Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4

Journal of Experimental Medicine

Volumn 197, Issue 1, 2003, Pages 129-135

  Chikuma, Shunsuke ^a,b   Imboden, John B ^b   Bluestone, Jeffrey A ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Costimulation; GEM; Immunological synapse; Negative signal; T cells

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GLYCOLIPID; LIPID; RECEPTOR SUBTYPE; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ZETA CHAIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN BINDING; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; IMMUNOMODULATION; INHIBITION KINETICS; LIGATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LIPID INTERACTION; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SYNAPSE; T LYMPHOCYTE ACTIVATION; WILD TYPE;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD3; ANTIGENS, DIFFERENTIATION; GENE DELETION; HUMANS; IMMUNOCONJUGATES; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MEMBRANE MICRODOMAINS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0037244012     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20021646     Document Type: Article

References (25)

1. Greenwald, R.J., Y.E. Latchman, and A.H. Sharpe. 2002. Negative co-receptors on lymphocytes. Curr. Opin. Immunol. 14:391-396.
2. Waterhouse, P., J.M. Penninger, E. Timms, A. Wakeham, A. Shahinian, K.P. Lee, C.B. Thompson, H. Griesser, and T.W. Mak. 1995. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science. 270:985-988.
3. Tivol, E.A., F. Borriello, A.N. Schweitzer, W.P. Lynch, J.A. Bluestone, and A.H. Sharpe. 1995. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity. 3:541-547.
4. Krummel, M.F., and M.M. Davis. 2002. Dynamics of the immunological synapse: finding, establishing and solidifying a connection. Curr. Opin. Immunol. 14:66-74.
5. Dustin, M.L., and A.C. Chan. 2000. Signaling takes shape in the immune system. Cell. 103:283-294.
6. Cherukuri, A., M. Dykstra, and S.K. Pierce. 2001. Floating the raft hypothesis: lipid rafts play a role in immune cell activation. Immunity. 14:657-660.
7. Xavier, R., T. Brennan, Q. Li, C. McCormack, and B. Seed. 1998. Membrane compartmentation is required for efficient T cell activation. Immunity. 8:723-732.
8. Darlington, P.J., M.L. Baroja, T.A. Chau, E. Siu, V. Ling, B.M. Carreno, and J. Madrenas. 2002. Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activation. J. Exp. Med. 195:1337-1347.
9. Chikuma, S., M. Murakami, K. Tanaka, and T. Uede. 2000. Janus kinase 2 is associated with a box 1-like motif and phosphorylates a critical tyrosine residue in the cytoplasmic region of cytotoxic T lymphocyte associated molecule-4. J. Cell. Biochem. 78:241-250.
10. Masteller, E.L., E. Chuang, A.C. Mullen, S.L. Reiner, and C.B. Thompson. 2000. Structural analysis of CTLA-4 function in vivo. J. Immunol. 164:5319-5327.
11. Tang, Q., S.K. Subudhi, K.J. Henriksen, C.G. Long, F. Vives, and J.A. Bluestone. 2002. The Src family kinase Fyn mediates signals induced by TCR antagonists. J. Immunol. 168:4480-4487.
12. Lee, K.M., E. Chuang, M. Griffin, R. Khattri, D.K. Hong, W. Zhang, D. Straus, L.E. Samelson, C.B. Thompson, and J.A. Bluestone. 1998. Molecular basis of T cell inactivation by CTLA-4. Science. 282:2263-2266.
13. Samelson, L.E., A.F. Phillips, E.T. Luong, and R.D. Klausner. 1990. Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor. Proc. Natl. Acad. Sci. USA. 87: 4358-4362.
14. Chuang, E., K.M. Lee, M.D. Robbins, J.M. Duerr, M.L. Alegre, J.E. Hambor, M.J. Neveu, J.A. Bluestone, and C.B. Thompson. 1999. Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases. J. Immunol. 162:1270-1277.
15. Khattri, R., J.A. Auger, M.D. Griffin, A.H. Sharpe, and J.A. Bluestone. 1999. Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses. J. Immunol. 162:5784-5791.
16. Martin, M., H. Schneider, A. Azouz, and C.E. Rudd. 2001. Cytotoxic T lymphocyte antigen 4 and CD28 modulate cell surface raft expression in their regulation of T cell function. J. Exp. Med. 194:1675-1681.
17. Katagiri, Y.U., T. Mori, H. Nakajima, C. Katagiri, T. Taguchi, T. Takeda, N. Kiyokawa, and J. Fujimoto. 1999. Activation of Src family kinase yes induced by Shiga toxin binding to globotriaosyl ceramide (Gb3/CD77) in low density, detergent-insoluble microdomains. J. Biol. Chem. 274:35278-35282.
18. Schneider, H., S. da Rocha Dias, H. Hu, and C.E. Rudd. 2001. A regulatory role for cytoplasmic YVKM motif in CTLA-4 inhibition of TCR signaling. Eur. J. Immunol. 31: 2042-2050.
19. Calvo, C.R., D. Amsen, and A.M. Kruisbeek. 1997. Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70. J. Exp. Med. 186:1645-1653.
20. Egen, J.G., and J.P. Allison. 2002. Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength. Immunity. 16:23-35.
21. Egen, J.G., M.S. Kuhns, and J.P. Allison. 2002. CTLA-4: new insights into its biological function and use in tumor immunotherapy. Nat. Immunol. 3:611-618.
22. Marengere, L.E., P. Waterhouse, G.S. Duncan, H.W. Mittrucker, G.S. Feng, and T.W. Mak. 1996. Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science. 272:1170-1173.
23. Guntermann, C., and D.R. Alexander. 2002. CTLA-4 suppresses proximal TCR signaling in resting human CD4(+) T cells by inhibiting ZAP-70 Tyr(319) phosphorylation: a potential role for tyrosine phosphatases. J. Immunol. 168:4420-4429.
24. Schwartz, J.C., X. Zhang, S.G. Nathenson, and S.C. Almo. 2002. Structural mechanisms of costimulation. Nat. Immunol. 3:427-434.
25. Krummel, M.F., M.D. Sjaastad, C. Wulfing, and M.M. Davis. 2000. Differential clustering of CD4 and CD3ζ during T cell recognition. Science. 289:1349-1352.