Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling

Cell Reports

Volumn 16, Issue 1, 2016, Pages 28-36

  Hwang, So Young ^a   Deng, Xianming ^b   Byun, Sanguine ^a   Lee, Chan ^a   Lee, Seung Joo ^c   Suh, Hyunsuk ^c   Zhang, Jianming ^a   Kang, Qiaofeng ^b   Zhang, Ting ^b   Westover, Kenneth D ^d   Mandinova, Anna ^a,e   Lee, Sam W ^a,e  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b XIAMEN UNIVERSITY   (China)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; METHYL 3 [[(4 METHYLPHENYL)SULFONYL]AMINO]BENZOATE; PROTEASOME; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; WNT PROTEIN; 3 AMINOBENZOIC ACID DERIVATIVE; BENZOIC ACID DERIVATIVE; METHYL 3-(((4-METHYLPHENYL)SULFONYL)AMINO)BENZOATE; SULFONAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG DISTRIBUTION; DRUG STRUCTURE; DRUG TARGETING; DRUG TISSUE LEVEL; ENZYME DEGRADATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALIGNANT NEOPLASM; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; ANIMAL; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; METABOLISM; MOLECULAR LIBRARY; ONCOGENE; PHARMACOLOGY; PROTEIN DEGRADATION; TUMOR CELL LINE; WNT SIGNALING;

ANIMALS; BENZOATES; BETA CATENIN; CELL LINE, TUMOR; META-AMINOBENZOATES; MICE; ONCOGENES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; SMALL MOLECULE LIBRARIES; SULFONAMIDES; WNT SIGNALING PATHWAY; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84991063920     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.05.071     Document Type: Article

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