-
2
-
-
78649737749
-
Induction of glucose metabolism in stimulated T lymphocytes is regulated by mitogen-activated protein kinase signaling
-
Marko AJ, Miller RA, Kelman A, Frauwirth KA. Induction of glucose metabolism in stimulated T lymphocytes is regulated by mitogen-activated protein kinase signaling. PLoS One (2010) 5:e15425. doi:10.1371/journal.pone.0015425
-
(2010)
PLoS One
, vol.5
-
-
Marko, A.J.1
Miller, R.A.2
Kelman, A.3
Frauwirth, K.A.4
-
3
-
-
0141863388
-
Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival
-
Rathmell JC, Fox CJ, Plas DR, Hammerman PS, Cinalli RM, Thompson CB. Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Mol Cell Biol (2003) 23:7315-28. doi:10.1128/MCB.23.20.7315-7328.2003
-
(2003)
Mol Cell Biol
, vol.23
, pp. 7315-7328
-
-
Rathmell, J.C.1
Fox, C.J.2
Plas, D.R.3
Hammerman, P.S.4
Cinalli, R.M.5
Thompson, C.B.6
-
4
-
-
84859057520
-
PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis
-
Schultze SM, Hemmings BA, Niessen M, Tschopp O. PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis. Expert Rev Mol Med (2012) 14:e1. doi:10.1017/S1462399411002109
-
(2012)
Expert Rev Mol Med
, vol.14
-
-
Schultze, S.M.1
Hemmings, B.A.2
Niessen, M.3
Tschopp, O.4
-
5
-
-
1842581892
-
Regulation of T lymphocyte metabolism
-
Frauwirth KA, Thompson CB. Regulation of T lymphocyte metabolism. J Immunol (2004) 172:4661-5. doi:10.4049/jimmunol.172.8.4661
-
(2004)
J Immunol
, vol.172
, pp. 4661-4665
-
-
Frauwirth, K.A.1
Thompson, C.B.2
-
6
-
-
0036069699
-
The CD28 signaling pathway regulates glucose metabolism
-
Frauwirth KA, Riley JL, Harris MH, Parry RV, Rathmell JC, Plas DR, et al. The CD28 signaling pathway regulates glucose metabolism. Immunity (2002) 16:769-77. doi:10.1016/S1074-7613(02)00323-0
-
(2002)
Immunity
, vol.16
, pp. 769-777
-
-
Frauwirth, K.A.1
Riley, J.L.2
Harris, M.H.3
Parry, R.V.4
Rathmell, J.C.5
Plas, D.R.6
-
7
-
-
0041975825
-
Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma
-
Rathmell JC, Elstrom RL, Cinalli RM, Thompson CB. Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma. Eur J Immunol (2003) 33:2223-32. doi:10.1002/eji.200324048
-
(2003)
Eur J Immunol
, vol.33
, pp. 2223-2232
-
-
Rathmell, J.C.1
Elstrom, R.L.2
Cinalli, R.M.3
Thompson, C.B.4
-
8
-
-
0018217918
-
Immunological induction of T lymphocytes: role of antigen and the lymphocyte costimulator
-
Lafferty KJ, Warren HS, Woolnough JA, Talmage DW. Immunological induction of T lymphocytes: role of antigen and the lymphocyte costimulator. Blood Cells (1978) 4:395-406
-
(1978)
Blood Cells
, vol.4
, pp. 395-406
-
-
Lafferty, K.J.1
Warren, H.S.2
Woolnough, J.A.3
Talmage, D.W.4
-
9
-
-
0033524482
-
A two-step, two-signal model for the primary activation of precursor helper T cells
-
Bretscher PA. A two-step, two-signal model for the primary activation of precursor helper T cells. Proc Natl Acad Sci U S A (1999) 96:185-90. doi:10.1073/pnas.96.1.185
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 185-190
-
-
Bretscher, P.A.1
-
10
-
-
0036669785
-
The interaction properties of costimulatory molecules revisited
-
Collins AV, Brodie DW, Gilbert RJ, Iaboni A, Manso-Sancho R, Walse B, et al. The interaction properties of costimulatory molecules revisited. Immunity (2002) 17:201-10. doi:10.1016/S1074-7613(02)00362-X
-
(2002)
Immunity
, vol.17
, pp. 201-210
-
-
Collins, A.V.1
Brodie, D.W.2
Gilbert, R.J.3
Iaboni, A.4
Manso-Sancho, R.5
Walse, B.6
-
11
-
-
0037902480
-
T cell anergy and costimulation
-
Appleman LJ, Boussiotis VA. T cell anergy and costimulation. Immunol Rev (2003) 192:161-80. doi:10.1034/j.1600-065X.2003.00009.x
-
(2003)
Immunol Rev
, vol.192
, pp. 161-180
-
-
Appleman, L.J.1
Boussiotis, V.A.2
-
12
-
-
0030844271
-
Co-stimulation in T cell responses
-
Chambers CA, Allison JP. Co-stimulation in T cell responses. Curr Opin Immunol (1997) 9:396-404. doi:10.1016/S0952-7915(97)80087-8
-
(1997)
Curr Opin Immunol
, vol.9
, pp. 396-404
-
-
Chambers, C.A.1
Allison, J.P.2
-
14
-
-
84879215734
-
Manipulating the PD-1 pathway to improve immunity
-
Kamphorst AO, Ahmed R. Manipulating the PD-1 pathway to improve immunity. Curr Opin Immunol (2013) 25:381-8. doi:10.1016/j.coi.2013.03.003
-
(2013)
Curr Opin Immunol
, vol.25
, pp. 381-388
-
-
Kamphorst, A.O.1
Ahmed, R.2
-
15
-
-
77953747963
-
The PD-1 pathway in tolerance and autoimmunity
-
Francisco LM, Sage PT, Sharpe AH. The PD-1 pathway in tolerance and autoimmunity. Immunol Rev (2010) 236:219-42. doi:10.1111/j.1600-065X.2010.00923.x
-
(2010)
Immunol Rev
, vol.236
, pp. 219-242
-
-
Francisco, L.M.1
Sage, P.T.2
Sharpe, A.H.3
-
16
-
-
0028791059
-
Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4
-
Waterhouse P, Penninger JM, Timms E, Wakeham A, Shahinian A, Lee KP, et al. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science (1995) 270:985-8. doi:10.1126/science.270.5238.985
-
(1995)
Science
, vol.270
, pp. 985-988
-
-
Waterhouse, P.1
Penninger, J.M.2
Timms, E.3
Wakeham, A.4
Shahinian, A.5
Lee, K.P.6
-
17
-
-
0028867420
-
Loss of CTLA4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA4
-
Tivol EA, Borriello F, Schweitzer NA, Lynch WP, Bluestone JA, Sharpe AH. Loss of CTLA4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA4. Immunity (1995) 3:541-7. doi:10.1016/1074-7613(95)90125-6
-
(1995)
Immunity
, vol.3
, pp. 541-547
-
-
Tivol, E.A.1
Borriello, F.2
Schweitzer, N.A.3
Lynch, W.P.4
Bluestone, J.A.5
Sharpe, A.H.6
-
18
-
-
84967103686
-
The TNF receptor superfamily in co-stimulating and co-inhibitory responses
-
Ward-Kavanagh LK, Lin WW, Šedỳ JR, Ware CF. The TNF receptor superfamily in co-stimulating and co-inhibitory responses. Immunity (2016) 44:1005-19. doi:10.1016/j.immuni.2016.04.019
-
(2016)
Immunity
, vol.44
, pp. 1005-1019
-
-
Ward-Kavanagh, L.K.1
Lin, W.W.2
Šedỳ, J.R.3
Ware, C.F.4
-
19
-
-
84966832820
-
Lag-3, Tim-3, and TIGIT: co-inhibitory receptors with specialized functions in immune regulation
-
Anderson AC, Joller N, Kuchroo VK. Lag-3, Tim-3, and TIGIT: co-inhibitory receptors with specialized functions in immune regulation. Immunity (2016) 44:989-1004. doi:10.1016/j.immuni.2016.05.001
-
(2016)
Immunity
, vol.44
, pp. 989-1004
-
-
Anderson, A.C.1
Joller, N.2
Kuchroo, V.K.3
-
20
-
-
84966738229
-
Coinhibitory pathways in the B7-CD28 ligand-receptor family
-
Schildberg FA, Klein SR, Freeman GJ, Sharpe AH. Coinhibitory pathways in the B7-CD28 ligand-receptor family. Immunity (2016) 44:955-72. doi:10.1016/j.immuni.2016.05.002
-
(2016)
Immunity
, vol.44
, pp. 955-972
-
-
Schildberg, F.A.1
Klein, S.R.2
Freeman, G.J.3
Sharpe, A.H.4
-
21
-
-
73949088551
-
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
-
Francisco LM, Salinas VH, Brown KE, Vanguri VK, Freeman GJ, Kuchroo VK, et al. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med (2009) 206:3015-29. doi:10.1084/jem.20090847
-
(2009)
J Exp Med
, vol.206
, pp. 3015-3029
-
-
Francisco, L.M.1
Salinas, V.H.2
Brown, K.E.3
Vanguri, V.K.4
Freeman, G.J.5
Kuchroo, V.K.6
-
22
-
-
53749094183
-
CTLA-4 control over Foxp3+ regulatory T cell function
-
Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T, Miyara M, Fehervari Z, et al. CTLA-4 control over Foxp3+ regulatory T cell function. Science (2008) 322:271-5. doi:10.1126/science.1160062
-
(2008)
Science
, vol.322
, pp. 271-275
-
-
Wing, K.1
Onishi, Y.2
Prieto-Martin, P.3
Yamaguchi, T.4
Miyara, M.5
Fehervari, Z.6
-
23
-
-
84966762527
-
Costimulatory and coinhibitory receptor pathways in infectious disease
-
Attanasio J, Wherry EJ. Costimulatory and coinhibitory receptor pathways in infectious disease. Immunity (2016) 44:1052-68. doi:10.1016/j.immuni.2016.04.022
-
(2016)
Immunity
, vol.44
, pp. 1052-1068
-
-
Attanasio, J.1
Wherry, E.J.2
-
24
-
-
84885670616
-
Fueling immunity: insights into metabolism and lymphocyte function
-
Pearce EL, Poffenberger MC, Chang CH, Jones RG. Fueling immunity: insights into metabolism and lymphocyte function. Science (2013) 342:1242454. doi:10.1126/science.1242454
-
(2013)
Science
, vol.342
-
-
Pearce, E.L.1
Poffenberger, M.C.2
Chang, C.H.3
Jones, R.G.4
-
26
-
-
84876758617
-
Metabolic pathways in immune cell activation and quiescence
-
Pearce EL, Pearce EJ. Metabolic pathways in immune cell activation and quiescence. Immunity (2013) 38:633-43. doi:10.1016/j.immuni.2013.04.005
-
(2013)
Immunity
, vol.38
, pp. 633-643
-
-
Pearce, E.L.1
Pearce, E.J.2
-
27
-
-
80051617288
-
The tuberous sclerosis complex-mammalian target of rapamycin pathway maintains the quiescence and survival of naive T cells
-
Wu Q, Liu Y, Chen C, Ikenoue T, Qiao Y, Li CS, et al. The tuberous sclerosis complex-mammalian target of rapamycin pathway maintains the quiescence and survival of naive T cells. J Immunol (2011) 187:1106-12. doi:10.4049/jimmunol.1003968
-
(2011)
J Immunol
, vol.187
, pp. 1106-1112
-
-
Wu, Q.1
Liu, Y.2
Chen, C.3
Ikenoue, T.4
Qiao, Y.5
Li, C.S.6
-
28
-
-
80051997049
-
The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function
-
Yang K, Neale G, Green DR, He W, Chi H. The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function. Nat Immunol (2011) 12:888-97. doi:10.1038/ni.2068
-
(2011)
Nat Immunol
, vol.12
, pp. 888-897
-
-
Yang, K.1
Neale, G.2
Green, D.R.3
He, W.4
Chi, H.5
-
29
-
-
0035892899
-
IL-7 enhances the survival and maintains the size of naive T cells
-
Rathmell JC, Farkash EA, Gao W, Thompson CB. IL-7 enhances the survival and maintains the size of naive T cells. J Immunol (2001) 167:6869-76. doi:10.4049/jimmunol.167.12.6869
-
(2001)
J Immunol
, vol.167
, pp. 6869-6876
-
-
Rathmell, J.C.1
Farkash, E.A.2
Gao, W.3
Thompson, C.B.4
-
30
-
-
84255199079
-
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
-
Wang R, Dillon CP, Shi LZ, Milasta S, Carter R, Finkelstein D, et al. The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity (2011) 35:871-82. doi:10.1016/j.immuni.2011.09.021
-
(2011)
Immunity
, vol.35
, pp. 871-882
-
-
Wang, R.1
Dillon, C.P.2
Shi, L.Z.3
Milasta, S.4
Carter, R.5
Finkelstein, D.6
-
31
-
-
33644556146
-
Prolonged TCR/CD28 engagement drives IL-2-independent T cell clonal expansion through signaling mediated by the mammalian target of rapamycin
-
Colombetti S, Basso V, Mueller DL, Mondino A. Prolonged TCR/CD28 engagement drives IL-2-independent T cell clonal expansion through signaling mediated by the mammalian target of rapamycin. J Immunol (2006) 176:2730-8. doi:10.4049/jimmunol.176.5.2730
-
(2006)
J Immunol
, vol.176
, pp. 2730-2738
-
-
Colombetti, S.1
Basso, V.2
Mueller, D.L.3
Mondino, A.4
-
32
-
-
44449165597
-
Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways
-
Jacobs SR, Herman CE, Maciver NJ, Wofford JA, Wieman HL, Hammen JJ, et al. Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways. J Immunol (2008) 180:4476-86. doi:10.4049/jimmunol.180.7.4476
-
(2008)
J Immunol
, vol.180
, pp. 4476-4486
-
-
Jacobs, S.R.1
Herman, C.E.2
Maciver, N.J.3
Wofford, J.A.4
Wieman, H.L.5
Hammen, J.J.6
-
34
-
-
78650510609
-
mTOR: from growth signal integration to cancer, diabetes and ageing
-
Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol (2011) 12:21-35. doi:10.1038/nrm3025
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
Efeyan, A.2
Sabatini, D.M.3
-
35
-
-
84856183120
-
Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development
-
van der Windt GJ, Everts B, Chang CH, Curtis JD, Freitas TC, Amiel E, et al. Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. Immunity (2012) 36:68-78. doi:10.1016/j.immuni.2011.12.007
-
(2012)
Immunity
, vol.36
, pp. 68-78
-
-
van der Windt, G.J.1
Everts, B.2
Chang, C.H.3
Curtis, J.D.4
Freitas, T.C.5
Amiel, E.6
-
36
-
-
84976478216
-
Mitochondrial dynamics controls T cell fate through metabolic programming
-
Buck MD, O'Sullivan D, Klein Geltink RI, Curtis JD, Chang CH, Sanin DE, et al. Mitochondrial dynamics controls T cell fate through metabolic programming. Cell (2016) 166:63-76. doi:10.1016/j.cell.2016.05.035
-
(2016)
Cell
, vol.166
, pp. 63-76
-
-
Buck, M.D.1
O'Sullivan, D.2
Klein Geltink, R.I.3
Curtis, J.D.4
Chang, C.H.5
Sanin, D.E.6
-
37
-
-
84904392273
-
Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development
-
O'Sullivan D, van der Windt GJ, Huang SC, Curtis JD, Chang CH, Buck MD, et al. Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development. Immunity (2014) 41:75-88. doi:10.1016/j.immuni.2014.06.005
-
(2014)
Immunity
, vol.41
, pp. 75-88
-
-
O'Sullivan, D.1
van der Windt, G.J.2
Huang, S.C.3
Curtis, J.D.4
Chang, C.H.5
Buck, M.D.6
-
38
-
-
33947730608
-
Asymmetric T lymphocyte division in the initiation of adaptive immune responses
-
Chang JT, Palanivel VR, Kinjyo I, Schambach F, Intlekofer AM, Banerjee A, et al. Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science (2007) 315:1687-91. doi:10.1126/science.1139393
-
(2007)
Science
, vol.315
, pp. 1687-1691
-
-
Chang, J.T.1
Palanivel, V.R.2
Kinjyo, I.3
Schambach, F.4
Intlekofer, A.M.5
Banerjee, A.6
-
39
-
-
84964527036
-
Metabolic maintenance of cell asymmetry following division in activated T lymphocytes
-
Verbist KC, Guy CS, Milasta S, Liedmann S, Kaminski MM, Wang R, et al. Metabolic maintenance of cell asymmetry following division in activated T lymphocytes. Nature (2016) 532:389-93. doi:10.1038/nature17442
-
(2016)
Nature
, vol.532
, pp. 389-393
-
-
Verbist, K.C.1
Guy, C.S.2
Milasta, S.3
Liedmann, S.4
Kaminski, M.M.5
Wang, R.6
-
41
-
-
41149158001
-
Memory CD4 T cells emerge from effector T-cell progenitors
-
Harrington LE, Janowski KM, Oliver JR, Zajac AJ, Weaver CT. Memory CD4 T cells emerge from effector T-cell progenitors. Nature (2008) 452:356-60. doi:10.1038/nature06672
-
(2008)
Nature
, vol.452
, pp. 356-360
-
-
Harrington, L.E.1
Janowski, K.M.2
Oliver, J.R.3
Zajac, A.J.4
Weaver, C.T.5
-
42
-
-
67650074206
-
mTOR regulates memory CD8 T-cell differentiation
-
Araki K, Turner AP, Shaffer VO, Gangappa S, Keller SA, Bachmann MF, et al. mTOR regulates memory CD8 T-cell differentiation. Nature (2009) 460:108-12. doi:10.1038/nature08155
-
(2009)
Nature
, vol.460
, pp. 108-112
-
-
Araki, K.1
Turner, A.P.2
Shaffer, V.O.3
Gangappa, S.4
Keller, S.A.5
Bachmann, M.F.6
-
43
-
-
67650096912
-
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
-
Pearce EL, Walsh MC, Cejas PJ, Harms GM, Shen H, Wang LS, et al. Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature (2009) 460:103-7. doi:10.1038/nature08097
-
(2009)
Nature
, vol.460
, pp. 103-107
-
-
Pearce, E.L.1
Walsh, M.C.2
Cejas, P.J.3
Harms, G.M.4
Shen, H.5
Wang, L.S.6
-
44
-
-
84957963858
-
Mammalian target of rapamycin complex 2 controls CD8 T cell memory differentiation in a foxo1-dependent manner
-
Zhang L, Tschumi BO, Lopez-Mejia IC, Oberle SG, Meyer M, Samson G, et al. Mammalian target of rapamycin complex 2 controls CD8 T cell memory differentiation in a foxo1-dependent manner. Cell Rep (2016) 14:1206-17. doi:10.1016/j.celrep.2015.12.095
-
(2016)
Cell Rep
, vol.14
, pp. 1206-1217
-
-
Zhang, L.1
Tschumi, B.O.2
Lopez-Mejia, I.C.3
Oberle, S.G.4
Meyer, M.5
Samson, G.6
-
45
-
-
35748956420
-
Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells
-
Kopf H, de la Rosa GM, Howard OM, Chen X. Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells. Int Immunopharmacol (2007) 7:1819-24. doi:10.1016/j.intimp.2007.08.027
-
(2007)
Int Immunopharmacol
, vol.7
, pp. 1819-1824
-
-
Kopf, H.1
de la Rosa, G.M.2
Howard, O.M.3
Chen, X.4
-
46
-
-
66949173728
-
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
-
Delgoffe GM, Kole TP, Zheng Y, Zarek PE, Matthews KL, Xiao B, et al. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity (2009) 30:832-44. doi:10.1016/j.immuni.2009.04.014
-
(2009)
Immunity
, vol.30
, pp. 832-844
-
-
Delgoffe, G.M.1
Kole, T.P.2
Zheng, Y.3
Zarek, P.E.4
Matthews, K.L.5
Xiao, B.6
-
47
-
-
79953172571
-
Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets
-
Michalek RD, Gerriets VA, Jacobs SR, Macintyre AN, MacIver NJ, Mason EF, et al. Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J Immunol (2011) 186:3299-303. doi:10.4049/jimmunol.1003613
-
(2011)
J Immunol
, vol.186
, pp. 3299-3303
-
-
Michalek, R.D.1
Gerriets, V.A.2
Jacobs, S.R.3
Macintyre, A.N.4
MacIver, N.J.5
Mason, E.F.6
-
48
-
-
79960369458
-
HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
-
Shi LZ, Wang R, Huang G, Vogel P, Neale G, Green DR, et al. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J Exp Med (2011) 208:1367-76. doi:10.1084/jem.20110278
-
(2011)
J Exp Med
, vol.208
, pp. 1367-1376
-
-
Shi, L.Z.1
Wang, R.2
Huang, G.3
Vogel, P.4
Neale, G.5
Green, D.R.6
-
49
-
-
80052277906
-
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1
-
Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y, et al. Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell (2011) 146:772-84. doi:10.1016/j.cell.2011.07.033
-
(2011)
Cell
, vol.146
, pp. 772-784
-
-
Dang, E.V.1
Barbi, J.2
Yang, H.Y.3
Jinasena, D.4
Yu, H.5
Zheng, Y.6
-
50
-
-
79952985551
-
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
-
Delgoffe GM, Pollizzi KN, Waickman AT, Heikamp E, Meyers DJ, Horton MR, et al. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat Immunol (2011) 12:295-303. doi:10.1038/ni.2005
-
(2011)
Nat Immunol
, vol.12
, pp. 295-303
-
-
Delgoffe, G.M.1
Pollizzi, K.N.2
Waickman, A.T.3
Heikamp, E.4
Meyers, D.J.5
Horton, M.R.6
-
51
-
-
84878831880
-
Posttranscriptional control of T cell effector function by aerobic glycolysis
-
Chang CH, Curtis JD, Maggi LB Jr, Faubert B, Villarino AV, O'Sullivan D, et al. Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell (2013) 153:1239-51. doi:10.1016/j.cell.2013.05.016
-
(2013)
Cell
, vol.153
, pp. 1239-1251
-
-
Chang, C.H.1
Curtis, J.D.2
Maggi, L.B.3
Faubert, B.4
Villarino, A.V.5
O'Sullivan, D.6
-
52
-
-
84886721392
-
Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch
-
Gubser PM, Bantug GR, Razik L, Fischer M, Dimeloe S, Hoenger G, et al. Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch. Nat Immunol (2013) 14:1064-72. doi:10.1038/ni.2687
-
(2013)
Nat Immunol
, vol.14
, pp. 1064-1072
-
-
Gubser, P.M.1
Bantug, G.R.2
Razik, L.3
Fischer, M.4
Dimeloe, S.5
Hoenger, G.6
-
53
-
-
84905510173
-
Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells
-
Cao Y, Rathmell JC, Macintyre AN. Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells. PLoS One (2014) 9:e104104. doi:10.1371/journal.pone.0104104
-
(2014)
PLoS One
, vol.9
-
-
Cao, Y.1
Rathmell, J.C.2
Macintyre, A.N.3
-
54
-
-
0025078266
-
Expression of a new set of glycolytic isozymes in activated human peripheral lymphocytes
-
Marjanovic S, Eriksson I, Nelson BD. Expression of a new set of glycolytic isozymes in activated human peripheral lymphocytes. Biochim Biophys Acta (1990) 1087:1-6. doi:10.1016/0167-4781(90)90113-G
-
(1990)
Biochim Biophys Acta
, vol.1087
, pp. 1-6
-
-
Marjanovic, S.1
Eriksson, I.2
Nelson, B.D.3
-
55
-
-
84866842363
-
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
-
Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, et al. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat Chem Biol (2012) 8:839-47. doi:10.1038/nchembio1212-1008b
-
(2012)
Nat Chem Biol
, vol.8
, pp. 839-847
-
-
Anastasiou, D.1
Yu, Y.2
Israelsen, W.J.3
Jiang, J.K.4
Boxer, M.B.5
Hong, B.S.6
-
56
-
-
0037087472
-
CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells
-
Appleman LJ, van Puijenbroek AA, Shu KM, Nadler LM, Boussiotis VA. CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells. J Immunol (2002) 168:2729-36. doi:10.4049/jimmunol.168.6.2729
-
(2002)
J Immunol
, vol.168
, pp. 2729-2736
-
-
Appleman, L.J.1
van Puijenbroek, A.A.2
Shu, K.M.3
Nadler, L.M.4
Boussiotis, V.A.5
-
57
-
-
33745837261
-
Differential regulation of T-cell growth by IL-2 and IL-15
-
Cornish GH, Sinclair LV, Cantrell DA. Differential regulation of T-cell growth by IL-2 and IL-15. Blood (2006) 108:600-8. doi:10.1182/blood-2005-12-4827
-
(2006)
Blood
, vol.108
, pp. 600-608
-
-
Cornish, G.H.1
Sinclair, L.V.2
Cantrell, D.A.3
-
58
-
-
34247184208
-
Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking
-
Wieman HL, Wofford JA, Rathmell JC. Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. Mol Biol Cell (2007) 18:1437-46. doi:10.1091/mbc.E06-07-0593
-
(2007)
Mol Biol Cell
, vol.18
, pp. 1437-1446
-
-
Wieman, H.L.1
Wofford, J.A.2
Rathmell, J.C.3
-
59
-
-
0030748651
-
Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades
-
Deprez J, Vertommen D, Alessi DR, Hue L, Rider MH. Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades. J Biol Chem (1997) 272:17269-75. doi:10.1074/jbc.272.28.17269
-
(1997)
J Biol Chem
, vol.272
, pp. 17269-17275
-
-
Deprez, J.1
Vertommen, D.2
Alessi, D.R.3
Hue, L.4
Rider, M.H.5
-
60
-
-
34250788809
-
AKT/PKB signaling: navigating downstream
-
Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell (2007) 129:1261-74. doi:10.1016/j.cell.2007.06.009
-
(2007)
Cell
, vol.129
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
61
-
-
84874271196
-
mTOR, linking metabolism and immunity
-
Xu X, Ye L, Araki K, Ahmed R. mTOR, linking metabolism and immunity. Semin Immunol (2012) 24:429-35. doi:10.1016/j.smim.2012.12.005
-
(2012)
Semin Immunol
, vol.24
, pp. 429-435
-
-
Xu, X.1
Ye, L.2
Araki, K.3
Ahmed, R.4
-
62
-
-
77955475969
-
Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation
-
Carr EL, Kelman A, Wu GS, Gopaul R, Senkevitch E, Aghvanyan A, et al. Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation. J Immunol (2010) 185:1037-44. doi:10.4049/jimmunol.0903586
-
(2010)
J Immunol
, vol.185
, pp. 1037-1044
-
-
Carr, E.L.1
Kelman, A.2
Wu, G.S.3
Gopaul, R.4
Senkevitch, E.5
Aghvanyan, A.6
-
63
-
-
0035027828
-
Transcription factor HIF-1 is a necessary mediator of the Pasteur effect in mammalian cells
-
Seagroves TN, Ryan HE, Lu H, Wouters BG, Knapp M, Thibault P, et al. Transcription factor HIF-1 is a necessary mediator of the Pasteur effect in mammalian cells. Mol Cell Biol (2001) 21:3436-44. doi:10.1128/MCB.21.10.3436-3444.2001
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3436-3444
-
-
Seagroves, T.N.1
Ryan, H.E.2
Lu, H.3
Wouters, B.G.4
Knapp, M.5
Thibault, P.6
-
64
-
-
84886672916
-
Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen
-
Doedens AL, Phan AT, Stradner MH, Fujimoto JK, Nguyen JV, Yang E, et al. Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen. Nat Immunol (2013) 14:1173-82. doi:10.1038/ni.2714
-
(2013)
Nat Immunol
, vol.14
, pp. 1173-1182
-
-
Doedens, A.L.1
Phan, A.T.2
Stradner, M.H.3
Fujimoto, J.K.4
Nguyen, J.V.5
Yang, E.6
-
65
-
-
0028114542
-
Prevention of T cell anergy by signaling through the γc chain of the IL-2 receptor
-
Boussiotis VA, Barber DL, Nakarai T, Freeman GJ, Gribben JG, Bernstein GM, et al. Prevention of T cell anergy by signaling through the γc chain of the IL-2 receptor. Science (1994) 266:1039-42. doi:10.1126/science.7973657
-
(1994)
Science
, vol.266
, pp. 1039-1042
-
-
Boussiotis, V.A.1
Barber, D.L.2
Nakarai, T.3
Freeman, G.J.4
Gribben, J.G.5
Bernstein, G.M.6
-
66
-
-
41349093966
-
IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival
-
Wofford JA, Wieman HL, Jacobs SR, Zhao Y, Rathmell JC. IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. Blood (2008) 111:2101-11. doi:10.1182/blood-2007-06-096297
-
(2008)
Blood
, vol.111
, pp. 2101-2111
-
-
Wofford, J.A.1
Wieman, H.L.2
Jacobs, S.R.3
Zhao, Y.4
Rathmell, J.C.5
-
67
-
-
0025319665
-
Role of calcium ions in regulation of mammalian intramitochondrial metabolism
-
McCormack JG, Halestrap AP, Denton RM. Role of calcium ions in regulation of mammalian intramitochondrial metabolism. Physiol Rev (1990) 70:391-425
-
(1990)
Physiol Rev
, vol.70
, pp. 391-425
-
-
McCormack, J.G.1
Halestrap, A.P.2
Denton, R.M.3
-
69
-
-
84865289879
-
LKB1 and AMPK: central regulators of lymphocyte metabolism and function
-
Blagih J, Krawczyk CM, Jones RG. LKB1 and AMPK: central regulators of lymphocyte metabolism and function. Immunol Rev (2012) 249:59-71. doi:10.1111/j.1600-065X.2012.01157.x
-
(2012)
Immunol Rev
, vol.249
, pp. 59-71
-
-
Blagih, J.1
Krawczyk, C.M.2
Jones, R.G.3
-
70
-
-
84921309472
-
The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo
-
Blagih J, Coulombe F, Vincent EE, Dupuy F, Galicia-Vázquez G, Yurchenko E, et al. The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo. Immunity (2015) 42:41-54. doi:10.1016/j.immuni.2014.12.030
-
(2015)
Immunity
, vol.42
, pp. 41-54
-
-
Blagih, J.1
Coulombe, F.2
Vincent, E.E.3
Dupuy, F.4
Galicia-Vázquez, G.5
Yurchenko, E.6
-
71
-
-
84858782079
-
AMPK: a nutrient and energy sensor that maintains energy homeostasis
-
Hardie DG, Ross FA, Hawley SA. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol (2012) 13:251-62. doi:10.1038/nrm3311
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 251-262
-
-
Hardie, D.G.1
Ross, F.A.2
Hawley, S.A.3
-
72
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell (2003) 115:577-90. doi:10.1016/S0092-8674(03)00929-2
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
73
-
-
3042818799
-
Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
-
Corradetti MN, Inoki K, Bardeesy N, DePinho RA, Guan KL. Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev (2004) 18:1533-8. doi:10.1101/gad.1199104
-
(2004)
Genes Dev
, vol.18
, pp. 1533-1538
-
-
Corradetti, M.N.1
Inoki, K.2
Bardeesy, N.3
DePinho, R.A.4
Guan, K.L.5
-
74
-
-
0043127125
-
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
-
Inoki K, Li Y, Xu T, Guan KL. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev (2003) 17:1829-34. doi:10.1101/gad.1110003
-
(2003)
Genes Dev
, vol.17
, pp. 1829-1834
-
-
Inoki, K.1
Li, Y.2
Xu, T.3
Guan, K.L.4
-
75
-
-
42949139481
-
AMPK phosphorylation of raptor mediates a metabolic checkpoint
-
Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell (2008) 30:214-26. doi:10.1016/j.molcel.2008.03.003
-
(2008)
Mol Cell
, vol.30
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
-
76
-
-
0025830902
-
CTLA-4 is a second receptor for the B cell activation antigen B7
-
Linsley PS, Brady W, Urnes M, Grosmaire LS, Damle NK, Ledbetter JA. CTLA-4 is a second receptor for the B cell activation antigen B7. J Exp Med (1991) 174:561-9. doi:10.1084/jem.174.3.561
-
(1991)
J Exp Med
, vol.174
, pp. 561-569
-
-
Linsley, P.S.1
Brady, W.2
Urnes, M.3
Grosmaire, L.S.4
Damle, N.K.5
Ledbetter, J.A.6
-
77
-
-
0033587768
-
Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4(+) T cell responses
-
Chambers CA, Kuhns MS, Allison JP. Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4(+) T cell responses. Proc Natl Acad Sci U S A (1999) 96:8603-8. doi:10.1073/pnas.96.15.8603
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 8603-8608
-
-
Chambers, C.A.1
Kuhns, M.S.2
Allison, J.P.3
-
78
-
-
0035102196
-
CTLA-4 regulates induction of anergy in vivo
-
Greenwald RJ, Boussiotis VA, Lorsbach RB, Abbas AK, Sharpe AH. CTLA-4 regulates induction of anergy in vivo. Immunity (2001) 14:145-55. doi:10.1016/S1074-7613(01)00097-8
-
(2001)
Immunity
, vol.14
, pp. 145-155
-
-
Greenwald, R.J.1
Boussiotis, V.A.2
Lorsbach, R.B.3
Abbas, A.K.4
Sharpe, A.H.5
-
79
-
-
0029953858
-
CTLA-4 ligation blocks CD28-dependent T cell activation
-
Walunas TL, Bakker CY, Bluestone JA. CTLA-4 ligation blocks CD28-dependent T cell activation. J Exp Med (1996) 183:2541-50. doi:10.1084/jem.183.6.2541
-
(1996)
J Exp Med
, vol.183
, pp. 2541-2550
-
-
Walunas, T.L.1
Bakker, C.Y.2
Bluestone, J.A.3
-
80
-
-
0029899783
-
CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
-
Krummel MF, Allison JP. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J Exp Med (1996) 183:2533-40. doi:10.1084/jem.183.6.2533
-
(1996)
J Exp Med
, vol.183
, pp. 2533-2540
-
-
Krummel, M.F.1
Allison, J.P.2
-
81
-
-
33751561177
-
CTLA-4 dysregulation of self/tumor-reactive CD8+ T-cell function is CD4+ T-cell dependent
-
Gattinoni L, Ranganathan A, Surman DR, Palmer DC, Antony PA, Theoret MR, et al. CTLA-4 dysregulation of self/tumor-reactive CD8+ T-cell function is CD4+ T-cell dependent. Blood (2006) 108:3818-23. doi:10.1182/blood-2006-07-034066
-
(2006)
Blood
, vol.108
, pp. 3818-3823
-
-
Gattinoni, L.1
Ranganathan, A.2
Surman, D.R.3
Palmer, D.C.4
Antony, P.A.5
Theoret, M.R.6
-
82
-
-
0031405867
-
Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells
-
Chambers CA, Sullivan TJ, Allison JP. Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells. Immunity (1997) 7:885-95. doi:10.1016/S1074-7613(00)80406-9
-
(1997)
Immunity
, vol.7
, pp. 885-895
-
-
Chambers, C.A.1
Sullivan, T.J.2
Allison, J.P.3
-
83
-
-
0031678645
-
Secondary but not primary T cell responses are enhanced in CTLA-4-deficient CD8+ T cells
-
Chambers CA, Sullivan TJ, Truong T, Allison JP. Secondary but not primary T cell responses are enhanced in CTLA-4-deficient CD8+ T cells. Eur J Immunol (1998) 28:3137-43. doi:10.1002/(SICI)1521-4141(199810)28:10<3137::AID-IMMU3137>3.3.CO;2-O
-
(1998)
Eur J Immunol
, vol.28
, pp. 3137-3143
-
-
Chambers, C.A.1
Sullivan, T.J.2
Truong, T.3
Allison, J.P.4
-
84
-
-
0034710983
-
Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells
-
Luhder F, Chambers C, Allison JP, Benoist C, Mathis D. Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells. Proc Natl Acad Sci U S A (2000) 97:12204-9. doi:10.1073/pnas.200348397
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 12204-12209
-
-
Luhder, F.1
Chambers, C.2
Allison, J.P.3
Benoist, C.4
Mathis, D.5
-
85
-
-
34548718561
-
Induction of autoimmune disease in CTLA-4-/-mice depends on a specific CD28 motif that is required for in vivo costimulation
-
Tai X, Van Laethem F, Sharpe AH, Singer A. Induction of autoimmune disease in CTLA-4-/-mice depends on a specific CD28 motif that is required for in vivo costimulation. Proc Natl Acad Sci U S A (2007) 104:13756-61. doi:10.1073/pnas.0706509104
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 13756-13761
-
-
Tai, X.1
Van Laethem, F.2
Sharpe, A.H.3
Singer, A.4
-
86
-
-
79955529454
-
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4
-
Qureshi OS, Zheng Y, Nakamura K, Attridge K, Manzotti C, Schmidt EM, et al. Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science (2011) 332:600-3. doi:10.1126/science.1202947
-
(2011)
Science
, vol.332
, pp. 600-603
-
-
Qureshi, O.S.1
Zheng, Y.2
Nakamura, K.3
Attridge, K.4
Manzotti, C.5
Schmidt, E.M.6
-
87
-
-
0036852170
-
CTLA-4-Ig regulates tryptophan catabolism in vivo
-
Grohmann U, Orabona C, Fallarino F, Vacca C, Calcinaro F, Falorni A, et al. CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat Immunol (2002) 3:1097-101. doi:10.1038/ni846
-
(2002)
Nat Immunol
, vol.3
, pp. 1097-1101
-
-
Grohmann, U.1
Orabona, C.2
Fallarino, F.3
Vacca, C.4
Calcinaro, F.5
Falorni, A.6
-
88
-
-
0034254301
-
CTLA-4 (CD152) can inhibit T cell activation by two different mechanisms depending on its level of cell surface expression
-
Carreno BM, Bennett F, Chau TA, Ling V, Luxenberg D, Jussif J, et al. CTLA-4 (CD152) can inhibit T cell activation by two different mechanisms depending on its level of cell surface expression. J Immunol (2000) 165:1352-6. doi:10.4049/jimmunol.165.3.1352
-
(2000)
J Immunol
, vol.165
, pp. 1352-1356
-
-
Carreno, B.M.1
Bennett, F.2
Chau, T.A.3
Ling, V.4
Luxenberg, D.5
Jussif, J.6
-
89
-
-
0037244012
-
Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4
-
Chikuma S, Imboden JB, Bluestone JA. Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4. J Exp Med (2003) 197:129-35. doi:10.1084/jem.20021646
-
(2003)
J Exp Med
, vol.197
, pp. 129-135
-
-
Chikuma, S.1
Imboden, J.B.2
Bluestone, J.A.3
-
90
-
-
0033083788
-
Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases
-
Chuang E, Lee KM, Robbins MD, Duerr JM, Alegre ML, Hambor JE, et al. Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases. J Immunol (1999) 162:1270-7
-
(1999)
J Immunol
, vol.162
, pp. 1270-1277
-
-
Chuang, E.1
Lee, K.M.2
Robbins, M.D.3
Duerr, J.M.4
Alegre, M.L.5
Hambor, J.E.6
-
91
-
-
0032501103
-
Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4
-
Schneider H, Schwartzberg PL, Rudd CE. Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4. Biochem Biophys Res Commun (1998) 252:14-9. doi:10.1006/bbrc.1998.9559
-
(1998)
Biochem Biophys Res Commun
, vol.252
, pp. 14-19
-
-
Schneider, H.1
Schwartzberg, P.L.2
Rudd, C.E.3
-
92
-
-
0032547259
-
Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152)
-
Miyatake S, Nakaseko C, Umemori H, Yamamoto T, Saito T. Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152). Biochem Biophys Res Commun (1998) 249:444-8. doi:10.1006/bbrc.1998.9191
-
(1998)
Biochem Biophys Res Commun
, vol.249
, pp. 444-448
-
-
Miyatake, S.1
Nakaseko, C.2
Umemori, H.3
Yamamoto, T.4
Saito, T.5
-
93
-
-
0032545452
-
Molecular basis of T cell inactivation by CTLA-4
-
Lee KM, Chuang E, Griffin M, Khattri R, Hong DK, Zhang W, et al. Molecular basis of T cell inactivation by CTLA-4. Science (1998) 282:2263-6. doi:10.1126/science.282.5397.2263
-
(1998)
Science
, vol.282
, pp. 2263-2266
-
-
Lee, K.M.1
Chuang, E.2
Griffin, M.3
Khattri, R.4
Hong, D.K.5
Zhang, W.6
-
94
-
-
0030001318
-
Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4
-
Marengère LE, Waterhouse P, Duncan GS, Mittrücker HW, Feng GS, Mak TW. Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science (1996) 272:1170-3. doi:10.1126/science.272.5265.1170
-
(1996)
Science
, vol.272
, pp. 1170-1173
-
-
Marengère, L.E.1
Waterhouse, P.2
Duncan, G.S.3
Mittrücker, H.W.4
Feng, G.S.5
Mak, T.W.6
-
95
-
-
38349074305
-
CTLA-4 disrupts ZAP70 microcluster formation with reduced T cell/APC dwell times and calcium mobilization
-
Schneider H, Smith X, Liu H, Bismuth G, Rudd CE. CTLA-4 disrupts ZAP70 microcluster formation with reduced T cell/APC dwell times and calcium mobilization. Eur J Immunol (2008) 38:40-7. doi:10.1002/eji.200737423
-
(2008)
Eur J Immunol
, vol.38
, pp. 40-47
-
-
Schneider, H.1
Smith, X.2
Liu, H.3
Bismuth, G.4
Rudd, C.E.5
-
96
-
-
33749038866
-
Reversal of the TCR stop signal by CTLA-4
-
Schneider H, Downey J, Smith A, Zinselmeyer BH, Rush C, Brewer JM, et al. Reversal of the TCR stop signal by CTLA-4. Science (2006) 313:1972-5. doi:10.1126/science.1131078
-
(2006)
Science
, vol.313
, pp. 1972-1975
-
-
Schneider, H.1
Downey, J.2
Smith, A.3
Zinselmeyer, B.H.4
Rush, C.5
Brewer, J.M.6
-
97
-
-
0037093856
-
Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A
-
Baroja ML, Vijayakrishnan L, Bettelli E, Darlington PJ, Chau TA, Ling V, et al. Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A. J Immunol (2002) 168:5070-8. doi:10.4049/jimmunol.168.10.5070
-
(2002)
J Immunol
, vol.168
, pp. 5070-5078
-
-
Baroja, M.L.1
Vijayakrishnan, L.2
Bettelli, E.3
Darlington, P.J.4
Chau, T.A.5
Ling, V.6
-
98
-
-
0033662376
-
The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A
-
Chuang E, Fisher TS, Morgan RW, Robbins MD, Duerr JM, Vander Heiden MG, et al. The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A. Immunity (2000) 13:313-22. doi:10.1016/S1074-7613(00)00031-5
-
(2000)
Immunity
, vol.13
, pp. 313-322
-
-
Chuang, E.1
Fisher, T.S.2
Morgan, R.W.3
Robbins, M.D.4
Duerr, J.M.5
Vander Heiden, M.G.6
-
99
-
-
0033553471
-
CTLA-4 ligation suppresses CD28-induced NF-kappaB and AP-1 activity in mouse T cell blasts
-
Olsson C, Riesbeck K, Dohlsten M, Michaëlsson E. CTLA-4 ligation suppresses CD28-induced NF-kappaB and AP-1 activity in mouse T cell blasts. J Biol Chem (1999) 274:14400-5. doi:10.1074/jbc.274.20.14400
-
(1999)
J Biol Chem
, vol.274
, pp. 14400-14405
-
-
Olsson, C.1
Riesbeck, K.2
Dohlsten, M.3
Michaëlsson, E.4
-
100
-
-
0033048961
-
CTLA4 ligation attenuates AP-1, NFAT and NF-kappaB activity in activated T cells
-
Fraser JH, Rincón M, McCoy KD, Le Gros G. CTLA4 ligation attenuates AP-1, NFAT and NF-kappaB activity in activated T cells. Eur J Immunol (1999) 29:838-44. doi:10.1002/(SICI)1521-4141(199903)29:03<838::AID-IMMU838>3.0.CO;2-P
-
(1999)
Eur J Immunol
, vol.29
, pp. 838-844
-
-
Fraser, J.H.1
Rincón, M.2
McCoy, K.D.3
Le Gros, G.4
-
101
-
-
0028852073
-
Cytotoxic T lymphocyte-associated molecule-4, a high-avidity receptor for CD80 and CD86, contains an intracellular localization motif in its cytoplasmic tail
-
Leung HT, Bradshaw J, Cleaveland JS, Linsley PS. Cytotoxic T lymphocyte-associated molecule-4, a high-avidity receptor for CD80 and CD86, contains an intracellular localization motif in its cytoplasmic tail. J Biol Chem (1995) 270:25107-14. doi:10.1074/jbc.270.42.25107
-
(1995)
J Biol Chem
, vol.270
, pp. 25107-25114
-
-
Leung, H.T.1
Bradshaw, J.2
Cleaveland, J.S.3
Linsley, P.S.4
-
102
-
-
0030176371
-
Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement
-
Linsley PS, Bradshaw J, Greene J, Peach R, Bennett KL, Mittler RS. Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement. Immunity (1996) 4:535-43. doi:10.1016/S1074-7613(00)80480-X
-
(1996)
Immunity
, vol.4
, pp. 535-543
-
-
Linsley, P.S.1
Bradshaw, J.2
Greene, J.3
Peach, R.4
Bennett, K.L.5
Mittler, R.S.6
-
103
-
-
0030443168
-
Regulation of surface and intracellular expression of CTLA4 on mouse T cells
-
Alegre ML, Noel PJ, Eisfelder BJ, Chuang E, Clark MR, Reiner SL, et al. Regulation of surface and intracellular expression of CTLA4 on mouse T cells. J Immunol (1996) 157:4762-70
-
(1996)
J Immunol
, vol.157
, pp. 4762-4770
-
-
Alegre, M.L.1
Noel, P.J.2
Eisfelder, B.J.3
Chuang, E.4
Clark, M.R.5
Reiner, S.L.6
-
104
-
-
0031181647
-
Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression
-
Chuang E, Alegre ML, Duckett CS, Noel PJ, Vander Heiden MG, Thompson CB. Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression. J Immunol (1997) 159:144-51
-
(1997)
J Immunol
, vol.159
, pp. 144-151
-
-
Chuang, E.1
Alegre, M.L.2
Duckett, C.S.3
Noel, P.J.4
Vander Heiden, M.G.5
Thompson, C.B.6
-
105
-
-
0030611358
-
Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein
-
Zhang Y, Allison JP. Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein. Proc Natl Acad Sci U S A (1997) 94:9273-8. doi:10.1073/pnas.94.17.9273
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 9273-9278
-
-
Zhang, Y.1
Allison, J.P.2
-
106
-
-
0030917081
-
Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2
-
Shiratori T, Miyatake S, Ohno H, Nakaseko C, Isono K, Bonifacino JS, et al. Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2. Immunity (1997) 6:583-9. doi:10.1016/S1074-7613(00)80346-5
-
(1997)
Immunity
, vol.6
, pp. 583-589
-
-
Shiratori, T.1
Miyatake, S.2
Ohno, H.3
Nakaseko, C.4
Isono, K.5
Bonifacino, J.S.6
-
107
-
-
0036172220
-
Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength
-
Egen JG, Allison JP. Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength. Immunity (2002) 16:23-35. doi:10.1016/S1074-7613(01)00259-X
-
(2002)
Immunity
, vol.16
, pp. 23-35
-
-
Egen, J.G.1
Allison, J.P.2
-
108
-
-
84920921528
-
Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens
-
Gubin MM, Zhang X, Schuster H, Caron E, Ward JP, Noguchi T, et al. Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens. Nature (2014) 515:577-81. doi:10.1038/nature13988
-
(2014)
Nature
, vol.515
, pp. 577-581
-
-
Gubin, M.M.1
Zhang, X.2
Schuster, H.3
Caron, E.4
Ward, J.P.5
Noguchi, T.6
-
109
-
-
0026700235
-
Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
-
Ishida Y, Agata Y, Shibahara K, Honjo T. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J (1992) 11:3887-95
-
(1992)
EMBO J
, vol.11
, pp. 3887-3895
-
-
Ishida, Y.1
Agata, Y.2
Shibahara, K.3
Honjo, T.4
-
110
-
-
0029964018
-
Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4-CD8-) thymocytes
-
Nishimura H, Agata Y, Kawasaki A, Sato M, Imamura S, Minato N, et al. Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4-CD8-) thymocytes. Int Immunol (1996) 8:773-80. doi:10.1093/intimm/8.5.773
-
(1996)
Int Immunol
, vol.8
, pp. 773-780
-
-
Nishimura, H.1
Agata, Y.2
Kawasaki, A.3
Sato, M.4
Imamura, S.5
Minato, N.6
-
111
-
-
84872154060
-
Notch signaling regulates PD-1 expression during CD8(+) T-cell activation
-
Mathieu M, Cotta-Grand N, Daudelin JF, Thébault P, Labrecque N. Notch signaling regulates PD-1 expression during CD8(+) T-cell activation. Immunol Cell Biol (2013) 91:82-8. doi:10.1038/icb.2012.53
-
(2013)
Immunol Cell Biol
, vol.91
, pp. 82-88
-
-
Mathieu, M.1
Cotta-Grand, N.2
Daudelin, J.F.3
Thébault, P.4
Labrecque, N.5
-
112
-
-
84912111808
-
The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infection
-
Staron MM, Gray SM, Marshall HD, Parish IA, Chen JH, Perry CJ, et al. The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infection. Immunity (2014) 41:802-14. doi:10.1016/j.immuni.2014.10.013
-
(2014)
Immunity
, vol.41
, pp. 802-814
-
-
Staron, M.M.1
Gray, S.M.2
Marshall, H.D.3
Parish, I.A.4
Chen, J.H.5
Perry, C.J.6
-
113
-
-
58149314579
-
NFATc1 regulates PD-1 expression upon T cell activation
-
Oestreich KJ, Yoon H, Ahmed R, Boss JM. NFATc1 regulates PD-1 expression upon T cell activation. J Immunol (2008) 181:4832-9. doi:10.4049/jimmunol.181.7.4832
-
(2008)
J Immunol
, vol.181
, pp. 4832-4839
-
-
Oestreich, K.J.1
Yoon, H.2
Ahmed, R.3
Boss, J.M.4
-
114
-
-
79956077563
-
T cell exhaustion
-
Wherry EJ. T cell exhaustion. Nat Immunol (2011) 12:492-9. doi:10.1038/ni.2035
-
(2011)
Nat Immunol
, vol.12
, pp. 492-499
-
-
Wherry, E.J.1
-
115
-
-
54449088740
-
Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade
-
Blackburn SD, Shin H, Freeman GJ, Wherry EJ. Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade. Proc Natl Acad Sci U S A (2008) 105:15016-21. doi:10.1073/pnas.0801497105
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 15016-15021
-
-
Blackburn, S.D.1
Shin, H.2
Freeman, G.J.3
Wherry, E.J.4
-
116
-
-
84872685720
-
The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood
-
Sage PT, Francisco LM, Carman CV, Sharpe AH. The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood. Nat Immunol (2013) 14:152-61. doi:10.1038/ni.2496
-
(2013)
Nat Immunol
, vol.14
, pp. 152-161
-
-
Sage, P.T.1
Francisco, L.M.2
Carman, C.V.3
Sharpe, A.H.4
-
117
-
-
33749338938
-
PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection
-
Petrovas C, Casazza JP, Brenchley JM, Price DA, Gostick E, Adams WC, et al. PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection. J Exp Med (2006) 203:2281-92. doi:10.1084/jem.20061496
-
(2006)
J Exp Med
, vol.203
, pp. 2281-2292
-
-
Petrovas, C.1
Casazza, J.P.2
Brenchley, J.M.3
Price, D.A.4
Gostick, E.5
Adams, W.C.6
-
118
-
-
34547794178
-
PD-1 and PD-1 ligands: from discovery to clinical application
-
Okazaki T, Honjo T. PD-1 and PD-1 ligands: from discovery to clinical application. Int Immunol (2007) 19:813-24. doi:10.1093/intimm/dxm057
-
(2007)
Int Immunol
, vol.19
, pp. 813-824
-
-
Okazaki, T.1
Honjo, T.2
-
119
-
-
3142688997
-
SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation
-
Chemnitz JM, Parry RV, Nichols KE, June CH, Riley JL. SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation. J Immunol (2004) 173:945-54. doi:10.4049/jimmunol.173.2.945
-
(2004)
J Immunol
, vol.173
, pp. 945-954
-
-
Chemnitz, J.M.1
Parry, R.V.2
Nichols, K.E.3
June, C.H.4
Riley, J.L.5
-
120
-
-
84881308659
-
PD-1 increases PTEN phosphatase activity while decreasing PTEN protein stability by inhibiting casein kinase 2
-
Patsoukis N, Li L, Sari D, Petkova V, Boussiotis VA. PD-1 increases PTEN phosphatase activity while decreasing PTEN protein stability by inhibiting casein kinase 2. Mol Cell Biol (2013) 33:3091-8. doi:10.1128/MCB.00319-13
-
(2013)
Mol Cell Biol
, vol.33
, pp. 3091-3098
-
-
Patsoukis, N.1
Li, L.2
Sari, D.3
Petkova, V.4
Boussiotis, V.A.5
-
121
-
-
27144496045
-
CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms
-
Parry RV, Chemnitz JM, Frauwirth KA, Lanfranco AR, Braunstein I, Kobayashi SV, et al. CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms. Mol Cell Biol (2005) 25:9543-53. doi:10.1128/MCB.25.21.9543-9553.2005
-
(2005)
Mol Cell Biol
, vol.25
, pp. 9543-9553
-
-
Parry, R.V.1
Chemnitz, J.M.2
Frauwirth, K.A.3
Lanfranco, A.R.4
Braunstein, I.5
Kobayashi, S.V.6
-
122
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
-
Maehama T, Dixon JE. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem (1998) 273:13375-8. doi:10.1074/jbc.273.22.13375
-
(1998)
J Biol Chem
, vol.273
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
123
-
-
0033514509
-
Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway
-
Ramaswamy S, Nakamura N, Vazquez F, Batt DB, Perera S, Roberts TM, et al. Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway. Proc Natl Acad Sci U S A (1999) 96:2110-5. doi:10.1073/pnas.96.5.2110
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 2110-2115
-
-
Ramaswamy, S.1
Nakamura, N.2
Vazquez, F.3
Batt, D.B.4
Perera, S.5
Roberts, T.M.6
-
124
-
-
84863089861
-
Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation
-
Patsoukis N, Brown J, Petkova V, Liu F, Li L, Boussiotis VA. Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation. Sci Signal (2012) 5:ra46. doi:10.1126/scisignal.2002796
-
(2012)
Sci Signal
, vol.5
-
-
Patsoukis, N.1
Brown, J.2
Petkova, V.3
Liu, F.4
Li, L.5
Boussiotis, V.A.6
-
125
-
-
0032524389
-
RasGRP, a Ras guanyl nucleotide-releasing protein with calcium-and diacylglycerol-binding motifs
-
Ebinu JO, Bottorff DA, Chan EY, Stang SL, Dunn RJ, Stone JC. RasGRP, a Ras guanyl nucleotide-releasing protein with calcium-and diacylglycerol-binding motifs. Science (1998) 280:1082-6. doi:10.1126/science.280.5366.1082
-
(1998)
Science
, vol.280
, pp. 1082-1086
-
-
Ebinu, J.O.1
Bottorff, D.A.2
Chan, E.Y.3
Stang, S.L.4
Dunn, R.J.5
Stone, J.C.6
-
126
-
-
84925688346
-
PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
-
Patsoukis N, Bardhan K, Chatterjee P, Sari D, Liu B, Bell LN, et al. PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation. Nat Commun (2015) 6:6692. doi:10.1038/ncomms7692
-
(2015)
Nat Commun
, vol.6
, pp. 6692
-
-
Patsoukis, N.1
Bardhan, K.2
Chatterjee, P.3
Sari, D.4
Liu, B.5
Bell, L.N.6
-
127
-
-
41149113441
-
The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells
-
Haxhinasto S, Mathis D, Benoist C. The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells. J Exp Med (2008) 205:565-74. doi:10.1084/jem.20071477
-
(2008)
J Exp Med
, vol.205
, pp. 565-574
-
-
Haxhinasto, S.1
Mathis, D.2
Benoist, C.3
-
128
-
-
0026681864
-
Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens
-
Baixeras E, Huard B, Miossec C, Jitsukawa S, Martin M, Hercend T, et al. Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens. J Exp Med (1992) 176:327-37. doi:10.1084/jem.176.2.327
-
(1992)
J Exp Med
, vol.176
, pp. 327-337
-
-
Baixeras, E.1
Huard, B.2
Miossec, C.3
Jitsukawa, S.4
Martin, M.5
Hercend, T.6
-
129
-
-
0029129218
-
CD4/major histocompatibility complex class II interaction analyzed with CD4-and lymphocyte activation gene-3 (LAG-3)-Ig fusion proteins
-
Huard B, Prigent P, Tournier M, Bruniquel D, Triebel F. CD4/major histocompatibility complex class II interaction analyzed with CD4-and lymphocyte activation gene-3 (LAG-3)-Ig fusion proteins. Eur J Immunol (1995) 25:2718-21. doi:10.1002/eji.1830250949
-
(1995)
Eur J Immunol
, vol.25
, pp. 2718-2721
-
-
Huard, B.1
Prigent, P.2
Tournier, M.3
Bruniquel, D.4
Triebel, F.5
-
131
-
-
2142815854
-
Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo
-
Workman CJ, Cauley LS, Kim IJ, Blackman MA, Woodland DL, Vignali DA. Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo. J Immunol (2004) 172:5450-5. doi:10.4049/jimmunol.172.9.5450
-
(2004)
J Immunol
, vol.172
, pp. 5450-5455
-
-
Workman, C.J.1
Cauley, L.S.2
Kim, I.J.3
Blackman, M.A.4
Woodland, D.L.5
Vignali, D.A.6
-
132
-
-
0037111520
-
Cutting edge: molecular analysis of the negative regulatory function of lymphocyte activation gene-3
-
Workman CJ, Dugger KJ, Vignali DA. Cutting edge: molecular analysis of the negative regulatory function of lymphocyte activation gene-3. J Immunol (2002) 169:5392-5. doi:10.4049/jimmunol.169.10.5392
-
(2002)
J Immunol
, vol.169
, pp. 5392-5395
-
-
Workman, C.J.1
Dugger, K.J.2
Vignali, D.A.3
-
133
-
-
36048963838
-
LAG-3 regulates CD8+ T cell accumulation and effector function in murine self-and tumor-tolerance systems
-
Grosso JF, Kelleher CC, Harris TJ, Maris CH, Hipkiss EL, De Marzo A, et al. LAG-3 regulates CD8+ T cell accumulation and effector function in murine self-and tumor-tolerance systems. J Clin Invest (2007) 117:3383-92. doi:10.1172/JCI31184
-
(2007)
J Clin Invest
, vol.117
, pp. 3383-3392
-
-
Grosso, J.F.1
Kelleher, C.C.2
Harris, T.J.3
Maris, C.H.4
Hipkiss, E.L.5
De Marzo, A.6
-
134
-
-
5644263642
-
Role of LAG-3 in regulatory T cells
-
Huang CT, Workman CJ, Flies D, Pan X, Marson AL, Zhou G, et al. Role of LAG-3 in regulatory T cells. Immunity (2004) 21:503-13. doi:10.1016/j.immuni.2004.08.010
-
(2004)
Immunity
, vol.21
, pp. 503-513
-
-
Huang, C.T.1
Workman, C.J.2
Flies, D.3
Pan, X.4
Marson, A.L.5
Zhou, G.6
-
135
-
-
44449110691
-
Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II
-
Liang B, Workman C, Lee J, Chew C, Dale BM, Colonna L, et al. Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II. J Immunol (2008) 180:5916-26. doi:10.4049/jimmunol.180.9.5916
-
(2008)
J Immunol
, vol.180
, pp. 5916-5926
-
-
Liang, B.1
Workman, C.2
Lee, J.3
Chew, C.4
Dale, B.M.5
Colonna, L.6
-
136
-
-
84910659812
-
Lymphocyte activation gene 3 (LAG-3) modulates the ability of CD4 T-cells to be suppressed in vivo
-
Durham NM, Nirschl CJ, Jackson CM, Elias J, Kochel CM, Anders RA, et al. Lymphocyte activation gene 3 (LAG-3) modulates the ability of CD4 T-cells to be suppressed in vivo. PLoS One (2014) 9:e109080. doi:10.1371/journal.pone.0109080
-
(2014)
PLoS One
, vol.9
-
-
Durham, N.M.1
Nirschl, C.J.2
Jackson, C.M.3
Elias, J.4
Kochel, C.M.5
Anders, R.A.6
-
137
-
-
84863115998
-
Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape
-
Woo SR, Turnis ME, Goldberg MV, Bankoti J, Selby M, Nirschl CJ, et al. Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Cancer Res (2011) 72:917-27. doi:10.1158/0008-5472.CAN-11-1620
-
(2011)
Cancer Res
, vol.72
, pp. 917-927
-
-
Woo, S.R.1
Turnis, M.E.2
Goldberg, M.V.3
Bankoti, J.4
Selby, M.5
Nirschl, C.J.6
-
138
-
-
33846551969
-
Metalloproteases regulate T-cell proliferation and effector function via LAG-3
-
Li N, Wang Y, Forbes K, Vignali KM, Heale BS, Saftig P, et al. Metalloproteases regulate T-cell proliferation and effector function via LAG-3. EMBO J (2007) 26:494-504. doi:10.1038/sj.emboj.7601520
-
(2007)
EMBO J
, vol.26
, pp. 494-504
-
-
Li, N.1
Wang, Y.2
Forbes, K.3
Vignali, K.M.4
Heale, B.S.5
Saftig, P.6
-
139
-
-
84863188195
-
Modulation of redox balance leaves murine diabetogenic TH1 T cells "LAG-3-ing" behind
-
Delmastro MM, et al. Modulation of redox balance leaves murine diabetogenic TH1 T cells "LAG-3-ing" behind. Diabetes (2012) 61:1760-8. doi:10.2337/db11-1591
-
(2012)
Diabetes
, vol.61
, pp. 1760-1768
-
-
Delmastro, M.M.1
-
140
-
-
85018773594
-
Lymphocyte activation gene 3 (LAG-3) regulates activation-induced CD4+ T cell metabolic transition (IRM6P. 725) [abstract]
-
63.17
-
Previte D, Delmastro-Greenwood M, Piganelli J. Lymphocyte activation gene 3 (LAG-3) regulates activation-induced CD4+ T cell metabolic transition (IRM6P. 725) [abstract]. J Immunol (2014) 192(Suppl 1):63.17
-
(2014)
J Immunol
, vol.192
-
-
Previte, D.1
Delmastro-Greenwood, M.2
Piganelli, J.3
-
141
-
-
0037203867
-
Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease
-
Monney L, Sabatos CA, Gaglia JL, Ryu A, Waldner H, Chernova T, et al. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature (2002) 415:536-41. doi:10.1038/415536a
-
(2002)
Nature
, vol.415
, pp. 536-541
-
-
Monney, L.1
Sabatos, C.A.2
Gaglia, J.L.3
Ryu, A.4
Waldner, H.5
Chernova, T.6
-
142
-
-
23144447812
-
The TIM gene family regulates autoimmune and allergic diseases
-
Meyers JH, Sabatos CA, Chakravarti S, Kuchroo VK. The TIM gene family regulates autoimmune and allergic diseases. Trends Mol Med (2005) 11:362-9. doi:10.1016/j.molmed.2005.06.008
-
(2005)
Trends Mol Med
, vol.11
, pp. 362-369
-
-
Meyers, J.H.1
Sabatos, C.A.2
Chakravarti, S.3
Kuchroo, V.K.4
-
143
-
-
0242708767
-
Tim-3 inhibits T helper type 1-mediated auto-and alloimmune responses and promotes immunological tolerance
-
Sánchez-Fueyo A, Tian J, Picarella D, Domenig C, Zheng XX, Sabatos CA, et al. Tim-3 inhibits T helper type 1-mediated auto-and alloimmune responses and promotes immunological tolerance. Nat Immunol (2003) 4:1093-101. doi:10.1038/ni987
-
(2003)
Nat Immunol
, vol.4
, pp. 1093-1101
-
-
Sánchez-Fueyo, A.1
Tian, J.2
Picarella, D.3
Domenig, C.4
Zheng, X.X.5
Sabatos, C.A.6
-
144
-
-
0242539820
-
Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance
-
Sabatos CA, Chakravarti S, Cha E, Schubart A, Sánchez-Fueyo A, Zheng XX, et al. Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat Immunol (2003) 4:1102-10. doi:10.1038/ni988
-
(2003)
Nat Immunol
, vol.4
, pp. 1102-1110
-
-
Sabatos, C.A.1
Chakravarti, S.2
Cha, E.3
Schubart, A.4
Sánchez-Fueyo, A.5
Zheng, X.X.6
-
145
-
-
30044434075
-
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
-
Zhu C, Anderson AC, Schubart A, Xiong H, Imitola J, Khoury SJ, et al. The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol (2005) 6:1245-52. doi:10.1038/ni1271
-
(2005)
Nat Immunol
, vol.6
, pp. 1245-1252
-
-
Zhu, C.1
Anderson, A.C.2
Schubart, A.3
Xiong, H.4
Imitola, J.5
Khoury, S.J.6
-
146
-
-
33947190606
-
T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface
-
Cao E, Zang X, Ramagopal UA, Mukhopadhaya A, Fedorov A, Fedorov E, et al. T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface. Immunity (2007) 26:311-21. doi:10.1016/j.immuni.2007.01.016
-
(2007)
Immunity
, vol.26
, pp. 311-321
-
-
Cao, E.1
Zang, X.2
Ramagopal, U.A.3
Mukhopadhaya, A.4
Fedorov, A.5
Fedorov, E.6
-
147
-
-
84921449533
-
CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
-
Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, et al. CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature (2015) 517:386-90. doi:10.1038/nature13848
-
(2015)
Nature
, vol.517
, pp. 386-390
-
-
Huang, Y.H.1
Zhu, C.2
Kondo, Y.3
Anderson, A.C.4
Gandhi, A.5
Russell, A.6
-
148
-
-
77949900365
-
T cell/transmembrane, Ig, and mucin-3 allelic variants differentially recognize phosphatidylserine and mediate phagocytosis of apoptotic cells
-
DeKruyff RH, Bu X, Ballesteros A, Santiago C, Chim YL, Lee HH, et al. T cell/transmembrane, Ig, and mucin-3 allelic variants differentially recognize phosphatidylserine and mediate phagocytosis of apoptotic cells. J Immunol (2010) 184:1918-30. doi:10.4049/jimmunol.0903059
-
(2010)
J Immunol
, vol.184
, pp. 1918-1930
-
-
DeKruyff, R.H.1
Bu, X.2
Ballesteros, A.3
Santiago, C.4
Chim, Y.L.5
Lee, H.H.6
-
149
-
-
80053608320
-
Phosphotyrosine-dependent coupling of Tim-3 to T-cell receptor signaling pathways
-
Lee J, Su EW, Zhu C, Hainline S, Phuah J, Moroco JA, et al. Phosphotyrosine-dependent coupling of Tim-3 to T-cell receptor signaling pathways. Mol Cell Biol (2011) 31:3963-74. doi:10.1128/MCB.05297-11
-
(2011)
Mol Cell Biol
, vol.31
, pp. 3963-3974
-
-
Lee, J.1
Su, E.W.2
Zhu, C.3
Hainline, S.4
Phuah, J.5
Moroco, J.A.6
-
150
-
-
33750530833
-
A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9
-
van de Weyer PS, Muehlfeit M, Klose C, Bonventre JV, Walz G, Kuehn EW. A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9. Biochem Biophys Res Commun (2006) 351:571-6. doi:10.1016/j.bbrc.2006.10.079
-
(2006)
Biochem Biophys Res Commun
, vol.351
, pp. 571-576
-
-
van de Weyer, P.S.1
Muehlfeit, M.2
Klose, C.3
Bonventre, J.V.4
Walz, G.5
Kuehn, E.W.6
-
151
-
-
84868669212
-
Bat3 promotes T cell responses and autoimmunity by repressing Tim-3-mediated cell death and exhaustion
-
Rangachari M, Zhu C, Sakuishi K, Xiao S, Karman J, Chen A, et al. Bat3 promotes T cell responses and autoimmunity by repressing Tim-3-mediated cell death and exhaustion. Nat Med (2012) 18:1394-400. doi:10.1038/nm.2871
-
(2012)
Nat Med
, vol.18
, pp. 1394-1400
-
-
Rangachari, M.1
Zhu, C.2
Sakuishi, K.3
Xiao, S.4
Karman, J.5
Chen, A.6
-
152
-
-
58149277359
-
Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection
-
Jones RB, Ndhlovu LC, Barbour JD, Sheth PM, Jha AR, Long BR, et al. Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection. J Exp Med (2008) 205:2763-79. doi:10.1084/jem.20081398
-
(2008)
J Exp Med
, vol.205
, pp. 2763-2779
-
-
Jones, R.B.1
Ndhlovu, L.C.2
Barbour, J.D.3
Sheth, P.M.4
Jha, A.R.5
Long, B.R.6
-
153
-
-
69449091993
-
Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells
-
Golden-Mason L, Palmer BE, Kassam N, Townshend-Bulson L, Livingston S, McMahon BJ, et al. Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells. J Virol (2009) 83:9122-30. doi:10.1128/JVI.00639-09
-
(2009)
J Virol
, vol.83
, pp. 9122-9130
-
-
Golden-Mason, L.1
Palmer, B.E.2
Kassam, N.3
Townshend-Bulson, L.4
Livingston, S.5
McMahon, B.J.6
-
154
-
-
78649903057
-
Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity
-
McMahan RH, Golden-Mason L, Nishimura MI, McMahon BJ, Kemper M, Allen TM, et al. Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity. J Clin Invest (2010) 120:4546-57. doi:10.1172/JCI43127
-
(2010)
J Clin Invest
, vol.120
, pp. 4546-4557
-
-
McMahan, R.H.1
Golden-Mason, L.2
Nishimura, M.I.3
McMahon, B.J.4
Kemper, M.5
Allen, T.M.6
-
155
-
-
77957059176
-
Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection
-
Jin HT, Anderson AC, Tan WG, West EE, Ha SJ, Araki K, et al. Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proc Natl Acad Sci U S A (2010) 107:14733-8. doi:10.1073/pnas.1009731107
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 14733-14738
-
-
Jin, H.T.1
Anderson, A.C.2
Tan, W.G.3
West, E.E.4
Ha, S.J.5
Araki, K.6
-
156
-
-
77957744369
-
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
-
Sakuishi K, Apetoh L, Sullivan JM, Blazar BR, Kuchroo VK, Anderson AC. Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. J Exp Med (2010) 207:2187-94. doi:10.1084/jem.20100643
-
(2010)
J Exp Med
, vol.207
, pp. 2187-2194
-
-
Sakuishi, K.1
Apetoh, L.2
Sullivan, J.M.3
Blazar, B.R.4
Kuchroo, V.K.5
Anderson, A.C.6
-
157
-
-
84905967067
-
Too much of a good thing?. Tim-3 and TCR signaling in T cell exhaustion
-
Ferris RL, Lu B, Kane LP. Too much of a good thing? Tim-3 and TCR signaling in T cell exhaustion. J Immunol (2014) 193:1525-30. doi:10.4049/jimmunol.1400557
-
(2014)
J Immunol
, vol.193
, pp. 1525-1530
-
-
Ferris, R.L.1
Lu, B.2
Kane, L.P.3
-
158
-
-
84868159278
-
Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection
-
Nebbia G, Peppa D, Schurich A, Khanna P, Singh HD, Cheng Y, et al. Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection. PLoS One (2012) 7:e47648. doi:10.1371/journal.pone.0047648
-
(2012)
PLoS One
, vol.7
-
-
Nebbia, G.1
Peppa, D.2
Schurich, A.3
Khanna, P.4
Singh, H.D.5
Cheng, Y.6
-
159
-
-
84859701005
-
IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma
-
Yang ZZ, Grote DM, Ziesmer SC, Niki T, Hirashima M, Novak AJ, et al. IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma. J Clin Invest (2012) 122:1271-82. doi:10.1172/JCI59806
-
(2012)
J Clin Invest
, vol.122
, pp. 1271-1282
-
-
Yang, Z.Z.1
Grote, D.M.2
Ziesmer, S.C.3
Niki, T.4
Hirashima, M.5
Novak, A.J.6
-
160
-
-
84857159981
-
TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression
-
Gao X, Zhu Y, Li G, Huang H, Zhang G, Wang F, et al. TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression. PLoS One (2012) 7:e30676. doi:10.1371/journal.pone.0030676
-
(2012)
PLoS One
, vol.7
-
-
Gao, X.1
Zhu, Y.2
Li, G.3
Huang, H.4
Zhang, G.5
Wang, F.6
-
161
-
-
77957723967
-
Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients
-
Fourcade J, Sun Z, Pagliano O, Guillaume P, Luescher IF, Sander C, et al. Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients. J Exp Med (2010) 207:2175-86. doi:10.1084/jem.20100637
-
(2010)
J Exp Med
, vol.207
, pp. 2175-2186
-
-
Fourcade, J.1
Sun, Z.2
Pagliano, O.3
Guillaume, P.4
Luescher, I.F.5
Sander, C.6
-
162
-
-
84859468877
-
Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering
-
Stengel KF, Harden-Bowles K, Yu X, Rouge L, Yin J, Comps-Agrar L, et al. Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering. Proc Natl Acad Sci U S A (2012) 109:5399-404. doi:10.1073/pnas.1120606109
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 5399-5404
-
-
Stengel, K.F.1
Harden-Bowles, K.2
Yu, X.3
Rouge, L.4
Yin, J.5
Comps-Agrar, L.6
-
163
-
-
79953064126
-
Vstm3 is a member of the CD28 family and an important modulator of T-cell function
-
Levin SD, Taft DW, Brandt CS, Bucher C, Howard ED, Chadwick EM, et al. Vstm3 is a member of the CD28 family and an important modulator of T-cell function. Eur J Immunol (2011) 41:902-15. doi:10.1002/eji.201041136
-
(2011)
Eur J Immunol
, vol.41
, pp. 902-915
-
-
Levin, S.D.1
Taft, D.W.2
Brandt, C.S.3
Bucher, C.4
Howard, E.D.5
Chadwick, E.M.6
-
164
-
-
84925743331
-
Balancing natural killer cell activation through paired receptors
-
Martinet L, Smyth MJ. Balancing natural killer cell activation through paired receptors. Nat Rev Immunol (2015) 15:243-54. doi:10.1038/nri3799
-
(2015)
Nat Rev Immunol
, vol.15
, pp. 243-254
-
-
Martinet, L.1
Smyth, M.J.2
-
165
-
-
57849101994
-
The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells
-
Yu X, Harden K, Gonzalez LC, Francesco M, Chiang E, Irving B, et al. The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat Immunol (2009) 10:48-57. doi:10.1038/ni.1674
-
(2009)
Nat Immunol
, vol.10
, pp. 48-57
-
-
Yu, X.1
Harden, K.2
Gonzalez, L.C.3
Francesco, M.4
Chiang, E.5
Irving, B.6
-
166
-
-
79251572651
-
Cutting edge: TIGIT has T cell-intrinsic inhibitory functions
-
Joller N, Hafler JP, Brynedal B, Kassam N, Spoerl S, Levin SD, et al. Cutting edge: TIGIT has T cell-intrinsic inhibitory functions. J Immunol (2011) 186:1338-42. doi:10.4049/jimmunol.1003081
-
(2011)
J Immunol
, vol.186
, pp. 1338-1342
-
-
Joller, N.1
Hafler, J.P.2
Brynedal, B.3
Kassam, N.4
Spoerl, S.5
Levin, S.D.6
-
167
-
-
84898681799
-
Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses
-
Joller N, Lozano E, Burkett PR, Patel B, Xiao S, Zhu C, et al. Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity (2014) 40:569-81. doi:10.1016/j.immuni.2014.02.012
-
(2014)
Immunity
, vol.40
, pp. 569-581
-
-
Joller, N.1
Lozano, E.2
Burkett, P.R.3
Patel, B.4
Xiao, S.5
Zhu, C.6
-
168
-
-
84929000784
-
TIGIT and PD-1 impair tumor antigen-specific CD8(+) T cells in melanoma patients
-
Chauvin JM, Pagliano O, Fourcade J, Sun Z, Wang H, Sander C, et al. TIGIT and PD-1 impair tumor antigen-specific CD8(+) T cells in melanoma patients. J Clin Invest (2015) 125:2046-58. doi:10.1172/JCI80445
-
(2015)
J Clin Invest
, vol.125
, pp. 2046-2058
-
-
Chauvin, J.M.1
Pagliano, O.2
Fourcade, J.3
Sun, Z.4
Wang, H.5
Sander, C.6
-
169
-
-
84919494669
-
The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function
-
Johnston RJ, Comps-Agrar L, Hackney J, Yu X, Huseni M, Yang Y, et al. The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function. Cancer Cell (2014) 26:923-37. doi:10.1016/j.ccell.2014.10.018
-
(2014)
Cancer Cell
, vol.26
, pp. 923-937
-
-
Johnston, R.J.1
Comps-Agrar, L.2
Hackney, J.3
Yu, X.4
Huseni, M.5
Yang, Y.6
-
170
-
-
0027295531
-
A novel 80-kD cell surface structure identifies human circulating lymphocytes with natural killer activity
-
Maïza H, Leca G, Mansur IG, Schiavon V, Boumsell L, Bensussan A. A novel 80-kD cell surface structure identifies human circulating lymphocytes with natural killer activity. J Exp Med (1993) 178:1121-6. doi:10.1084/jem.178.3.1121
-
(1993)
J Exp Med
, vol.178
, pp. 1121-1126
-
-
Maïza, H.1
Leca, G.2
Mansur, I.G.3
Schiavon, V.4
Boumsell, L.5
Bensussan, A.6
-
171
-
-
0032530695
-
Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes
-
Anumanthan A, Bensussan A, Boumsell L, Christ AD, Blumberg RS, Voss SD, et al. Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes. J Immunol (1998) 161:2780-90
-
(1998)
J Immunol
, vol.161
, pp. 2780-2790
-
-
Anumanthan, A.1
Bensussan, A.2
Boumsell, L.3
Christ, A.D.4
Blumberg, R.S.5
Voss, S.D.6
-
172
-
-
0033083193
-
Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells
-
Agrawal S, Marquet J, Freeman GJ, Tawab A, Bouteiller PL, Roth P, et al. Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells. J Immunol (1999) 162:1223-6
-
(1999)
J Immunol
, vol.162
, pp. 1223-1226
-
-
Agrawal, S.1
Marquet, J.2
Freeman, G.J.3
Tawab, A.4
Bouteiller, P.L.5
Roth, P.6
-
173
-
-
0027366674
-
Significant enlargement of a specific subset of CD3+CD8+ peripheral blood leukocytes mediating cytotoxic T-lymphocyte activity during human immunodeficiency virus infection
-
Bensussan A, Rabian C, Schiavon V, Bengoufa D, Leca G, Boumsell L. Significant enlargement of a specific subset of CD3+CD8+ peripheral blood leukocytes mediating cytotoxic T-lymphocyte activity during human immunodeficiency virus infection. Proc Natl Acad Sci U S A (1993) 90:9427-30. doi:10.1073/pnas.90.20.9427
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 9427-9430
-
-
Bensussan, A.1
Rabian, C.2
Schiavon, V.3
Bengoufa, D.4
Leca, G.5
Boumsell, L.6
-
174
-
-
2442477456
-
An inhibitory Ig superfamily protein expressed by lymphocytes and APCs is also an early marker of thymocyte positive selection
-
Han P, Goularte OD, Rufner K, Wilkinson B, Kaye J. An inhibitory Ig superfamily protein expressed by lymphocytes and APCs is also an early marker of thymocyte positive selection. J Immunol (2004) 172:5931-9. doi:10.4049/jimmunol.172.10.5931
-
(2004)
J Immunol
, vol.172
, pp. 5931-5939
-
-
Han, P.1
Goularte, O.D.2
Rufner, K.3
Wilkinson, B.4
Kaye, J.5
-
175
-
-
0037810670
-
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
-
Watanabe N, Gavrieli M, Sedy JR, Yang J, Fallarino F, Loftin SK, et al. BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol (2003) 4:670-9. doi:10.1038/ni944
-
(2003)
Nat Immunol
, vol.4
, pp. 670-679
-
-
Watanabe, N.1
Gavrieli, M.2
Sedy, J.R.3
Yang, J.4
Fallarino, F.5
Loftin, S.K.6
-
176
-
-
84892146573
-
Inhibitory receptor expression depends more dominantly on differentiation and activation than "exhaustion" of human CD8 T cells
-
Legat A, Speiser DE, Pircher H, Zehn D, Fuertes Marraco SA. Inhibitory receptor expression depends more dominantly on differentiation and activation than "exhaustion" of human CD8 T cells. Front Immunol (2013) 4:455. doi:10.3389/fimmu.2013.00455
-
(2013)
Front Immunol
, vol.4
, pp. 455
-
-
Legat, A.1
Speiser, D.E.2
Pircher, H.3
Zehn, D.4
Fuertes Marraco, S.A.5
-
177
-
-
14844357247
-
B and T lymphocyte attenuator exhibits structural and expression polymorphisms and is highly Induced in anergic CD4+ T cells
-
Hurchla MA, Sedy JR, Gavrieli M, Drake CG, Murphy TL, Murphy KM. B and T lymphocyte attenuator exhibits structural and expression polymorphisms and is highly Induced in anergic CD4+ T cells. J Immunol (2005) 174:3377-85. doi:10.4049/jimmunol.174.9.5884a
-
(2005)
J Immunol
, vol.174
, pp. 3377-3385
-
-
Hurchla, M.A.1
Sedy, J.R.2
Gavrieli, M.3
Drake, C.G.4
Murphy, T.L.5
Murphy, K.M.6
-
178
-
-
49449113696
-
Development of autoimmune hepatitis-like disease and production of autoantibodies to nuclear antigens in mice lacking B and T lymphocyte attenuator
-
Oya Y, Watanabe N, Owada T, Oki M, Hirose K, Suto A, et al. Development of autoimmune hepatitis-like disease and production of autoantibodies to nuclear antigens in mice lacking B and T lymphocyte attenuator. Arthritis Rheum (2008) 58:2498-510. doi:10.1002/art.23674
-
(2008)
Arthritis Rheum
, vol.58
, pp. 2498-2510
-
-
Oya, Y.1
Watanabe, N.2
Owada, T.3
Oki, M.4
Hirose, K.5
Suto, A.6
-
179
-
-
65249168307
-
Cutting edge: a critical role of B and T lymphocyte attenuator in peripheral T cell tolerance induction
-
Liu X, Alexiou M, Martin-Orozco N, Chung Y, Nurieva RI, Ma L, et al. Cutting edge: a critical role of B and T lymphocyte attenuator in peripheral T cell tolerance induction. J Immunol (2009) 182:4516-20. doi:10.4049/jimmunol.0803161
-
(2009)
J Immunol
, vol.182
, pp. 4516-4520
-
-
Liu, X.1
Alexiou, M.2
Martin-Orozco, N.3
Chung, Y.4
Nurieva, R.I.5
Ma, L.6
-
180
-
-
19944433635
-
B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator
-
Sedy JR, Gavrieli M, Potter KG, Hurchla MA, Lindsley RC, Hildner K, et al. B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator. Nat Immunol (2005) 6:90-8. doi:10.1038/ni1144
-
(2005)
Nat Immunol
, vol.6
, pp. 90-98
-
-
Sedy, J.R.1
Gavrieli, M.2
Potter, K.G.3
Hurchla, M.A.4
Lindsley, R.C.5
Hildner, K.6
-
181
-
-
38349149016
-
CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator
-
Cai G, Anumanthan A, Brown JA, Greenfield EA, Zhu B, Freeman GJ. CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator. Nat Immunol (2008) 9:176-85. doi:10.1038/ni1554
-
(2008)
Nat Immunol
, vol.9
, pp. 176-185
-
-
Cai, G.1
Anumanthan, A.2
Brown, J.A.3
Greenfield, E.A.4
Zhu, B.5
Freeman, G.J.6
-
182
-
-
47249148425
-
Targeting lymphocyte activation through the lymphotoxin and LIGHT pathways
-
Ware CF. Targeting lymphocyte activation through the lymphotoxin and LIGHT pathways. Immunol Rev (2008) 223:186-201. doi:10.1111/j.1600-065X.2008.00629.x
-
(2008)
Immunol Rev
, vol.223
, pp. 186-201
-
-
Ware, C.F.1
-
183
-
-
0030298375
-
Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family
-
Montgomery RI, Warner MS, Lum BJ, Spear PG. Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. Cell (1996) 87:427-36. doi:10.1016/S0092-8674(00)81363-X
-
(1996)
Cell
, vol.87
, pp. 427-436
-
-
Montgomery, R.I.1
Warner, M.S.2
Lum, B.J.3
Spear, P.G.4
-
184
-
-
0035451607
-
The TNF superfamily members LIGHT and CD154 (CD40 ligand) costimulate induction of dendritic cell maturation and elicit specific CTL activity
-
Morel Y, Truneh A, Sweet RW, Olive D, Costello RT. The TNF superfamily members LIGHT and CD154 (CD40 ligand) costimulate induction of dendritic cell maturation and elicit specific CTL activity. J Immunol (2001) 167:2479-86. doi:10.4049/jimmunol.167.5.2479
-
(2001)
J Immunol
, vol.167
, pp. 2479-2486
-
-
Morel, Y.1
Truneh, A.2
Sweet, R.W.3
Olive, D.4
Costello, R.T.5
-
185
-
-
0344495270
-
Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B and T lymphocyte attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2
-
Gavrieli M, Watanabe N, Loftin SK, Murphy TL, Murphy KM. Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B and T lymphocyte attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2. Biochem Biophys Res Commun (2003) 312:1236-43. doi:10.1016/j.bbrc.2003.11.070
-
(2003)
Biochem Biophys Res Commun
, vol.312
, pp. 1236-1243
-
-
Gavrieli, M.1
Watanabe, N.2
Loftin, S.K.3
Murphy, T.L.4
Murphy, K.M.5
-
186
-
-
0036096598
-
BY55/CD160 acts as a co-receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression
-
Nikolova M, Marie-Cardine A, Boumsell L, Bensussan A. BY55/CD160 acts as a co-receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression. Int Immunol (2002) 14:445-51. doi:10.1093/intimm/14.5.445
-
(2002)
Int Immunol
, vol.14
, pp. 445-451
-
-
Nikolova, M.1
Marie-Cardine, A.2
Boumsell, L.3
Bensussan, A.4
-
187
-
-
55249114228
-
Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells
-
Cham CM, Driessens G, O'Keefe JP, Gajewski TF. Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells. Eur J Immunol (2008) 38:2438-50. doi:10.1002/eji.200838289
-
(2008)
Eur J Immunol
, vol.38
, pp. 2438-2450
-
-
Cham, C.M.1
Driessens, G.2
O'Keefe, J.P.3
Gajewski, T.F.4
-
188
-
-
65349118810
-
PD-1 signaling in primary T cells
-
Riley JL. PD-1 signaling in primary T cells. Immunol Rev (2009) 229:114-25. doi:10.1111/j.1600-065X.2009.00767.x
-
(2009)
Immunol Rev
, vol.229
, pp. 114-125
-
-
Riley, J.L.1
-
189
-
-
55849101681
-
Fat metabolism links germline stem cells and longevity in C. elegans
-
Wang MC, O'Rourke EJ, Ruvkun G. Fat metabolism links germline stem cells and longevity in C. elegans. Science (2008) 322:957-60. doi:10.1126/science.1162011
-
(2008)
Science
, vol.322
, pp. 957-960
-
-
Wang, M.C.1
O'Rourke, E.J.2
Ruvkun, G.3
-
190
-
-
84891708632
-
Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality
-
Saha A, Aoyama K, Taylor PA, Koehn BH, Veenstra RG, Panoskaltsis-Mortari A, et al. Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality. Blood (2013) 122:3062-73. doi:10.1182/blood-2013-05-500801
-
(2013)
Blood
, vol.122
, pp. 3062-3073
-
-
Saha, A.1
Aoyama, K.2
Taylor, P.A.3
Koehn, B.H.4
Veenstra, R.G.5
Panoskaltsis-Mortari, A.6
-
191
-
-
77954523037
-
Mitochondrial reactive oxygen species control T cell activation by regulating IL-2 and IL-4 expression: mechanism of ciprofloxacin-mediated immunosuppression
-
Kaminski MM, Sauer SW, Klemke CD, Süss D, Okun JG, Krammer PH, et al. Mitochondrial reactive oxygen species control T cell activation by regulating IL-2 and IL-4 expression: mechanism of ciprofloxacin-mediated immunosuppression. J Immunol (2010) 184:4827-41. doi:10.4049/jimmunol.0901662
-
(2010)
J Immunol
, vol.184
, pp. 4827-4841
-
-
Kaminski, M.M.1
Sauer, S.W.2
Klemke, C.D.3
Süss, D.4
Okun, J.G.5
Krammer, P.H.6
-
192
-
-
84870462073
-
T cell activation is driven by an ADP-dependent glucokinase linking enhanced glycolysis with mitochondrial reactive oxygen species generation
-
Kaminski MM, Sauer SW, Kaminski M, Opp S, Ruppert T, Grigaravicius P, et al. T cell activation is driven by an ADP-dependent glucokinase linking enhanced glycolysis with mitochondrial reactive oxygen species generation. Cell Rep (2012) 2:1300-15. doi:10.1016/j.celrep.2012.10.009
-
(2012)
Cell Rep
, vol.2
, pp. 1300-1315
-
-
Kaminski, M.M.1
Sauer, S.W.2
Kaminski, M.3
Opp, S.4
Ruppert, T.5
Grigaravicius, P.6
-
193
-
-
84931431126
-
Programmed death-1 controls T cell survival by regulating oxidative metabolism
-
Tkachev V, Goodell S, Opipari AW, Hao LY, Franchi L, Glick GD, et al. Programmed death-1 controls T cell survival by regulating oxidative metabolism. J Immunol (2015) 194:5789-800. doi:10.4049/jimmunol.1402180
-
(2015)
J Immunol
, vol.194
, pp. 5789-5800
-
-
Tkachev, V.1
Goodell, S.2
Opipari, A.W.3
Hao, L.Y.4
Franchi, L.5
Glick, G.D.6
-
194
-
-
33749999530
-
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators
-
St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, Jäger S, et al. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell (2006) 127:397-408. doi:10.1016/j.cell.2006.09.024
-
(2006)
Cell
, vol.127
, pp. 397-408
-
-
St-Pierre, J.1
Drori, S.2
Uldry, M.3
Silvaggi, J.M.4
Rhee, J.5
Jäger, S.6
-
195
-
-
80155126156
-
PGC1alpha promotes tumor growth by inducing gene expression programs supporting lipogenesis
-
Bhalla K, Hwang BJ, Dewi RE, Ou L, Twaddel W, Fang HB, et al. PGC1alpha promotes tumor growth by inducing gene expression programs supporting lipogenesis. Cancer Res (2011) 71:6888-98. doi:10.1158/0008-5472.CAN-11-1011
-
(2011)
Cancer Res
, vol.71
, pp. 6888-6898
-
-
Bhalla, K.1
Hwang, B.J.2
Dewi, R.E.3
Ou, L.4
Twaddel, W.5
Fang, H.B.6
-
196
-
-
36749081539
-
mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex
-
Cunningham JT, Rodgers JT, Arlow DH, Vazquez F, Mootha VK, Puigserver P. mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature (2007) 450:736-40. doi:10.1038/nature06322
-
(2007)
Nature
, vol.450
, pp. 736-740
-
-
Cunningham, J.T.1
Rodgers, J.T.2
Arlow, D.H.3
Vazquez, F.4
Mootha, V.K.5
Puigserver, P.6
-
197
-
-
84997706268
-
Bioenergetic insufficiencies due to metabolic alterations regulated by the inhibitory receptor PD-1 are an early driver of CD8+ T cell exhaustion
-
Bengsch B, Johnson AL, Kurachi M, Odorizzi PM, Pauken KE, Attanasio J, et al. Bioenergetic insufficiencies due to metabolic alterations regulated by the inhibitory receptor PD-1 are an early driver of CD8+ T cell exhaustion. Immunity (2016) 45:358-73. doi:10.1016/j.immuni.2016.07.008
-
(2016)
Immunity
, vol.45
, pp. 358-373
-
-
Bengsch, B.1
Johnson, A.L.2
Kurachi, M.3
Odorizzi, P.M.4
Pauken, K.E.5
Attanasio, J.6
-
198
-
-
84997766028
-
The tumor microenvironment represses T cell mitochondrial biogenesis to drive intratumoral T cell metabolic insufficiency and dysfunction
-
Scharping NE, Menk AV, Moreci RS, Whetstone RD, Dadey R, Watkins SC, et al. The tumor microenvironment represses T cell mitochondrial biogenesis to drive intratumoral T cell metabolic insufficiency and dysfunction. Immunity (2016) 45:701-3. doi:10.1016/j.immuni.2016.08.009
-
(2016)
Immunity
, vol.45
, pp. 701-703
-
-
Scharping, N.E.1
Menk, A.V.2
Moreci, R.S.3
Whetstone, R.D.4
Dadey, R.5
Watkins, S.C.6
-
199
-
-
84948430497
-
Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells
-
Odorizzi PM, Pauken KE, Paley MA, Sharpe A, Wherry EJ. Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells. J Exp Med (2015) 212:1125-37. doi:10.1084/jem.20142237
-
(2015)
J Exp Med
, vol.212
, pp. 1125-1137
-
-
Odorizzi, P.M.1
Pauken, K.E.2
Paley, M.A.3
Sharpe, A.4
Wherry, E.J.5
-
200
-
-
5844264920
-
PD-L2 is a second ligand for PD-1 and inhibits T cell activation
-
Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol (2001) 2:261-8. doi:10.1038/85330
-
(2001)
Nat Immunol
, vol.2
, pp. 261-268
-
-
Latchman, Y.1
Wood, C.R.2
Chernova, T.3
Chaudhary, D.4
Borde, M.5
Chernova, I.6
-
201
-
-
84879703551
-
Strength of PD-1 signaling differentially affects T-cell effector functions
-
Wei F, Zhong S, Ma Z, Kong H, Medvec A, Ahmed R, et al. Strength of PD-1 signaling differentially affects T-cell effector functions. Proc Natl Acad Sci U S A (2013) 110:E2480-9. doi:10.1073/pnas.1305394110
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. E2480-E2489
-
-
Wei, F.1
Zhong, S.2
Ma, Z.3
Kong, H.4
Medvec, A.5
Ahmed, R.6
-
202
-
-
84941655289
-
Metabolic reprogramming of immune cells in cancer progression
-
Biswas SK. Metabolic reprogramming of immune cells in cancer progression. Immunity (2015) 43:435-49. doi:10.1016/j.immuni.2015.09.001
-
(2015)
Immunity
, vol.43
, pp. 435-449
-
-
Biswas, S.K.1
-
203
-
-
84984843599
-
The PD-1/PD-L1 axis contributes to immune metabolic dysfunctions of monocytes in chronic lymphocytic leukemia
-
Qorraj M, Bruns H, Böttcher M, Weigand L, Saul D, Mackensen A, et al. The PD-1/PD-L1 axis contributes to immune metabolic dysfunctions of monocytes in chronic lymphocytic leukemia. Leukemia (2017) 31(2):470-8. doi:10.1038/leu.2016.214
-
(2017)
Leukemia
, vol.31
, Issue.2
, pp. 470-478
-
-
Qorraj, M.1
Bruns, H.2
Böttcher, M.3
Weigand, L.4
Saul, D.5
Mackensen, A.6
-
204
-
-
84941344937
-
Metabolic competition in the tumor microenvironment is a driver of cancer progression
-
Chang CH, Qiu J, O'Sullivan D, Buck MD, Noguchi T, Curtis JD, et al. Metabolic competition in the tumor microenvironment is a driver of cancer progression. Cell (2015) 162:1229-41. doi:10.1016/j.cell.2015.08.016
-
(2015)
Cell
, vol.162
, pp. 1229-1241
-
-
Chang, C.H.1
Qiu, J.2
O'Sullivan, D.3
Buck, M.D.4
Noguchi, T.5
Curtis, J.D.6
-
205
-
-
43549115533
-
B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells
-
Azuma T, Yao S, Zhu G, Flies AS, Flies SJ, Chen L. B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells. Blood (2008) 111:3635-43. doi:10.1182/blood-2007-11-123141
-
(2008)
Blood
, vol.111
, pp. 3635-3643
-
-
Azuma, T.1
Yao, S.2
Zhu, G.3
Flies, A.S.4
Flies, S.J.5
Chen, L.6
-
206
-
-
84941367700
-
Melanoma cell-intrinsic PD-1 receptor functions promote tumor growth
-
Kleffel S, Posch C, Barthel SR, Mueller H, Schlapbach C, Guenova E, et al. Melanoma cell-intrinsic PD-1 receptor functions promote tumor growth. Cell (2015) 162:1242-56. doi:10.1016/j.cell.2015.08.052
-
(2015)
Cell
, vol.162
, pp. 1242-1256
-
-
Kleffel, S.1
Posch, C.2
Barthel, S.R.3
Mueller, H.4
Schlapbach, C.5
Guenova, E.6
-
207
-
-
38349165576
-
Identification of cells initiating human melanomas
-
Schatton T, Murphy GF, Frank NY, Yamaura K, Waaga-Gasser AM, Gasser M, et al. Identification of cells initiating human melanomas. Nature (2008) 451:345-9. doi:10.1038/nature06489
-
(2008)
Nature
, vol.451
, pp. 345-349
-
-
Schatton, T.1
Murphy, G.F.2
Frank, N.Y.3
Yamaura, K.4
Waaga-Gasser, A.M.5
Gasser, M.6
-
208
-
-
85017194520
-
Clinical significance of T cell metabolic reprogramming in cancer
-
Herbel C, Patsoukis N, Bardhan K, Seth P, Weaver JD, Boussiotis VA. Clinical significance of T cell metabolic reprogramming in cancer. Clin Transl Med (2016) 5:29. doi:10.1186/s40169-016-0110-9
-
(2016)
Clin Transl Med
, vol.5
, pp. 29
-
-
Herbel, C.1
Patsoukis, N.2
Bardhan, K.3
Seth, P.4
Weaver, J.D.5
Boussiotis, V.A.6
|