Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4-CD8-) thymocytes

International Immunology

Volumn 8, Issue 5, 1996, Pages 773-780

  Nishimura, Hiroyuki ^a   Agata, Yasutoshi ^a   Kawasaki, Akemi ^b   Sato, Masaki ^a   Imamura, Sadao ^a   Minato, Nagahiro ^a   Yagita, Hideo ^b   Nakano, Toru ^a   Honjo, Tasuku ^a  

^a KYOTO UNIVERSITY   (Japan)

^b JUNTENDO UNIVERSITY   (Japan)

Author keywords

Anti CD3 stimulation; Double negative thymocytes; PD 1; RAG 2( ) mice; T cell development

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; HERMES ANTIGEN; INTERLEUKIN 2 RECEPTOR; MEMBRANE ANTIGEN; MONOCLONAL ANTIBODY; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; LYMPHOCYTE CLONE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; THYMOCYTE; THYMUS;

EID: 0029964018     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/8.5.773     Document Type: Article

References (29)

1. Adkins, B , Mueller, C , Okada, C Y., Reichert, R A , Weissman, I L and Spangrude, G J 1987 Early events in T-cell maturation Annu Rev Immunol. 5:325
2. von Boehmer, H 1994, Positive selection of lymphocytes Cell 76.219.
3. Nessal, G J V 1994 Negative selection of lymphocytes Cell 76:229
4. von Boehmer, H. 1990 Developmental biology of T cells in T cell-receptor transgenic mice. Annu Rev Immunol. 8 531.
5. Pearse, M , Wu, L , Egerton, M , Wilson, A , Shortman, K. and Scollay, R. 1989, A murine early thymocytes developmental sequence is marked by transient expression of the interleukin 2 receptor Proc. Natl Acad Sci. USA 86 1614.
6. - triple-negative adult mouse thymocytes defined by CD44 and CD25 J Immunol 150:4244
7. Shinkai, Y , Rathbun, G , Lam, K-P , Oltz, E M , Stewart, V., Mendelsohn, M , Charron, J , Datta, M , Young, F Stall, A. M. and Alt, F. W 1992 RAG2-deficient mice lack mature lymphocyte owing to inability to initiate V(D)J rearrangement Cell 68 855
8. Momberts, P , Iacomini, J , Johnson, R. S , Herrup, K , Tonegawa, S and Papaioannou, V. E 1992 RAG1-deficient mice have no mature B and T lymphocytes Cell 68 869
9. Mombaerts, P , Clarke, A. R , Rudnicki, M. A., Iacomini, J., Itohara, S., Lafaille, J J , Wang, L , Ichikawa, Y , Jaenisch, R , Hooper, M. L. and Tonegawa, S. 1992. Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages. Nature 360 225
10. - thymocyte differentiation. J Immunol. 152:4783.
11. Shinkai, Y , Koyasu, S , Nakayama, K , Murphy, K. M , Loh, D Y , Reinherz, D. L and Alt, F W 1993 Restoration of T cell Development in RAG2-deficient mice by functional TCR transgenes. Science 259:822.
12. Groettrup, M., Ungewiss, K , Azogul, O., Palacios, R., Owen, M J , Hayday, A. C and von Boehmer, H 1993 A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor β chain and a 33 kd glycoprotein Cell 75:283
13. Saint-Ruf, C , Ungewiss, K , Groettrup, M., Bruno, L , Fehoing, H. J. and von Boehmer, H. 1994 Analysis and expression of a cloned Pre-T cell receptor gene. Science 266 1208.
14. Fehling, H. J., Krotkova, A , Saint-Ruf, C and von Beohmer, H. 1995 Crucial role of the pre-T cell receptor a gene in development of αβ but not γδ T cells Nature 375 795
15. -/- mice in the absence of TCR β chain expression Int. Immunol 6:995
16. Carding, S. R., Hayday, A C and Bottomly, K. 1991. Cytokines in T-cell development Immunol Today 12:239.
17. Ishida Y , Agata, Y., Shibahara, K and Honjo, T. 1992. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death EMBO J 11:3887
18. Weiss, A. 1993 T cell antigen receptor signal transduction, a tale of tails and cytoplasmic protein-tyrosine kinases Cell 73:209.
19. Agata, Y , Kawasaki, A., Nishimura, H., Ishida, Y., Tsubata, T , Yagita, H and Honjo, T 1996 Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int. Immunol 8:765.
20. Leo, O., Foo, M , Sachs, D H., Samelson, L. E and Bluestone, J. A 1987 Identification of a monoclonal antibody specific for a murine T3 polypeptide Proc Natl Acad Sci USA 84 1374
21. Koo, G and Peppard, J R 1984 Establishment of monoclonal anti-NK1 1 antibody Hybridoma 3 301
22. + subset. J. Immunol 145:1039
23. Godfrey, D I , Zlotnik, A and Suda, T 1992 Phenotypic and functional characterization of c-kit expression during intrathymic T cell development J . Immunol 149 2281.
24. + thymocytes. Variable influence of self-antigens on T cell receptor V beta usage. J Immunol. 146:1134.
25. Shi, Y , Bissonnette, R P , Parfrey, N , Szalay, M , Kubo. R T and Green, D. R. 1991 In vivo administration of monoclonal antibodies to the CD3 T cell receptor complex induces cell death (apoptosis) in immature thymocytes. J Immunol. 146:3340.
26. Havran, W L and Allison, J P. 1988. Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors. Nature 335 443
27. Itohara, S., Nakanishi, N., Kanagawa, O., Kubo, R and Tonegawa, S 1989 Monoclonal antibodies specific to native murine T-cell receptor γδ analysis of γδ T cells during thymic ontogeny and in peripheral lymphoid organs. Proc. Natl Acad. Sci. USA 86:5094.
28. - thymocytes Int. Immunol. 2:209.
29. Rothenberg, E. V , Chen, D. and Diamond, R. A. 1993. Functional and phenotypic analysis of thymocytes in SCID mice. Evidence for functional response transitions before and after the SCID arrest point J Immunol 151.3530