Stroma-directed imatinib therapy impairs the tumor-promoting effect of bone marrow-derived mesenchymal stem cells in an orthotopic transplantation model of colon cancer

International Journal of Cancer

Volumn 132, Issue 4, 2012, Pages 813-823

  Shinagawa, Kei ^a   Kitadai, Yasuhiko ^a   Tanaka, Miwako ^a   Sumida, Tomonori ^a   Onoyama, Mieko ^a   Ohnishi, Mayu ^a   Ohara, Eiji ^a   Higashi, Yukihito ^a   Tanaka, Shinji ^b   Yasui, Wataru ^a   Chayama, Kazuaki ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY HOSPITAL   (Japan)

Author keywords

carcinoma associated fibroblasts; imatinib; mesenchymal stem cells; orthotopic colon cancer model; platelet derived growth factor receptor

Indexed keywords

IMATINIB; PLATELET DERIVED GROWTH FACTOR RECEPTOR;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CELL INTERACTION; CELL PROLIFERATION; COLON CANCER; CONTROLLED STUDY; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER METASTASIS; MESENCHYMAL STEM CELL TRANSPLANTATION; MOUSE; NONHUMAN; ORTHOTOPIC TRANSPLANTATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR BLOCKING; SIGNAL TRANSDUCTION; TUMOR MICROENVIRONMENT; TUMOR VOLUME;

ANIMALS; APOPTOSIS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; COLONIC NEOPLASMS; FEMALE; HUMANS; LIVER NEOPLASMS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; PIPERAZINES; PYRIMIDINES; RANDOM ALLOCATION; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; SIGNAL TRANSDUCTION; TRANSPLANTATION, HETEROLOGOUS; TUMOR MICROENVIRONMENT;

EID: 84871365780     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.27735     Document Type: Article

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