The TIM gene family regulates autoimmune and allergic diseases

Trends in Molecular Medicine

Volumn 11, Issue 8, 2005, Pages 362-369

  Meyers, Jennifer Hartt ^a   Sabatos, Catherine A ^a   Chakravarti, Sumone ^a   Kuchroo, Vijay K ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 2; PROTEIN; PROTEIN TIM; PROTEIN TIM 1; PROTEIN TIM 2; PROTEIN TIME 3; UNCLASSIFIED DRUG; VIRUS RECEPTOR;

ALLERGIC DISEASE; ALLERGIC ENCEPHALOMYELITIS; ALLOGRAFT; ASTHMA; AUTOIMMUNE DISEASE; CELLULAR IMMUNITY; CHROMOSOME 11; CHROMOSOME 5; CYTOKINE PRODUCTION; DENDRITIC CELL; DIABETES MELLITUS; DISEASE ASSOCIATION; GENE CLUSTER; GENE EXPRESSION; HEPATITIS A VIRUS; HUMAN; IMMUNE RESPONSE; MOUSE STRAIN; MULTIGENE FAMILY; NONHUMAN; PHENOTYPE; PSEUDOGENE; REVIEW; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

ANIMALS; CYTOKINES; GENE EXPRESSION REGULATION; HUMANS; IMMUNE SYSTEM DISEASES; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICE; RECEPTORS, VIRUS; RESPIRATORY HYPERSENSITIVITY; TH1 CELLS; TH2 CELLS;

HEPATITIS A VIRUS;

EID: 23144447812     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmed.2005.06.008     Document Type: Review

References (50)

1. T.R. Mosmann Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins J. Immunol. 136 1986 2348 2357
2. A. O'Garra, and N. Arai The molecular basis of T helper 1 and T helper 2 cell differentiation Trends Cell Biol. 10 2000 542 550
3. A.K. Abbas Functional diversity of helper T lymphocytes Nature 383 1996 787 793
4. S.J. Szabo Molecular mechanisms regulating Th1 immune responses Annu. Rev. Immunol. 21 2003 713 758
5. + T cells in the pathogenesis of organ-specific autoimmune diseases Immunol. Today 16 1995 34 38
6. A. Sher, and R.L. Coffman Regulation of immunity to parasites by T cells and T cell-derived cytokines Annu. Rev. Immunol. 10 1992 385 409
7. C. Venkataraman Cutting edge: chandra, a novel four-transmembrane domain protein differentially expressed in helper type I lymphocytes J. Immunol. 165 2000 632 636
8. R. Bonecchi Differential expression of chemokine receptors and chemotactic responsiveness of type I T helper cells (Th1s) and Th2s J. Exp. Med. 187 1998 129 134
9. M. Lohning T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function Proc. Natl. Acad. Sci. U. S. A. 95 1998 6930 6935
10. L. Monney Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease Nature 415 2002 536 541
11. K. Natarajan Structure and function of natural killer cell receptors: multiple molecular solutions to self, nonself discrimination Annu. Rev. Immunol. 20 2002 853 885
12. + T cells Curr. Opin. Immunol. 13 2001 465 470
13. J.H. Meyers Cutting edge: CD94/NKG2 is expressed on Th1 but not Th2 cells and costimulates Th1 effector functions J. Immunol. 169 2002 5382 5386
14. Dardalhon, V. et al. CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions. J. Immunol. (in press)
15. J.J. McIntire Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family Nat. Immunol. 2 2001 1109 1116
16. V.K. Kuchroo The TIM gene family: emerging roles in immunity and disease Nat. Rev. Immunol. 3 2003 454 462
17. G.G. Loots Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons Science 288 2000 136 140
18. A.J. Walley Linkage and allelic association of chromosome 5 cytokine cluster genetic markers with atopy and asthma associated traits Genomics 72 2001 15 20
19. J.A. Encinas, and V.K. Kuchroo Mapping and identification of autoimmunity genes Curr. Opin. Immunol. 12 2000 691 697
20. G. Kaplan Identification of a surface glycoprotein on African green monkey kidney cells as a receptor for hepatitis A virus EMBO J. 15 1996 4282 4296
21. D. Feigelstock The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor J. Virol. 72 1998 6621 6628
22. E. Silberstein Neutralization of hepatitis A virus (HAV) by an immunoadhesin containing the cysteine-rich region of HAV cellular receptor-1 J. Virol. 75 2001 717 725
23. E. Silberstein Alteration of hepatitis A virus (HAV) particles by a soluble form of HAV cellular receptor 1 containing the immunoglobin-and mucin-like regions J. Virol. 77 2003 8765 8774
24. S.K. Shaw, and M.B. Brenner The β7 integrins in mucosal homing and retention Semin. Immunol. 7 1995 335 342
25. E.L. Berg L-selectin-mediated lymphocyte rolling on MAdCAM-1 Nature 366 1993 630 631
26. T. Ichimura Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury J. Biol. Chem. 273 1998 4135 4142
27. E.W. Kuehn Kidney injury molecule-1 expression in murine polycystic kidney disease Am. J. Physiol. Renal Physiol. 283 2002 F1326 F1336
28. V. Bailly Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration J. Biol. Chem. 277 2002 39739 39748
29. W.K. Han Kidney injury molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury Kidney Int. 62 2002 237 244
30. T. Ichimura Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury Am. J. Physiol. Renal Physiol. 286 2004 F552 F563
31. C.A. Sabatos Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance Nat. Immunol. 4 2003 1102 1110
32. M. Khademi T cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis J. Immunol. 172 2004 7169 7176
33. A. Sanchez-Fueyo Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance Nat. Immunol. 4 2003 1093 1101
34. J.H. Meyers TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation Nat. Immunol. 6 2005 455 464
35. Chakravarti, S. et al. A Th2-specific molecule, Tim-2, regulates Th2 responses and autoimmunity. J. Exp. Med. (in press)
36. A. Kumanogoh Class IV semaphorin Sema4A enhances T cell activation and interacts with Tim-2 Nature 419 2002 629 633
37. A. Kumanogoh Nonredundant roles of Sema4A in the immune system: defective T cell priming and Th1/Th2 regulation in Sema4A-deficient mice Immunity 22 2005 305 316
38. P.M. Matricardi Hay fever and asthma in relation to markers of infection in the United States J. Allergy Clin. Immunol. 110 2002 381 387
39. J.J. McIntire Immunology: hepatitis A virus link to atopic disease Nature 425 2003 576
40. S.E. Umetsu TIM-1 induces T cell activation and inhibits the development of peripheral tolerance Nat. Immunol. 6 2005 447 454
41. L. Racioppi Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling J. Exp. Med. 177 1993 1047 1060
42. A.N. Shakhov SMUCKLER/TIM4 is a distinct member of TIM family expressed by stromal cells of secondary lymphoid tissues and associated with lymphotoxin signaling Eur. J. Immunol. 34 2004 494 503
43. + tumor-specific Th1 cells colocalize with and inhibit development and growth of murine neoplasms J. Immunol. 174 2005 1405 1415
44. S.C. Chae Molecular variations in the promoter and coding regions of human Tim-1 gene and their association in Koreans with asthma Hum. Immunol. 64 2003 1177 1182
45. S.C. Chae The association of the exon 4 variations of Tim-1 gene with allergic diseases in a Korean population Biochem. Biophys. Res. Commun. 312 2003 346 350
46. S.C. Chae The exon 4 variations of Tim-1 gene are associated with rheumatoid arthritis in a Korean population Biochem. Biophys. Res. Commun. 315 2004 971 975
47. S.C. Chae The polymorphisms of Tim-1 promoter region are associated with rheumatoid arthritis in a Korean population Immunogenetics 56 2005 696 701
48. S.C. Chae Molecular variations in Th1-specific cell surface gene Tim-3 Exp. Mol. Med. 36 2004 274 278
49. S.C. Chae The association of TIM-3 gene polymorphism with atopic disease in Korean population Hum. Immunol. 65 2004 1427 1431
50. S.C. Chae The polymorphisms of Th1 cell surface gene Tim-3 are associated in a Korean population with rheumatoid arthritis Immunol. Lett. 95 2004 91 95