-
1
-
-
79551643707
-
Framework models of tumor dormancy from patient-derived observations
-
Klein, C. A. Framework models of tumor dormancy from patient-derived observations. Curr. Opin. Genet. Dev. 21, 42-49 (2010
-
(2010)
Curr. Opin. Genet. Dev
, vol.21
, pp. 42-49
-
-
Klein, C.A.1
-
2
-
-
78649467513
-
Does tumour dormancy offer a therapeutic target?
-
Goss, P. E. & Chambers, A. F. Does tumour dormancy offer a therapeutic target?. Nature Rev. Cancer 10, 871-877 (2010
-
(2010)
Nature Rev. Cancer
, vol.10
, pp. 871-877
-
-
Goss, P.E.1
Chambers, A.F.2
-
3
-
-
84884369881
-
Selection and adaptation during metastatic cancer progression
-
Klein, C. A. Selection and adaptation during metastatic cancer progression. Nature 501, 365-372 (2013
-
(2013)
Nature
, vol.501
, pp. 365-372
-
-
Klein, C.A.1
-
4
-
-
35548936833
-
Models mechanisms and clinical evidence for cancer dormancy
-
Aguirre-Ghiso, J. A. Models, mechanisms and clinical evidence for cancer dormancy. Nature Rev. Cancer 7, 834-846 (2007
-
(2007)
Nature Rev. Cancer
, vol.7
, pp. 834-846
-
-
Aguirre-Ghiso, J.A.1
-
5
-
-
24044520722
-
Breast cancer recurrence dynamics following adjuvant CMF is consistent with tumor dormancy and mastectomy-driven acceleration of the metastatic process
-
Demicheli, R. et al. Breast cancer recurrence dynamics following adjuvant CMF is consistent with tumor dormancy and mastectomy-driven acceleration of the metastatic process. Ann. Oncol. 16, 1449-1457 (2005
-
(2005)
Ann. Oncol
, vol.16
, pp. 1449-1457
-
-
Demicheli, R.1
-
6
-
-
0007712368
-
The dormant cancer cell
-
Hadfield, G. The dormant cancer cell. Br. Med. J. 2, 607-610 (1954
-
(1954)
Br. Med. J.
, vol.2
, pp. 607-610
-
-
Hadfield, G.1
-
7
-
-
68549137924
-
Cancer micrometastases
-
Pantel, K., Alix-Panabieres, C. & Riethdorf, S. Cancer micrometastases. Nature Rev. Clin. Oncol. 6, 339-351 (2009
-
(2009)
Nature Rev. Clin. Oncol
, vol.6
, pp. 339-351
-
-
Pantel, K.1
Alix-Panabieres, C.2
Riethdorf, S.3
-
9
-
-
63049102497
-
Parallel progression of primary tumours and metastases
-
Klein, C. A. Parallel progression of primary tumours and metastases. Nature Rev. Cancer 9, 302-312 (2009
-
(2009)
Nature Rev. Cancer
, vol.9
, pp. 302-312
-
-
Klein, C.A.1
-
10
-
-
77956611808
-
Targeting leukemic stem cells by breaking their dormancy
-
Essers, M. A. & Trumpp, A. Targeting leukemic stem cells by breaking their dormancy. Mol. Oncol. 4, 443-450 (2010
-
(2010)
Mol. Oncol
, vol.4
, pp. 443-450
-
-
Essers, M.A.1
Trumpp, A.2
-
11
-
-
80052867880
-
ERK1/2 and p38α/β signaling in tumor cell quiescence: Opportunities to control dormant residual disease
-
Sosa, M. S., Avivar-Valderas, A., Bragado, P., Wen, H. C. & Aguirre-Ghiso, J. A. ERK1/2 and p38α/β signaling in tumor cell quiescence: Opportunities to control dormant residual disease. Clin. Cancer Res. 17, 5850-5857 (2011
-
(2011)
Clin. Cancer Res
, vol.17
, pp. 5850-5857
-
-
Sosa, M.S.1
Avivar-Valderas, A.2
Bragado, P.3
Wen, H.C.4
Aguirre-Ghiso, J.A.5
-
12
-
-
84877816994
-
Tumor cell dissemination: Emerging biological insights from animal models and cancer patients
-
Kang, Y. & Pantel, K. Tumor cell dissemination: Emerging biological insights from animal models and cancer patients. Cancer Cell 23, 573-581 (2013
-
(2013)
Cancer Cell
, vol.23
, pp. 573-581
-
-
Kang, Y.1
Pantel, K.2
-
13
-
-
84887981252
-
Mechanisms governing metastatic dormancy and reactivation
-
Giancotti, F. G. Mechanisms governing metastatic dormancy and reactivation. Cell 155, 750-764 (2013
-
(2013)
Cell
, vol.155
, pp. 750-764
-
-
Giancotti, F.G.1
-
14
-
-
46149112156
-
Cancer cell-derived clusterin modulates the phosphatidylinositol 3'-kinase-Akt pathway through attenuation of insulin-like growth factor 1 during serum deprivation
-
Jo, H., Jia, Y., Subramanian, K. K., Hattori, H. & Luo, H. R. Cancer cell-derived clusterin modulates the phosphatidylinositol 3'-kinase-Akt pathway through attenuation of insulin-like growth factor 1 during serum deprivation. Mol. Cell. Biol. 28, 4285-4299 (2008
-
(2008)
Mol. Cell. Biol
, vol.28
, pp. 4285-4299
-
-
Jo, H.1
Jia, Y.2
Subramanian, K.K.3
Hattori, H.4
Luo, H.R.5
-
15
-
-
77649182472
-
Differential epidermal growth factor receptor signaling regulates anchorage-independent growth by modulation of the PI3K/AKT pathway
-
Humtsoe, J. O. & Kramer, R. H. Differential epidermal growth factor receptor signaling regulates anchorage-independent growth by modulation of the PI3K/AKT pathway. Oncogene 29, 1214-1226 (2010
-
(2010)
Oncogene
, vol.29
, pp. 1214-1226
-
-
Humtsoe, J.O.1
Kramer, R.H.2
-
16
-
-
84860668033
-
The interplay of HER2/HER3/PI3K and EGFR/HER2/PLC γ1 signalling in breast cancer cell migration and dissemination
-
Balz, L. M. et al. The interplay of HER2/HER3/PI3K and EGFR/HER2/PLC γ1 signalling in breast cancer cell migration and dissemination. J. Pathol. 227, 234-244 (2012
-
(2012)
J. Pathol
, vol.227
, pp. 234-244
-
-
Balz, L.M.1
-
17
-
-
48749105093
-
ATF6α Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo
-
Schewe, D. M. & Aguirre-Ghiso, J. A. ATF6α Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo. Proc. Natl Acad. Sci. USA 105, 10519-10524 (2008
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 10519-10524
-
-
Schewe, D.M.1
Aguirre-Ghiso, J.A.2
-
18
-
-
84887219089
-
TGF β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling
-
Bragado, P. et al. TGF β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling. Nature Cell Biol. 15, 1351-1361 (2013
-
(2013)
Nature Cell Biol
, vol.15
, pp. 1351-1361
-
-
Bragado, P.1
-
19
-
-
83455208311
-
VCAM 1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1 positive osteoclast progenitors
-
Lu, X. et al. VCAM 1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1 positive osteoclast progenitors. Cancer Cell 20, 701-714 (2011
-
(2011)
Cancer Cell
, vol.20
, pp. 701-714
-
-
Lu, X.1
-
20
-
-
0026503190
-
Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor
-
Aslakson, C. J. & Miller, F. R. Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor. Cancer Res. 52, 1399-1405 (1992
-
(1992)
Cancer Res
, vol.52
, pp. 1399-1405
-
-
Aslakson, C.J.1
Miller, F.R.2
-
21
-
-
0025964244
-
Differential influence of organ site on three subpopulations of a single mouse mammary tumor at two distinct steps in metastasis
-
Aslakson, C. J., Rak, J. W., Miller, B. E. & Miller, F. R. Differential influence of organ site on three subpopulations of a single mouse mammary tumor at two distinct steps in metastasis. Int. J. Cancer 47, 466-472 (1991
-
(1991)
Int. J. Cancer
, vol.47
, pp. 466-472
-
-
Aslakson, C.J.1
Rak, J.W.2
Miller, B.E.3
Miller, F.R.4
-
22
-
-
84885582468
-
Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK
-
Avivar-Valderas, A. et al. Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK. Oncogene 32, 4932-4940 (2013
-
(2013)
Oncogene
, vol.32
, pp. 4932-4940
-
-
Avivar-Valderas, A.1
-
23
-
-
84855405986
-
Modulation of AKT activity is associated with reversible dormancy in ascites-derived epithelial ovarian cancer spheroids
-
Correa, R. J., Peart, T., Valdes, Y. R., DiMattia, G. E. & Shepherd, T. G. Modulation of AKT activity is associated with reversible dormancy in ascites-derived epithelial ovarian cancer spheroids. Carcinogenesis 33, 49-58 (2012
-
(2012)
Carcinogenesis
, vol.33
, pp. 49-58
-
-
Correa, R.J.1
Peart, T.2
Valdes, Y.R.3
Dimattia, G.E.4
Shepherd, T.G.5
-
24
-
-
77956495728
-
Ovarian cancer development and metastasis
-
Lengyel, E. Ovarian cancer development and metastasis. Am. J. Pathol. 177, 1053-1064 (2010
-
(2010)
Am. J. Pathol
, vol.177
, pp. 1053-1064
-
-
Lengyel, E.1
-
25
-
-
57449121645
-
The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells
-
Lu, Z. et al. The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells. J. Clin. Invest. 118, 3917-3929 (2008
-
(2008)
J. Clin. Invest
, vol.118
, pp. 3917-3929
-
-
Lu, Z.1
-
26
-
-
77956282607
-
Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST)
-
Gupta, A. et al. Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST). Proc. Natl Acad. Sci. USA 107, 14333-14338 (2010
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 14333-14338
-
-
Gupta, A.1
-
27
-
-
84859639962
-
Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress
-
Lee, I. H. et al. Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress. Science 336, 225-228 (2012
-
(2012)
Science
, vol.336
, pp. 225-228
-
-
Lee, I.H.1
-
28
-
-
79952728102
-
The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance
-
Mortensen, M. et al. The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance. J. Exp. Med. 208, 455-467 (2011
-
(2011)
J. Exp. Med
, vol.208
, pp. 455-467
-
-
Mortensen, M.1
-
29
-
-
80052342419
-
PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment
-
Avivar-Valderas, A. et al. PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment. Mol. Cell. Biol. 31, 3616-3629 (2011
-
(2011)
Mol. Cell. Biol
, vol.31
, pp. 3616-3629
-
-
Avivar-Valderas, A.1
-
30
-
-
33947250696
-
The energy sensing LKB1 AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis
-
Liang, J. et al. The energy sensing LKB1 AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nature Cell Biol. 9, 218-224 (2007
-
(2007)
Nature Cell Biol
, vol.9
, pp. 218-224
-
-
Liang, J.1
-
31
-
-
60549106248
-
Inhibition of eIF2α dephosphorylation maximizes bortezomib efficiency and eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy
-
Schewe, D. M. & Aguirre-Ghiso, J. A. Inhibition of eIF2α dephosphorylation maximizes bortezomib efficiency and eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy. Cancer Res. 69, 1545-1552 (2009
-
(2009)
Cancer Res
, vol.69
, pp. 1545-1552
-
-
Schewe, D.M.1
Aguirre-Ghiso, J.A.2
-
32
-
-
79959916680
-
MET-independent lung cancer cells evading EGFR kinase inhibitors are therapeutically susceptible to BH3 mimetic agents
-
Fan, W. et al. MET-independent lung cancer cells evading EGFR kinase inhibitors are therapeutically susceptible to BH3 mimetic agents. Cancer Res. 71, 4494-4505 (2011
-
(2011)
Cancer Res
, vol.71
, pp. 4494-4505
-
-
Fan, W.1
-
33
-
-
84880033826
-
Par 4 downregulation promotes breast cancer recurrence by preventing multinucleation following targeted therapy
-
Alvarez, J. V. et al. Par 4 downregulation promotes breast cancer recurrence by preventing multinucleation following targeted therapy. Cancer Cell 24, 30-44 (2013
-
(2013)
Cancer Cell
, vol.24
, pp. 30-44
-
-
Alvarez, J.V.1
-
34
-
-
65949118505
-
Mirk/Dyrk1B maintains the viability of quiescent pancreatic cancer cells by reducing levels of reactive oxygen species
-
Deng, X., Ewton, D. Z. & Friedman, E. Mirk/Dyrk1B maintains the viability of quiescent pancreatic cancer cells by reducing levels of reactive oxygen species. Cancer Res. 69, 3317-3324 (2009
-
(2009)
Cancer Res
, vol.69
, pp. 3317-3324
-
-
Deng, X.1
Ewton, D.Z.2
Friedman, E.3
-
35
-
-
69249110053
-
Mirk regulates the exit of colon cancer cells from quiescence
-
Jin, K., Ewton, D. Z., Park, S., Hu, J. & Friedman, E. Mirk regulates the exit of colon cancer cells from quiescence. J. Biol. Chem. 284, 22916-22925 (2009
-
(2009)
J. Biol. Chem
, vol.284
, pp. 22916-22925
-
-
Jin, K.1
Ewton, D.Z.2
Park, S.3
Hu, J.4
Friedman, E.5
-
36
-
-
81055127017
-
Inactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells
-
Ewton, D. Z. et al. Inactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells. Mol. Cancer Ther. 10, 2104-2114 (2011
-
(2011)
Mol. Cancer Ther
, vol.10
, pp. 2104-2114
-
-
Ewton, D.Z.1
-
37
-
-
79961121875
-
Transient arrest in a quiescent state allows ovarian cancer cells to survive suboptimal growth conditions and is mediated by both Mirk/dyrk1b and p130/RB2
-
Hu, J., Nakhla, H. & Friedman, E. Transient arrest in a quiescent state allows ovarian cancer cells to survive suboptimal growth conditions and is mediated by both Mirk/dyrk1b and p130/RB2. Int. J. Cancer 129, 307-318 (2011
-
(2011)
Int. J. Cancer
, vol.129
, pp. 307-318
-
-
Hu, J.1
Nakhla, H.2
Friedman, E.3
-
38
-
-
34547630697
-
The survival kinase Mirk/Dyrk1B is a downstream effector of oncogenic K-ras in pancreatic cancer
-
Jin, K., Park, S., Ewton, D. Z. & Friedman, E. The survival kinase Mirk/Dyrk1B is a downstream effector of oncogenic K-ras in pancreatic cancer. Cancer Res. 67, 7247-7255 (2007
-
(2007)
Cancer Res
, vol.67
, pp. 7247-7255
-
-
Jin, K.1
Park, S.2
Ewton, D.Z.3
Friedman, E.4
-
39
-
-
79955432610
-
DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly
-
Litovchick, L., Florens, L. A., Swanson, S. K., Washburn, M. P. & DeCaprio, J. A. DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly. Genes Dev. 25, 801-813 (2011
-
(2011)
Genes Dev
, vol.25
, pp. 801-813
-
-
Litovchick, L.1
Florens, L.A.2
Swanson, S.K.3
Washburn, M.P.4
Decaprio, J.A.5
-
40
-
-
47649125318
-
Tuning gene expression to changing environments: From rapid responses to evolutionary adaptation
-
Lopez-Maury, L., Marguerat, S. & Bahler, J. Tuning gene expression to changing environments: From rapid responses to evolutionary adaptation. Nature Rev. Genet. 9, 583-593 (2008
-
(2008)
Nature Rev. Genet
, vol.9
, pp. 583-593
-
-
Lopez-Maury, L.1
Marguerat, S.2
Bahler, J.3
-
41
-
-
79955434511
-
Farnesyl transferase inhibitor treatment of breast cancer cells leads to altered RhoA and RhoC GTPase activity and induces a dormant phenotype
-
Chatterjee, M. & van Golen, K. L. Farnesyl transferase inhibitor treatment of breast cancer cells leads to altered RhoA and RhoC GTPase activity and induces a dormant phenotype. Int. J. Cancer 129, 61-69 (2011
-
(2011)
Int. J. Cancer
, vol.129
, pp. 61-69
-
-
Chatterjee, M.1
Van Golen, K.L.2
-
42
-
-
33644502513
-
The p38 kinases MKK4 and MKK6 suppress metastatic colonization in human ovarian carcinoma
-
Hickson, J. A. et al. The p38 kinases MKK4 and MKK6 suppress metastatic colonization in human ovarian carcinoma. Cancer Res. 66, 2264-2270 (2006
-
(2006)
Cancer Res
, vol.66
, pp. 2264-2270
-
-
Hickson, J.A.1
-
43
-
-
28244493042
-
Suppression of metastatic colonization by the context-dependent activation of the c-Jun NH2 terminal kinase kinases JNKK1/MKK4 and MKK7
-
Vander Griend, D. J. et al. Suppression of metastatic colonization by the context-dependent activation of the c-Jun NH2 terminal kinase kinases JNKK1/MKK4 and MKK7. Cancer Res. 65, 10984-10991 (2005
-
(2005)
Cancer Res
, vol.65
, pp. 10984-10991
-
-
Vander Griend, D.J.1
-
44
-
-
67651003108
-
Computational identification of a p38SAPK regulated transcription factor network required for tumor cell quiescence
-
Adam, A. P. et al. Computational identification of a p38SAPK regulated transcription factor network required for tumor cell quiescence. Cancer Res. 69, 5664-5672 (2009
-
(2009)
Cancer Res
, vol.69
, pp. 5664-5672
-
-
Adam, A.P.1
-
45
-
-
33644502513
-
The p38 kinases MKK4 and MKK6 suppress metastatic colonization in human ovarian carcinoma
-
Hickson, J. A. et al. The p38 kinases MKK4 and MKK6 suppress metastatic colonization in human ovarian carcinoma. Cancer Res. 66, 2264-2270 (2006
-
(2006)
Cancer Res
, vol.66
, pp. 2264-2270
-
-
Hickson, J.A.1
-
46
-
-
84892903022
-
Combined SFK/MEK inhibition prevents metastatic outgrowth of dormant tumor cells
-
El Touny, L. H. et al. Combined SFK/MEK inhibition prevents metastatic outgrowth of dormant tumor cells. J. Clin. Invest. 124, 156-168 (2014
-
(2014)
J. Clin. Invest
, vol.124
, pp. 156-168
-
-
El Touny, L.H.1
-
47
-
-
0034677067
-
Activation of the p38 mitogen-Activated protein kinase pathway arrests cell cycle progression and differentiation of immature thymocytes in vivo
-
Diehl, N. L. et al. Activation of the p38 mitogen-Activated protein kinase pathway arrests cell cycle progression and differentiation of immature thymocytes in vivo. J. Exp. Med. 191, 321-334 (2000
-
(2000)
J. Exp. Med
, vol.191
, pp. 321-334
-
-
Diehl, N.L.1
-
48
-
-
79954441639
-
Notch3 mediated regulation of MKP 1 levels promotes survival of T acute lymphoblastic leukemia cells
-
Masiero, M. et al. Notch3 mediated regulation of MKP 1 levels promotes survival of T acute lymphoblastic leukemia cells. Leukemia 25, 588-598 (2011
-
(2011)
Leukemia
, vol.25
, pp. 588-598
-
-
Masiero, M.1
-
49
-
-
82255173966
-
The unfolded protein response: From stress pathway to homeostatic regulation
-
Walter, P. & Ron, D. The unfolded protein response: From stress pathway to homeostatic regulation. Science 334, 1081-1086 (2011
-
(2011)
Science
, vol.334
, pp. 1081-1086
-
-
Walter, P.1
Ron, D.2
-
50
-
-
32944478891
-
Functional coupling of p38 induced up-regulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells
-
Ranganathan, A. C., Zhang, L., Adam, A. P. & Aguirre-Ghiso, J. A. Functional coupling of p38 induced up-regulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells. Cancer Res. 66, 1702-1711 (2006
-
(2006)
Cancer Res
, vol.66
, pp. 1702-1711
-
-
Ranganathan, A.C.1
Zhang, L.2
Adam, A.P.3
Aguirre-Ghiso, J.A.4
-
51
-
-
34248549003
-
GRP78/BiP inhibits endoplasmic reticulum BIK and protects human breast cancer cells against estrogen starvation-induced apoptosis
-
Fu, Y., Li, J. & Lee, A. S. GRP78/BiP inhibits endoplasmic reticulum BIK and protects human breast cancer cells against estrogen starvation-induced apoptosis. Cancer Res. 67, 3734-3740 (2007
-
(2007)
Cancer Res
, vol.67
, pp. 3734-3740
-
-
Fu, Y.1
Li, J.2
Lee, A.S.3
-
52
-
-
77954592806
-
Discovery of a novel unfolded protein response phenotype of cancer stem/progenitor cells from the bone marrow of breast cancer patients
-
Bartkowiak, K. et al. Discovery of a novel unfolded protein response phenotype of cancer stem/progenitor cells from the bone marrow of breast cancer patients. J. Proteome Res. 9, 3158-3168 (2010
-
(2010)
J. Proteome Res
, vol.9
, pp. 3158-3168
-
-
Bartkowiak, K.1
-
53
-
-
65249142761
-
Two-dimensional differential gel electrophoresis of a cell line derived from a breast cancer micrometastasis revealed a stem/ progenitor cell protein profile
-
Bartkowiak, K. et al. Two-dimensional differential gel electrophoresis of a cell line derived from a breast cancer micrometastasis revealed a stem/ progenitor cell protein profile. J. Proteome Res. 8, 2004-2014 (2009
-
(2009)
J. Proteome Res
, vol.8
, pp. 2004-2014
-
-
Bartkowiak, K.1
-
54
-
-
27144458505
-
ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth
-
Bi, M. et al. ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. EMBO J. 24, 3470-3481 (2005
-
(2005)
EMBO J.
, vol.24
, pp. 3470-3481
-
-
Bi, M.1
-
55
-
-
84900342698
-
Direct measurement of local oxygen concentration in the bone marrow of live animals
-
Spencer, J. A. et al. Direct measurement of local oxygen concentration in the bone marrow of live animals. Nature 508, 269-273 (2014
-
(2014)
Nature
, vol.508
, pp. 269-273
-
-
Spencer, J.A.1
-
56
-
-
84862072111
-
Low glucose under hypoxic conditions induces unfolded protein response and produces reactive oxygen species in lens epithelial cells
-
Elanchezhian, R. et al. Low glucose under hypoxic conditions induces unfolded protein response and produces reactive oxygen species in lens epithelial cells. Cell Death Dis. 3, e301 (2012
-
(2012)
Cell Death Dis
, vol.3
-
-
Elanchezhian, R.1
-
57
-
-
79959979647
-
Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE 1 pathways and of caspase 12
-
Badiola, N. et al. Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE 1 pathways and of caspase 12. Cell Death Dis. 2, e149 (2011
-
(2011)
Cell Death Dis
, vol.2
-
-
Badiola, N.1
-
58
-
-
33748076770
-
GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer
-
Lee, E. et al. GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer. Cancer Res. 66, 7849-7853 (2006
-
(2006)
Cancer Res
, vol.66
, pp. 7849-7853
-
-
Lee, E.1
-
59
-
-
67349261322
-
Cytokeratin 19 regulates endoplasmic reticulum stress and inhibits ERp29 expression via p38 MAPK/XBP 1 signaling in breast cancer cells
-
Bambang, I. F. et al. Cytokeratin 19 regulates endoplasmic reticulum stress and inhibits ERp29 expression via p38 MAPK/XBP 1 signaling in breast cancer cells. Exp. Cell Res. 315, 1964-1974 (2009
-
(2009)
Exp. Cell Res
, vol.315
, pp. 1964-1974
-
-
Bambang, I.F.1
-
60
-
-
84891882638
-
Brain metastases from breast cancer: Lessons from experimental magnetic resonance imaging studies and clinical implications
-
Murrell, D. H., Foster, P. J. & Chambers, A. F. Brain metastases from breast cancer: Lessons from experimental magnetic resonance imaging studies and clinical implications. J. Mol. Med. 92, 5-12 (2014
-
(2014)
J. Mol. Med
, vol.92
, pp. 5-12
-
-
Murrell, D.H.1
Foster, P.J.2
Chambers, A.F.3
-
61
-
-
33750624652
-
In vivo MRI of cancer cell fate at the single-cell level in a mouse model of breast cancer metastasis to the brain
-
Heyn, C. et al. In vivo MRI of cancer cell fate at the single-cell level in a mouse model of breast cancer metastasis to the brain. Magn. Reson. Med. 56, 1001-1010 (2006
-
(2006)
Magn. Reson. Med
, vol.56
, pp. 1001-1010
-
-
Heyn, C.1
-
62
-
-
0347504928
-
Ineffectiveness of doxorubicin treatment on solitary dormant mammary carcinoma cells or late-developing metastases
-
Naumov, G. N. et al. Ineffectiveness of doxorubicin treatment on solitary dormant mammary carcinoma cells or late-developing metastases. Breast Cancer Res. Treat 82, 199-206 (2003
-
(2003)
Breast Cancer Res. Treat
, vol.82
, pp. 199-206
-
-
Naumov, G.N.1
-
63
-
-
84875173347
-
Metastasis awakening: Targeting dormant cancer
-
Aguirre-Ghiso, J. A., Bragado, P. & Sosa, M. S. Metastasis awakening: Targeting dormant cancer. Nature Med. 19, 276-277 (2013
-
(2013)
Nature Med
, vol.19
, pp. 276-277
-
-
Aguirre-Ghiso, J.A.1
Bragado, P.2
Sosa, M.S.3
-
64
-
-
84860595935
-
Microenvironments dictating tumor cell dormancy
-
Bragado, P., Sosa, M. S., Keely, P., Condeelis, J. & Aguirre-Ghiso, J. A. Microenvironments dictating tumor cell dormancy. Recent Results Cancer Res. 195, 25-39 (2012
-
(2012)
Recent Results Cancer Res
, vol.195
, pp. 25-39
-
-
Bragado, P.1
Sosa, M.S.2
Keely, P.3
Condeelis, J.4
Aguirre-Ghiso, J.A.5
-
65
-
-
24944534497
-
Genomic analysis of single cytokeratin-positive cells from bone marrow reveals early mutational events in breast cancer
-
Schardt, J. A. et al. Genomic analysis of single cytokeratin-positive cells from bone marrow reveals early mutational events in breast cancer. Cancer Cell 8, 227-239 (2005
-
(2005)
Cancer Cell
, vol.8
, pp. 227-239
-
-
Schardt, J.A.1
-
66
-
-
37349079197
-
Systemic spread is an early step in breast cancer
-
Husemann, Y. et al. Systemic spread is an early step in breast cancer. Cancer Cell 13, 58-68 (2008
-
(2008)
Cancer Cell
, vol.13
, pp. 58-68
-
-
Husemann, Y.1
-
67
-
-
43749115751
-
The bone marrow niche: Habitat to hematopoietic and mesenchymal stem cells, and unwitting host to molecular parasites
-
Shiozawa, Y., Havens, A. M., Pienta, K. J. & Taichman, R. S. The bone marrow niche: Habitat to hematopoietic and mesenchymal stem cells, and unwitting host to molecular parasites. Leukemia 22, 941-950 (2008
-
(2008)
Leukemia
, vol.22
, pp. 941-950
-
-
Shiozawa, Y.1
Havens, A.M.2
Pienta, K.J.3
Taichman, R.S.4
-
68
-
-
84884222594
-
Erythropoietin supports the survival of prostate cancer, but not growth and bone metastasis
-
Shiozawa, Y. et al. Erythropoietin supports the survival of prostate cancer, but not growth and bone metastasis. J. Cell. Biochem. 114, 2471-2478 (2013
-
(2013)
J. Cell. Biochem
, vol.114
, pp. 2471-2478
-
-
Shiozawa, Y.1
-
69
-
-
84863338444
-
Disseminated prostate cancer cells can instruct hematopoietic stem and progenitor cells to regulate bone phenotype
-
Joseph, J. et al. Disseminated prostate cancer cells can instruct hematopoietic stem and progenitor cells to regulate bone phenotype. Mol. Cancer Res.: MCR 10, 282-292 (2012
-
(2012)
Mol. Cancer Res.: MCR
, vol.10
, pp. 282-292
-
-
Joseph, J.1
-
70
-
-
79953331206
-
Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow
-
Shiozawa, Y. et al. Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow. J. Clin. Invest. 121, 1298-1312 (2011
-
(2011)
J. Clin. Invest
, vol.121
, pp. 1298-1312
-
-
Shiozawa, Y.1
-
71
-
-
84862917865
-
Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone
-
Kobayashi, A. et al. Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone. J. Exp. Med. 208, 2641-2655 (2011
-
(2011)
J. Exp. Med
, vol.208
, pp. 2641-2655
-
-
Kobayashi, A.1
-
72
-
-
84865218588
-
The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites
-
Gao, H. et al. The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites. Cell 150, 764-779 (2012
-
(2012)
Cell
, vol.150
, pp. 764-779
-
-
Gao, H.1
-
73
-
-
0034710974
-
Hematopoietic progenitor cells grow on 3T3 fibroblast monolayers that overexpress growth arrest-specific gene 6 (GAS6)
-
Dormady, S. P., Zhang, X. M. & Basch, R. S. Hematopoietic progenitor cells grow on 3T3 fibroblast monolayers that overexpress growth arrest-specific gene 6 (GAS6). Proc. Natl Acad. Sci. USA 97, 12260-12265 (2000
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 12260-12265
-
-
Dormady, S.P.1
Zhang, X.M.2
Basch, R.S.3
-
74
-
-
76749109371
-
GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche
-
Shiozawa, Y. et al. GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche. Neoplasia 12, 116-127 (2010
-
(2010)
Neoplasia
, vol.12
, pp. 116-127
-
-
Shiozawa, Y.1
-
75
-
-
0037379794
-
ERKMAPK activity as a determinant of tumor growth and dormancy; Regulation by p38SAPK
-
Aguirre-Ghiso, J. A., Estrada, Y., Liu, D. & Ossowski, L. ERKMAPK activity as a determinant of tumor growth and dormancy; regulation by p38SAPK. Cancer Res. 63, 1684-1695 (2003
-
(2003)
Cancer Res
, vol.63
, pp. 1684-1695
-
-
Aguirre-Ghiso, J.A.1
Estrada, Y.2
Liu, D.3
Ossowski, L.4
-
76
-
-
5644222639
-
Green fluorescent protein tagging of extracellular signal-regulated kinase and p38 pathways reveals novel dynamics of pathway activation during primary and metastatic growth
-
Aguirre-Ghiso, J. A., Ossowski, L. & Rosenbaum, S. K. Green fluorescent protein tagging of extracellular signal-regulated kinase and p38 pathways reveals novel dynamics of pathway activation during primary and metastatic growth. Cancer Res. 64, 7336-7345 (2004
-
(2004)
Cancer Res
, vol.64
, pp. 7336-7345
-
-
Aguirre-Ghiso, J.A.1
Ossowski, L.2
Rosenbaum, S.K.3
-
77
-
-
84863012773
-
N-myc downstream regulated gene 1 modulates Wnt-β-catenin signalling and pleiotropically suppresses metastasis
-
Liu, W. et al. N-myc downstream regulated gene 1 modulates Wnt-β-catenin signalling and pleiotropically suppresses metastasis. EMBO Mol. Med. 4, 93-108 (2012
-
(2012)
EMBO Mol. Med
, vol.4
, pp. 93-108
-
-
Liu, W.1
-
78
-
-
77955015464
-
AACR centennial series: The biology of cancer metastasis: Historical perspective
-
Talmadge, J. E. & Fidler, I. J. AACR centennial series: The biology of cancer metastasis: Historical perspective. Cancer Res. 70, 5649-5669 (2010
-
(2010)
Cancer Res
, vol.70
, pp. 5649-5669
-
-
Talmadge, J.E.1
Fidler, I.J.2
-
79
-
-
84866061054
-
Effect of inhibition of the lysophosphatidic Acid receptor 1 on metastasis and metastatic dormancy in breast cancer
-
Marshall, J. C. et al. Effect of inhibition of the lysophosphatidic Acid receptor 1 on metastasis and metastatic dormancy in breast cancer. J. Natl Cancer Inst. 104, 1306-1319 (2012
-
(2012)
J. Natl Cancer Inst
, vol.104
, pp. 1306-1319
-
-
Marshall, J.C.1
-
80
-
-
84880332704
-
The perivascular niche regulates breast tumour dormancy
-
Ghajar, C. M. et al. The perivascular niche regulates breast tumour dormancy. Nature Cell Biol. 15, 807-817 (2013
-
(2013)
Nature Cell Biol
, vol.15
, pp. 807-817
-
-
Ghajar, C.M.1
-
81
-
-
84855425160
-
Interactions between cancer stem cells and their niche govern metastatic colonization
-
Malanchi, I. et al. Interactions between cancer stem cells and their niche govern metastatic colonization. Nature 481, 85-89 (2012
-
(2012)
Nature
, vol.481
, pp. 85-89
-
-
Malanchi, I.1
-
82
-
-
51049119424
-
Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton
-
Barkan, D. et al. Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton. Cancer Res. 68, 6241-6250 (2008
-
(2008)
Cancer Res
, vol.68
, pp. 6241-6250
-
-
Barkan, D.1
-
83
-
-
84991885325
-
Micro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells
-
Cheng, G., Tse, J., Jain, R. K. & Munn, L. L. Micro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells. PLoS ONE 4, e4632 (2009
-
(2009)
PLoS ONE
, vol.4
-
-
Cheng, G.1
Tse, J.2
Jain, R.K.3
Munn, L.L.4
-
84
-
-
0036596352
-
EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma
-
Liu, D., Aguirre Ghiso, J., Estrada, Y. & Ossowski, L. EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma. Cancer Cell 1, 445-457 (2002
-
(2002)
Cancer Cell
, vol.1
, pp. 445-457
-
-
Liu, D.1
Aguirre Ghiso, J.2
Estrada, Y.3
Ossowski, L.4
-
85
-
-
0037061762
-
Inhibition of FAK signaling activated by urokinase receptor induces dormancy in human carcinoma cells in vivo
-
Aguirre Ghiso, J. A. Inhibition of FAK signaling activated by urokinase receptor induces dormancy in human carcinoma cells in vivo. Oncogene 21, 2513-2524 (2002
-
(2002)
Oncogene
, vol.21
, pp. 2513-2524
-
-
Aguirre Ghiso, J.A.1
-
86
-
-
67649849871
-
Integrin β1 focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs
-
Shibue, T. & Weinberg, R. A. Integrin β1 focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs. Proc. Natl Acad. Sci. USA 106, 10290-10295 (2009
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 10290-10295
-
-
Shibue, T.1
Weinberg, R.A.2
-
87
-
-
79953736762
-
Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells
-
Schrader, J. et al. Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells. Hepatology 53, 1192-1205 (2011
-
(2011)
Hepatology
, vol.53
, pp. 1192-1205
-
-
Schrader, J.1
-
88
-
-
77955021301
-
Metastatic growth from dormant cells induced by a col-I-enriched fibrotic environment
-
Barkan, D. et al. Metastatic growth from dormant cells induced by a col-I-enriched fibrotic environment. Cancer Res. 70, 5706-5716 (2010
-
(2010)
Cancer Res
, vol.70
, pp. 5706-5716
-
-
Barkan, D.1
-
89
-
-
84861116448
-
Tumor microenvironment complexity: Emerging roles in cancer therapy
-
Swartz, M. A. et al. Tumor microenvironment complexity: Emerging roles in cancer therapy. Cancer Res. 72, 2473-2480 (2012
-
(2012)
Cancer Res
, vol.72
, pp. 2473-2480
-
-
Swartz, M.A.1
-
90
-
-
84255196931
-
Immune microenvironments in solid tumors: New targets for therapy
-
Shiao, S. L., Ganesan, A. P., Rugo, H. S. & Coussens, L. M. Immune microenvironments in solid tumors: New targets for therapy. Genes Dev. 25, 2559-2572 (2011
-
(2011)
Genes Dev
, vol.25
, pp. 2559-2572
-
-
Shiao, S.L.1
Ganesan, A.P.2
Rugo, H.S.3
Coussens, L.M.4
-
91
-
-
0037421593
-
Fatal melanoma transferred in a donated kidney 16 years after melanoma surgery
-
MacKie, R. M., Reid, R. & Junor, B. Fatal melanoma transferred in a donated kidney 16 years after melanoma surgery. New Engl. J. Med. 348, 567-568 (2003
-
(2003)
New Engl. J. Med
, vol.348
, pp. 567-568
-
-
Mackie, R.M.1
Reid, R.2
Junor, B.3
-
92
-
-
77953225810
-
Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma
-
Eyles, J. et al. Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma. J. Clin. Invest. 120, 2030-2039 (2010
-
(2010)
J. Clin. Invest
, vol.120
, pp. 2030-2039
-
-
Eyles, J.1
-
93
-
-
36849010167
-
Adaptive immunity maintains occult cancer in an equilibrium state
-
Koebel, C. M. et al. Adaptive immunity maintains occult cancer in an equilibrium state. Nature 450, 903-907 (2007
-
(2007)
Nature
, vol.450
, pp. 903-907
-
-
Koebel, C.M.1
-
94
-
-
44449137591
-
TNFR1 signaling and IFN-γ signaling determine whether T cells induce tumor dormancy or promote multistage carcinogenesis
-
Muller-Hermelink, N. et al. TNFR1 signaling and IFN-γ signaling determine whether T cells induce tumor dormancy or promote multistage carcinogenesis. Cancer Cell 13, 507-518 (2008
-
(2008)
Cancer Cell
, vol.13
, pp. 507-518
-
-
Muller-Hermelink, N.1
-
95
-
-
84863116270
-
Vaccines targeting tumor blood vessel antigens promote CD8+ T cell-dependent tumor eradication or dormancy in HLA A2 transgenic mice
-
Zhao, X. et al. Vaccines targeting tumor blood vessel antigens promote CD8+ T cell-dependent tumor eradication or dormancy in HLA A2 transgenic mice. J. Immunol. 188, 1782-1788 (2012
-
(2012)
J. Immunol
, vol.188
, pp. 1782-1788
-
-
Zhao, X.1
-
96
-
-
84874192617
-
T-helper 1 cell cytokines drive cancer into senescence
-
Braumuller, H. et al. T-helper 1 cell cytokines drive cancer into senescence. Nature 494, 361-365 (2013
-
(2013)
Nature
, vol.494
, pp. 361-365
-
-
Braumuller, H.1
-
97
-
-
0028951043
-
Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression
-
Holmgren, L., O'Reilly, M. S. & Folkman, J. Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nature Med. 1, 149-153 (1995
-
(1995)
Nature Med
, vol.1
, pp. 149-153
-
-
Holmgren, L.1
O'reilly, M.S.2
Folkman, J.3
-
98
-
-
59149083473
-
Transcriptional switch of dormant tumors to fast-growing angiogenic phenotype
-
Almog, N. et al. Transcriptional switch of dormant tumors to fast-growing angiogenic phenotype. Cancer Res. 69, 836-844 (2009
-
(2009)
Cancer Res
, vol.69
, pp. 836-844
-
-
Almog, N.1
-
99
-
-
33845680615
-
Prolonged dormancy of human liposarcoma is associated with impaired tumor angiogenesis
-
Almog, N. et al. Prolonged dormancy of human liposarcoma is associated with impaired tumor angiogenesis. FASEB J.: Official Publ. Feder. Am. Societies Exp. Biol. 20, 947-949 (2006
-
(2006)
FASEB J.: Official Publ. Feder. Am. Societies Exp. Biol
, vol.20
, pp. 947-949
-
-
Almog, N.1
-
100
-
-
0029754648
-
Inhibition of angiogenesis in human glioblastomas by chromosome 10 induction of thrombospondin 1
-
Hsu, S. C. et al. Inhibition of angiogenesis in human glioblastomas by chromosome 10 induction of thrombospondin 1. Cancer Res. 56, 5684-5691 (1996
-
(1996)
Cancer Res
, vol.56
, pp. 5684-5691
-
-
Hsu, S.C.1
-
101
-
-
0028609624
-
Transfection of thrombospondin 1 complementary DNA into a human breast carcinoma cell line reduces primary tumor growth, metastatic potential, and angiogenesis
-
Weinstat-Saslow, D. L. et al. Transfection of thrombospondin 1 complementary DNA into a human breast carcinoma cell line reduces primary tumor growth, metastatic potential, and angiogenesis. Cancer Res. 54, 6504-6511 (1994
-
(1994)
Cancer Res
, vol.54
, pp. 6504-6511
-
-
Weinstat-Saslow, D.L.1
-
102
-
-
60549117358
-
Cross-Talk between tumor and endothelial cells involving the Notch3 Dll4 interaction marks escape from tumor dormancy
-
Indraccolo, S. et al. Cross-Talk between tumor and endothelial cells involving the Notch3 Dll4 interaction marks escape from tumor dormancy. Cancer Res. 69, 1314-1323 (2009
-
(2009)
Cancer Res
, vol.69
, pp. 1314-1323
-
-
Indraccolo, S.1
-
103
-
-
84855453198
-
Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice
-
Panigrahy, D. et al. Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice. J. Clin. Invest. 122, 178-191 (2012
-
(2012)
J. Clin. Invest
, vol.122
, pp. 178-191
-
-
Panigrahy, D.1
-
104
-
-
84870052886
-
Convergent multi-miRNA targeting of ApoE drives LRP1/LRP8 dependent melanoma metastasis and angiogenesis
-
Pencheva, N. et al. Convergent multi-miRNA targeting of ApoE drives LRP1/LRP8 dependent melanoma metastasis and angiogenesis. Cell 151, 1068-1082 (2012
-
(2012)
Cell
, vol.151
, pp. 1068-1082
-
-
Pencheva, N.1
-
105
-
-
84895782011
-
Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations
-
Magnus, N. et al. Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations. Proc. Natl Acad. Sci. USA 111, 3544-3549 (2014
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 3544-3549
-
-
Magnus, N.1
-
106
-
-
84880054971
-
The dormancy dilemma: Quiescence versus balanced proliferation
-
Wells, A., Griffith, L., Wells, J. Z. & Taylor, D. P. The dormancy dilemma: Quiescence versus balanced proliferation. Cancer Res. 73, 3811-3816 (2013
-
(2013)
Cancer Res
, vol.73
, pp. 3811-3816
-
-
Wells, A.1
Griffith, L.2
Wells, J.Z.3
Taylor, D.P.4
-
107
-
-
84874908195
-
Modeling boundary conditions for balanced proliferation in metastatic latency
-
Taylor, D. P., Wells, J. Z., Savol, A., Chennubhotla, C. & Wells, A. Modeling boundary conditions for balanced proliferation in metastatic latency. Clin. Cancer Res. 19, 1063-1070 (2013
-
(2013)
Clin. Cancer Res
, vol.19
, pp. 1063-1070
-
-
Taylor, D.P.1
Wells, J.Z.2
Savol, A.3
Chennubhotla, C.4
Wells, A.5
-
108
-
-
73849129203
-
Real-Time imaging reveals the single steps of brain metastasis formation
-
Kienast, Y. et al. Real-Time imaging reveals the single steps of brain metastasis formation. Nature Med. 16, 116-122 (2010
-
(2010)
Nature Med
, vol.16
, pp. 116-122
-
-
Kienast, Y.1
-
109
-
-
84876545834
-
GAS6 receptor status is associated with dormancy and bone metastatic tumor formation
-
Taichman, R. S. et al. GAS6 receptor status is associated with dormancy and bone metastatic tumor formation. PloS ONE 8, e61873 (2013
-
(2013)
PloS ONE
, vol.8
-
-
Taichman, R.S.1
-
110
-
-
84863337757
-
Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells
-
Tsai, H. C. et al. Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells. Cancer Cell 21, 430-446 (2012
-
(2012)
Cancer Cell
, vol.21
, pp. 430-446
-
-
Tsai, H.C.1
-
111
-
-
84859994398
-
Dormancy signatures and metastasis in estrogen receptor positive and negative breast cancer
-
Kim, R. S. et al. Dormancy signatures and metastasis in estrogen receptor positive and negative breast cancer. PloS ONE 7, e35569 (2012
-
(2012)
PloS ONE
, vol.7
-
-
Kim, R.S.1
-
112
-
-
84894343125
-
Mutation frequencies of GNAQ, GNA11, BAP1, SF3B1, EIF1AX and TERT in uveal melanoma: Detection of an activating mutation in the TERT gene promoter in a single case of uveal melanoma
-
Dono, M. et al. Mutation frequencies of GNAQ, GNA11, BAP1, SF3B1, EIF1AX and TERT in uveal melanoma: Detection of an activating mutation in the TERT gene promoter in a single case of uveal melanoma. Br. J. Cancer 110, 1058-1065 (2014
-
(2014)
Br. J. Cancer
, vol.110
, pp. 1058-1065
-
-
Dono, M.1
-
113
-
-
84856023489
-
Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma
-
Landreville, S. et al. Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma. Clin. Cancer Res. 18, 408-416 (2012
-
(2012)
Clin. Cancer Res
, vol.18
, pp. 408-416
-
-
Landreville, S.1
-
114
-
-
84860508493
-
An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-Term regeneration
-
Chen, T. et al. An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-Term regeneration. Nature 485, 104-108 (2012
-
(2012)
Nature
, vol.485
, pp. 104-108
-
-
Chen, T.1
-
115
-
-
34547145922
-
Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling
-
Kobielak, K., Stokes, N., de la Cruz, J., Polak, L. & Fuchs, E. Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling. Proc. Natl Acad. Sci. USA 104, 10063-10068 (2007
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 10063-10068
-
-
Kobielak, K.1
Stokes, N.2
De La Cruz, J.3
Polak, L.4
Fuchs, E.5
-
116
-
-
58749108674
-
A quantitative trait locus on chromosome 4 affects cycling of hematopoietic stem and progenitor cells through regulation of TGF β2 responsiveness
-
Avagyan, S., Glouchkova, L., Choi, J. & Snoeck, H. W. A quantitative trait locus on chromosome 4 affects cycling of hematopoietic stem and progenitor cells through regulation of TGF β2 responsiveness. J. Immunol. 181, 5904-5911 (2008
-
(2008)
J. Immunol
, vol.181
, pp. 5904-5911
-
-
Avagyan, S.1
Glouchkova, L.2
Choi, J.3
Snoeck, H.W.4
-
117
-
-
0346024089
-
Quantitative trait analysis reveals transforming growth factor beta2 as a positive regulator of early hematopoietic progenitor and stem cell function
-
Langer, J. C., Henckaerts, E., Orenstein, J. & Snoeck, H. W. Quantitative trait analysis reveals transforming growth factor beta2 as a positive regulator of early hematopoietic progenitor and stem cell function. J. Exp. Med. 199, 5-14 (2004
-
(2004)
J. Exp. Med
, vol.199
, pp. 5-14
-
-
Langer, J.C.1
Henckaerts, E.2
Orenstein, J.3
Snoeck, H.W.4
-
118
-
-
71849114718
-
Balancing dormant and self-renewing hematopoietic stem cells
-
Wilson, A., Laurenti, E. & Trumpp, A. Balancing dormant and self-renewing hematopoietic stem cells. Curr. Opin. Genet. Dev. 19, 461-468 (2009
-
(2009)
Curr. Opin. Genet. Dev
, vol.19
, pp. 461-468
-
-
Wilson, A.1
Laurenti, E.2
Trumpp, A.3
-
119
-
-
56549128268
-
Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair
-
Wilson, A. et al. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell 135, 1118-1129 (2008
-
(2008)
Cell
, vol.135
, pp. 1118-1129
-
-
Wilson, A.1
-
120
-
-
84891344481
-
Stem cell quiescence acts as a tumour suppressor in squamous tumours
-
White, A. C. et al. Stem cell quiescence acts as a tumour suppressor in squamous tumours. Nature Cell Biol. 16, 99-107 (2014
-
(2014)
Nature Cell Biol
, vol.16
, pp. 99-107
-
-
White, A.C.1
-
121
-
-
84859218238
-
Chromatin-modifying enzymes as modulators of reprogramming
-
Onder, T. T. et al. Chromatin-modifying enzymes as modulators of reprogramming. Nature 483, 598-602 (2012
-
(2012)
Nature
, vol.483
, pp. 598-602
-
-
Onder, T.T.1
-
122
-
-
80051967505
-
Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
-
Gupta, P. B. et al. Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell 146, 633-644 (2011
-
(2011)
Cell
, vol.146
, pp. 633-644
-
-
Gupta, P.B.1
-
123
-
-
71449109765
-
Direct cell reprogramming is a stochastic process amenable to acceleration
-
Hanna, J. et al. Direct cell reprogramming is a stochastic process amenable to acceleration. Nature 462, 595-601 (2009
-
(2009)
Nature
, vol.462
, pp. 595-601
-
-
Hanna, J.1
-
124
-
-
67650999875
-
The basics of epithelial-mesenchymal transition
-
Kalluri, R. & Weinberg, R. A. The basics of epithelial-mesenchymal transition. J. Clin. Invest. 119, 1420-1428 (2009
-
(2009)
J. Clin. Invest
, vol.119
, pp. 1420-1428
-
-
Kalluri, R.1
Weinberg, R.A.2
-
125
-
-
43049165453
-
The epithelial-mesenchymal transition generates cells with properties of stem cells
-
Mani, S. A. et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133, 704-715 (2008
-
(2008)
Cell
, vol.133
, pp. 704-715
-
-
Mani, S.A.1
-
126
-
-
84879983245
-
Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity
-
Chaffer, C. L. et al. Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity. Cell 154, 61-74 (2013
-
(2013)
Cell
, vol.154
, pp. 61-74
-
-
Chaffer, C.L.1
-
127
-
-
84856044714
-
Analysis of marker-defined HNSCC subpopulations reveals a dynamic regulation of tumor initiating properties
-
Bragado, P. et al. Analysis of marker-defined HNSCC subpopulations reveals a dynamic regulation of tumor initiating properties. PloS ONE 7, e29974 (2012
-
(2012)
PloS ONE
, vol.7
-
-
Bragado, P.1
-
128
-
-
33645730667
-
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
-
Ito, K. et al. Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nature Med. 12, 446-451 (2006
-
(2006)
Nature Med
, vol.12
, pp. 446-451
-
-
Ito, K.1
-
129
-
-
69349094006
-
A p53 mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
-
Marion, R. M. et al. A p53 mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature 460, 1149-1153 (2009
-
(2009)
Nature
, vol.460
, pp. 1149-1153
-
-
Marion, R.M.1
-
130
-
-
84857817163
-
Slug and Sox9 cooperatively determine the mammary stem cell state
-
Guo, W. et al. Slug and Sox9 cooperatively determine the mammary stem cell state. Cell 148, 1015-1028 (2012
-
(2012)
Cell
, vol.148
, pp. 1015-1028
-
-
Guo, W.1
-
131
-
-
84878240136
-
Molecular regulation of stem cell quiescence
-
Cheung, T. H. & Rando, T. A. Molecular regulation of stem cell quiescence. Nature Rev. Mol. Cell Biol. 14, 329-340 (2013
-
(2013)
Nature Rev. Mol. Cell Biol
, vol.14
, pp. 329-340
-
-
Cheung, T.H.1
Rando, T.A.2
-
132
-
-
0033551238
-
Comparative genomic hybridization, loss of heterozygosity, and DNA sequence analysis of single cells
-
Klein, C. A. et al. Comparative genomic hybridization, loss of heterozygosity, and DNA sequence analysis of single cells. Proc. Natl Acad. Sci. USA 96, 4494-4499 (1999
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 4494-4499
-
-
Klein, C.A.1
-
133
-
-
0038271868
-
From latent disseminated cells to overt metastasis: Genetic analysis of systemic breast cancer progression
-
Schmidt-Kittler, O. et al. From latent disseminated cells to overt metastasis: Genetic analysis of systemic breast cancer progression. Proc. Natl Acad. Sci. USA 100, 7737-7742 (2003
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 7737-7742
-
-
Schmidt-Kittler, O.1
-
134
-
-
84879644550
-
The gene desert mammary carcinoma susceptibility locus Mcs1a regulates Nr2f1 modifying mammary epithelial cell differentiation and proliferation
-
Smits, B. M. et al. The gene desert mammary carcinoma susceptibility locus Mcs1a regulates Nr2f1 modifying mammary epithelial cell differentiation and proliferation. PLoS Genet. 9, e1003549 (2013
-
(2013)
PLoS Genet
, vol.9
-
-
Smits, B.M.1
-
135
-
-
84884549440
-
Breast cancer metastasis: Issues for the personalization of its prevention and treatment
-
Marino, N. et al. Breast cancer metastasis: Issues for the personalization of its prevention and treatment. Am. J. Pathol. 183, 1084-1095 (2013
-
(2013)
Am. J. Pathol
, vol.183
, pp. 1084-1095
-
-
Marino, N.1
-
136
-
-
84861716177
-
Perspective: The right trials
-
Steeg, P. S. Perspective: The right trials. Nature 485, S58-59 (2012
-
(2012)
Nature
, vol.485
-
-
Steeg, P.S.1
-
137
-
-
34848819728
-
Current status in human breast cancer micrometastasis
-
Alix-Panabieres, C., Muller, V. & Pantel, K. Current status in human breast cancer micrometastasis. Curr. Opin. Oncol. 19, 558-563 (2007
-
(2007)
Curr. Opin. Oncol
, vol.19
, pp. 558-563
-
-
Alix-Panabieres, C.1
Muller, V.2
Pantel, K.3
-
138
-
-
23944466427
-
A pooled analysis of bone marrow micrometastasis in breast cancer
-
Braun, S. et al. A pooled analysis of bone marrow micrometastasis in breast cancer. New Engl. J. Med. 353, 793-802 (2005
-
(2005)
New Engl. J. Med
, vol.353
, pp. 793-802
-
-
Braun, S.1
-
139
-
-
0029977016
-
Prognostic significance of bone marrow micrometastases in patients with gastric cancer
-
Jauch, K. W. et al. Prognostic significance of bone marrow micrometastases in patients with gastric cancer. J. Clin. Oncol. 14, 1810-1817 (1996
-
(1996)
J. Clin. Oncol
, vol.14
, pp. 1810-1817
-
-
Jauch, K.W.1
-
140
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: The next generation. Cell 144, 646-674 (2011
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
141
-
-
38549131901
-
GATA 3 links tumor differentiation and dissemination in a luminal breast cancer model
-
Kouros-Mehr, H. et al. GATA 3 links tumor differentiation and dissemination in a luminal breast cancer model. Cancer Cell 13, 141-152 (2008
-
(2008)
Cancer Cell
, vol.13
, pp. 141-152
-
-
Kouros-Mehr, H.1
-
142
-
-
0032190629
-
Premature senescence involving p53 and p16 is activated in response to constitutive MEK/ MAPK mitogenic signaling
-
Lin, A. W. et al. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/ MAPK mitogenic signaling. Genes Dev. 12, 3008-3019 (1998
-
(1998)
Genes Dev
, vol.12
, pp. 3008-3019
-
-
Lin, A.W.1
-
143
-
-
50149117285
-
Control of the reversibility of cellular quiescence by the transcriptional repressor HES1
-
Sang, L., Coller, H. A. & Roberts, J. M. Control of the reversibility of cellular quiescence by the transcriptional repressor HES1. Science 321, 1095-1100 (2008
-
(2008)
Science
, vol.321
, pp. 1095-1100
-
-
Sang, L.1
Coller, H.A.2
Roberts, J.M.3
-
144
-
-
33846937033
-
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
-
Xue, W. et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 445, 656-660 (2007
-
(2007)
Nature
, vol.445
, pp. 656-660
-
-
Xue, W.1
-
145
-
-
33746752125
-
A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation
-
Narita, M. et al. A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Cell 126, 503-514 (2006
-
(2006)
Cell
, vol.126
, pp. 503-514
-
-
Narita, M.1
-
147
-
-
28644432204
-
VEGFR1 positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
-
Kaplan, R. N. et al. VEGFR1 positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 438, 820-827 (2005
-
(2005)
Nature
, vol.438
, pp. 820-827
-
-
Kaplan, R.N.1
-
148
-
-
33750627972
-
A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes
-
Sharma, S. V. et al. A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes. Cancer Cell 10, 425-435 (2006
-
(2006)
Cancer Cell
, vol.10
, pp. 425-435
-
-
Sharma, S.V.1
-
149
-
-
77950809059
-
A chromatin-mediated reversible drug-Tolerant state in cancer cell subpopulations
-
Sharma, S. V. et al. A chromatin-mediated reversible drug-Tolerant state in cancer cell subpopulations. Cell 141, 69-80 (2010
-
(2010)
Cell
, vol.141
, pp. 69-80
-
-
Sharma, S.V.1
-
150
-
-
42949150219
-
Direct genetic analysis of single disseminated cancer cells for prediction of outcome and therapy selection in esophageal cancer
-
Stoecklein, N. H. et al. Direct genetic analysis of single disseminated cancer cells for prediction of outcome and therapy selection in esophageal cancer. Cancer Cell 13, 441-453 (2008
-
(2008)
Cancer Cell
, vol.13
, pp. 441-453
-
-
Stoecklein, N.H.1
-
151
-
-
84890259230
-
A novel model of dormancy for bone metastatic breast cancer cells
-
Marlow, R. et al. A novel model of dormancy for bone metastatic breast cancer cells. Cancer Res. 73, 6886-6899 (2013
-
(2013)
Cancer Res
, vol.73
, pp. 6886-6899
-
-
Marlow, R.1
-
152
-
-
78549292810
-
A therapeutic OX40 agonist dynamically alters dendritic, endothelial, and T cell subsets within the established tumor microenvironment
-
Pardee, A. D. et al. A therapeutic OX40 agonist dynamically alters dendritic, endothelial, and T cell subsets within the established tumor microenvironment. Cancer Res. 70, 9041-9052 (2010
-
(2010)
Cancer Res
, vol.70
, pp. 9041-9052
-
-
Pardee, A.D.1
-
153
-
-
0035172910
-
Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo
-
Aguirre-Ghiso, J. A., Liu, D., Mignatti, A., Kovalski, K. & Ossowski, L. Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo. Mol. Biol. Cell 12, 863-879 (2001
-
(2001)
Mol. Biol. Cell
, vol.12
, pp. 863-879
-
-
Aguirre-Ghiso, J.A.1
Liu, D.2
Mignatti, A.3
Kovalski, K.4
Ossowski, L.5
|