Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche

Nature Medicine

Volumn 21, Issue 1, 2015, Pages 62-70

  Davis, Hayley ^a   Irshad, Shazia ^a   Bansal, Mukesh ^b   Rafferty, Hannah ^a   Boitsova, Tatjana ^a,c   Bardella, Chiara ^a   Jaeger, Emma ^a   Lewis, Annabelle ^a   Freeman Mills, Luke ^a   Giner, Francesc C ^a   Rodenas Cuadrado, Pedro ^a   Mallappa, Sreelakshmi ^d   Clark, Susan ^d   Thomas, Huw ^d   Jeffery, Rosemary ^c   Poulsom, Richard ^c   Rodriguez Justo, Manuel ^e   Novelli, Marco ^e   Chetty, Runjan ^f   Silver, Andrew ^c   Sansom, Owen J ^g   Greten, Florian R ^h   Wang, Lai Mun ⁱ   East, James E ^j   Tomlinson, Ian ^a   Leedham, Simon J ^a,j   more..

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b NewYork Presbyterian Hospital   (United States)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^d ST MARK S HOSPITAL   (United Kingdom)

^e UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^f UNIVERSITY HEALTH NETWORK   (Canada)

^g BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^h INSTITUTE FOR TUMOR BIOLOGY AND EXPERIMENTAL THERAPY   (Germany)

ⁱ JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^j UNIVERSITY OF OXFORD   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GREM1 PROTEIN, HUMAN; LGR5 PROTEIN, MOUSE; SIGNAL PEPTIDE;

ANIMAL; BIOSYNTHESIS; CARCINOGENESIS; CELL PROLIFERATION; COLORECTAL TUMOR; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; INTESTINE MUCOSA; METABOLISM; MOUSE; MUTATION; PATHOLOGY; STEM CELL NICHE;

ANIMALS; CARCINOGENESIS; CELL PROLIFERATION; COLORECTAL NEOPLASMS; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTESTINAL MUCOSA; MICE; MUTATION; RECEPTORS, G-PROTEIN-COUPLED; STEM CELL NICHE;

EID: 84924244580     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3750     Document Type: Article

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