Mitochondrial reactive oxygen species control T cell activation by regulating IL-2 and IL-4 expression: Mechanism of ciprofloxacin-mediated immunosuppression

Journal of Immunology

Volumn 184, Issue 9, 2010, Pages 4827-4841

  Kamiński, Marcin M ^a   Sauer, Sven W ^a   Klemke, Claus Detlev ^b   Süss, Dorothee ^a   Okun, Jürgen G ^a   Krammer, Peter H ^a   Gülow, Karsten ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; CHAPERONE NDUFAF1; CIPROFLOXACIN; COMPLEX I INHIBITOR; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; INTERLEUKIN 4; MITOCHONDRIAL DNA; OXIDOREDUCTASE INHIBITOR; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SMALL INTERFERING RNA; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; IL2 PROTEIN, HUMAN; IL4 PROTEIN, HUMAN; IMMUNOSUPPRESSIVE AGENT; LYMPHOCYTE ANTIGEN RECEPTOR; NDUFAF1 PROTEIN, HUMAN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE;

ARTICLE; ATOPIC DERMATITIS; CELL ISOLATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOSE RESPONSE; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; MEDIATOR; MITOCHONDRIAL DNA DEPLETION; MITOCHONDRION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; REGULATORY MECHANISM; RESPIRATORY CHAIN; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; BIOSYNTHESIS; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; IMMUNOPHENOTYPING; LEUKEMIA CELL LINE; LYMPHOCYTE ACTIVATION; METABOLISM; SECRETION; TH2 CELL; TIME;

CELLS, CULTURED; CIPROFLOXACIN; DERMATITIS, ATOPIC; DNA, MITOCHONDRIAL; ELECTRON TRANSPORT COMPLEX I; GENE EXPRESSION REGULATION; HUMANS; IMMUNOPHENOTYPING; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-2; INTERLEUKIN-4; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MITOCHONDRIA; NADH DEHYDROGENASE; REACTIVE OXYGEN SPECIES; RECEPTORS, ANTIGEN, T-CELL; RNA, SMALL INTERFERING; T-LYMPHOCYTES; TH2 CELLS; TIME FACTORS;

EID: 77954523037     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0901662     Document Type: Article

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