Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-α

Science

Volumn 330, Issue 6005, 2010, Pages 827-830

  Kraman, Matthew ^a   Bambrough, Paul J ^a   Arnold, James N ^a   Roberts, Edward W ^a   Magiera, Lukasz ^a   Jones, James O ^a   Gopinathan, Aarthi ^b,c   Tuveson, David A ^b   Fearon, Douglas T ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b CANCER RESEARCH UK CAMBRIDGE RESEARCH INSTITUTE   (United Kingdom)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ATAXIN 1; CD34 ANTIBODY; COLLAGEN TYPE 1; DIPHTHERIA TOXIN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; SEPRASE; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

CANCER; CARCINOGEN; CELL ORGANELLE; DISEASE CONTROL; FUNCTIONAL MORPHOLOGY; GAMMA RAY RADIATION; GENE EXPRESSION; HYPOXIA; IMMUNE SYSTEM; PROTEIN; RODENT; TUMOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CANCER IMMUNOTHERAPY; CELL DEATH; CELLULAR IMMUNITY; HUMAN; HUMAN CELL; LEWIS CARCINOMA; MOUSE; NONHUMAN; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; STROMA CELL; TRANSGENIC MOUSE; TUMOR IMMUNITY; TUMOR MICROENVIRONMENT;

ANIMALS; ANTIGENS, NEOPLASM; CANCER VACCINES; CARCINOMA, LEWIS LUNG; CARCINOMA, PANCREATIC DUCTAL; CELL HYPOXIA; CELL LINE, TUMOR; CELL SURVIVAL; GELATINASES; IMMUNE TOLERANCE; INTERFERON-GAMMA; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; NECROSIS; NEOPLASM TRANSPLANTATION; SERINE ENDOPEPTIDASES; STROMAL CELLS; TUMOR MICROENVIRONMENT; TUMOR NECROSIS FACTOR-ALPHA;

MUS MUSCULUS;

EID: 78149298209     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1195300     Document Type: Article

References (32)

1. P. van der Bruggen et al., Science 254, 1643 (1991).
2. G. Willimsky et al., J. Exp. Med. 205, 1687 (2008).
3. G. P. Dunn, C. M. Koebel, R. D. Schreiber, Nat. Rev. Immunol. 6, 836 (2006).
4. D. E. Speiser et al., J. Immunol. 177, 1338 (2006).
5. S. A. Rosenberg et al., J. Immunol. 175, 6169 (2005).
6. D. Valmori et al., Proc. Natl. Acad. Sci. U.S.A. 104, 8947 (2007).
7. C. Uyttenhove et al., Nat. Med. 9, 1269 (2003).
8. G. Klein, H. O. Sjogren, E. Klein, K. E. Hellstrom, Cancer Res. 20, 1561 (1960).
9. M. J. Berendt, R. J. North, J. Exp. Med. 151, 69 (1980).
10. L. A. Pekarek, B. A. Starr, A. Y. Toledano, H. Schreiber, J. Exp. Med. 181, 435 (1995).
11. I. Marigo, L. Dolcetti, P. Serafini, P. Zanovello, V. Bronte, Immunol. Rev. 222, 162 (2008).
12. A. Mantovani, P. Allavena, A. Sica, F. Balkwill, Nature 454, 436 (2008).
13. M. Terabe et al., J. Exp. Med. 202, 1627 (2005).
14. P. Yu et al., J. Exp. Med. 201, 779 (2005).
15. A. Orimo et al., Cell 121, 335 (2005).
16. P. Garin-Chesa, L. J. Old, W. J. Rettig, Proc. Natl. Acad. Sci. U.S.A. 87, 7235 (1990).
17. H. Dolznig et al., Cancer Immun. 5, 10 (2005).
18. S. Bauer et al., Arthritis Res. Ther. 8, R171 (2006).
19. Materials and methods are available as supporting material on Science Online.
20. A. Peister et al., Blood 103, 1662 (2004).
21. S. Bae et al., Br. J. Haematol. 142, 827 (2008).
22. R. Bucala, L. A. Spiegel, J. Chesney, M. Hogan, A. Cerami, Mol. Med. 1, 71 (1994).
23. A. M. Santos, J. Jung, N. Aziz, J. L. Kissil, E. Puré, J. Clin. Invest. 119, 3613 (2009).
24. D. J. Nelson et al., J. Immunol. 166, 5557 (2001).
25. J. Doukas, J. S. Pober, J. Immunol. 145, 1727 (1990).
26. C. Rüegg et al., Nat. Med. 4, 408 (1998).
27. K. P. Olive et al., Science 324, 1457 (2009); 10.1126/science.1171362.
28. B. Zhang, T. Karrison, D. A. Rowley, H. Schreiber, J. Clin. Invest. 118, 1398 (2008).
29. T. Schüler, T. Blankenstein, J. Immunol. 170, 4427 (2003).
30. H. F. Dvorak, N. Engl. J. Med. 315, 1650 (1986).
31. K. S. Peggs, S. A. Quezada, J. P. Allison, Immunol. Rev. 224, 141 (2008).
32. We thank A. Betz, F. Randow, and C. Feig for their discussions. This research was supported by the Wellcome Trust and the National Institutes for Health Research Cambridge Biomedical Research Centre. D.A.T. was supported by Cancer Research UK, Hutchison Whampoa, and the University of Cambridge.