-
1
-
-
0029947568
-
Enhancement of antitumor immunity by CTLA-4 blockade
-
Leach, R. L., M. F. Krummel, and J. P. Allison. 1996 Enhancement of antitumor immunity by CTLA-4 blockade. Science 271:1734.
-
(1996)
Science
, vol.271
, pp. 1734
-
-
Leach, R.L.1
Krummel, M.F.2
Allison, J.P.3
-
2
-
-
0030853610
-
Enhanced induction of antitumor T-cell responses by cytotoxic T lymphocyte-associated molecule-4 blockade: The effect is manifested only at the restricted tumor-bearing stages
-
Yang, Y. F., J. P. Zou, J. Mu, R. Wijesuriya, S. Ono, T. Walunas, J. Bluestone, H. Fujiwara, and T. Hamaoka. 1997. Enhanced induction of antitumor T-cell responses by cytotoxic T lymphocyte-associated molecule-4 blockade: the effect is manifested only at the restricted tumor-bearing stages. Cancer Res. 57:4036.
-
(1997)
Cancer Res.
, vol.57
, pp. 4036
-
-
Yang, Y.F.1
Zou, J.P.2
Mu, J.3
Wijesuriya, R.4
Ono, S.5
Walunas, T.6
Bluestone, J.7
Fujiwara, H.8
Hamaoka, T.9
-
3
-
-
0029789389
-
CTLA-4: A negative regulator of autoimmune disease
-
Karandikar, N. J., C. L. Vanderlugt, T. L. Walunas, S. D. Miller, and J. A. Bluestone. 1996. CTLA-4: a negative regulator of autoimmune disease. J. Exp. Med. 184:783.
-
(1996)
J. Exp. Med.
, vol.184
, pp. 783
-
-
Karandikar, N.J.1
Vanderlugt, C.L.2
Walunas, T.L.3
Miller, S.D.4
Bluestone, J.A.5
-
4
-
-
2642655282
-
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes
-
Luhder, F., P. Hoglund, J. P. Allison, C. Benoist, and D. Mathis. 1998. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes. J. Exp. Med. 187:427.
-
(1998)
J. Exp. Med.
, vol.187
, pp. 427
-
-
Luhder, F.1
Hoglund, P.2
Allison, J.P.3
Benoist, C.4
Mathis, D.5
-
5
-
-
0030586626
-
CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis
-
Perrin, P. J., J. H. Maldonado, T. A. Davis, C. H. June, and M. K. Racke. 1996. CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis. J. Immunol. 157:1333.
-
(1996)
J. Immunol.
, vol.157
, pp. 1333
-
-
Perrin, P.J.1
Maldonado, J.H.2
Davis, T.A.3
June, C.H.4
Racke, M.K.5
-
6
-
-
0028791059
-
Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4
-
Waterhouse, P., J. M. Penninger, E. Timms, A. Wakeham, A. Shahinian, K. P. Lee, C. B. Thompson, H. Griesser, and T. W. Mak. 1995. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 270:985.
-
(1995)
Science
, vol.270
, pp. 985
-
-
Waterhouse, P.1
Penninger, J.M.2
Timms, E.3
Wakeham, A.4
Shahinian, A.5
Lee, K.P.6
Thompson, C.B.7
Griesser, H.8
Mak, T.W.9
-
7
-
-
0028867420
-
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
-
Tivol, E. A., F. Borriello, A. N. Schweitzer, W. P. Lynch, J. A. Bluestone, and A. H. Sharpe. 1995. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3:541.
-
(1995)
Immunity
, vol.3
, pp. 541
-
-
Tivol, E.A.1
Borriello, F.2
Schweitzer, A.N.3
Lynch, W.P.4
Bluestone, J.A.5
Sharpe, A.H.6
-
8
-
-
0029899783
-
CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
-
Krummel, M. F., and J. P. Allison. 1996. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J. Exp. Med. 183:2533.
-
(1996)
J. Exp. Med.
, vol.183
, pp. 2533
-
-
Krummel, M.F.1
Allison, J.P.2
-
9
-
-
0029953858
-
CTLA-4 ligation blocks CD28-dependent T cell activation
-
Walunas, T. L., C. Y. Bakker, and J. A. Bluestone. 1996. CTLA-4 ligation blocks CD28-dependent T cell activation. J. Exp. Med. 183:2541.
-
(1996)
J. Exp. Med.
, vol.183
, pp. 2541
-
-
Walunas, T.L.1
Bakker, C.Y.2
Bluestone, J.A.3
-
10
-
-
0030707866
-
2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor ζ and ZAP70
-
2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor ζ and ZAP70. J Exp. Med. 186:1645.
-
(1997)
J Exp. Med.
, vol.186
, pp. 1645
-
-
Revilla Calvo, C.1
Amsen, D.2
Kruisbeek, A.M.3
-
11
-
-
0030001318
-
Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4
-
Marengere, L. E., P. Waterhouse, G. S. Duncan, H. W. Mittrucker, G. S. Feng, and T. W. Mak. 1996. Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science 272:1170.
-
(1996)
Science
, vol.272
, pp. 1170
-
-
Marengere, L.E.1
Waterhouse, P.2
Duncan, G.S.3
Mittrucker, H.W.4
Feng, G.S.5
Mak, T.W.6
-
12
-
-
0027403027
-
SH2 domains recognize specific phosphopeptide sequences
-
Songyang, Z., S. E. Shoelson, M. Chaudhuri, G. Gish, T. Pawson, W. G. Haser, F. King, T. Roberts, S. Ratnofsky, R. J. Lechleider, et al. 1993. SH2 domains recognize specific phosphopeptide sequences. Cell 72:767.
-
(1993)
Cell
, vol.72
, pp. 767
-
-
Songyang, Z.1
Shoelson, S.E.2
Chaudhuri, M.3
Gish, G.4
Pawson, T.5
Haser, W.G.6
King, F.7
Roberts, T.8
Ratnofsky, S.9
Lechleider, R.J.10
-
13
-
-
0028910221
-
CTLA-4 binding to lipid kinase phosphatidylinositol 3-kinase in T cells
-
Schneider, H., K. V. S. Prasad, S. E. Shoelson, and C. E. Rudd. 1995. CTLA-4 binding to lipid kinase phosphatidylinositol 3-kinase in T cells. J. Exp. Med. 181:351.
-
(1995)
J. Exp. Med.
, vol.181
, pp. 351
-
-
Schneider, H.1
Prasad, K.V.S.2
Shoelson, S.E.3
Rudd, C.E.4
-
14
-
-
0030611358
-
Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein
-
Zhang, Y., and J. P. Allison. 1997. Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein. Proc. Natl. Acad. Sci. USA 94:9273.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 9273
-
-
Zhang, Y.1
Allison, J.P.2
-
15
-
-
0030917081
-
Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2
-
Shiratori, T., S. Miyatake, H. Ohno, C. Nakaseko, K. Isono, J. S. Bonifacino, and T. Saito. 1997. Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2. Immunity 6:593.
-
(1997)
Immunity
, vol.6
, pp. 593
-
-
Shiratori, T.1
Miyatake, S.2
Ohno, H.3
Nakaseko, C.4
Isono, K.5
Bonifacino, J.S.6
Saito, T.7
-
16
-
-
0031181647
-
Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression
-
Chuang, E., M.-L. Alegre, C. S. Duckett, P. J. Noel, M. G. VanderHeiden, and C. B. Thompson. 1997. Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression. J. Immunol. 159:144.
-
(1997)
J. Immunol.
, vol.159
, pp. 144
-
-
Chuang, E.1
Alegre, M.-L.2
Duckett, C.S.3
Noel, P.J.4
Vanderheiden, M.G.5
Thompson, C.B.6
-
17
-
-
0031471027
-
Interaction of the cytoplasmic tail of CTLA-4 (CD152) with a clathrin-associated protein is negatively regulated by tyrosine phosphorylation
-
Bradshaw, J. D., P. Lu, G. Leytze, J. Rodgers, G. L. Schieven, K. L. Bennett, P. S. Linsley, and S. E. Kurtz. 1997. Interaction of the cytoplasmic tail of CTLA-4 (CD152) with a clathrin-associated protein is negatively regulated by tyrosine phosphorylation. Biochemistry 36:15975.
-
(1997)
Biochemistry
, vol.36
, pp. 15975
-
-
Bradshaw, J.D.1
Lu, P.2
Leytze, G.3
Rodgers, J.4
Schieven, G.L.5
Bennett, K.L.6
Linsley, P.S.7
Kurtz, S.E.8
-
18
-
-
0028484545
-
CTLA-4 can function as a negative regulator of T cell activation
-
Walunas, T. L., D. J. Lenschow, C. Y. Bakker, P. S. Linsley, G. J. Freeman, J. M. Green, C. B. Thompson, and J. A. Bluestone. 1994. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1:405.
-
(1994)
Immunity
, vol.1
, pp. 405
-
-
Walunas, T.L.1
Lenschow, D.J.2
Bakker, C.Y.3
Linsley, P.S.4
Freeman, G.J.5
Green, J.M.6
Thompson, C.B.7
Bluestone, J.A.8
-
19
-
-
0027531637
-
SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases
-
Feng, G.-S., Hui, C.-C. and Pawson, T. 1993. SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science 259:1607.
-
(1993)
Science
, vol.259
, pp. 1607
-
-
Feng, G.-S.1
Hui, C.-C.2
Pawson, T.3
-
20
-
-
0025872369
-
Reconstitution of an active surface CD2 by DNA transfer in CD2-CD3+ Jurkat cells facilitates CD3-T cell receptor-mediated IL-2 production
-
Makni, H., J. S. Malter, J. C. Reed, S. Nobuhiko, G. Lang, D. Kioussis, G. Trinchieri, and M. Kamoun. 1991. Reconstitution of an active surface CD2 by DNA transfer in CD2-CD3+ Jurkat cells facilitates CD3-T cell receptor-mediated IL-2 production. J. Immunol. 146:2522.
-
(1991)
J. Immunol.
, vol.146
, pp. 2522
-
-
Makni, H.1
Malter, J.S.2
Reed, J.C.3
Nobuhiko, S.4
Lang, G.5
Kioussis, D.6
Trinchieri, G.7
Kamoun, M.8
-
21
-
-
0025819491
-
Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations
-
Gajewski, T. F., M. Pinnas, T. Wong, and F. W. Fitch. 1991. Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations. J. Immunol. 146:1750.
-
(1991)
J. Immunol.
, vol.146
, pp. 1750
-
-
Gajewski, T.F.1
Pinnas, M.2
Wong, T.3
Fitch, F.W.4
-
22
-
-
0032498231
-
LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
-
Zhang, W., J. Sloan-Lancaster, J. Kitchen, R. P. Trible, and L. E. Samelson. 1998. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92:83.
-
(1998)
Cell
, vol.92
, pp. 83
-
-
Zhang, W.1
Sloan-Lancaster, J.2
Kitchen, J.3
Trible, R.P.4
Samelson, L.E.5
-
23
-
-
0024991898
-
pEF-BOS, a powerful mammalian expression vector
-
Mizushima, S., and S. Nagata. 1990. pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res. 18:5322.
-
(1990)
Nucleic Acids Res.
, vol.18
, pp. 5322
-
-
Mizushima, S.1
Nagata, S.2
-
24
-
-
0030250114
-
Complex complexes: Signaling at the TCR
-
Wange, R. L., and L. E. Samelson. 1996. Complex complexes: signaling at the TCR. Immunity 5:197.
-
(1996)
Immunity
, vol.5
, pp. 197
-
-
Wange, R.L.1
Samelson, L.E.2
-
25
-
-
0026522204
-
lck
-
lck. Nature 357:161.
-
(1992)
Nature
, vol.357
, pp. 161
-
-
Molina, T.J.1
Kishihara, K.2
Siderovski, D.P.3
Van Ewijk, W.4
Narendran, A.5
Timms, E.6
Wakeham, A.7
Paige, C.J.8
Hartmann, K.U.9
Veillette, A.10
Davidson, D.11
Mak, T.W.12
-
26
-
-
0026705903
-
Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor
-
Straus, D. B., and A. Weiss. 1992. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell 70:585.
-
(1992)
Cell
, vol.70
, pp. 585
-
-
Straus, D.B.1
Weiss, A.2
-
27
-
-
0029655668
-
Signal transduction by the lymphocyte-specific tyrosine protein kinase p56lck
-
Weil, R., and A. Veillette. 1996. Signal transduction by the lymphocyte-specific tyrosine protein kinase p56lck. Curr. Tap. Microbiol. Immunol. 205:63.
-
(1996)
Curr. Tap. Microbiol. Immunol.
, vol.205
, pp. 63
-
-
Weil, R.1
Veillette, A.2
-
28
-
-
0029972114
-
Differential phosphorylation of the T lymphocyte costimulatory receptor CD28: Activation-dependent changes and regulation by protein kinase C
-
Hutchcroft, J. E., B. Tsai, and B. E. Bierer. 1996. Differential phosphorylation of the T lymphocyte costimulatory receptor CD28: activation-dependent changes and regulation by protein kinase C. J. Biol. Chem. 271:13362.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 13362
-
-
Hutchcroft, J.E.1
Tsai, B.2
Bierer, B.E.3
-
29
-
-
0028981212
-
fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: Implications for T-cell costimulation
-
fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation. Proc. Natl. Acad. Sci. USA 92:8891.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 8891
-
-
Raab, M.1
Cai, Y.-C.2
Bunnell, S.C.3
Heyeck, S.D.4
Berg, L.J.5
Rudd, C.E.6
-
30
-
-
0029989312
-
Functional LCK is required for optimal CD28-mediated activation of the TEC family tyrosine kinase EMT/ITK
-
Gibson, S., A. August, D. Branch, B. Dupont, and G. M. Mills. 1996. Functional LCK is required for optimal CD28-mediated activation of the TEC family tyrosine kinase EMT/ITK. J. Biol. Chem. 271:7079.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 7079
-
-
Gibson, S.1
August, A.2
Branch, D.3
Dupont, B.4
Mills, G.M.5
-
31
-
-
0027940531
-
CD28 signal transduction: Tyrosine phosphorylation and receptor association of phosphoinositide-3 kinase correlate with Ca(2+)-independent costimulatory activity
-
Lu, Y., C. A. Phillips, J. M. Bjorndahl, and J. M. Trevillyan. 1994. CD28 signal transduction: tyrosine phosphorylation and receptor association of phosphoinositide-3 kinase correlate with Ca(2+)-independent costimulatory activity. Eur. J. Immunol. 24:2732.
-
(1994)
Eur. J. Immunol.
, vol.24
, pp. 2732
-
-
Lu, Y.1
Phillips, C.A.2
Bjorndahl, J.M.3
Trevillyan, J.M.4
-
32
-
-
0031896945
-
Two distinct regions of the CD28 intracytoplasmic domain are involved in the tyrosine phosphorylation of Vav and GTPase activating protein-associated p62 protein
-
Klasen, S., F. Pages, J. F. Peyron, D. A. Cantrell, and D. Olive. 1998. Two distinct regions of the CD28 intracytoplasmic domain are involved in the tyrosine phosphorylation of Vav and GTPase activating protein-associated p62 protein. Int. Immunol. 10:481.
-
(1998)
Int. Immunol.
, vol.10
, pp. 481
-
-
Klasen, S.1
Pages, F.2
Peyron, J.F.3
Cantrell, D.A.4
Olive, D.5
-
33
-
-
0028989144
-
Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling
-
Pani, G., M. Kozlowski, J. C. Cambier, G. B. Mills, and K. A. Siminovitch. 1995. Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling. J. Exp. Med. 181:2077.
-
(1995)
J. Exp. Med.
, vol.181
, pp. 2077
-
-
Pani, G.1
Kozlowski, M.2
Cambier, J.C.3
Mills, G.B.4
Siminovitch, K.A.5
-
34
-
-
0029787216
-
Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C lyrosine phosphatase
-
Pani, G., K.-D. Fischer, I. Mlinaric-Rascan, and K. A. Siminovitch. 1996. Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C lyrosine phosphatase. J. Exp. Med. 184:839.
-
(1996)
J. Exp. Med.
, vol.184
, pp. 839
-
-
Pani, G.1
Fischer, K.-D.2
Mlinaric-Rascan, I.3
Siminovitch, K.A.4
-
35
-
-
0029904138
-
Direct regulation of Zap70 by SHP-1 in T cell antigen receptor signaling
-
Plas, D. R., R. Johnson, J. T. Pingel, R. J. Matthews, M. Dalton, G. Roy, A. C. Chan, and M. L. Thomas. 1996. Direct regulation of Zap70 by SHP-1 in T cell antigen receptor signaling. Science 272:1173.
-
(1996)
Science
, vol.272
, pp. 1173
-
-
Plas, D.R.1
Johnson, R.2
Pingel, J.T.3
Matthews, R.J.4
Dalton, M.5
Roy, G.6
Chan, A.C.7
Thomas, M.L.8
-
36
-
-
0030024788
-
Recruitment of tyrosine phosphatase HCP by the killer cell inhibitory receptor
-
Burshtyn, D. N., A. M. Scharenberg, N. Wagtmann, S. Rajagopalan, K. Berrada, T. Yi, J.-P. Kinet, and E. O. Long. 1996. Recruitment of tyrosine phosphatase HCP by the killer cell inhibitory receptor. Immunity 4:77.
-
(1996)
Immunity
, vol.4
, pp. 77
-
-
Burshtyn, D.N.1
Scharenberg, A.M.2
Wagtmann, N.3
Rajagopalan, S.4
Berrada, K.5
Yi, T.6
Kinet, J.-P.7
Long, E.O.8
-
37
-
-
0008900035
-
Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases
-
Olcese, L., P. Lang, F. Vely, A. Cambiaggi, D. Marguet, M. Blery, K. L. Hippen, R. Biassoni, A. Moretta, L. Moretta, J. C. Cambier, and E. Vivier. 1996. Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases. J. Immunol. 156.
-
(1996)
J. Immunol.
, vol.156
-
-
Olcese, L.1
Lang, P.2
Vely, F.3
Cambiaggi, A.4
Marguet, D.5
Blery, M.6
Hippen, K.L.7
Biassoni, R.8
Moretta, A.9
Moretta, L.10
Cambier, J.C.11
Vivier, E.12
-
38
-
-
0027432407
-
Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor
-
Lechleider, R. J., S. Sugimoto, A. M. Bennett, A. S. Kashishian, J. A. Cooper, S. E. Shoelson, C. T. Walsh, and B. G. Neel. 1993. Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor. J. Biol. Chem. 268:21478.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 21478
-
-
Lechleider, R.J.1
Sugimoto, S.2
Bennett, A.M.3
Kashishian, A.S.4
Cooper, J.A.5
Shoelson, S.E.6
Walsh, C.T.7
Neel, B.G.8
-
39
-
-
0028123457
-
A new function for a phosphotyrosine phosphatase: Linking GRB2-Sos to a receptor tyrosine kinase
-
Li, W., R. Nishimura, A. Kashishian, A. G. Batzer, W. J. Kim, J. A. Cooper, and J. Schlessinger. 1994. A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase. Mol. Cell. Biol. 14:509.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 509
-
-
Li, W.1
Nishimura, R.2
Kashishian, A.3
Batzer, A.G.4
Kim, W.J.5
Cooper, J.A.6
Schlessinger, J.7
-
40
-
-
0028895654
-
Modular binding domains in signal transduction proteins
-
Cohen, G. B., Ren, R., and Baltimore, D. 1995. Modular binding domains in signal transduction proteins. Cell 80:237.
-
(1995)
Cell
, vol.80
, pp. 237
-
-
Cohen, G.B.1
Ren, R.2
Baltimore, D.3
-
41
-
-
0032482171
-
The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated protein kinase (MAPK) pathway in Jurkat T cells
-
Frearson, J. A., and D. R. Alexander. 1998. The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated protein kinase (MAPK) pathway in Jurkat T cells. J. Exp. Med. 187:1417.
-
(1998)
J. Exp. Med.
, vol.187
, pp. 1417
-
-
Frearson, J.A.1
Alexander, D.R.2
|