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Volumn 35, Issue 4, 2014, Pages 170-177

Single cell behavior in T cell differentiation

Author keywords

Asymmetric cell division; Cell extrinsic signals; Cellular heterogeneity; Population asymmetry; Single cell tracking; T cell differentiation

Indexed keywords

ASYMMETRIC CELL DIVISION; CELL FATE; CELL PROTECTION; CELL SHAPE; CELL TRACKING; HUMAN; IMMUNOLOGICAL MEMORY; INTRACELLULAR SIGNALING; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIMARY INFECTION; REVIEW; SINGLE CELL ANALYSIS; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; ANIMAL; CELL DIFFERENTIATION; CYTOLOGY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION;

EID: 84897461216     PISSN: 14714906     EISSN: 14714981     Source Type: Journal    
DOI: 10.1016/j.it.2014.02.006     Document Type: Review
Times cited : (27)

References (71)
  • 1
    • 79251572042 scopus 로고    scopus 로고
    • The descent of memory T cells
    • Gerlach C., et al. The descent of memory T cells. Ann. N. Y. Acad. Sci. 2011, 1217:139-153.
    • (2011) Ann. N. Y. Acad. Sci. , vol.1217 , pp. 139-153
    • Gerlach, C.1
  • 2
    • 0037331132 scopus 로고    scopus 로고
    • The repertoires of circulating human CD8(+) central and effector memory T cell subsets are largely distinct
    • Baron V., et al. The repertoires of circulating human CD8(+) central and effector memory T cell subsets are largely distinct. Immunity 2003, 18:193-204.
    • (2003) Immunity , vol.18 , pp. 193-204
    • Baron, V.1
  • 3
    • 14244259568 scopus 로고    scopus 로고
    • Lineage relationships, homeostasis, and recall capacities of central- and effector-memory CD8 T cells in vivo
    • Bouneaud C., et al. Lineage relationships, homeostasis, and recall capacities of central- and effector-memory CD8 T cells in vivo. J. Exp. Med. 2005, 201:579-590.
    • (2005) J. Exp. Med. , vol.201 , pp. 579-590
    • Bouneaud, C.1
  • 4
    • 33745116185 scopus 로고    scopus 로고
    • Early establishment of diverse T cell receptor profiles for influenza-specific CD8(+)CD62L(hi) memory T cells
    • Kedzierska K., et al. Early establishment of diverse T cell receptor profiles for influenza-specific CD8(+)CD62L(hi) memory T cells. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:9184-9189.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 9184-9189
    • Kedzierska, K.1
  • 5
    • 84863563586 scopus 로고    scopus 로고
    • The origin of diversity: studying the evolution of multi-faceted CD8+ T cell responses
    • Buchholz V.R., et al. The origin of diversity: studying the evolution of multi-faceted CD8+ T cell responses. Cell. Mol. Life Sci. 2012, 69:1585-1595.
    • (2012) Cell. Mol. Life Sci. , vol.69 , pp. 1585-1595
    • Buchholz, V.R.1
  • 6
    • 84856278095 scopus 로고    scopus 로고
    • Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes
    • Newell E.W., et al. Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes. Immunity 2012, 36:142-152.
    • (2012) Immunity , vol.36 , pp. 142-152
    • Newell, E.W.1
  • 7
    • 84856269120 scopus 로고    scopus 로고
    • The numerology of T cell functional diversity
    • Haining W.N. The numerology of T cell functional diversity. Immunity 2012, 36:10-12.
    • (2012) Immunity , vol.36 , pp. 10-12
    • Haining, W.N.1
  • 8
    • 84858774008 scopus 로고    scopus 로고
    • Behavior and function of tissue-resident memory T cells
    • Ariotti S., et al. Behavior and function of tissue-resident memory T cells. Adv. Immunol. 2012, 114:203-216.
    • (2012) Adv. Immunol. , vol.114 , pp. 203-216
    • Ariotti, S.1
  • 9
    • 84883720814 scopus 로고    scopus 로고
    • The smallest unit: effector and memory CD8(+) T cell differentiation on the single cell level
    • Buchholz V.R., et al. The smallest unit: effector and memory CD8(+) T cell differentiation on the single cell level. Front. Immunol. 2013, 4:31.
    • (2013) Front. Immunol. , vol.4 , pp. 31
    • Buchholz, V.R.1
  • 10
    • 79958263078 scopus 로고    scopus 로고
    • Strategies for homeostatic stem cell self-renewal in adult tissues
    • Simons B.D., Clevers H. Strategies for homeostatic stem cell self-renewal in adult tissues. Cell 2011, 145:851-862.
    • (2011) Cell , vol.145 , pp. 851-862
    • Simons, B.D.1    Clevers, H.2
  • 11
    • 84870230968 scopus 로고    scopus 로고
    • Functional immunoimaging: the revolution continues
    • Bousso P., Moreau H.D. Functional immunoimaging: the revolution continues. Nat. Rev. Immunol. 2012, 12:858-864.
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 858-864
    • Bousso, P.1    Moreau, H.D.2
  • 12
    • 34548381245 scopus 로고    scopus 로고
    • TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets
    • Wong J., et al. TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets. J. Exp. Med. 2007, 204:2039-2045.
    • (2007) J. Exp. Med. , vol.204 , pp. 2039-2045
    • Wong, J.1
  • 13
    • 0029072262 scopus 로고
    • Cell expansion and growth arrest phases during the transition from precursor (CD4-8-) to immature (CD4+8+) thymocytes in normal and genetically modified mice
    • Penit C., et al. Cell expansion and growth arrest phases during the transition from precursor (CD4-8-) to immature (CD4+8+) thymocytes in normal and genetically modified mice. J. Immunol. 1995, 154:5103-5113.
    • (1995) J. Immunol. , vol.154 , pp. 5103-5113
    • Penit, C.1
  • 14
    • 0029082346 scopus 로고
    • Thymic selection and cell division
    • Ernst B., et al. Thymic selection and cell division. J. Exp. Med. 1995, 182:961-971.
    • (1995) J. Exp. Med. , vol.182 , pp. 961-971
    • Ernst, B.1
  • 15
    • 84883319318 scopus 로고    scopus 로고
    • Differential postselection proliferation dynamics of alphabeta T cells, Foxp3+ regulatory T cells, and invariant NKT cells monitored by genetic pulse labeling
    • Fohse L., et al. Differential postselection proliferation dynamics of alphabeta T cells, Foxp3+ regulatory T cells, and invariant NKT cells monitored by genetic pulse labeling. J. Immunol. 2013, 191:2384-2392.
    • (2013) J. Immunol. , vol.191 , pp. 2384-2392
    • Fohse, L.1
  • 16
    • 77956176530 scopus 로고    scopus 로고
    • Mapping the life histories of T cells
    • Schumacher T.N.M., et al. Mapping the life histories of T cells. Nat. Rev. Immunol. 2010, 10:621-631.
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 621-631
    • Schumacher, T.N.M.1
  • 17
    • 84877625807 scopus 로고    scopus 로고
    • Disparate individual fates compose robust CD8+ T cell immunity
    • Buchholz V.R., et al. Disparate individual fates compose robust CD8+ T cell immunity. Science 2013, 340:630-635.
    • (2013) Science , vol.340 , pp. 630-635
    • Buchholz, V.R.1
  • 18
    • 77953520973 scopus 로고    scopus 로고
    • One naive T cell, multiple fates in CD8+ T cell differentiation
    • Gerlach C., et al. One naive T cell, multiple fates in CD8+ T cell differentiation. J. Exp. Med. 2010, 207:1235-1246.
    • (2010) J. Exp. Med. , vol.207 , pp. 1235-1246
    • Gerlach, C.1
  • 19
    • 84877601429 scopus 로고    scopus 로고
    • Heterogeneous differentiation patterns of individual CD8+ T cells
    • Gerlach C., et al. Heterogeneous differentiation patterns of individual CD8+ T cells. Science 2013, 340:635-639.
    • (2013) Science , vol.340 , pp. 635-639
    • Gerlach, C.1
  • 20
    • 53349143662 scopus 로고    scopus 로고
    • Dissecting T cell lineage relationships by cellular barcoding
    • Schepers K., et al. Dissecting T cell lineage relationships by cellular barcoding. J. Exp. Med. 2008, 205:2309-2318.
    • (2008) J. Exp. Med. , vol.205 , pp. 2309-2318
    • Schepers, K.1
  • 21
    • 69949127813 scopus 로고    scopus 로고
    • Recruitment of antigen-specific CD8+ T cells in response to infection is markedly efficient
    • van Heijst J.W.J., et al. Recruitment of antigen-specific CD8+ T cells in response to infection is markedly efficient. Science 2009, 325:1265-1269.
    • (2009) Science , vol.325 , pp. 1265-1269
    • van Heijst, J.W.J.1
  • 22
    • 84882603974 scopus 로고    scopus 로고
    • Environmental cues dictate the fate of individual CD8 T cells responding to infection
    • Plumlee C.R., et al. Environmental cues dictate the fate of individual CD8 T cells responding to infection. Immunity 2013, 39:347-356.
    • (2013) Immunity , vol.39 , pp. 347-356
    • Plumlee, C.R.1
  • 23
    • 37049013109 scopus 로고    scopus 로고
    • A single naive CD8+ T cell precursor can develop into diverse effector and memory subsets
    • Stemberger C., et al. A single naive CD8+ T cell precursor can develop into diverse effector and memory subsets. Immunity 2007, 27:985-997.
    • (2007) Immunity , vol.27 , pp. 985-997
    • Stemberger, C.1
  • 24
    • 84877710866 scopus 로고    scopus 로고
    • Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection
    • Tubo N.J., et al. Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection. Cell 2013, 153:785-796.
    • (2013) Cell , vol.153 , pp. 785-796
    • Tubo, N.J.1
  • 25
    • 84864146822 scopus 로고    scopus 로고
    • Cell lineage analysis of acute leukemia relapse uncovers the role of replication-rate heterogeneity and microsatellite instability
    • Shlush L.I., et al. Cell lineage analysis of acute leukemia relapse uncovers the role of replication-rate heterogeneity and microsatellite instability. Blood 2012, 120:603-612.
    • (2012) Blood , vol.120 , pp. 603-612
    • Shlush, L.I.1
  • 26
    • 33947730608 scopus 로고    scopus 로고
    • Asymmetric T lymphocyte division in the initiation of adaptive immune responses
    • Chang J.T., et al. Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science 2007, 315:1687-1691.
    • (2007) Science , vol.315 , pp. 1687-1691
    • Chang, J.T.1
  • 27
    • 79954906546 scopus 로고    scopus 로고
    • Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division
    • Chang J.T., et al. Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division. Immunity 2011, 34:492-504.
    • (2011) Immunity , vol.34 , pp. 492-504
    • Chang, J.T.1
  • 28
    • 84856071457 scopus 로고    scopus 로고
    • Asymmetric B cell division in the germinal center reaction
    • Barnett B.E., et al. Asymmetric B cell division in the germinal center reaction. Science 2012, 335:342-344.
    • (2012) Science , vol.335 , pp. 342-344
    • Barnett, B.E.1
  • 29
    • 84867814099 scopus 로고    scopus 로고
    • T cell affinity regulates asymmetric division, effector cell differentiation, and tissue pathology
    • King C.G., et al. T cell affinity regulates asymmetric division, effector cell differentiation, and tissue pathology. Immunity 2012, 37:709-720.
    • (2012) Immunity , vol.37 , pp. 709-720
    • King, C.G.1
  • 30
    • 62249131518 scopus 로고    scopus 로고
    • Complete but curtailed T-cell response to very low-affinity antigen
    • Zehn D., et al. Complete but curtailed T-cell response to very low-affinity antigen. Nature 2009, 458:211-214.
    • (2009) Nature , vol.458 , pp. 211-214
    • Zehn, D.1
  • 31
    • 0034628471 scopus 로고    scopus 로고
    • Localization of apical epithelial determinants by the basolateral PDZ protein Scribble
    • Bilder D., Perrimon N. Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature 2000, 403:676-680.
    • (2000) Nature , vol.403 , pp. 676-680
    • Bilder, D.1    Perrimon, N.2
  • 32
    • 0037318955 scopus 로고    scopus 로고
    • Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry
    • Albertson R., Doe C.Q. Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry. Nat. Cell Biol. 2003, 5:166-170.
    • (2003) Nat. Cell Biol. , vol.5 , pp. 166-170
    • Albertson, R.1    Doe, C.Q.2
  • 33
    • 84877760790 scopus 로고    scopus 로고
    • Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity
    • Hawkins E.D., et al. Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity. Nat. Commun. 2013, 4:1801.
    • (2013) Nat. Commun. , vol.4 , pp. 1801
    • Hawkins, E.D.1
  • 34
    • 0014421064 scopus 로고
    • Evolutionary rate at the molecular level
    • Kimura M. Evolutionary rate at the molecular level. Nature 1968, 217:624-626.
    • (1968) Nature , vol.217 , pp. 624-626
    • Kimura, M.1
  • 35
    • 84865372949 scopus 로고    scopus 로고
    • Dynamic in situ cytometry uncovers T cell receptor signaling during immunological synapses and kinapses in vivo
    • Moreau H.D., et al. Dynamic in situ cytometry uncovers T cell receptor signaling during immunological synapses and kinapses in vivo. Immunity 2012, 37:351-363.
    • (2012) Immunity , vol.37 , pp. 351-363
    • Moreau, H.D.1
  • 36
    • 84881440947 scopus 로고    scopus 로고
    • Phenotypic CD8+ T cell diversification occurs before, during, and after the first T cell division
    • Lemaitre F., et al. Phenotypic CD8+ T cell diversification occurs before, during, and after the first T cell division. J. Immunol. 2013, 191:1578-1585.
    • (2013) J. Immunol. , vol.191 , pp. 1578-1585
    • Lemaitre, F.1
  • 37
    • 84856072934 scopus 로고    scopus 로고
    • Activation-induced B cell fates are selected by intracellular stochastic competition
    • Duffy K.R., et al. Activation-induced B cell fates are selected by intracellular stochastic competition. Science 2012, 335:338-341.
    • (2012) Science , vol.335 , pp. 338-341
    • Duffy, K.R.1
  • 38
    • 66249136447 scopus 로고    scopus 로고
    • Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis
    • Spencer S.L., et al. Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature 2009, 459:428-432.
    • (2009) Nature , vol.459 , pp. 428-432
    • Spencer, S.L.1
  • 39
    • 0030797355 scopus 로고    scopus 로고
    • Robustness in simple biochemical networks
    • Barkai N., Leibler S. Robustness in simple biochemical networks. Nature 1997, 387:913-917.
    • (1997) Nature , vol.387 , pp. 913-917
    • Barkai, N.1    Leibler, S.2
  • 40
    • 25144450143 scopus 로고    scopus 로고
    • Contributions of low molecule number and chromosomal positioning to stochastic gene expression
    • Becskei A., et al. Contributions of low molecule number and chromosomal positioning to stochastic gene expression. Nat. Genet. 2005, 37:937-944.
    • (2005) Nat. Genet. , vol.37 , pp. 937-944
    • Becskei, A.1
  • 41
    • 0037119587 scopus 로고    scopus 로고
    • Stochastic gene expression in a single cell
    • Elowitz M.B., et al. Stochastic gene expression in a single cell. Science 2002, 297:1183-1186.
    • (2002) Science , vol.297 , pp. 1183-1186
    • Elowitz, M.B.1
  • 42
    • 19544379881 scopus 로고    scopus 로고
    • Stochasticity in gene expression: from theories to phenotypes
    • Kaern M., et al. Stochasticity in gene expression: from theories to phenotypes. Nat. Rev. Genet. 2005, 6:451-464.
    • (2005) Nat. Rev. Genet. , vol.6 , pp. 451-464
    • Kaern, M.1
  • 43
    • 33745220278 scopus 로고    scopus 로고
    • Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise
    • Newman J.R., et al. Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise. Nature 2006, 441:840-846.
    • (2006) Nature , vol.441 , pp. 840-846
    • Newman, J.R.1
  • 44
    • 33745287724 scopus 로고    scopus 로고
    • Noise in protein expression scales with natural protein abundance
    • Bar-Even A., et al. Noise in protein expression scales with natural protein abundance. Nat. Genet. 2006, 38:636-643.
    • (2006) Nat. Genet. , vol.38 , pp. 636-643
    • Bar-Even, A.1
  • 45
    • 33845257870 scopus 로고    scopus 로고
    • Variability and memory of protein levels in human cells
    • Sigal A., et al. Variability and memory of protein levels in human cells. Nature 2006, 444:643-646.
    • (2006) Nature , vol.444 , pp. 643-646
    • Sigal, A.1
  • 46
    • 84876297531 scopus 로고    scopus 로고
    • Diverse and heritable lineage imprinting of early haematopoietic progenitors
    • Naik S.H., et al. Diverse and heritable lineage imprinting of early haematopoietic progenitors. Nature 2013, 496:229-232.
    • (2013) Nature , vol.496 , pp. 229-232
    • Naik, S.H.1
  • 47
    • 50149090966 scopus 로고    scopus 로고
    • Variability and robustness in T cell activation from regulated heterogeneity in protein levels
    • Feinerman O., et al. Variability and robustness in T cell activation from regulated heterogeneity in protein levels. Science 2008, 321:1081-1084.
    • (2008) Science , vol.321 , pp. 1081-1084
    • Feinerman, O.1
  • 48
    • 77957020259 scopus 로고    scopus 로고
    • Visualizing the functional diversification of CD8+ T cell responses in lymph nodes
    • Beuneu H., et al. Visualizing the functional diversification of CD8+ T cell responses in lymph nodes. Immunity 2010, 33:412-423.
    • (2010) Immunity , vol.33 , pp. 412-423
    • Beuneu, H.1
  • 49
    • 69449098336 scopus 로고    scopus 로고
    • A single-cell pedigree analysis of alternative stochastic lymphocyte fates
    • Hawkins E.D., et al. A single-cell pedigree analysis of alternative stochastic lymphocyte fates. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:13457-13462.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 13457-13462
    • Hawkins, E.D.1
  • 50
    • 33947238281 scopus 로고    scopus 로고
    • A model of immune regulation as a consequence of randomized lymphocyte division and death times
    • Hawkins E.D., et al. A model of immune regulation as a consequence of randomized lymphocyte division and death times. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:5032-5037.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 5032-5037
    • Hawkins, E.D.1
  • 51
    • 33746013487 scopus 로고    scopus 로고
    • Inflaming the CD8+ T cell response
    • Haring J.S., et al. Inflaming the CD8+ T cell response. Immunity 2006, 25:19-29.
    • (2006) Immunity , vol.25 , pp. 19-29
    • Haring, J.S.1
  • 52
    • 77953749960 scopus 로고    scopus 로고
    • Generation of effector CD8+ T cells and their conversion to memory T cells
    • Cui W., Kaech S.M. Generation of effector CD8+ T cells and their conversion to memory T cells. Immunol. Rev. 2010, 236:151-166.
    • (2010) Immunol. Rev. , vol.236 , pp. 151-166
    • Cui, W.1    Kaech, S.M.2
  • 53
    • 79953068965 scopus 로고    scopus 로고
    • Cytokines and the inception of CD8 T cell responses
    • Cox M.A., et al. Cytokines and the inception of CD8 T cell responses. Trends Immunol. 2011, 32:180-186.
    • (2011) Trends Immunol. , vol.32 , pp. 180-186
    • Cox, M.A.1
  • 54
    • 77952515476 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor/tumor necrosis factor family members in antiviral CD8 T-cell immunity
    • Salek-Ardakani S., Croft M. Tumor necrosis factor receptor/tumor necrosis factor family members in antiviral CD8 T-cell immunity. J. Interferon Cytokine Res. 2010, 30:205-218.
    • (2010) J. Interferon Cytokine Res. , vol.30 , pp. 205-218
    • Salek-Ardakani, S.1    Croft, M.2
  • 55
    • 71749113233 scopus 로고    scopus 로고
    • Diversity in T cell memory: an embarrassment of riches
    • Jameson S.C., Masopust D. Diversity in T cell memory: an embarrassment of riches. Immunity 2009, 31:859-871.
    • (2009) Immunity , vol.31 , pp. 859-871
    • Jameson, S.C.1    Masopust, D.2
  • 56
    • 38949174996 scopus 로고    scopus 로고
    • Intercellular adhesion molecule-1-dependent stable interactions between T cells and dendritic cells determine CD8+ T cell memory
    • Scholer A., et al. Intercellular adhesion molecule-1-dependent stable interactions between T cells and dendritic cells determine CD8+ T cell memory. Immunity 2008, 28:258-270.
    • (2008) Immunity , vol.28 , pp. 258-270
    • Scholer, A.1
  • 57
    • 74549156399 scopus 로고    scopus 로고
    • CD4+ T cell regulation of CD25 expression controls development of short-lived effector CD8+ T cells in primary and secondary responses
    • Obar J.J., et al. CD4+ T cell regulation of CD25 expression controls development of short-lived effector CD8+ T cells in primary and secondary responses. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:193-198.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 193-198
    • Obar, J.J.1
  • 58
    • 77957986990 scopus 로고    scopus 로고
    • Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate
    • Beinke S., et al. Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:16234-16239.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 16234-16239
    • Beinke, S.1
  • 59
    • 79957708430 scopus 로고    scopus 로고
    • Expression of chemokine receptor CXCR3 on T cells affects the balance between effector and memory CD8 T-cell generation
    • Hu J.K., et al. Expression of chemokine receptor CXCR3 on T cells affects the balance between effector and memory CD8 T-cell generation. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:E118-E127.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108
    • Hu, J.K.1
  • 60
    • 84864020108 scopus 로고    scopus 로고
    • Signal 3 cytokines as modulators of primary immune responses during infections: the interplay of type I IFN and IL-12 in CD8 T cell responses
    • Keppler S.J., et al. Signal 3 cytokines as modulators of primary immune responses during infections: the interplay of type I IFN and IL-12 in CD8 T cell responses. PLoS ONE 2012, 7:e40865.
    • (2012) PLoS ONE , vol.7
    • Keppler, S.J.1
  • 61
    • 0033559126 scopus 로고    scopus 로고
    • Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells
    • Curtsinger J.M., et al. Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells. J. Immunol. 1999, 162:3256-3262.
    • (1999) J. Immunol. , vol.162 , pp. 3256-3262
    • Curtsinger, J.M.1
  • 62
    • 0033198139 scopus 로고    scopus 로고
    • Adjuvant effect of IL-12: conversion of peptide antigen administration from tolerizing to immunizing for CD8+ T cells in vivo
    • Schmidt C.S., Mescher M.F. Adjuvant effect of IL-12: conversion of peptide antigen administration from tolerizing to immunizing for CD8+ T cells in vivo. J. Immunol. 1999, 163:2561-2567.
    • (1999) J. Immunol. , vol.163 , pp. 2561-2567
    • Schmidt, C.S.1    Mescher, M.F.2
  • 63
    • 33645775256 scopus 로고    scopus 로고
    • Direct stimulation of T cells by type I IFN enhances the CD8+ T cell response during cross-priming
    • Le Bon A., et al. Direct stimulation of T cells by type I IFN enhances the CD8+ T cell response during cross-priming. J. Immunol. 2006, 176:4682-4689.
    • (2006) J. Immunol. , vol.176 , pp. 4682-4689
    • Le Bon, A.1
  • 64
    • 67649220219 scopus 로고    scopus 로고
    • IFN-alpha enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor activity
    • Sikora A.G., et al. IFN-alpha enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor activity. J. Immunol. 2009, 182:7398-7407.
    • (2009) J. Immunol. , vol.182 , pp. 7398-7407
    • Sikora, A.G.1
  • 65
    • 34548027000 scopus 로고    scopus 로고
    • Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor
    • Joshi N.S., et al. Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity 2007, 27:281-295.
    • (2007) Immunity , vol.27 , pp. 281-295
    • Joshi, N.S.1
  • 66
    • 84892534048 scopus 로고    scopus 로고
    • IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivo
    • Starbeck-Miller G.R., et al. IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivo. J. Exp. Med. 2014, 211:105-120.
    • (2014) J. Exp. Med. , vol.211 , pp. 105-120
    • Starbeck-Miller, G.R.1
  • 67
    • 74549162832 scopus 로고    scopus 로고
    • Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo
    • Kalia V., et al. Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo. Immunity 2010, 32:91-103.
    • (2010) Immunity , vol.32 , pp. 91-103
    • Kalia, V.1
  • 68
    • 79958251745 scopus 로고    scopus 로고
    • T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
    • Moran A.E., et al. T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J. Exp. Med. 2011, 208:1279-1289.
    • (2011) J. Exp. Med. , vol.208 , pp. 1279-1289
    • Moran, A.E.1
  • 69
    • 0035500504 scopus 로고    scopus 로고
    • Viral infections induce abundant numbers of senescent CD8 T cells
    • (Baltimore, Md: 1950)
    • Voehringer D., et al. Viral infections induce abundant numbers of senescent CD8 T cells. J. Immunol. 2001, 167:4838-4843. (Baltimore, Md: 1950).
    • (2001) J. Immunol. , vol.167 , pp. 4838-4843
    • Voehringer, D.1
  • 70
    • 0347382593 scopus 로고    scopus 로고
    • Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
    • Kaech S.M., et al. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat. Immunol. 2003, 4:1191-1198.
    • (2003) Nat. Immunol. , vol.4 , pp. 1191-1198
    • Kaech, S.M.1
  • 71
    • 1842681952 scopus 로고    scopus 로고
    • Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets
    • Huster K.M., et al. Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:5610-5615.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 5610-5615
    • Huster, K.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.