Molecular basis of T cell inactivation by CTLA-4

Science

Volumn 282, Issue 5397, 1998, Pages 2263-2266

  Lee, Kyung Mi ^a   Chuang, Ellen ^b   Griffin, Matthew ^a   Khattri, Roli ^a   Hong, David K ^a   Zhang, Weiguo ^c   Straus, David ^a   Samelson, Lawrence E ^c   Thompson, Craig B ^a   Bluestone, Jeffrey A ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; T LYMPHOCYTE RECEPTOR;

ANTIGEN EXPRESSION; ARTICLE; CELL CYCLE; CROSS LINKING; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; CELL LINE; CELLS, CULTURED; HUMANS; IMMUNOCONJUGATES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MODELS, IMMUNOLOGICAL; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTORS, ANTIGEN, T-CELL; RECOMBINANT FUSION PROTEINS; SHP1 PROTEIN TYROSINE PHOSPHATASE; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; T-LYMPHOCYTES; TRANSFECTION;

EID: 0032545452     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.282.5397.2263     Document Type: Article

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37. Supported by the National Institutes of Health (PHS PO1 AI35294-6). Additional support was provided by a Howard Hughes Medical Institute Medical Student Research Training Fellowship (D.K.H.) and a Mayo Foundation Scholarship (M.G.). We thank G. Feng for the reagents; A. Sharpe for CTLA-4 knockout mice; N. Patel and C. Long for technical assistance; S. Thomas, M. Fonstein, and W. Buikema for services provided at the Cancer Research Center (CRC) DNA Sequencing Facility; and M. Clark for critical reading of the manuscript.