Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients

Journal of Experimental Medicine

Volumn 207, Issue 10, 2010, Pages 2175-2186

  Fourcade, Julien ^a   Sun, Zhaojun ^a   Benallaoua, Mourad ^a   Guillaume, Philippe ^b   Luescher, Immanuel F ^b   Sander, Cindy ^a   Kirkwood, John M ^a   Kuchroo, Vijay ^c   Zarour, Hassane M ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 2; MEMBRANE PROTEIN; NY ESO 1 ANTIGEN; PROGRAMMED DEATH 1; PROGRAMMED DEATH 1 LIGAND 1; T CELL IMMUNOGLOBULIN AND MUCIN DOMAIN CONTAINING MOLECULE 3; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNE DISEASE; CANCER PATIENT; CD8+ T LYMPHOCYTE; CELL EXPANSION; CELL PROLIFERATION; CLINICAL ARTICLE; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; EX VIVO STUDY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOSTIMULATION; MELANOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ANTIGENS, CD; ANTIGENS, NEOPLASM; APOPTOSIS REGULATORY PROTEINS; CD8-POSITIVE T-LYMPHOCYTES; EPITOPES, T-LYMPHOCYTE; HUMANS; IMMUNITY, CELLULAR; INTERFERON-GAMMA; INTERLEUKIN-2; MELANOMA; MEMBRANE PROTEINS; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 77957723967     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20100637     Document Type: Article

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