
-
(2007)
Cancer Cell
, vol.11
, pp. 259-273
-
-
Shipitsin, M.1
-
136
-
-
70350497349
-
Autocrine TGF-ß signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors
-
Ikushima, H. et al. Autocrine TGF-ß signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors. Cell Stem Cell 5, 504-514 (2009).
-
(2009)
Cell Stem Cell
, vol.5
, pp. 504-514
-
-
Ikushima, H.1
-
137
-
-
78649986150
-
high glioma-initiating cell population in human glioblastoma
-
high glioma-initiating cell population in human glioblastoma. Cancer Cell 18, 655-668 (2010).
-
(2010)
Cancer Cell
, vol.18
, pp. 655-668
-
-
Anido, J.1
-
138
-
-
63249123273
-
TGF-β increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma
-
Penuelas, S. et al. TGF-β increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma. Cancer Cell 15, 315-327 (2009).
-
(2009)
Cancer Cell
, vol.15
, pp. 315-327
-
-
Penuelas, S.1
-
139
-
-
76249087423
-
TGF-β-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia
-
Naka, K. et al. TGF-β-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia. Nature 463, 676-680 (2010).
-
(2010)
Nature
, vol.463
, pp. 676-680
-
-
Naka, K.1
-
140
-
-
84872499919
-
Microenvironmental signals dictate disseminated tumor cells (DTCs) fate through regulation of TGFβII and p38α
-
Abstract 5234
-
Bragado, P. et al. Microenvironmental signals dictate disseminated tumor cells (DTCs) fate through regulation of TGFβII and p38α. Cancer Res. 72 (Suppl. 1), Abstract 5234 (2012).
-
(2012)
Cancer Res.
, vol.72
, Issue.SUPPL. 1
-
-
Bragado, P.1
-
141
-
-
84872498099
-
Development of murine models of breast cancer metastasis for the evaluation of the efficacy of TGF-β inhibitors as therapeutic agents
-
Abstract 1366
-
Biswas, T., Yang, J., Zhao, L. & Sun, L. Z. Development of murine models of breast cancer metastasis for the evaluation of the efficacy of TGF-β inhibitors as therapeutic agents. Cancer Res. 72 (Suppl. 1), Abstract 1366 (2012).
-
(2012)
Cancer Res.
, vol.72
, Issue.SUPPL. 1
-
-
Biswas, T.1
Yang, J.2
Zhao, L.3
Sun, L.Z.4
-
142
-
-
0032534450
-
Blockade of tumor cell transforming growth factor-βs enhances cell cycle progression and sensitizes human breast carcinoma cells to cytotoxic chemotherapy
-
Ohmori, T., Yang, J. L., Price, J. O. & Arteaga, C. L. Blockade of tumor cell transforming growth factor-βs enhances cell cycle progression and sensitizes human breast carcinoma cells to cytotoxic chemotherapy. Exp. Cell Res. 245, 350-359 (1998).
-
(1998)
Exp. Cell Res.
, vol.245
, pp. 350-359
-
-
Ohmori, T.1
Yang, J.L.2
Price, J.O.3
Arteaga, C.L.4
-
143
-
-
79953788906
-
Transforming growth factor-β decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells
-
Ehata, S. et al. Transforming growth factor-β decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells. Oncogene 30, 1693-1705 (2011).
-
(2011)
Oncogene
, vol.30
, pp. 1693-1705
-
-
Ehata, S.1
-
144
-
-
34548706039
-
Transforming growth factor-β can suppress tumorigenesis through effects on the putative cancer stem or early progenitor cell and committed progeny in a breast cancer xenograft model
-
Tang, B. et al. Transforming growth factor-β can suppress tumorigenesis through effects on the putative cancer stem or early progenitor cell and committed progeny in a breast cancer xenograft model. Cancer Res. 67, 8643-8652 (2007).
-
(2007)
Cancer Res.
, vol.67
, pp. 8643-8652
-
-
Tang, B.1
-
145
-
-
79751501829
-
Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth
-
Quante, M. et al. Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth. Cancer Cell 19, 257-272 (2011).
-
(2011)
Cancer Cell
, vol.19
, pp. 257-272
-
-
Quante, M.1
-
146
-
-
9344245148
-
Transforming growth factor β receptor i kinase inhibitor down-regulates cytokine secretion and multiple myeloma cell growth in the bone marrow microenvironment
-
Hayashi, T. et al. Transforming growth factor β receptor I kinase inhibitor down-regulates cytokine secretion and multiple myeloma cell growth in the bone marrow microenvironment. Clin. Cancer Res. 10, 7540-7546 (2004).
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 7540-7546
-
-
Hayashi, T.1
-
147
-
-
77953765387
-
Doxorubicin in combination with a small TGFβ inhibitor: A potential novel therapy for metastatic breast cancer in mouse models
-
Bandyopadhyay, A. et al. Doxorubicin in combination with a small TGFβ inhibitor: a potential novel therapy for metastatic breast cancer in mouse models. PLoS ONE 5, e10365 (2010).
-
(2010)
PLoS ONE
, vol.5
-
-
Bandyopadhyay, A.1
-
148
-
-
78650305162
-
TGF-β inhibition restores terminal osteoblast differentiation to suppress myeloma growth
-
Takeuchi, K. et al. TGF-β inhibition restores terminal osteoblast differentiation to suppress myeloma growth. PLoS ONE 5, e9870 (2010).
-
(2010)
PLoS ONE
, vol.5
-
-
Takeuchi, K.1
-
149
-
-
0032918414
-
TGF-β signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development
-
Yin, J. J. et al. TGF-β signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. J. Clin. Invest. 103, 197-206 (1999).
-
(1999)
J. Clin. Invest.
, vol.103
, pp. 197-206
-
-
Yin, J.J.1
-
150
-
-
77954843259
-
Combination effect of a TGF-β receptor kinase inhibitor with 5-FU analog S1 on lymph node metastasis of scirrhous gastric cancer in mice
-
Shinto, O. et al. Combination effect of a TGF-β receptor kinase inhibitor with 5-FU analog S1 on lymph node metastasis of scirrhous gastric cancer in mice. Cancer Sci. 101, 1846-1852 (2010).
-
(2010)
Cancer Sci.
, vol.101
, pp. 1846-1852
-
-
Shinto, O.1
-
151
-
-
33847635618
-
Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-β signaling
-
Kano, M. R. et al. Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-β signaling. Proc. Natl Acad. Sci. USA 104, 3460-3465 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 3460-3465
-
-
Kano, M.R.1
-
152
-
-
84859883741
-
Cancer and innate immune system interactions: Translational potentials for cancer immunotherapy
-
Liu, Y. & Zeng, G. Cancer and innate immune system interactions: translational potentials for cancer immunotherapy. J. Immunother. 35, 299-308 (2012).
-
(2012)
J. Immunother.
, vol.35
, pp. 299-308
-
-
Liu, Y.1
Zeng, G.2
-
154
-
-
33748293112
-
+ T cells activates the antitumor immune response cycle
-
+ T cells activates the antitumor immune response cycle. Mol. Cancer Ther. 5, 1733-1743 (2006).
-
(2006)
Mol. Cancer Ther.
, vol.5
, pp. 1733-1743
-
-
Zhang, Q.1
-
155
-
-
52449122955
-
Transforming growth factor-β receptor blockade augments the effectiveness of adoptive T-cell therapy of established solid cancers
-
Wallace, A. et al. Transforming growth factor-β receptor blockade augments the effectiveness of adoptive T-cell therapy of established solid cancers. Clin. Cancer Res. 14, 3966-3974 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 3966-3974
-
-
Wallace, A.1
-
156
-
-
84872495358
-
Outgrowth of drug-resistant carcinomas expressing markers of tumor aggression after long term TßRI/II kinase inhibition with LY2109761
-
Connolly, E. C. et al. Outgrowth of drug-resistant carcinomas expressing markers of tumor aggression after long term TßRI/II kinase inhibition with LY2109761. Cancer Res. 71, 1-11 (2011).
-
(2011)
Cancer Res.
, vol.71
, pp. 1-11
-
-
Connolly, E.C.1
-
157
-
-
82655181475
-
Blockade of TGF-β signaling by the TGFßR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma
-
Zhang, M. et al. Blockade of TGF-β signaling by the TGFßR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma. Cancer Res. 71, 7155-7167 (2011).
-
(2011)
Cancer Res.
, vol.71
, pp. 7155-7167
-
-
Zhang, M.1
-
158
-
-
67549086678
-
Transforming growth factor-β in breast cancer: Too much, too late
-
Barcellos-Hoff, M. H. & Akhurst, R. J. Transforming growth factor-β in breast cancer: too much, too late. Breast Cancer Res. 11, 202 (2009).
-
(2009)
Breast Cancer Res.
, vol.11
, pp. 202
-
-
Barcellos-Hoff, M.H.1
Akhurst, R.J.2
-
159
-
-
33845303212
-
Inhibition of transforming growth factor-β1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress
-
Kirshner, J. et al. Inhibition of transforming growth factor-β1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress. Cancer Res. 66, 10861-10869 (2006).
-
(2006)
Cancer Res.
, vol.66
, pp. 10861-10869
-
-
Kirshner, J.1
-
160
-
-
79551518231
-
Reduced SMAD7 leads to overactivation of TGF-β signaling in MDS that can be reversed by a specific inhibitor of TGF-β receptor i kinase
-
Zhou, L. et al. Reduced SMAD7 leads to overactivation of TGF-β signaling in MDS that can be reversed by a specific inhibitor of TGF-β receptor I kinase. Cancer Res. 71, 955-963 (2011).
-
(2011)
Cancer Res.
, vol.71
, pp. 955-963
-
-
Zhou, L.1
-
161
-
-
84857390959
-
Management of idiopathic pulmonary fibrosis
-
Cerri, S., Spagnolo, P., Luppi, F. & Richeldi, L. Management of idiopathic pulmonary fibrosis. Clin. Chest Med. 33, 85-94 (2012).
-
(2012)
Clin. Chest Med.
, vol.33
, pp. 85-94
-
-
Cerri, S.1
Spagnolo, P.2
Luppi, F.3
Richeldi, L.4
-
162
-
-
33745808765
-
Transforming growth factor β: A central modulator of pulmonary and airway inflammation and fibrosis
-
Sheppard, D. Transforming growth factor β: a central modulator of pulmonary and airway inflammation and fibrosis. Proc. Am. Thorac. Soc. 3, 413-417 (2006).
-
(2006)
Proc. Am. Thorac. Soc.
, vol.3
, pp. 413-417
-
-
Sheppard, D.1
-
163
-
-
84855259695
-
Blocking TGFβ via inhibition of the αvβ6 integrin: A possible therapy for systemic sclerosis interstitial lung disease
-
Katsumoto, T. R., Violette, S. M. & Sheppard, D. Blocking TGFβ via inhibition of the αvβ6 integrin: a possible therapy for systemic sclerosis interstitial lung disease. Int. J. Rheumatol. 2011, 208219 (2011).
-
(2011)
Int. J. Rheumatol.
, vol.2011
, pp. 208219
-
-
Katsumoto, T.R.1
Violette, S.M.2
Sheppard, D.3
-
164
-
-
79951805332
-
Epithelial-mesenchymal interactions in pulmonary fibrosis
-
Chapman, H. A. Epithelial-mesenchymal interactions in pulmonary fibrosis. Annu. Rev. Physiol. 73, 413-435 (2011).
-
(2011)
Annu. Rev. Physiol.
, vol.73
, pp. 413-435
-
-
Chapman, H.A.1
-
165
-
-
84859334535
-
Pirfenidone treatment of idiopathic pulmonary fibrosis
-
Azuma, A. Pirfenidone treatment of idiopathic pulmonary fibrosis. Ther. Adv. Respir. Dis. 6, 107-114 (2012).
-
(2012)
Ther. Adv. Respir. Dis.
, vol.6
, pp. 107-114
-
-
Azuma, A.1
-
166
-
-
34547755121
-
Gene transfer of soluble transforming growth factor type II receptor by in vivo electroporation attenuates lung injury and fibrosis
-
Yamada, M. et al. Gene transfer of soluble transforming growth factor type II receptor by in vivo electroporation attenuates lung injury and fibrosis. J. Clin. Pathol. 60, 916-920 (2007).
-
(2007)
J. Clin. Pathol.
, vol.60
, pp. 916-920
-
-
Yamada, M.1
-
167
-
-
79251639838
-
Therapeutic effect of a peptide inhibitor of TGF-β on pulmonary fibrosis
-
Arribillaga, L. et al. Therapeutic effect of a peptide inhibitor of TGF-β on pulmonary fibrosis. Cytokine 53, 327-333 (2011).
-
(2011)
Cytokine
, vol.53
, pp. 327-333
-
-
Arribillaga, L.1
-
168
-
-
84859369630
-
Deal watch: Biogen acquires Stromedix to pursue novel fibrosis therapy
-
Crunkhorn, S. Deal watch: Biogen acquires Stromedix to pursue novel fibrosis therapy. Nature Rev. Drug Discov. 11, 260 (2012).
-
(2012)
Nature Rev. Drug Discov.
, vol.11
, pp. 260
-
-
Crunkhorn, S.1
-
169
-
-
84865692752
-
Stromedix acquisition signals growing interest in fibrosis
-
Allison, M. Stromedix acquisition signals growing interest in fibrosis. Nature Biotech. 30, 375-376 (2012).
-
(2012)
Nature Biotech.
, vol.30
, pp. 375-376
-
-
Allison, M.1
-
170
-
-
33644638349
-
Renal fibrosis: New insights into the pathogenesis and therapeutics
-
Liu, Y. Renal fibrosis: new insights into the pathogenesis and therapeutics. Kidney Int. 69, 213-217 (2006).
-
(2006)
Kidney Int.
, vol.69
, pp. 213-217
-
-
Liu, Y.1
-
171
-
-
79955955054
-
Epithelial-mesenchymal transition in renal fibrosis-evidence for and against
-
Fragiadaki, M. & Mason, R. M. Epithelial-mesenchymal transition in renal fibrosis-evidence for and against. Int. J. Exp. Pathol. 92, 143-150 (2011).
-
(2011)
Int. J. Exp. Pathol.
, vol.92
, pp. 143-150
-
-
Fragiadaki, M.1
Mason, R.M.2
-
172
-
-
79956353613
-
Protective effect of decorin on acute ischaemia-reperfusion injury in the rat kidney
-
Alan, C., Kocoglu, H., Altintas, R., Alici, B. & Resit Ersay, A. Protective effect of decorin on acute ischaemia-reperfusion injury in the rat kidney. Arch. Med. Sci. 7, 211-216 (2011).
-
(2011)
Arch. Med. Sci.
, vol.7
, pp. 211-216
-
-
Alan, C.1
Kocoglu, H.2
Altintas, R.3
Alici, B.4
Resit Ersay, A.5
-
173
-
-
0036181284
-
Gene transfer of Smad7 using electroporation of adenovirus prevents renal fibrosis in post-obstructed kidney
-
Terada, Y. et al. Gene transfer of Smad7 using electroporation of adenovirus prevents renal fibrosis in post-obstructed kidney. Kidney Int. 61, S94-S98 (2002).
-
(2002)
Kidney Int.
, vol.61
-
-
Terada, Y.1
-
174
-
-
0035852766
-
Angiotensin II blockade reverses myocardial fibrosis in a transgenic mouse model of human hypertrophic cardiomyopathy
-
Lim, D. S. et al. Angiotensin II blockade reverses myocardial fibrosis in a transgenic mouse model of human hypertrophic cardiomyopathy. Circulation 103, 789-791 (2001).
-
(2001)
Circulation
, vol.103
, pp. 789-791
-
-
Lim, D.S.1
-
175
-
-
59849114044
-
Searching for miR-acles in cardiac fibrosis
-
van Rooij, E. & Olson, E. N. Searching for miR-acles in cardiac fibrosis. Circ. Res. 104, 138-140 (2009).
-
(2009)
Circ. Res.
, vol.104
, pp. 138-140
-
-
Van Rooij, E.1
Olson, E.N.2
-
176
-
-
43549115057
-
Validity, reliability, and feasibility of durometer measurements of scleroderma skin disease in a multicenter treatment trial
-
Merkel, P. A. et al. Validity, reliability, and feasibility of durometer measurements of scleroderma skin disease in a multicenter treatment trial. Arthritis Rheum. 59, 699-705 (2008).
-
(2008)
Arthritis Rheum.
, vol.59
, pp. 699-705
-
-
Merkel, P.A.1
-
177
-
-
77954461099
-
TGF-β signaling in atherosclerosis and restenosis
-
McCaffrey, T. A. TGF-β signaling in atherosclerosis and restenosis. Front. Biosci. (Schol. Ed.) 1, 236-245 (2009).
-
(2009)
Front. Biosci. (Schol. Ed.)
, vol.1
, pp. 236-245
-
-
McCaffrey, T.A.1
-
178
-
-
4644256352
-
Intimal hyperplasia and expression of transforming growth factor-β1 in saphenous veins and internal mammary arteries before coronary artery surgery
-
Friedl, R. et al. Intimal hyperplasia and expression of transforming growth factor-β1 in saphenous veins and internal mammary arteries before coronary artery surgery. Ann. Thorac. Surg. 78, 1312-1318 (2004).
-
(2004)
Ann. Thorac. Surg.
, vol.78
, pp. 1312-1318
-
-
Friedl, R.1
-
179
-
-
70249120320
-
Adenovirus-mediated gene transfer of fibromodulin inhibits neointimal hyperplasia in an organ culture model of human saphenous vein graft disease
-
Ranjzad, P., Salem, H. K. & Kingston, P. A. Adenovirus-mediated gene transfer of fibromodulin inhibits neointimal hyperplasia in an organ culture model of human saphenous vein graft disease. Gene Ther. 16, 1154-1162 (2009).
-
(2009)
Gene Ther.
, vol.16
, pp. 1154-1162
-
-
Ranjzad, P.1
Salem, H.K.2
Kingston, P.A.3
-
180
-
-
80053655283
-
Inhibition of transforming growth factor-β restores endothelial thromboresistance in vein grafts
-
Kapur, N. K. et al. Inhibition of transforming growth factor-β restores endothelial thromboresistance in vein grafts. J. Vasc. Surg. 54, 1117-1123.e1 (2011).
-
(2011)
J. Vasc. Surg.
, vol.54
-
-
Kapur, N.K.1
-
181
-
-
34249688228
-
Marfan syndrome: From molecular pathogenesis to clinical treatment
-
Ramirez, F. & Dietz, H. C. Marfan syndrome: from molecular pathogenesis to clinical treatment. Curr. Opin. Genet. Dev. 17, 252-258 (2007).
-
(2007)
Curr. Opin. Genet. Dev.
, vol.17
, pp. 252-258
-
-
Ramirez, F.1
Dietz, H.C.2
-
182
-
-
79954625123
-
Noncanonical TGFβ signaling contributes to aortic aneurysm progression in Marfan syndrome mice
-
Holm, T. M. et al. Noncanonical TGFβ signaling contributes to aortic aneurysm progression in Marfan syndrome mice. Science 332, 358-361 (2011).
-
(2011)
Science
, vol.332
, pp. 358-361
-
-
Holm, T.M.1
-
183
-
-
0036190919
-
2 monoclonal antibody-a new modulator of wound healing in trabeculectomy: A randomized placebo controlled clinical study
-
2 monoclonal antibody-a new modulator of wound healing in trabeculectomy: a randomized placebo controlled clinical study. Ophthalmology 109, 427-431 (2002).
-
(2002)
Ophthalmology
, vol.109
, pp. 427-431
-
-
Siriwardena, D.1
-
184
-
-
34748861947
-
2 monoclonal antibody (CAT-152) to prevent scarring after first-time trabeculectomy
-
2 monoclonal antibody (CAT-152) to prevent scarring after first-time trabeculectomy. Ophthalmology 114, 1822-1830 (2007).
-
(2007)
Ophthalmology
, vol.114
, pp. 1822-1830
-
-
Khaw, P.1
-
185
-
-
81355147841
-
Long-term follow-up after lamellar keratoplasty in a patient with bilateral idiopathic corneal keloid
-
Fukuda, K., Chikama, T., Takahashi, M. & Nishida, T. Long-term follow-up after lamellar keratoplasty in a patient with bilateral idiopathic corneal keloid. Cornea 30, 1491-1494 (2011).
-
(2011)
Cornea
, vol.30
, pp. 1491-1494
-
-
Fukuda, K.1
Chikama, T.2
Takahashi, M.3
Nishida, T.4
-
186
-
-
84863012105
-
Mouse and human strategies identify PTPN14 as a modifier of angiogenesis and hereditary haemorrhagic telangiectasia
-
Benzinou, M. et al. Mouse and human strategies identify PTPN14 as a modifier of angiogenesis and hereditary haemorrhagic telangiectasia. Nature Commun. 3, 616 (2012).
-
(2012)
Nature Commun.
, vol.3
, pp. 616
-
-
Benzinou, M.1
-
187
-
-
0031039041
-
Mapping of a major genetic modifier of embryonic lethality in TGFβ1 knockout mice
-
Bonyadi, M. et al. Mapping of a major genetic modifier of embryonic lethality in TGFβ1 knockout mice. Nature Genet. 15, 207-211 (1997).
-
(1997)
Nature Genet.
, vol.15
, pp. 207-211
-
-
Bonyadi, M.1
-
188
-
-
34247617701
-
Development and validation of a phosphorylated SMAD ex vivo stimulation assay
-
Farrington, D. L. et al. Development and validation of a phosphorylated SMAD ex vivo stimulation assay. Biomarkers 12, 313-330 (2007).
-
(2007)
Biomarkers
, vol.12
, pp. 313-330
-
-
Farrington, D.L.1
-
189
-
-
33745817085
-
+ T reg cells
-
+ T reg cells. J. Exp. Med. 203, 1701-1711 (2006).
-
(2006)
J. Exp. Med.
, vol.203
, pp. 1701-1711
-
-
Liu, W.1
-
190
-
-
79955028001
-
Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes
-
McClymont, S. A. et al. Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes. J. Immunol. 186, 3918-3926 (2011).
-
(2011)
J. Immunol.
, vol.186
, pp. 3918-3926
-
-
McClymont, S.A.1
-
191
-
-
34547204632
-
Adaptive TGF-β-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment
-
You, S. et al. Adaptive TGF-β-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment. Proc. Natl Acad. Sci. USA 104, 6335-6340 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 6335-6340
-
-
You, S.1
-
192
-
-
0034901519
-
Assays for monitoring cellular immune responses to active immunotherapy of cancer
-
Clay, T. M., Hobeika, A. C., Mosca, P. J., Lyerly, H. K. & Morse, M. A. Assays for monitoring cellular immune responses to active immunotherapy of cancer. Clin. Cancer Res. 7, 1127-1135 (2001).
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 1127-1135
-
-
Clay, T.M.1
Hobeika, A.C.2
Mosca, P.J.3
Lyerly, H.K.4
Morse, M.A.5
-
193
-
-
39149139338
-
TGF-β signalling-related markers in cancer patients with bone metastasis
-
Baselga, J. et al. TGF-β signalling-related markers in cancer patients with bone metastasis. Biomarkers 13, 217-236 (2008).
-
(2008)
Biomarkers
, vol.13
, pp. 217-236
-
-
Baselga, J.1
-
194
-
-
70449338760
-
Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation
-
Bornstein, S. et al. Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation. J. Clin. Invest. 11 9, 3408-3419 (2009).
-
(2009)
J. Clin. Invest.
, vol.11
, pp. 93408-93419
-
-
Bornstein, S.1
-
195
-
-
33646537475
-
Loss of transforming growth factor-β type II receptor promotes metastatic head-and-neck squamous cell carcinoma
-
Lu, S. L. et al. Loss of transforming growth factor-β type II receptor promotes metastatic head-and-neck squamous cell carcinoma. Genes Dev. 20, 1331-1342 (2006).
-
(2006)
Genes Dev.
, vol.20
, pp. 1331-1342
-
-
Lu, S.L.1
-
196
-
-
33748208668
-
C/EBPβ at the core of the TGFβ cytostatic response and its evasion in metastatic breast cancer cells
-
Gomis, R. R., Alarcon, C., Nadal, C., Van Poznak, C. & Massague, J. C/EBPβ at the core of the TGFβ cytostatic response and its evasion in metastatic breast cancer cells. Cancer Cell 10, 203-214 (2006).
-
(2006)
Cancer Cell
, vol.10
, pp. 203-214
-
-
Gomis, R.R.1
Alarcon, C.2
Nadal, C.3
Van Poznak, C.4
Massague, J.5
-
197
-
-
70349213381
-
The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-β signaling
-
Micalizzi, D. S. et al. The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-β signaling. J. Clin. Invest. 11 9, 2678-2690 (2009).
-
(2009)
J. Clin. Invest.
, vol.11
, pp. 92678-92690
-
-
Micalizzi, D.S.1
-
198
-
-
77955295090
-
Epigenetic downregulation of human disabled homolog 2 switches TGF-β from a tumor suppressor to a tumor promoter
-
Hannigan, A. et al. Epigenetic downregulation of human disabled homolog 2 switches TGF-β from a tumor suppressor to a tumor promoter. J. Clin. Invest. 120, 2842-2857 (2010).
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 2842-2857
-
-
Hannigan, A.1
-
199
-
-
0036888908
-
Rapamycin potentiates transforming growth factor β-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells
-
Law, B. K. et al. Rapamycin potentiates transforming growth factor β-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells. Mol. Cell. Biol. 22, 8184-8198 (2002).
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 8184-8198
-
-
Law, B.K.1
-
200
-
-
43749107912
-
Acquired resistance to tyrosine kinase inhibitors during cancer therapy
-
Engelman, J. A. & Settleman, J. Acquired resistance to tyrosine kinase inhibitors during cancer therapy. Curr. Opin. Genet. Dev. 18, 73-79 (2008).
-
(2008)
Curr. Opin. Genet. Dev.
, vol.18
, pp. 73-79
-
-
Engelman, J.A.1
Settleman, J.2
-
201
-
-
78649436372
-
BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation
-
Corcoran, R. B. et al. BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation. Sci. Signal. 3, ra84 (2010).
-
(2010)
Sci. Signal.
, vol.3
-
-
Corcoran, R.B.1
-
202
-
-
78649819162
-
H17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice
-
H17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice. J. Clin. Invest. 120, 4445-4452 (2010).
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 4445-4452
-
-
Acharya, M.1
-
203
-
-
78649807601
-
H17 cell development and experimental autoimmune encephalomyelitis in mice
-
H17 cell development and experimental autoimmune encephalomyelitis in mice. J. Clin. Invest. 120, 4436-4444 (2010).
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 4436-4444
-
-
Melton, A.C.1
-
204
-
-
79959933148
-
Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling
-
Yadav, H. et al. Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling. Cell Metab. 14, 67-79 (2011).
-
(2011)
Cell Metab.
, vol.14
, pp. 67-79
-
-
Yadav, H.1
-
205
-
-
27644494876
-
Smad transcription factors
-
Massague, J., Seoane, J. & Wotton, D. Smad transcription factors. Genes Dev. 19, 2783-2810 (2005).
-
(2005)
Genes Dev.
, vol.19
, pp. 2783-2810
-
-
Massague, J.1
Seoane, J.2
Wotton, D.3
-
206
-
-
79551527246
-
Interaction of TGFβ and BMP signaling pathways during chondrogenesis
-
Keller, B. et al. Interaction of TGFβ and BMP signaling pathways during chondrogenesis. PLoS ONE 6, e16421 (2011).
-
(2011)
PLoS ONE
, vol.6
-
-
Keller, B.1
-
207
-
-
51249084135
-
Activin/TGFβ and BMP crosstalk determines digit chondrogenesis
-
Montero, J. A., Lorda-Diez, C. I., Ganan, Y., Macias, D. & Hurle, J. M. Activin/TGFβ and BMP crosstalk determines digit chondrogenesis. Dev. Biol. 321, 343-356 (2008).
-
(2008)
Dev. Biol.
, vol.321
, pp. 343-356
-
-
Montero, J.A.1
Lorda-Diez, C.I.2
Ganan, Y.3
MacIas, D.4
Hurle, J.M.5
-
208
-
-
0242330126
-
Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFβ/ALK5 signaling
-
Goumans, M. J. et al. Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFβ/ALK5 signaling. Mol. Cell 12, 817-828 (2003).
-
(2003)
Mol. Cell
, vol.12
, pp. 817-828
-
-
Goumans, M.J.1
-
209
-
-
34547187636
-
Inhibition of TGF-β2 with AP 12009 in recurrent malignant gliomas: From preclinical to phase I/II studies
-
Hau, P. et al. Inhibition of TGF-β2 with AP 12009 in recurrent malignant gliomas: from preclinical to phase I/II studies. Oligonucleotides 17, 201-212 (2007).
-
(2007)
Oligonucleotides
, vol.17
, pp. 201-212
-
-
Hau, P.1
-
210
-
-
79959962129
-
Convection-enhanced delivery of a transforming growth factor-β2 inhibitor trabedersen for recurrent high-grade gliomas: Efficacy real or imagined?, in reference to Bogdahn et al. (Neuro-Oncology 2011;13: 132-142)
-
author reply 561-552
-
Chamberlain, M. C. Convection-enhanced delivery of a transforming growth factor-β2 inhibitor trabedersen for recurrent high-grade gliomas: efficacy real or imagined?, in reference to Bogdahn et al. (Neuro-Oncology 2011;13: 132-142). Neuro Oncol. 13, 558-559; author reply 561-552 (2011).
-
(2011)
Neuro Oncol.
, vol.13
, pp. 558-559
-
-
Chamberlain, M.C.1
-
211
-
-
79959946947
-
Trabedersen to Target Transforming Growth Factor-β: When the Journey Is Not the Reward in Reference to Bogdahn et al. (Neuro-Oncology 2011;13: 132-142)
-
author reply 561-552
-
Wick, W. & Weller, M. Trabedersen to target transforming growth factor-β: when the journey is not the reward, in reference to Bogdahn et al. (Neuro-Oncology 2011;13: 132-142). Neuro Oncol. 13, 559-560; author reply 561-552 (2011).
-
(2011)
Neuro Oncol.
, vol.13
, pp. 559-560
-
-
Wick, W.1
Weller, M.2
-
212
-
-
84863415618
-
Extended adjuvant temozolomide for treatment of newly diagnosed glioblastoma multiforme
-
Roldan Urgoiti, G. B., Singh, A. D. & Easaw, J. C. Extended adjuvant temozolomide for treatment of newly diagnosed glioblastoma multiforme. J. Neurooncol. 108, 173-177 (2012).
-
(2012)
J. Neurooncol.
, vol.108
, pp. 173-177
-
-
Roldan Urgoiti, G.B.1
Singh, A.D.2
Easaw, J.C.3
-
213
-
-
84874307053
-
The oral transforming growth factor-β TGF-β) receptor i kinase inhibitor LY2157299 plus lomustine in patients with treatment-refractory malignant glioma: The first human dose study
-
Abstract 2042
-
Azaro, A. et al. The oral transforming growth factor-β (TGF-β) receptor I kinase inhibitor LY2157299 plus lomustine in patients with treatment-refractory malignant glioma: the first human dose study. J. Clin. Oncol. 30, Abstract 2042 (2012).
-
(2012)
J. Clin. Oncol.
, vol.30
-
-
Azaro, A.1
-
214
-
-
79960969401
-
Discovery and development of avotermin (recombinant human transforming growth factor β3): A new class of prophylactic therapeutic for the improvement of scarring
-
Occleston, N. L. et al. Discovery and development of avotermin (recombinant human transforming growth factor β3): a new class of prophylactic therapeutic for the improvement of scarring. Wound Repair Regen. 19 (Suppl. 1), S38-S48 (2011).
-
(2011)
Wound Repair Regen.
, vol.19
, Issue.SUPPL. 1
-
-
Occleston, N.L.1
-
215
-
-
0035400114
-
N-[3 4-dimethoxycinnamoyl]-anthranilic Acid (tranilast) Inhibits Transforming Growth Factor-β Relesase and Reduces Migration and Invasiveness of Human Malignant Glioma Cells
-
Platten, M. et al. N-[3, 4-dimethoxycinnamoyl]-anthranilic acid (tranilast) inhibits transforming growth factor-β relesase and reduces migration and invasiveness of human malignant glioma cells. Int. J. Cancer 93, 53-61 (2001).
-
(2001)
Int. J. Cancer
, vol.93
, pp. 53-61
-
-
Platten, M.1
-
216
-
-
0034028237
-
Inhibitory effects of tranilast on the proliferation and functions of human pterygium-derived fibroblasts
-
Isaji, M. et al. Inhibitory effects of tranilast on the proliferation and functions of human pterygium-derived fibroblasts. Cornea 19, 364-368 (2000).
-
(2000)
Cornea
, vol.19
, pp. 364-368
-
-
Isaji, M.1
-
217
-
-
25444497522
-
The TGF-β1 antisense oligonucleotide AP 11014 for the treatment of non-small cell lung, colorectal and prostate cancer: Preclinical studies
-
Abstract 3132
-
Schlingensiepen, K. H. et al. The TGF-β1 antisense oligonucleotide AP 11014 for the treatment of non-small cell lung, colorectal and prostate cancer: preclinical studies. J. Clin. Oncol. 22, Abstract 3132 (2004).
-
(2004)
J. Clin. Oncol.
, vol.22
-
-
Schlingensiepen, K.H.1
-
218
-
-
33745685865
-
Bone sialoprotein mediates the tumor cell-targeted prometastatic activity of transforming growth factor β in a mouse model of breast cancer
-
Nam, J. S. et al. Bone sialoprotein mediates the tumor cell-targeted prometastatic activity of transforming growth factor β in a mouse model of breast cancer. Cancer Res. 66, 6327-6335 (2006).
-
(2006)
Cancer Res.
, vol.66
, pp. 6327-6335
-
-
Nam, J.S.1
-
219
-
-
42249099019
-
LY2109761, a novel transforming growth factor β receptor type i and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis
-
Melisi, D. et al. LY2109761, a novel transforming growth factor β receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis. Mol. Cancer Ther. 7, 829-840 (2008).
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 829-840
-
-
Melisi, D.1
-
220
-
-
43949140575
-
Blocking transforming growth factor-β up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells
-
Fransvea, E., Angelotti, U., Antonaci, S. & Giannelli, G. Blocking transforming growth factor-β up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells. Hepatology 47, 1557-1566 (2008).
-
(2008)
Hepatology
, vol.47
, pp. 1557-1566
-
-
Fransvea, E.1
Angelotti, U.2
Antonaci, S.3
Giannelli, G.4
-
221
-
-
70350059078
-
Inhibition of transforming growth factor β receptor i kinase blocks hepatocellular carcinoma growth through neo-angiogenesis regulation
-
Mazzocca, A., Fransvea, E., Lavezzari, G., Antonaci, S. & Giannelli, G. Inhibition of transforming growth factor β receptor I kinase blocks hepatocellular carcinoma growth through neo-angiogenesis regulation. Hepatology 50, 1140-1151 (2009).
-
(2009)
Hepatology
, vol.50
, pp. 1140-1151
-
-
Mazzocca, A.1
Fransvea, E.2
Lavezzari, G.3
Antonaci, S.4
Giannelli, G.5
-
222
-
-
61849183646
-
Targeting transforming growth factor-β signaling in liver metastasis of colon cancer
-
Zhang, B., Halder, S. K., Zhang, S. & Datta, P. K. Targeting transforming growth factor-β signaling in liver metastasis of colon cancer. Cancer Lett. 277, 114-120 (2009).
-
(2009)
Cancer Lett.
, vol.277
, pp. 114-120
-
-
Zhang, B.1
Halder, S.K.2
Zhang, S.3
Datta, P.K.4
-
223
-
-
0036085920
-
SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type i activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
-
Inman, G. J. et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol. Pharmacol. 62, 65-74 (2002).
-
(2002)
Mol. Pharmacol.
, vol.62
, pp. 65-74
-
-
Inman, G.J.1
-
224
-
-
4444341835
-
SB-431542, a small molecule transforming growth factor-β-receptor antagonist, inhibits human glioma cell line proliferation and motility
-
Hjelmeland, M. D. et al. SB-431542, a small molecule transforming growth factor-β-receptor antagonist, inhibits human glioma cell line proliferation and motility. Mol. Cancer Ther. 3, 737-745 (2004).
-
(2004)
Mol. Cancer Ther.
, vol.3
, pp. 737-745
-
-
Hjelmeland, M.D.1
-
225
-
-
1342265719
-
SB-505124 is a selective inhibitor of transforming growth factor-β type i receptors ALK4, ALK5, and ALK7
-
DaCosta Byfield, S., Major, C., Laping, N. J. & Roberts, A. B. SB-505124 is a selective inhibitor of transforming growth factor-β type I receptors ALK4, ALK5, and ALK7. Mol. Pharmacol. 65, 744-752 (2004).
-
(2004)
Mol. Pharmacol.
, vol.65
, pp. 744-752
-
-
Dacosta Byfield, S.1
Major, C.2
Laping, N.J.3
Roberts, A.B.4
-
226
-
-
7444226411
-
SD-208, a novel transforming growth factor β receptor i kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo
-
Uhl, M. et al. SD-208, a novel transforming growth factor β receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo. Cancer Res. 64, 7954-7961 (2004).
-
(2004)
Cancer Res.
, vol.64
, pp. 7954-7961
-
-
Uhl, M.1
-
227
-
-
33751320565
-
Inhibition of growth and metastasis of mouse mammary carcinoma by selective inhibitor of transforming growth factor-β type i receptor kinase in vivo
-
Ge, R. et al. Inhibition of growth and metastasis of mouse mammary carcinoma by selective inhibitor of transforming growth factor-β type I receptor kinase in vivo. Clin. Cancer Res. 12, 4315-4330 (2006).
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 4315-4330
-
-
Ge, R.1
-
228
-
-
33947246042
-
A novel small-molecule inhibitor of transforming growth factor β type i receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection
-
Suzuki, E. et al. A novel small-molecule inhibitor of transforming growth factor β type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection. Cancer Res. 67, 2351-2359 (2007).
-
(2007)
Cancer Res.
, vol.67
, pp. 2351-2359
-
-
Suzuki, E.1
-
229
-
-
57749107585
-
Systemic blockade of transforming growth factor-β signaling augments the efficacy of immunogene therapy
-
Kim, S. et al. Systemic blockade of transforming growth factor-β signaling augments the efficacy of immunogene therapy. Cancer Res. 68, 10247-10256 (2008).
-
(2008)
Cancer Res.
, vol.68
, pp. 10247-10256
-
-
Kim, S.1
-
230
-
-
33645665682
-
Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N- (tetrahydro-2H-pyran-4-yl)benzamide (GW788388): A potent, selective, and orally active transforming growth factor-β type i receptor inhibitor
-
Gellibert, F. et al. Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl] pyridin-2-yl}-N-(tetrahydro-2H-pyran-4-yl)benzamide (GW788388): a potent, selective, and orally active transforming growth factor-β type I receptor inhibitor. J. Med. Chem. 49, 2210-2221 (2006).
-
(2006)
J. Med. Chem.
, vol.49
, pp. 2210-2221
-
-
Gellibert, F.1
-
231
-
-
40049099699
-
Oral administration of GW788388, an inhibitor of TGF-β type i and II receptor kinases, decreases renal fibrosis
-
Petersen, M. et al. Oral administration of GW788388, an inhibitor of TGF-β type I and II receptor kinases, decreases renal fibrosis. Kidney Int. 73, 705-715 (2008).
-
(2008)
Kidney Int.
, vol.73
, pp. 705-715
-
-
Petersen, M.1
-
232
-
-
77951784020
-
Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction
-
Tan, S. M., Zhang, Y., Connelly, K. A., Gilbert, R. E. & Kelly, D. J. Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction. Am. J. Physiol. Heart Circ. Physiol. 298, H1415-H1425 (2010).
-
(2010)
Am. J. Physiol. Heart Circ. Physiol.
, vol.298
-
-
Tan, S.M.1
Zhang, Y.2
Connelly, K.A.3
Gilbert, R.E.4
Kelly, D.J.5
|